{ "uniprot_canonical_ac": "A0A096MJS9-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 595, "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" }, "uniprot_id": "A0A0G2K4A1_RAT", "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "reaction_enzymes": [ { "gene_name": "Ep300", "uniprot_ac": "B2RWS6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RWS6", "id": "B2RWS6", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RWS6", "id": "B2RWS6", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RWS6", "id": "B2RWS6", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat2a", "uniprot_ac": "D4ACX5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4ACX5", "id": "D4ACX5", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4ACX5", "id": "D4ACX5", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Nat8f7", "uniprot_ac": "E0CYR6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E0CYR6", "id": "E0CYR6", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E0CYR6", "id": "E0CYR6", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat6b", "uniprot_ac": "M0R4T9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R4T9", "id": "M0R4T9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R4T9", "id": "M0R4T9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Clock", "uniprot_ac": "O08785", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O08785", "id": "O08785", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O08785", "id": "O08785", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Ncoa3", "uniprot_ac": "O09000", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O09000", "id": "O09000", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O09000", "id": "O09000", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "HAT1", "uniprot_ac": "O14929", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O14929", "id": "O14929", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O14929", "id": "O14929", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "CLOCK", "uniprot_ac": "O15516", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O15516", "id": "O15516", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O15516", "id": "O15516", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "TAF1", "uniprot_ac": "P21675", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21675", "id": "P21675", "database": "UniProtKB" } ], "ec_number": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21675", "id": "P21675", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21675", "id": "P21675", "database": "UniProtKB" } ], "ec_number": "2.7.11.1", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21675", "id": "P21675", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Crebbp", "uniprot_ac": "P45481", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P45481", "id": "P45481", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P45481", "id": "P45481", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P45481", "id": "P45481", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Gtf2b", "uniprot_ac": "P62915", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P62915", "id": "P62915", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P62915", "id": "P62915", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Gtf2b", "uniprot_ac": "P62916", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P62916", "id": "P62916", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P62916", "id": "P62916", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Ncoa1", "uniprot_ac": "P70365", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P70365", "id": "P70365", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P70365", "id": "P70365", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "GTF2B", "uniprot_ac": "Q00403", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q00403", "id": "Q00403", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q00403", "id": "Q00403", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "EP300", "uniprot_ac": "Q09472", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q09472", "id": "Q09472", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q09472", "id": "Q09472", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q09472", "id": "Q09472", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "NCOA1", "uniprot_ac": "Q15788", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q15788", "id": "Q15788", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q15788", "id": "Q15788", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Naa60", "uniprot_ac": "Q3MHC1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3MHC1", "id": "Q3MHC1", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3MHC1", "id": "Q3MHC1", "database": "UniProtKB" } ], "ec_number": "2.3.1.259", "activity": "Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3MHC1", "id": "Q3MHC1", "database": "UniProtKB" } ], "ec_number": "2.3.1.259", "activity": "" } ] }, { "gene_name": "ESCO2", "uniprot_ac": "Q56NI9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q56NI9", "id": "Q56NI9", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "ESCO1", "uniprot_ac": "Q5FWF5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5FWF5", "id": "Q5FWF5", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "Hat1", "uniprot_ac": "Q5M939", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5M939", "id": "Q5M939", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5M939", "id": "Q5M939", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat7", "uniprot_ac": "Q5SVQ0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5SVQ0", "id": "Q5SVQ0", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5SVQ0", "id": "Q5SVQ0", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat6a", "uniprot_ac": "Q5TKR9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5TKR9", "id": "Q5TKR9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5TKR9", "id": "Q5TKR9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat8", "uniprot_ac": "Q5XI06", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5XI06", "id": "Q5XI06", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5XI06", "id": "Q5XI06", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Esco1", "uniprot_ac": "Q69Z69", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q69Z69", "id": "Q69Z69", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "Crebbp", "uniprot_ac": "Q6JHU9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6JHU9", "id": "Q6JHU9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6JHU9", "id": "Q6JHU9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6JHU9", "id": "Q6JHU9", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "Taf1", "uniprot_ac": "Q80UV9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q80UV9", "id": "Q80UV9", "database": "UniProtKB" } ], "ec_number": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q80UV9", "id": "Q80UV9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q80UV9", "id": "Q80UV9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q80UV9", "id": "Q80UV9", "database": "UniProtKB" } ], "ec_number": "2.7.11.1", "activity": "" } ] }, { "gene_name": "Gtf3c4", "uniprot_ac": "Q8BMQ2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BMQ2", "id": "Q8BMQ2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BMQ2", "id": "Q8BMQ2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat6b", "uniprot_ac": "Q8BRB7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BRB7", "id": "Q8BRB7", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BRB7", "id": "Q8BRB7", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Hat1", "uniprot_ac": "Q8BY71", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BY71", "id": "Q8BY71", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BY71", "id": "Q8BY71", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat6a", "uniprot_ac": "Q8BZ21", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BZ21", "id": "Q8BZ21", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BZ21", "id": "Q8BZ21", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat5", "uniprot_ac": "Q8CHK4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CHK4", "id": "Q8CHK4", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CHK4", "id": "Q8CHK4", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Esco2", "uniprot_ac": "Q8CIB9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CIB9", "id": "Q8CIB9", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "KAT6B", "uniprot_ac": "Q8WYB5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WYB5", "id": "Q8WYB5", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WYB5", "id": "Q8WYB5", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "CREBBP", "uniprot_ac": "Q92793", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92793", "id": "Q92793", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92793", "id": "Q92793", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92793", "id": "Q92793", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "KAT6A", "uniprot_ac": "Q92794", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92794", "id": "Q92794", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92794", "id": "Q92794", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "KAT2A", "uniprot_ac": "Q92830", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92830", "id": "Q92830", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92830", "id": "Q92830", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92830", "id": "Q92830", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "KAT2B", "uniprot_ac": "Q92831", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92831", "id": "Q92831", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92831", "id": "Q92831", "database": "UniProtKB" } ], "ec_number": "2.3.1.57", "activity": "Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92831", "id": "Q92831", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "KAT5", "uniprot_ac": "Q92993", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92993", "id": "Q92993", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92993", "id": "Q92993", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat5", "uniprot_ac": "Q99MK2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99MK2", "id": "Q99MK2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99MK2", "id": "Q99MK2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Elp3", "uniprot_ac": "Q9CZX0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9CZX0", "id": "Q9CZX0", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "Kat8", "uniprot_ac": "Q9D1P2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D1P2", "id": "Q9D1P2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D1P2", "id": "Q9D1P2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Naa60", "uniprot_ac": "Q9DBU2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBU2", "id": "Q9DBU2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBU2", "id": "Q9DBU2", "database": "UniProtKB" } ], "ec_number": "2.3.1.259", "activity": "Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBU2", "id": "Q9DBU2", "database": "UniProtKB" } ], "ec_number": "2.3.1.259", "activity": "" } ] }, { "gene_name": "Ncoa3", "uniprot_ac": "Q9EPU2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9EPU2", "id": "Q9EPU2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9EPU2", "id": "Q9EPU2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "NAA60", "uniprot_ac": "Q9H7X0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H7X0", "id": "Q9H7X0", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H7X0", "id": "Q9H7X0", "database": "UniProtKB" } ], "ec_number": "2.3.1.259", "activity": "Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H7X0", "id": "Q9H7X0", "database": "UniProtKB" } ], "ec_number": "2.3.1.259", "activity": "" } ] }, { "gene_name": "KAT8", "uniprot_ac": "Q9H7Z6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H7Z6", "id": "Q9H7Z6", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H7Z6", "id": "Q9H7Z6", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "ELP3", "uniprot_ac": "Q9H9T3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H9T3", "id": "Q9H9T3", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "Kat2b", "uniprot_ac": "Q9JHD1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JHD1", "id": "Q9JHD1", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JHD1", "id": "Q9JHD1", "database": "UniProtKB" } ], "ec_number": "2.3.1.57", "activity": "Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JHD1", "id": "Q9JHD1", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Kat2a", "uniprot_ac": "Q9JHD2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JHD2", "id": "Q9JHD2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JHD2", "id": "Q9JHD2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JHD2", "id": "Q9JHD2", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] }, { "gene_name": "Nat8f3", "uniprot_ac": "Q9JIY8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JIY8", "id": "Q9JIY8", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JIY8", "id": "Q9JIY8", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Nat8f3", "uniprot_ac": "Q9QXS4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9QXS4", "id": "Q9QXS4", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9QXS4", "id": "Q9QXS4", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "GTF3C4", "uniprot_ac": "Q9UKN8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UKN8", "id": "Q9UKN8", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UKN8", "id": "Q9UKN8", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "Cdyl", "uniprot_ac": "Q9WTK2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WTK2", "id": "Q9WTK2", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WTK2", "id": "Q9WTK2", "database": "UniProtKB" } ], "ec_number": "4.2.1.-", "activity": "" } ] }, { "gene_name": "Clock", "uniprot_ac": "Q9WVS9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WVS9", "id": "Q9WVS9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WVS9", "id": "Q9WVS9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "CDY2A", "uniprot_ac": "Q9Y6F7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y6F7", "id": "Q9Y6F7", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y6F7", "id": "Q9Y6F7", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "CDY1B", "uniprot_ac": "Q9Y6F8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y6F8", "id": "Q9Y6F8", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y6F8", "id": "Q9Y6F8", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] }, { "gene_name": "NCOA3", "uniprot_ac": "Q9Y6Q9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y6Q9", "id": "Q9Y6Q9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y6Q9", "id": "Q9Y6Q9", "database": "UniProtKB" } ], "ec_number": "2.3.1.48", "activity": "" } ] } ], "publication": [], "uniprot_ac": "A0A096MJS9", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJS9", "type": "synonym", "resource": "RefSeq", "name": "Esco2" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "type": "recommended", "resource": "UniProtKB", "name": "Esco2" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "type": "synonym", "resource": "UniProtKB", "name": "rCG_52137" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/45948", "id": "45948", "database": "Rhea" } ], "name": "", "cellular_location": "", "equation": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "input_participant_list": [], "enzyme_list": [ "Q5TKR9-1", "P62916-1", "M0R4T9-1", "Q9WVS9-1", "Q3MHC1-1", "Q5XI06-1", "Q99MK2-1", "Q9EPU2-1", "Q9QXS4-1", "Q5M939-1", "Q6JHU9-1", "D4ACX5-1", "Q9Y6F8-1", "O15516-1", "Q00403-1", "Q92993-1", "Q9H9T3-1", "Q8WYB5-1", "Q9Y6F7-1", "Q9H7Z6-1", "Q15788-1", "Q9H7X0-1", "Q56NI9-1", "P21675-1", "Q9UKN8-1", "Q92793-1", "Q92831-1", "Q92794-1", "Q09472-1", "Q5FWF5-1", "O14929-1", "Q9Y6Q9-1", "Q92830-1", "P70365-1", "Q9DBU2-1", "P62915-1", "Q5SVQ0-1", "O09000-1", "Q9JHD1-1", "Q8BY71-1", "Q8CHK4-1", "Q9D1P2-1", "Q8BRB7-1", "Q9JIY8-1", "Q9WTK2-1", "O08785-1", "Q8BZ21-1", "E0CYR6-1", "Q9JHD2-1", "Q80UV9-1", "Q8BMQ2-1", "P45481-1", "Q9CZX0-1", "Q8CIB9-1", "Q69Z69-1", "B2RWS6-1" ], "id": "45948", "summary": "" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#A0A096MJS9-1", "isoform_ac": "A0A096MJS9-1", "locus": { "end_pos": 42502450, "strand": "+", "start_pos": 42517559, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076451", "id": "ENSRNOT00000076451", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068247", "id": "ENSRNOP00000068247", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 595, "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#A0A0G2K4A1-1", "isoform_ac": "A0A0G2K4A1-1", "locus": { "end_pos": 42502450, "strand": "+", "start_pos": 42517553, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000081500", "id": "ENSRNOT00000081500", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072962", "id": "ENSRNOP00000072962", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K4A1-1|A0A096MJS9_RAT Computationally mapped isoform of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 587, "sequence": "MATFTPRKRKRHTLKADNDDSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTNKPMSSSVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#D4ABF1-1", "isoform_ac": "D4ABF1-1", "locus": { "end_pos": 42502450, "strand": "+", "start_pos": 42517556, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000021320", "id": "ENSRNOT00000021320", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000021320", "id": "ENSRNOP00000021320", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4ABF1-1|D4ABF1_RAT Computationally mapped isoform of Establishment of sister chromatid cohesion N-acetyltransferase 2 OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 594, "sequence": "MMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691979", "resource": "KEGG Pathway", "id": "rno:691979", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "description": "Establishment of Sister Chromatid Cohesion", "resource": "Reactome", "id": "R-RNO-2468052", "name": "Establishment of Sister Chromatid Cohesion" } ], "reaction_participants": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q56NI9-1", "protein_name": "N-acetyltransferase ESCO2", "sequence": { "length": 601, "sequence": "MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12432", "id": "12432", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "id": "A0A096MJS9", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ESCO2", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8CIB9-1", "protein_name": "N-acetyltransferase ESCO2", "sequence": { "length": 592, "sequence": "MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNKKHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKYYLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKRPEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKECSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFHN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12432", "id": "12432", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "id": "A0A096MJS9", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Esco2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543.1", "ac": "XP_003751543.1", "name": "N-acetyltransferase ESCO2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016407", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "acetyltransferase activity", "id": "GO:0016407" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004468", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "id": "GO:0004468" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "chromatin", "id": "GO:0000785" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "site of double-strand break", "id": "GO:0035861" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "chromosome", "id": "GO:0005694" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "chromocenter", "id": "GO:0010369" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "XY body", "id": "GO:0001741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031618", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "nuclear pericentric heterochromatin", "id": "GO:0031618" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "cell junction", "id": "GO:0030054" } ], "total": 9, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007062", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "sister chromatid cohesion", "id": "GO:0007062" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "chromosome segregation", "id": "GO:0007059" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "double-strand break repair", "id": "GO:0006302" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "regulation of DNA replication", "id": "GO:0006275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "protein localization to chromatin", "id": "GO:0071168" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034421", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "post-translational protein acetylation", "id": "GO:0034421" } ], "total": 7, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 290, "annotation": "n_glycosylation_sequon", "start_pos": 288 }, { "end_pos": 316, "annotation": "n_glycosylation_sequon", "start_pos": 314 }, { "end_pos": 476, "annotation": "n_glycosylation_sequon", "start_pos": 474 }, { "end_pos": 85, "annotation": "n_glycosylation_sequon", "start_pos": 83 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015921", "id": "ENSRNOG00000015921", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/691979", "id": "691979", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028005", "id": "IPR028005", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028009", "id": "IPR028009", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691979", "id": "rno:691979", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/VPRCPNK/", "id": "VPRCPNK", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1024179at2759", "id": "1024179at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF13878", "id": "PF13878", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13880", "id": "PF13880", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "id": "R-RNO-2468052", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543", "id": "XP_003751543", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543.1", "id": "XP_003751543.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593313", "id": "1593313", "database": "RGD" }, { "url": "https://www.rhea-db.org/rhea/45948", "id": "45948", "database": "Rhea" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9-1", "id": "A0A096MJS9-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4A1", "id": "A0A0G2K4A1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K4A1-1", "id": "A0A0G2K4A1-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/D4ABF1", "id": "D4ABF1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/D4ABF1-1", "id": "D4ABF1-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "disease_id": "DOID:5325", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:5325", "resource": "Disease Ontology", "description": "", "name": "SC phocomelia syndrome", "id": "DOID:5325" }, { "url": "http://disease-ontology.org/term/DOID:5325", "resource": "Disease Ontology", "description": "", "name": "LONG BONE DEFICIENCIES ASSOCIATED WITH CLEFT LIP-PALATE", "id": "DOID:5325" }, { "url": "http://disease-ontology.org/term/DOID:5325", "resource": "Disease Ontology", "description": "", "name": "RBS", "id": "DOID:5325" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "A rare genetic syndrome with an autosomal recessive pattern of inheritance. It is caused by a mutation in the ESCO2 gene. Clinical signs at birth include multiple limb and facial abnormalities. It is considered to be a mild variant of Roberts syndrome.", "name": "SC phocomelia syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "", "name": "phocomelia-pseudothalidomide syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "", "name": "Roberts-SC phocomelia syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "", "name": "pseudothalidomide syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "", "name": "SC phocomelia syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "", "name": "hypomelia hypotrichosis Facial hemangioma syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010009", "resource": "MONDO", "description": "", "name": "SC pseudothalidomide syndrome", "id": "MONDO:0010009" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "Roberts syndrome (RBS) is characterized by pre- and postnatal growth retardation, severe symmetric limb reduction defects, craniofacial anomalies and severe intellectual deficit. SC phocomelia is a milder form of RBS.", "name": "Roberts syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "Roberts tetraphocomelia syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "Appelt-Gerken-Lenz syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "SC phocomelia syndrome (mild variant of Roberts syndrome)", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "Roberts-SC phocomelia syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "long bone deficiencies associated with cleft LIP-palate", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "RBS", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "pseudothalidomide syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "Roberts syndrome/SC phocomelia", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "Roberts syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "long bone deficiencies associated with cleft Lip-palate", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "SC phocomelia", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "ROBERTS syndrome; RBS", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "SC pseudothalidomide syndrome", "id": "MONDO:0009997" }, { "url": "https://monarchinitiative.org/disease/MONDO:0009997", "resource": "MONDO", "description": "", "name": "Tetraphocomelia-cleft palate syndrome", "id": "MONDO:0009997" }, { "url": "https://www.omim.org/entry/269000", "resource": "MIM", "description": "SC phocomelia syndrome", "name": "SC phocomelia syndrome", "id": "MIM:269000" }, { "url": "https://www.omim.org/entry/268300", "resource": "MIM", "description": "Roberts syndrome", "name": "Roberts syndrome", "id": "MIM:268300" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:5325", "resource": "Disease Ontology", "description": "A syndrome characterized by tetraphocomelia, craniofacial anomalies, growth retardation, intellectual disability, and cardiac and renal abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in ESCO2 on chromosome 8p21.1.", "name": "Roberts syndrome", "id": "DOID:5325" }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/5325#disease-associations", "id": "5325", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 67698.0, "chemical_mass": 67698.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "name": "Esco2", "locus": { "end_pos": 42500929, "strand": "-", "start_pos": 42518855, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015921", "id": "ENSRNOG00000015921", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Establishment of sister chromatid cohesion N-acetyltransferase 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJS9", "type": "synonym", "resource": "RefSeq", "name": "N-acetyltransferase ESCO2" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RCG52137, isoform CRA_a" } ] }