{ "uniprot_canonical_ac": "A4Q9F3-1", "ptm_annotation": [], "sequence": { "header": "sp|A4Q9F3-1|TTL10_MOUSE Isoform 1 of Protein polyglycylase TTLL10 OS=Mus musculus OX=10090 GN=Ttll10 PE=1 SV=1 CANONICAL=A4Q9F3-1", "length": 704, "sequence": "MALHPQAGRPHRDGSEAQAEAAAQDLGRLPSPSKVGAAVCRIQGLGHRAARRPRRGIGTTSASRVPRPGALMPATRNRPRFIHCRGQPPRTRVSSKRSKRSRIHPCHTEVPGWTHEKQMGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLMEGDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPETYRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHTNCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLASSRPLNRLPNPNPNPNPNANPHPHPHPNPHPHPNPHPNANPHPPRPTCEAASSALSSARAAISERPGARKSMPSRGAPVCTPRKSRLSDSSGSSIAESEPSLCSGSLEGSRDTAREPSLGPPEEEREEEQRSTSHRGS" }, "uniprot_id": "V9GXB7_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [ { "gene_name": "Ttll3", "uniprot_ac": "A4Q9E5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "ec_number": "6.3.2.-", "activity": "" } ] }, { "gene_name": "Ttll8", "uniprot_ac": "A4Q9F1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F1", "id": "A4Q9F1", "database": "UniProtKB" } ], "ec_number": "6.3.2.-", "activity": "" } ] }, { "gene_name": "Ttll10", "uniprot_ac": "A4Q9F3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "ec_number": "6.3.2.-", "activity": "" } ] } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", "type": "PubMed", "id": "17499049" } ], "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ], "authors": "Janke C., Lacroix B., Rogowski K., van Dijk J., Miro J., Edde B.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18331838", "type": "PubMed", "id": "18331838" } ], "title": "TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1.", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ], "authors": "Setou M., Ikegami K., Mukai M., MacGregor G.R., Horigome D., Livnat I.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19427864", "type": "PubMed", "id": "19427864" } ], "title": "TTLL10 can perform tubulin glycylation when co-expressed with TTLL8.", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ], "authors": "Setou M., Ikegami K.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19524510", "type": "PubMed", "id": "19524510" } ], "title": "Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ], "authors": "Van Dorsselaer A., Strub J.-M., Thomas D., Gaertig J., Wloga D., Janke C., Rogowski K., van Dijk J., Bre M.-H., Juge F., Levilliers N.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24316575", "type": "PubMed", "id": "24316575" } ], "title": "The Vertebrate Genome Annotation browser 10 years on.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ], "authors": "Harrow JL, Steward CA, Frankish A, Gilbert JG, Gonzalez JM, Loveland JE, Mudge J, Sheppard D, Thomas M, Trevanion S, Wilming LG", "date": "2014" } ], "uniprot_ac": "A4Q9F3", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9F3", "type": "synonym", "resource": "RefSeq", "name": "4833412E22Rik; 4930595O22Rik; AU022799; BC042775; Ttl; Ttll5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9F3", "type": "synonym", "resource": "RefSeq", "name": "Ttll10" }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "type": "recommended", "resource": "UniProtKB", "name": "Ttll10" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8867370", "id": "R-MMU-8867370", "database": "Reactome" } ], "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A4Q9E5-1", "A4Q9F1-1", "A4Q9F3-1" ], "id": "R-MMU-8867370", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3#A4Q9F3-1", "isoform_ac": "A4Q9F3-1", "locus": {}, "sequence": { "header": "sp|A4Q9F3-1|TTL10_MOUSE Isoform 1 of Protein polyglycylase TTLL10 OS=Mus musculus OX=10090 GN=Ttll10 PE=1 SV=1 CANONICAL=A4Q9F3-1", "length": 704, "sequence": "MALHPQAGRPHRDGSEAQAEAAAQDLGRLPSPSKVGAAVCRIQGLGHRAARRPRRGIGTTSASRVPRPGALMPATRNRPRFIHCRGQPPRTRVSSKRSKRSRIHPCHTEVPGWTHEKQMGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLMEGDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPETYRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHTNCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLASSRPLNRLPNPNPNPNPNANPHPHPHPNPHPHPNPHPNANPHPPRPTCEAASSALSSARAAISERPGARKSMPSRGAPVCTPRKSRLSDSSGSSIAESEPSLCSGSLEGSRDTAREPSLGPPEEEREEEQRSTSHRGS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3#A4Q9F3-2", "isoform_ac": "A4Q9F3-2", "locus": {}, "sequence": { "header": "sp|A4Q9F3-2|TTL10_MOUSE Isoform 2 of Protein polyglycylase TTLL10 OS=Mus musculus OX=10090 GN=Ttll10 PE=1 SV=1 CANONICAL=A4Q9F3-1", "length": 675, "sequence": "MALHPQAGRPHRDGRLGHRAARRPRRGIGTTSASRVPRPGALMPATRNRPRFIHCRGQPPRTRVSSKRSKRSRIHPCHTEVPGWTHEKQMGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLMEGDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPETYRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHTNCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLASSRPLNRLPNPNPNPNPNANPHPHPHPNPHPHPNPHPNANPHPPRPTCEAASSALSSARAAISERPGARKSMPSRGAPVCTPRKSRLSDSSGSSIAESEPSLCSGSLEGSRDTAREPSLGPPEEEREEEQRSTSHRGS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3#B1ASM0-1", "isoform_ac": "B1ASM0-1", "locus": { "end_pos": 156034916, "strand": "+", "start_pos": 156048625, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000051509", "id": "ENSMUST00000051509", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000055671", "id": "ENSMUSP00000055671", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B1ASM0-1|TTL10_MOUSE Computationally mapped isoform of Protein polyglycylase TTLL10 OS=Mus musculus OX=10090 GN=Ttll10 PE=1 SV=1 CANONICAL=A4Q9F3-1", "length": 675, "sequence": "MALHPQAGRPHRDGRLGHRAARRPRRGIGTTSASRVPRPGALMPATRNRPRFIHCRGQPPRTRVSSKRSKRSRIHPCHTEVPGWTHEKQMGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLMEGDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPETYRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHTNCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLASSRPLNRLPNPHPNPNPNPHPHPHPHPNPNPHPHPHPNANPHPPRPTCEAASSALSSARAAISERPGARKSMPSRGAPVCTPRKSRLSDSSGSSIAESEPSLCSGSLEGSRDTAREPSLGPPEEEREEEQRSTSHRGS" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3#V9GXB7-1", "isoform_ac": "V9GXB7-1", "locus": { "end_pos": 156035300, "strand": "+", "start_pos": 156047623, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000184684", "id": "ENSMUST00000184684", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000139077", "id": "ENSMUSP00000139077", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|V9GXB7-1|V9GXB7_MOUSE Computationally mapped isoform of Protein polyglycylase TTLL10 OS=Mus musculus OX=10090 GN=Ttll10 PE=4 SV=1 CANONICAL=A4Q9F3-1", "length": 458, "sequence": "MGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLMEGDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPETYRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHTNCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLASSRPLNRLPN" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3#V9GXT8-1", "isoform_ac": "V9GXT8-1", "locus": { "end_pos": 156034916, "strand": "+", "start_pos": 156048625, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000184348", "id": "ENSMUST00000184348", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000139316", "id": "ENSMUSP00000139316", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|V9GXT8-1|V9GXT8_MOUSE Computationally mapped isoform of Protein polyglycylase TTLL10 OS=Mus musculus OX=10090 GN=Ttll10 PE=4 SV=1 CANONICAL=A4Q9F3-1", "length": 704, "sequence": "MALHPQAGRPHRDGSEAQAEATAQDLGRLPSPSKVGAAVCPIQGLGHRAARRPRRGIGTTSASRVPRPGALMPATRNRPRFIHCRGQPPRTRVSSKRSKRSRIHPCHTEVPGWTHEKQMGSSVKERLRPELSQLDQDADDLEEEEAARLPVTSPDGLLMEGDKQPSPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSHCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARMLPSTQTKVLKMEEFFPETYRLDIRDERQAFFALFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYTLLKESTVWTMEHLNRYINDKFRKTKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNANPALHTNCEVLKAVIPGVVIETLDLALETCQKSLHSQKMLPLLSQRRFVLLYNGETTDLWPRLASSRPLNRLPNPHPNPNPNPHPHPHPHPNPNPHPHPHPNANPHPPRPTCEAASSALSSARAAISERPGARKSMPSRGAPVCTPRKSRLSDSSGSSIAESEPSLCSGSLEGSRDTAREPSLGPPEEEREEEQRSTSHRGS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:330010", "resource": "KEGG Pathway", "id": "mmu:330010", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "description": "Carboxyterminal post-translational modifications of tubulin", "resource": "Reactome", "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3#function", "annotation": "Polyglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Polyglycylates alpha-tubulin and beta-tubulin, but is not able to initiate glycylation and only has activity toward monoglycylated tubulin. Has the ability to polyglycylate non-tubulin proteins such as NAP1; in this case it can initiate glycylation and does not require preliminary monoglycylation by another glycylase.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3#function", "id": "A4Q9F3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "annotation": "Recombinant TTLL10 incorporated glycine into recombinant nucleosome assembly protein 1 in vitro. GeneRIF: has a polyglycylase (i.e. glycine ligase) activity for nucleosome assembly protein 1 (NAP1).", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "annotation": "TTLL10 can strongly glycylate tubulin in a TTLL8-dependent manner. Furthermore, these two TTLL proteins can glycylate unidentified 170-, 110-, 75-, 40-, 35-, and 30-kDa acidic proteins.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "id": "NP_083540.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5XI57-1", "protein_name": "Protein polyglycylase TTLL10", "sequence": { "length": 679, "sequence": "MPLHPPARRPHGHRRNGSEAQTEATTQDTGRLSCPRRVGAAVCPIQGLGHRAARRPRRGVGTTSASRAPRPGALMPATRNRPRFIHYRVQPPRTHVSFKRPKRSRTHQSHTKVPGWTHEKRMGSSVEEGLRPELSQLEQDADNLGEEEAARLPVTSLNGLLMEGDRHPNPGQGPFFYIGGTNGASIISNYCESKGWQRTQDSRCEDYKLKWCEIKCRDNYCSFREGQQLLFQLPNNKLLTTKIGLLSALREHARTLSKARLMPSTQAKVLKMDEFFPETYRLDIRDERQAFFTLFDETQMWICKPTASNQGKGIFLIRSQEEAAALQAKTQSIEDDPIYRKMPFRAPQARVVQRYVQNPLLLDGKKFDVRSYMLIACAMPYMVFFGHGYARLTLSLYNPHSSDLSGHLTNQFMQKKSPLYMLLKDSTVWSMEHLNRYINDKFRKSKGLPRDWVFTTFTKRMQQIMSHCFLAVKSKLECKLGYFDLIGCDFLIDENFKVWLLEMNSNPALHTNCEVLKEVIPGVVMETLDLALETCQKSLHSQKMLPLQSQRRFVLLYNGETTDLWPRLGSSRPPIRLPYANSNHARSTCEISSSSLTSTRVTIADRPAARKSMSSRTAPICASRKSRLSDSGGVSIEESETSVCSGLPEGSRDAAREPSLGPTEEEREEEQRSTSHRGS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/51912", "id": "51912", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ttll10", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6ZVT0-1", "protein_name": "Inactive polyglycylase TTLL10", "sequence": { "length": 673, "sequence": "MDHSCTRFIHRRGPPTRTRAGFKRGKRPRIQQRPRARVSGTIPASRLHPAPASQPGPCPAPGHCPVGPAHERPMGSSQEEGLRCQPSQPDHDADGHCGPDLEGAERASATPGPPGLLNSHRPADSDDTNAAGPSAALLEGLLLGGGKPSPHSTRPGPFFYIGGSNGATIISSYCKSKGWQRIHDSRRDDYTLKWCEVKSRDSYGSFREGEQLLYQLPNNKLLTTKIGLLSTLRGRARAMSKASKVPGGVQARLEKDAAAPALEDLPWTSPGYLRPQRVLRMEEFFPETYRLDLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRNQEEVAALQAKTRSMEDDPIHHKTPFRGPQARVVQRYIQNPLLVDGRKFDVRSYLLIACTTPYMIFFGHGYARLTLSLYDPHSSDLGGHLTNQFMQKKSPLYMLLKEHTVWSMEHLNRYISDTFWKARGLAKDWVFTTLKKRMQQIMAHCFLAAKPKLDCKLGYFDLIGCDFLIDDNFKVWLLEMNSNPALHTNCEVLKEVIPGVVIETLDLVLETFRKSLRGQKMLPLLSQRRFVLLHNGEADPRPHLGGSCSLRRWPPLPTRQAKSSGPPMPHAPDQPGARRPAPPPLVPQRPRPPGPDLDSAHDGEPQAPGTEQSGTGNRHPAQEPSPGTAKEEREEPENARP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/51912", "id": "51912", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TTLL10", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540.1", "ac": "NP_083540.1", "name": "protein polyglycylase TTLL10 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070735", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "protein-glycine ligase activity", "id": "GO:0070735" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070737", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "protein-glycine ligase activity, elongating", "id": "GO:0070737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "microtubule cytoskeleton", "id": "GO:0015630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006464", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "cellular protein modification process", "id": "GO:0006464" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018094", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" } ], "name": "protein polyglycylation", "id": "GO:0018094" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029074", "id": "ENSMUSG00000029074", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/330010", "id": "330010", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", 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"https://www.uniprot.org/uniprot/V9GXT8-1", "id": "V9GXT8-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [ { "sequence_org": "E", "comment": "Abolishes polyglycylase activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "id": "A4Q9F3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18331838", "id": "18331838", "database": "PubMed" } ], "sequence_mut": "V", "start_pos": 499, "end_pos": 499 } ], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 79250.0, "chemical_mass": 79250.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3", "name": "Ttll10", "locus": { "end_pos": 156034840, "strand": "-", "start_pos": 156059414, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000029074", "id": "ENSMUSG00000029074", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A4Q9F3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "6.3.2.-" }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Protein polyglycylase TTLL10" }, { "url": "https://www.uniprot.org/uniprot/A4Q9F3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Tubulin--tyrosine ligase-like protein 10" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9F3", "type": "synonym", "resource": "RefSeq", "name": "protein polyglycylase TTLL10 isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9F3", "type": "synonym", "resource": "RefSeq", "name": "tubulin tyrosine ligase-like family, member 5; protein polyglycylase TTLL10; tubulin--tyrosine ligase-like protein 10" } ] }