{ "uniprot_canonical_ac": "A3KFX0-1", "ptm_annotation": [], "sequence": { "header": "sp|A3KFX0-1|5NT1A_MOUSE Isoform 1 of Cytosolic 5'-nucleotidase 1A OS=Mus musculus OX=10090 GN=Nt5c1a PE=1 SV=1 CANONICAL=A3KFX0-1", "length": 365, "sequence": "MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ" }, "uniprot_id": "5NT1A_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [ { "gene_name": "Nt5c1a", "uniprot_ac": "A3KFX0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5c3a", "uniprot_ac": "B2GUX5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2GUX5", "id": "B2GUX5", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2GUX5", "id": "B2GUX5", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "ACP3", "uniprot_ac": "P15309", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P15309", "id": "P15309", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P15309", "id": "P15309", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P15309", "id": "P15309", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "" } ] }, { "gene_name": "Acp3", "uniprot_ac": "P20646", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P20646", "id": "P20646", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P20646", "id": "P20646", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P20646", "id": "P20646", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "" } ] }, { "gene_name": "Nt5e", "uniprot_ac": "P21588", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21588", "id": "P21588", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21588", "id": "P21588", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "NT5E", "uniprot_ac": "P21589", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21589", "id": "P21589", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P21589", "id": "P21589", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "NT5C2", "uniprot_ac": "P49902", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P49902", "id": "P49902", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P49902", "id": "P49902", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5c3b", "uniprot_ac": "Q3UFY7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3UFY7", "id": "Q3UFY7", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3UFY7", "id": "Q3UFY7", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3UFY7", "id": "Q3UFY7", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3UFY7", "id": "Q3UFY7", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5c2", "uniprot_ac": "Q3V1L4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3V1L4", "id": "Q3V1L4", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q3V1L4", "id": "Q3V1L4", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5e", "uniprot_ac": "Q61503", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q61503", "id": "Q61503", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q61503", "id": "Q61503", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5c3b", "uniprot_ac": "Q6AYP7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6AYP7", "id": "Q6AYP7", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6AYP7", "id": "Q6AYP7", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6AYP7", "id": "Q6AYP7", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6AYP7", "id": "Q6AYP7", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "" } ] }, { "gene_name": "Acp3", "uniprot_ac": "Q8CE08", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CE08", "id": "Q8CE08", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CE08", "id": "Q8CE08", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CE08", "id": "Q8CE08", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "" } ] }, { "gene_name": "Nt5c1b", "uniprot_ac": "Q91YE9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91YE9", "id": "Q91YE9", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91YE9", "id": "Q91YE9", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "NT5C3B", "uniprot_ac": "Q969T7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q969T7", "id": "Q969T7", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q969T7", "id": "Q969T7", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q969T7", "id": "Q969T7", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q969T7", "id": "Q969T7", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "" } ] }, { "gene_name": "NT5C1B", "uniprot_ac": "Q96P26", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q96P26", "id": "Q96P26", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q96P26", "id": "Q96P26", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "NT5C1A", "uniprot_ac": "Q9BXI3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BXI3", "id": "Q9BXI3", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BXI3", "id": "Q9BXI3", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5c3a", "uniprot_ac": "Q9D020", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D020", "id": "Q9D020", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D020", "id": "Q9D020", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D020", "id": "Q9D020", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "NT5C3A", "uniprot_ac": "Q9H0P0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H0P0", "id": "Q9H0P0", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H0P0", "id": "Q9H0P0", "database": "UniProtKB" } ], "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H0P0", "id": "Q9H0P0", "database": "UniProtKB" } ], "ec_number": "3.1.3.5", "activity": "" } ] }, { "gene_name": "Nt5c", "uniprot_ac": "Q9JM14", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JM14", "id": "Q9JM14", "database": "UniProtKB" } ], "ec_number": "3.1.3.-", "activity": "" } ] } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15028287", "type": "PubMed", "id": "15028287" } ], "title": "Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "id": "NP_001078971.1", "database": "RefSeq" } ], "authors": "Onishi M, Yasunaga T, Tanaka H, Nishimune Y, Nozaki M", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21873433", "type": "PubMed", "id": "21873433" } ], "title": "Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "id": "NP_001078971.1", "database": "RefSeq" } ], "authors": "Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28325731", "type": "PubMed", "id": "28325731" } ], "title": "Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles.", "journal": "American journal of physiology. Endocrinology and metabolism", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "id": "NP_001078971.1", "database": "RefSeq" } ], "authors": "Kviklyte S, Vertommen D, Yerna X, Andersen H, Xu X, Gailly P, Bohlooly-Y M, Oscarsson J, Rider MH", "date": "2017" } ], "uniprot_ac": "A3KFX0", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFX0", "type": "synonym", "resource": "RefSeq", "name": "Cn; Cn1a; Gm49" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFX0", "type": "synonym", "resource": "RefSeq", "name": "Nt5c1a" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0", "type": "recommended", "resource": "UniProtKB", "name": "Nt5c1a" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/12484", "id": "12484", "database": "Rhea" } ], "name": "", "cellular_location": "", "equation": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "input_participant_list": [], "enzyme_list": [ "Q6AYP7-1", "P21588-1", "P20646-1", "B2GUX5-1", "Q969T7-1", "P21589-1", "Q96P26-1", "Q9BXI3-1", "P15309-1", "Q9H0P0-4", "P49902-1", "Q3UFY7-1", "Q9JM14-1", "Q8CE08-1", "A3KFX0-1", "Q61503-1", "Q91YE9-1", "Q3V1L4-1", "Q9D020-3" ], "id": "12484", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-109380", "id": "R-MMU-109380", "database": "Reactome" } ], "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A3KFX0-1" ], "id": "R-MMU-109380", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-109387", "id": "R-MMU-109387", "database": "Reactome" } ], "name": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A3KFX0-1" ], "id": "R-MMU-109387", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0#A3KFX0-1", "isoform_ac": "A3KFX0-1", "locus": { "end_pos": 123201558, "strand": "-", "start_pos": 123216204, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000068262", "id": "ENSMUST00000068262", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000069422", "id": "ENSMUSP00000069422", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KFX0-1|5NT1A_MOUSE Isoform 1 of Cytosolic 5'-nucleotidase 1A OS=Mus musculus OX=10090 GN=Nt5c1a PE=1 SV=1 CANONICAL=A3KFX0-1", "length": 365, "sequence": "MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230718", "resource": "KEGG Pathway", "id": "mmu:230718", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73621", "description": "Pyrimidine catabolism", "resource": "Reactome", "id": "R-MMU-73621", "name": "Pyrimidine catabolism" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-74259", "description": "Purine catabolism", "resource": "Reactome", "id": "R-MMU-74259", "name": "Purine catabolism" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0#function", "annotation": "Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0#function", "id": "A3KFX0", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "annotation": "NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "id": "NP_001078971.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "annotation": "The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "id": "NP_001078971.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZVD3-1", "protein_name": "5'-nucleotidase, cytosolic IA (Predicted)", "sequence": { "length": 362, "sequence": "MEPRQPPEAREPGPGAETAAVPRWEEAKTFYDNLSPKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKQLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSKDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRREKQSLGAQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/57173", "id": "57173", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A3KFX0/", "id": "A3KFX0", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Nt5c1a", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9BXI3-1", "protein_name": "Cytosolic 5'-nucleotidase 1A", "sequence": { "length": 368, "sequence": "MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/57173", "id": "57173", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A3KFX0/", "id": "A3KFX0", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "NT5C1A", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "ac": "NP_001078971.1", "name": "cytosolic 5'-nucleotidase 1A", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "magnesium ion binding", "id": "GO:0000287" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "nucleotide binding", "id": "GO:0000166" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008253", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "5'-nucleotidase activity", "id": "GO:0008253" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009128", "pmid": "21873433", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "purine nucleoside monophosphate catabolic process", "id": "GO:0009128" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009117", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "nucleotide metabolic process", "id": "GO:0009117" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046085", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" } ], "name": "adenosine metabolic process", "id": "GO:0046085" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 35, "annotation": "n_glycosylation_sequon", "start_pos": 33 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000054958", "id": "ENSMUSG00000054958", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/230718", "id": "230718", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010394", "id": "IPR010394", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230718", "id": "mmu:230718", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2155700", "id": "2155700", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/IRTLMAW/", "id": "IRTLMAW", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=694318at2759", "id": "694318at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31367", "id": "PTHR31367", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF06189", "id": "PF06189", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A3KFX0", "id": "PR_A3KFX0", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-73621", "id": "R-MMU-73621", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-74259", "id": "R-MMU-74259", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971", "id": "NP_001078971", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078971.1", "id": "NP_001078971.1", "database": "RefSeq" }, { "url": "https://www.rhea-db.org/rhea/12484", "id": "12484", "database": "Rhea" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0", "id": "A3KFX0", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0-1", "id": "A3KFX0-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 40678.0, "chemical_mass": 40678.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0", "name": "Nt5c1a", "locus": { "end_pos": 123216275, "strand": "+", "start_pos": 123201504, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000054958", "id": "ENSMUSG00000054958", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "3.1.3.5" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Cytosolic 5'-nucleotidase 1A" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Cytosolic 5'-nucleotidase IA" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFX0", "type": "synonym", "resource": "RefSeq", "name": "cN-IA; cytosolic 5' nucleotidase, type 1A; cytosolic 5'-nucleotidase IA" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "cN-IA" }, { "url": "https://www.uniprot.org/uniprot/A3KFX0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "cN1A" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFX0", "type": "synonym", "resource": "RefSeq", "name": "cytosolic 5'-nucleotidase 1A" } ] }