{ "uniprot_canonical_ac": "A2RUC4-1", "ptm_annotation": [], "sequence": { "header": "sp|A2RUC4-1|TYW5_HUMAN Isoform 1 of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 315, "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE" }, "uniprot_id": "TYW5_HUMAN", "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "reaction_enzymes": [ { "gene_name": "Tyw5", "uniprot_ac": "A2RSX7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSX7", "id": "A2RSX7", "database": "UniProtKB" } ], "ec_number": "1.14.11.42", "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSX7", "id": "A2RSX7", "database": "UniProtKB" } ], "ec_number": "1.14.11.42", "activity": "" } ] }, { "gene_name": "TYW5", "uniprot_ac": "A2RUC4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "ec_number": "1.14.11.42", "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" } ], "ec_number": "1.14.11.42", "activity": "" } ] } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20739293", "type": "PubMed", "id": "20739293" } ], "title": "Expanding role of the jumonji C domain as an RNA hydroxylase.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034782.1", "id": "NP_001034782.1", "database": "RefSeq" } ], "authors": "Suzuki T., Nagao A., Kato M., Nureki O., Ishitani R., Noma A.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20972222", "type": "PubMed", "id": "20972222" } ], "title": "Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.", "journal": "Nucleic Acids Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4", "id": "A2RUC4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034782.1", "id": "NP_001034782.1", "database": "RefSeq" } ], "authors": "Suzuki T., Nagao A., Kato M., Nureki O., Ishitani R., Noma A., Araiso Y.", "date": "2011" } ], "uniprot_ac": "A2RUC4", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RUC4", "type": "synonym", "resource": "RefSeq", "name": "C2orf60; hTYW5" }, { "url": "https://www.uniprot.org/uniprot/A2RUC4", "type": "synonym", "resource": "UniProtKB", "name": "C2orf60" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RUC4", "type": "synonym", "resource": "RefSeq", "name": "TYW5" }, { "url": "https://www.uniprot.org/uniprot/A2RUC4", "type": "recommended", "resource": "UniProtKB", "name": "TYW5" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/37899", "id": "37899", "database": "Rhea" } ], "name": "", "cellular_location": "", "equation": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "input_participant_list": [], "enzyme_list": [ "A2RUC4-1", "A2RSX7-1" ], "id": "37899", "summary": "" }, { "output_participant_list": [ "R-ALL-5278787" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6783455", "id": "R-HSA-6783455", "database": "Reactome" } ], "name": "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)", "cellular_location": "extracellular region", "equation": "", "input_participant_list": [ "R-ALL-1131511", "R-ALL-5278317" ], "enzyme_list": [ "A2RUC4-1" ], "id": "R-HSA-6783455", "summary": "TYW5 uses 2-oxoglutarate and molecular oxygen to hydroxylate yW-72 (7-(3-amino-3-carboxypropyl)wyosine) at nucleotide 37 of tRNA(Phe), yielding OHyW-72 (7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine), carbon dioxide, and succinate (Noma et al. 2010, Kato et al. 2011)." } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4#A2RUC4-1", "isoform_ac": "A2RUC4-1", "locus": { "end_pos": 199933070, "strand": "+", "start_pos": 199955470, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000354611", "id": "ENST00000354611", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000346627", "id": "ENSP00000346627", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RUC4-1|TYW5_HUMAN Isoform 1 of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 315, "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE" } }, { "url": "https://www.uniprot.org/uniprot/A2RUC4#A2RUC4-2", "isoform_ac": "A2RUC4-2", "locus": {}, "sequence": { "header": "sp|A2RUC4-2|TYW5_HUMAN Isoform 2 of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 152, "sequence": "MDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE" } }, { "url": "https://www.uniprot.org/uniprot/A2RUC4#A8KAJ9-1", "isoform_ac": "A8KAJ9-1", "locus": { "end_pos": 199939037, "strand": "+", "start_pos": 199955470, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000441832", "id": "ENST00000441832", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000398447", "id": "ENSP00000398447", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A8KAJ9-1|TYW5_HUMAN Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1 CANONICAL=A2RUC4-1", "length": 121, "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFIKLYLLTSWSRGQLKRNIKNSLFQRMRNTTYGHLEKTLERMLQISESSFLC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:129450", "resource": "KEGG Pathway", "id": "hsa:129450", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6782861", "description": "Synthesis of wybutosine at G37 of tRNA(Phe)", "resource": "Reactome", "id": "R-HSA-6782861", "name": "Synthesis of wybutosine at G37 of tRNA(Phe)" } ], "reaction_participants": [ { "crossref": [ { "url": "", "id": "15379", "database": "ChEBI" }, { "url": "", "id": "HMDB0001377", "database": "HMDB Metabolite" }, { "url": "", "id": "8145133", "database": "PubChem Substance" }, { "url": "", "id": "C00007", "database": "COMPOUND" } ], "participant_name": "O2 [cytoplasm]", "participant_id": "R-ALL-1131511" }, { "crossref": [ { "url": "", "id": "16810", "database": "ChEBI" }, { "url": "", "id": "000001532519", "database": "ZINC" }, { "url": "", "id": "2-KETOGLUTARATE", "database": "AraCyc" }, { "url": "", "id": "C00026", "database": "KEGG Gene" }, { "url": "", "id": "164533", "database": "PubChem" }, { "url": "", "id": "C00000769", "database": "KNApSAcK" }, { "url": "", "id": "328-50-7", "database": "CAS" } ], "participant_name": "2OG [cytoplasm]", "participant_id": "R-ALL-5278317" }, { "crossref": [ { "url": "", "id": "30031", "database": "ChEBI" }, { "url": "", "id": "000000895030", "database": "ZINC" } ], "participant_name": "SUCCA [cytoplasm]", "participant_id": "R-ALL-5278787" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4#function", "annotation": "tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RUC4#function", "id": "A2RUC4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A2RSX7-1", "protein_name": "tRNA wybutosine-synthesizing protein 5", "sequence": { "length": 315, "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72085", "id": "72085", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RUC4/", "id": "A2RUC4", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Tyw5", "tax_id": 10090 }, { "uniprot_canonical_ac": "D3ZY75-1", "protein_name": "tRNA-yW synthesizing protein 5", "sequence": { "length": 315, "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVAQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISQDERYYLRSLGEDPRKDIADIRQQFPSLGEDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFSPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNVFLKHLPSECYDTTDTYGNKDPVAASRAMQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNSE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72085", "id": "72085", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RUC4/", "id": "A2RUC4", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Tyw5", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.1%).", "sequence_org": "K", "start_pos": 139, "alt_nt": "C", "chr_id": "2", "subjects_positive": "1", "chr_pos": "200803727", "disease": [ { "disease_id": "DOID:2531", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic tumors", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic cancer", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "malignant hematopoietic neoplasm", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic neoplasm", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "Hematological tumors", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "Hematologic malignancy", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "hematopoietic and lymphoid system tumor", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "blood cancer", "id": "DOID:2531" }, { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "", "name": "Hematologic neoplasm", "id": "DOID:2531" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:2531", "resource": "Disease Ontology", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.", "name": "hematologic cancer", "id": "DOID:2531" } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "glycoeffect": [ "o-glyco-site-loss" ], "frequency": "2.1", "sequence_mut": "E", "subjects_tested": "48", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "end_pos": 139, "minor_allelic_frequency": "", "ref_nt": "T" }, { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%). In dbSNP: rs372920812.", "sequence_org": "R", "start_pos": 149, "alt_nt": "T", "chr_id": "2", "subjects_positive": "1", "chr_pos": "200803696", "disease": [ { "disease_id": "DOID:9256", "synonyms": [ { "url": "https://monarchinitiative.org/disease/MONDO:0023113", "resource": "MONDO", "description": "Familial colon cancer is a cluster of colon cancer within a family. Most cases ofcolon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes ( mutations ) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories.", "name": "familial colorectal cancer", "id": "MONDO:0023113" }, { "url": "https://monarchinitiative.org/disease/MONDO:0023113", "resource": "MONDO", "description": "", "name": "hereditary colorectal cancer", "id": "MONDO:0023113" }, { "url": "https://monarchinitiative.org/disease/MONDO:0023113", "resource": "MONDO", "description": "", "name": "colorectal cancer, familial", "id": "MONDO:0023113" }, { "url": "https://www.omim.org/entry/114500", "resource": "MIM", "description": "Colorectal cancer", "name": "Colorectal cancer", "id": "MIM:114500" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:9256", "resource": "Disease Ontology", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", "name": "colorectal cancer", "id": "DOID:9256" } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "1.1", "sequence_mut": "Q", "subjects_tested": "94", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "end_pos": 149, "minor_allelic_frequency": "", "ref_nt": "C" }, { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", "sequence_org": "W", "start_pos": 158, "alt_nt": "A", "chr_id": "2", "subjects_positive": "1", "chr_pos": "200803668", "disease": [ { "disease_id": "DOID:1781", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "neoplasm of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "malignant neoplasm of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "malignant tumour of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "Thyroid gland neoplasm", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "thyroid neoplasm", "id": "DOID:1781" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.", "name": "thyroid gland cancer", "id": "DOID:1781" } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "2.0", "sequence_mut": "C", "subjects_tested": "50", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "end_pos": 158, "minor_allelic_frequency": "", "ref_nt": "C" }, { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", "sequence_org": "V", "start_pos": 163, "alt_nt": "A", "chr_id": "2", "subjects_positive": "1", "chr_pos": "200801215", "disease": [ { "disease_id": "DOID:1781", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "neoplasm of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "malignant neoplasm of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "malignant tumour of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "Thyroid gland neoplasm", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "thyroid neoplasm", "id": "DOID:1781" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage.", "name": "thyroid gland cancer", "id": "DOID:1781" } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A2RUC4", "id": "A2RUC4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "2.0", "sequence_mut": "L", "subjects_tested": "50", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "end_pos": 163, "minor_allelic_frequency": "", "ref_nt": "C" }, { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", "sequence_org": "D", "start_pos": 225, "alt_nt": "C", "chr_id": "2", "subjects_positive": "1", "chr_pos": "200800671", "disease": [ { "disease_id": "DOID:1781", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "neoplasm of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "malignant neoplasm of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "malignant tumour of thyroid gland", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "Thyroid gland neoplasm", "id": "DOID:1781" }, { "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "description": "", "name": "thyroid neoplasm", "id": 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wybutosine-synthesizing protein 5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RUC4", "type": "synonym", "resource": "RefSeq", "name": "tRNA yW-synthesizing enzyme 5; jmjC domain-containing protein C2orf60; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase" }, { "url": "https://www.uniprot.org/uniprot/A2RUC4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase" } ] }