{
    "uniprot_canonical_ac": "A2RRU1-1", 
    "ptm_annotation": [
        {
            "annotation": "Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                    "id": "A2RRU1", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/", 
                    "id": "", 
                    "database": "PubMed"
                }
            ]
        }
    ], 
    "sequence": {
        "header": "sp|A2RRU1-1|GYS1_RAT Isoform 1 of Glycogen [starch] synthase, muscle  OS=Rattus norvegicus OX=10116 GN=Gys1 PE=1 SV=1 CANONICAL=A2RRU1-1", 
        "length": 738, 
        "sequence": "MPLSRSLSMSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADIFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLREDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN"
    }, 
    "uniprot_id": "GYS1_RAT", 
    "glycation": [], 
    "keywords": [
        "enzyme", 
        "glycosyltransferase-activity"
    ], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                    "id": "A2RRU1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "reaction_enzymes": [
        {
            "gene_name": "Gbe1", 
            "uniprot_ac": "A0A0G2JTB2", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JTB2", 
                            "id": "A0A0G2JTB2", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.18", 
                    "activity": "Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JTB2", 
                            "id": "A0A0G2JTB2", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.18", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Gys1", 
            "uniprot_ac": "A2RRU1", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                            "id": "A2RRU1", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                            "id": "A2RRU1", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Gyg1", 
            "uniprot_ac": "O08730", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O08730", 
                            "id": "O08730", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.186", 
                    "activity": "UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O08730", 
                            "id": "O08730", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.186", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "GYS1", 
            "uniprot_ac": "P13807", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P13807", 
                            "id": "P13807", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P13807", 
                            "id": "P13807", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Gys2", 
            "uniprot_ac": "P17625", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P17625", 
                            "id": "P17625", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P17625", 
                            "id": "P17625", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "GYS2", 
            "uniprot_ac": "P54840", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P54840", 
                            "id": "P54840", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P54840", 
                            "id": "P54840", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Gys2", 
            "uniprot_ac": "Q8VCB3", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q8VCB3", 
                            "id": "Q8VCB3", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q8VCB3", 
                            "id": "Q8VCB3", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Gys1", 
            "uniprot_ac": "Q9Z1E4", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9Z1E4", 
                            "id": "Q9Z1E4", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": "UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9Z1E4", 
                            "id": "Q9Z1E4", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.4.1.11", 
                    "activity": ""
                }
            ]
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19432592", 
                    "type": "PubMed", 
                    "id": "19432592"
                }
            ], 
            "title": "Glycogen content regulates insulin- but not contraction-mediated glycogen synthase activation in the rat slow-twitch soleus muscles.", 
            "journal": "Acta physiologica (Oxford, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lai YC, Lin FC, Jensen J", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19699667", 
                    "type": "PubMed", 
                    "id": "19699667"
                }
            ], 
            "title": "Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts.", 
            "journal": "Molecular genetics and metabolism", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Cameron JM, Levandovskiy V, MacKay N, Utgikar R, Ackerley C, Chiasson D, Halliday W, Raiman J, Robinson BH", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20597590", 
                    "type": "PubMed", 
                    "id": "20597590"
                }
            ], 
            "title": "Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents.", 
            "journal": "Archives of physiology and biochemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lai YC, Stuenaes JT, Kuo CH, Jensen J", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21356517", 
                    "type": "PubMed", 
                    "id": "21356517"
                }
            ], 
            "title": "Phosphate incorporation during glycogen synthesis and Lafora disease.", 
            "journal": "Cell metabolism", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tagliabracci VS, Heiss C, Karthik C, Contreras CJ, Glushka J, Ishihara M, Azadi P, Hurley TD, DePaoli-Roach AA, Roach PJ", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
                    "type": "PubMed", 
                    "id": "22673903"
                }
            ], 
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "journal": "Nature communications", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                    "id": "A2RRU1", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2RRU1", 
                    "id": "A2RRU1", 
                    "database": "iPTMnet"
                }
            ], 
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/6244274", 
                    "type": "PubMed", 
                    "id": "6244274"
                }
            ], 
            "title": "Epinephrine regulation of skeletal muscle glycogen metabolism. Studies utilizing the perfused rat hindlimb preparation.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dietz MR, Chiasson JL, Soderling TR, Exton JH", 
            "date": "1980"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8224611", 
                    "type": "PubMed", 
                    "id": "8224611"
                }
            ], 
            "title": "Glycogen synthesis in the astrocyte: from glycogenin to proglycogen to glycogen.", 
            "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lomako J, Lomako WM, Whelan WJ, Dombro RS, Neary JT, Norenberg MD", 
            "date": "1993"
        }
    ], 
    "uniprot_ac": "A2RRU1", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Gys1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Gys1"
        }
    ], 
    "reactions": [
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.rhea-db.org/rhea/18549", 
                    "id": "18549", 
                    "database": "Rhea"
                }
            ], 
            "name": "", 
            "cellular_location": "", 
            "equation": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "P17625-1", 
                "P13807-1", 
                "P54840-1", 
                "Q9Z1E4-1", 
                "Q8VCB3-1"
            ], 
            "id": "18549", 
            "summary": ""
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322001", 
                    "id": "R-RNO-3322001", 
                    "database": "Reactome"
                }
            ], 
            "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3322001", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322003", 
                    "id": "R-RNO-3322003", 
                    "database": "Reactome"
                }
            ], 
            "name": "Autoglucosylation of GYG1 complexed with GYS1-b", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3322003", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322005", 
                    "id": "R-RNO-3322005", 
                    "database": "Reactome"
                }
            ], 
            "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "A0A0G2JTB2-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3322005", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322025", 
                    "id": "R-RNO-3322025", 
                    "database": "Reactome"
                }
            ], 
            "name": "Autoglucosylation of GYG1 complexed with GYS1-a", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3322025", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322041", 
                    "id": "R-RNO-3322041", 
                    "database": "Reactome"
                }
            ], 
            "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3322041", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322057", 
                    "id": "R-RNO-3322057", 
                    "database": "Reactome"
                }
            ], 
            "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "A0A0G2JTB2-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3322057", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3781018", 
                    "id": "R-RNO-3781018", 
                    "database": "Reactome"
                }
            ], 
            "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3781018", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3781023", 
                    "id": "R-RNO-3781023", 
                    "database": "Reactome"
                }
            ], 
            "name": "PPP1R3C binds to glycogen:GYG1:GYS1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3781023", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3781024", 
                    "id": "R-RNO-3781024", 
                    "database": "Reactome"
                }
            ], 
            "name": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A2RRU1-1", 
                "O08730-1"
            ], 
            "id": "R-RNO-3781024", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU1#A2RRU1-1", 
            "isoform_ac": "A2RRU1-1", 
            "locus": {
                "end_pos": 101427410, 
                "strand": "-", 
                "start_pos": 101445830, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000028271", 
                        "id": "ENSRNOT00000028271", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000028271", 
                        "id": "ENSRNOP00000028271", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RRU1-1|GYS1_RAT Isoform 1 of Glycogen [starch] synthase, muscle  OS=Rattus norvegicus OX=10116 GN=Gys1 PE=1 SV=1 CANONICAL=A2RRU1-1", 
                "length": 738, 
                "sequence": "MPLSRSLSMSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADIFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLREDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:690987", 
            "resource": "KEGG Pathway", 
            "id": "rno:690987", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322077", 
            "description": "Glycogen synthesis", 
            "resource": "Reactome", 
            "id": "R-RNO-3322077", 
            "name": "Glycogen synthesis"
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
            "annotation": "After contraction insulin-stimulated glycogen synthesis was increased by rather similar magnitude at all glycogen contents in concert with increased glycogen synthase activation.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
            "annotation": "After contraction, glycogen synthase (GS) was increased to similar levels in muscles with low, normal and high glycogen content; rate of glycogen synthesis after contraction was also similar; insulin increased GS activation at all glycogen contents.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
                    "id": "NP_001103085.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU1#function", 
            "annotation": "Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRU1#function", 
                    "id": "A2RRU1", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "P13807-1", 
            "protein_name": "Glycogen [starch] synthase, muscle", 
            "sequence": {
                "length": 737, 
                "sequence": "MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RRU1/", 
                    "id": "A2RRU1", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/113557", 
                    "id": "113557", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "GYS1", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q9Z1E4-1", 
            "protein_name": "Glycogen [starch] synthase, muscle", 
            "sequence": {
                "length": 738, 
                "sequence": "MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RRU1/", 
                    "id": "A2RRU1", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/113557", 
                    "id": "113557", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Gys1", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
        "ac": "NP_001103085.1", 
        "name": "glycogen [starch] synthase, muscle", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", 
                        "pmid": "6244274", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen (starch) synthase activity", 
                        "id": "GO:0004373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", 
                        "pmid": "10572943", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen (starch) synthase activity", 
                        "id": "GO:0004373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", 
                        "pmid": "7671134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen (starch) synthase activity", 
                        "id": "GO:0004373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", 
                        "pmid": "6449198", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen (starch) synthase activity", 
                        "id": "GO:0004373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004373", 
                        "pmid": "8224611", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen (starch) synthase activity", 
                        "id": "GO:0004373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005536", 
                        "pmid": "6244274", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glucose binding", 
                        "id": "GO:0005536"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005536", 
                        "pmid": "7671134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glucose binding", 
                        "id": "GO:0005536"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein kinase binding", 
                        "id": "GO:0019901"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061547", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen synthase activity, transferring glucose-1-phosphate", 
                        "id": "GO:0061547"
                    }
                ], 
                "total": 9, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016234", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "inclusion body", 
                        "id": "GO:0016234"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", 
                        "pmid": "6244274", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen metabolic process", 
                        "id": "GO:0005977"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", 
                        "pmid": "10572943", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen metabolic process", 
                        "id": "GO:0005977"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005978", 
                        "pmid": "7671134", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen biosynthetic process", 
                        "id": "GO:0005978"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005978", 
                        "pmid": "6449198", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glycogen biosynthetic process", 
                        "id": "GO:0005978"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU1", 
                                "id": "A2RRU1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "heart development", 
                        "id": "GO:0007507"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 358, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 356
        }, 
        {
            "end_pos": 469, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 467
        }, 
        {
            "end_pos": 532, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 530
        }, 
        {
            "end_pos": 589, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 587
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020812", 
            "id": "ENSRNOG00000020812", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.cazy.org/fam/GT3.html", 
            "id": "GT3", 
            "database": "CAZy"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03793", 
            "id": "cd03793", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/690987", 
            "id": "690987", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RRU1*", 
            "id": "A2RRU1", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008631", 
            "id": "IPR008631", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:690987", 
            "id": "rno:690987", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/VFHPDFL/", 
            "id": "VFHPDFL", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=264593at2759", 
            "id": "264593at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10176", 
            "id": "PTHR10176", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF05693", 
            "id": "PF05693", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2RRU1", 
            "id": "PR_A2RRU1", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3322077", 
            "id": "R-RNO-3322077", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085", 
            "id": "NP_001103085", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103085.1", 
            "id": "NP_001103085.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589798", 
            "id": "1589798", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.rhea-db.org/rhea/18549", 
            "id": "18549", 
            "database": "Rhea"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU1", 
            "id": "A2RRU1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU1-1", 
            "id": "A2RRU1-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "disease_id": "DOID:1287", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:1287", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "disease of subdivision of hemolymphoid system", 
                    "id": "DOID:1287"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:1287", 
                "resource": "Disease Ontology", 
                "description": "A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.", 
                "name": "cardiovascular system disease", 
                "id": "DOID:1287"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1287#disease-associations", 
                    "id": "1287", 
                    "database": "Alliance of Genome Resources"
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