{ "uniprot_canonical_ac": "A2AT37-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AT37-1|RENT2_MOUSE Isoform 1 of Regulator of nonsense transcripts 2 OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1", "length": 1269, "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKPRDDLKVTAKKEVSKVPEDKKKRLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRYSDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEINDDTLELEGADEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" }, "uniprot_id": "RENT2_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": "PubMed", "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18483223", "type": "PubMed", "id": "18483223" } ], "title": "NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Weischenfeldt J, Damgaard I, Bryder D, Theilgaard-Monch K, Thoren LA, Nielsen FC, Jacobsen SE, Nerlov C, Porse BT", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20657840", "type": "PubMed", "id": "20657840" } ], "title": "UPF2 is a critical regulator of liver development, function and regeneration.", "journal": "PLoS ONE", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Borup R., Blom A.M., Bisgaard H.C., Porse B.T., Bergstroem F.C., Damgaard I., Jakobsen J.S., Noergaard G.A., Thoren L.A., Waage J., Weischenfeldt J.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22503102", "type": "PubMed", "id": "22503102" } ], "title": "Staufen1-mediated mRNA decay functions in adipogenesis.", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Cho H, Kim KM, Han S, Choe J, Park SG, Choi SS, Kim YK", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27149095", "type": "PubMed", "id": "27149095" } ], "title": "Chromatoid Body Protein TDRD6 Supports Long 3' UTR Triggered Nonsense Mediated mRNA Decay.", "journal": "PLoS Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Dahl A., Jessberger R., Akpinar M., Fanourgakis G., Lesche M.", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27149259", "type": "PubMed", "id": "27149259" } ], "title": "UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts.", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Bao J, Vitting-Seerup K, Waage J, Tang C, Ge Y, Porse BT, Yan W", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28444146", "type": "PubMed", "id": "28444146" } ], "title": "Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.", "journal": "Biology of reproduction", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "MacDonald CC, Grozdanov PN", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31585809", "type": "PubMed", "id": "31585809" } ], "title": "Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.", "journal": "Neuron", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ], "authors": "Johnson JL, Stoica L, Liu Y, Zhu PJ, Bhattacharya A, Buffington SA, Huq R, Eissa NT, Larsson O, Porse BT, Domingo D, Nawaz U, Carroll R, Jolly L, Scerri TS, Kim HG, Brignell A, Coleman MJ, Braden R, Kini U, Jackson V, Baxter A, Bahlo M, Scheffer IE, Amor DJ, Hildebrand MS, Bonnen PE, Beeton C, Gecz J, Morgan AT, Costa-Mattioli M", "date": "2019" } ], "uniprot_ac": "A2AT37", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AT37", "type": "synonym", "resource": "RefSeq", "name": "Upf2" }, { "url": "https://www.uniprot.org/uniprot/A2AT37", "type": "recommended", "resource": "UniProtKB", "name": "Upf2" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AT37#A2AT37-1", "isoform_ac": "A2AT37-1", "locus": { "end_pos": 5957489, "strand": "-", "start_pos": 6055439, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000060092", "id": "ENSMUST00000060092", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000058375", "id": "ENSMUSP00000058375", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AT37-1|RENT2_MOUSE Isoform 1 of Regulator of nonsense transcripts 2 OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1", "length": 1269, "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKPRDDLKVTAKKEVSKVPEDKKKRLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRYSDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEINDDTLELEGADEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" } }, { "url": "https://www.uniprot.org/uniprot/A2AT37#F6Q3G7-1", "isoform_ac": "F6Q3G7-1", "locus": { "end_pos": 6023339, "strand": "-", "start_pos": 6055441, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000128200", "id": "ENSMUST00000128200", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119348", "id": "ENSMUSP00000119348", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Q3G7-1|RENT2_MOUSE Computationally mapped isoform of Regulator of nonsense transcripts 2 OS=Mus musculus OX=10090 GN=Upf2 PE=1 SV=1 CANONICAL=A2AT37-1", "length": 523, "sequence": "XVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:326622", "resource": "KEGG Pathway", "id": "mmu:326622", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "resource": "Reactome", "id": "R-MMU-975957", "name": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AT37#function", "annotation": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37#function", "id": "A2AT37", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Our findings indicate that impaired UPF2-dependent nonsense-mediated decay leads to neurodevelopmental dysfunction", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies . Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "annotation": "We report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR transcripts, and that this role is independent of its canonical role in degrading 'premature termination codon' (PTC)-containing transcripts in somatic cell lineages Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZT03-1", "protein_name": "UPF2, regulator of nonsense mediated mRNA decay", "sequence": { "length": 1272, "sequence": "MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKSKDDLKITAKKEVSKVPEDKKKKLEEDKRKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLNFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSSKDDSKETGGYEPRNWRNRENENELMLEFESFLRATSTVHYTSSALEKGKRKKRRDEREQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRRKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDDEDEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQFNSGKVEKISELGTPFNVNLESTFHVKPQLRHGERNTRESTDTNIPLYVLSQEHNKKKMFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGR" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AT37/", "id": "A2AT37", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Upf2", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9HAU5-1", "protein_name": "Regulator of nonsense transcripts 2", "sequence": { "length": 1272, "sequence": "MPAERKKPASMEEKDSLPNNKEKDCSERRTVSSKERPKDDIKLTAKKEVSKAPEDKKKRLEDDKRKKEDKERKKKDEEKVKAEEESKKKEEEEKKKHQEEERKKQEEQAKRQQEEEAAAQMKEKEESIQLHQEAWERHHLRKELRSKNQNAPDSRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRPPLQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKDSKDSMTEGENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDNDDDEGEEEEEENTDYLTDSNKENETDEENTEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLKSQLRKGPPLGGGEGEAESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/6101", "id": "6101", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "UPF2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "ac": "NP_001074601.1", "name": "regulator of nonsense transcripts 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "telomeric DNA binding", "id": "GO:0042162" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005844", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "polysome", "id": "GO:0005844" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035145", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "exon-exon junction complex", "id": "GO:0035145" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "pmid": "20657840", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "liver development", "id": "GO:0001889" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031100", "pmid": "20657840", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "animal organ regeneration", "id": "GO:0031100" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "name": "response to unfolded protein", "id": "GO:0006986" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 1048, "annotation": "n_glycosylation_sequon", "start_pos": 1046 }, { "end_pos": 1085, "annotation": "n_glycosylation_sequon", "start_pos": 1083 }, { "end_pos": 198, "annotation": "n_glycosylation_sequon", "start_pos": 196 }, { "end_pos": 259, "annotation": "n_glycosylation_sequon", "start_pos": 257 }, { "end_pos": 336, "annotation": "n_glycosylation_sequon", "start_pos": 334 }, { "end_pos": 664, "annotation": "n_glycosylation_sequon", "start_pos": 662 }, { "end_pos": 682, "annotation": "n_glycosylation_sequon", "start_pos": 680 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043241", "id": "ENSMUSG00000043241", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/326622", "id": "326622", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AT37*", "id": "A2AT37", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003890", "id": "IPR003890", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007193", "id": "IPR007193", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016021", "id": "IPR016021", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039762", "id": "IPR039762", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:326622", "id": "mmu:326622", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2449307", "id": "2449307", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/TRPQWKL/", "id": "TRPQWKL", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=653534at2759", "id": "653534at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12839", "id": "PTHR12839", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02854", "id": "PF02854", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF04050", "id": "PF04050", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975957", "id": "R-MMU-975957", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601", "id": "NP_001074601", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074601.1", "id": "NP_001074601.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AT37-1", "id": "A2AT37-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F6Q3G7", "id": "F6Q3G7", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F6Q3G7-1", "id": "F6Q3G7-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Thr", "comment": "Phosphothreonine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "id": "A2AT37", "database": "UniProtKB" } ], "start_pos": 1085, "end_pos": 1085, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 147553.0, "chemical_mass": 147553.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AT37", "name": "Upf2", "locus": { "end_pos": 6056703, "strand": "+", "start_pos": 5951469, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000043241", "id": "ENSMUSG00000043241", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Nonsense mRNA reducing factor 2" }, { "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Regulator of nonsense transcripts 2" }, { "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Up-frameshift suppressor 2 homolog" }, { "url": "https://www.uniprot.org/uniprot/A2AT37#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Upf2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AT37", "type": "synonym", "resource": "RefSeq", "name": "nonsense mRNA reducing factor 2; up-frameshift suppressor 2 homolog" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AT37", "type": "synonym", "resource": "RefSeq", "name": "regulator of nonsense transcripts 2" } ] }