{
    "uniprot_canonical_ac": "A2APY7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2APY7-1|NDUF5_MOUSE Isoform 1 of Arginine-hydroxylase NDUFAF5, mitochondrial  OS=Mus musculus OX=10090 GN=Ndufaf5 PE=1 SV=1 CANONICAL=A2APY7-1", 
        "length": 343, 
        "sequence": "MLRKVVLLRLCPLLGRPAVSASSGSRREVASGVPPSGSTSPRALNIFDRELKRKQKNWAARQPDPMKFDYLKEEVGSRIADRVYDIARDFPLALDIGCGRGYIAQHLDKETVGKIFQTDIAEHALKNSLETDIPTVNILADEEFLPFQENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSIPATFQIYHMIGWKYHDSQARPAERGSATVSFGELAKLNDVMSHEKK"
    }, 
    "uniprot_id": "NDUF5_MOUSE", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2APY7", 
                    "id": "A2APY7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "reaction_enzymes": [
        {
            "gene_name": "Ndufaf5", 
            "uniprot_ac": "A2APY7", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A2APY7", 
                            "id": "A2APY7", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.1.1.-", 
                    "activity": ""
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A2APY7", 
                            "id": "A2APY7", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "1.-.-.-", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Mtnd1", 
            "uniprot_ac": "P03888", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03888", 
                            "id": "P03888", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03888", 
                            "id": "P03888", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Mtnd2", 
            "uniprot_ac": "P03893", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03893", 
                            "id": "P03893", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03893", 
                            "id": "P03893", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Mtnd3", 
            "uniprot_ac": "P03899", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03899", 
                            "id": "P03899", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03899", 
                            "id": "P03899", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Mtnd4", 
            "uniprot_ac": "P03911", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03911", 
                            "id": "P03911", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03911", 
                            "id": "P03911", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Mtnd5", 
            "uniprot_ac": "P03921", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03921", 
                            "id": "P03921", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03921", 
                            "id": "P03921", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Mtnd6", 
            "uniprot_ac": "P03925", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03925", 
                            "id": "P03925", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P03925", 
                            "id": "P03925", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Acad9", 
            "uniprot_ac": "Q8JZN5", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q8JZN5", 
                            "id": "Q8JZN5", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "1.3.8.-", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufs8", 
            "uniprot_ac": "Q8K3J1", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q8K3J1", 
                            "id": "Q8K3J1", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q8K3J1", 
                            "id": "Q8K3J1", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufs1", 
            "uniprot_ac": "Q91VD9", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q91VD9", 
                            "id": "Q91VD9", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q91VD9", 
                            "id": "Q91VD9", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufs2", 
            "uniprot_ac": "Q91WD5", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q91WD5", 
                            "id": "Q91WD5", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q91WD5", 
                            "id": "Q91WD5", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufv1", 
            "uniprot_ac": "Q91YT0", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q91YT0", 
                            "id": "Q91YT0", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q91YT0", 
                            "id": "Q91YT0", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufaf7", 
            "uniprot_ac": "Q9CWG8", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9CWG8", 
                            "id": "Q9CWG8", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.1.1.320", 
                    "activity": "2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega')-dimethyl-L-arginine."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9CWG8", 
                            "id": "Q9CWG8", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.1.1.320", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufv2", 
            "uniprot_ac": "Q9D6J6", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9D6J6", 
                            "id": "Q9D6J6", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9D6J6", 
                            "id": "Q9D6J6", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufs7", 
            "uniprot_ac": "Q9DC70", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9DC70", 
                            "id": "Q9DC70", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9DC70", 
                            "id": "Q9DC70", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ndufs3", 
            "uniprot_ac": "Q9DCT2", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9DCT2", 
                            "id": "Q9DCT2", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q9DCT2", 
                            "id": "Q9DCT2", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "7.1.1.2", 
                    "activity": ""
                }
            ]
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A2APY7", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "2310003L22Rik"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ndufaf5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ndufaf5"
        }
    ], 
    "reactions": [
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799179", 
                    "id": "R-MMU-6799179", 
                    "database": "Reactome"
                }
            ], 
            "name": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q91VD9-1", 
                "Q91WD5-1", 
                "Q9D6J6-1", 
                "Q8JZN5-1", 
                "Q91YT0-1", 
                "A2APY7-1", 
                "Q9DC70-1", 
                "P03893-1", 
                "P03911-1", 
                "P03925-1", 
                "Q8K3J1-1", 
                "Q9CWG8-1", 
                "Q9DCT2-1", 
                "P03888-1", 
                "P03899-1", 
                "P03921-1"
            ], 
            "id": "R-MMU-6799179", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799191", 
                    "id": "R-MMU-6799191", 
                    "database": "Reactome"
                }
            ], 
            "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q91WD5-1", 
                "A2APY7-1", 
                "Q9DC70-1", 
                "Q8K3J1-1", 
                "Q9CWG8-1", 
                "Q9DCT2-1", 
                "P03888-1"
            ], 
            "id": "R-MMU-6799191", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799196", 
                    "id": "R-MMU-6799196", 
                    "database": "Reactome"
                }
            ], 
            "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q91VD9-1", 
                "Q91WD5-1", 
                "Q9D6J6-1", 
                "Q8JZN5-1", 
                "Q91YT0-1", 
                "A2APY7-1", 
                "Q9DC70-1", 
                "P03893-1", 
                "P03911-1", 
                "P03925-1", 
                "Q8K3J1-1", 
                "Q9CWG8-1", 
                "Q9DCT2-1", 
                "P03888-1", 
                "P03899-1", 
                "P03921-1"
            ], 
            "id": "R-MMU-6799196", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799197", 
                    "id": "R-MMU-6799197", 
                    "database": "Reactome"
                }
            ], 
            "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q91WD5-1", 
                "Q8JZN5-1", 
                "A2APY7-1", 
                "Q9DC70-1", 
                "P03893-1", 
                "P03911-1", 
                "P03925-1", 
                "Q8K3J1-1", 
                "Q9CWG8-1", 
                "Q9DCT2-1", 
                "P03888-1", 
                "P03899-1", 
                "P03921-1"
            ], 
            "id": "R-MMU-6799197", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799202", 
                    "id": "R-MMU-6799202", 
                    "database": "Reactome"
                }
            ], 
            "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q91WD5-1", 
                "Q8JZN5-1", 
                "A2APY7-1", 
                "Q9DC70-1", 
                "P03893-1", 
                "P03925-1", 
                "Q8K3J1-1", 
                "Q9CWG8-1", 
                "Q9DCT2-1", 
                "P03888-1", 
                "P03899-1"
            ], 
            "id": "R-MMU-6799202", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#A2APY7-1", 
            "isoform_ac": "A2APY7-1", 
            "locus": {
                "end_pos": 140170712, 
                "strand": "-", 
                "start_pos": 140203615, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000044825", 
                        "id": "ENSMUST00000044825", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000035325", 
                        "id": "ENSMUSP00000035325", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2APY7-1|NDUF5_MOUSE Isoform 1 of Arginine-hydroxylase NDUFAF5, mitochondrial  OS=Mus musculus OX=10090 GN=Ndufaf5 PE=1 SV=1 CANONICAL=A2APY7-1", 
                "length": 343, 
                "sequence": "MLRKVVLLRLCPLLGRPAVSASSGSRREVASGVPPSGSTSPRALNIFDRELKRKQKNWAARQPDPMKFDYLKEEVGSRIADRVYDIARDFPLALDIGCGRGYIAQHLDKETVGKIFQTDIAEHALKNSLETDIPTVNILADEEFLPFQENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSIPATFQIYHMIGWKYHDSQARPAERGSATVSFGELAKLNDVMSHEKK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#A2APY7-2", 
            "isoform_ac": "A2APY7-2", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2APY7-2|NDUF5_MOUSE Isoform 2 of Arginine-hydroxylase NDUFAF5, mitochondrial  OS=Mus musculus OX=10090 GN=Ndufaf5 PE=1 SV=1 CANONICAL=A2APY7-1", 
                "length": 156, 
                "sequence": "MFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSIPATFQIYHMIGWKYHDSQARPAERGSATVSFGELAKLNDVMSHEKK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69487", 
            "resource": "KEGG Pathway", 
            "id": "mmu:69487", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799198", 
            "description": "Complex I biogenesis", 
            "resource": "Reactome", 
            "id": "R-MMU-6799198", 
            "name": "Complex I biogenesis"
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#function", 
            "annotation": "Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2APY7#function", 
                    "id": "A2APY7", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "B2GV71-1", 
            "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", 
            "sequence": {
                "length": 343, 
                "sequence": "MLRRVVLSRLYARLGGPAVSAGRGGRRGVASSVPPSGSTSPRALNIFDRELKRKQKNWAARQPEPMKFDYLKEEIGSRIADRVYDIARDFPLALDIGCGRGYIAQHLNKETVGKIFQTDIAEHALKNSIETDIPTVNILADEEFLPFPENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYSNEDGSIPATYQIYHMIGWKYHDSQARPAERGSATVSFGDLARLNDTMSQGKK"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2APY7/", 
                    "id": "A2APY7", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/11474", 
                    "id": "11474", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Ndufaf5", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q5TEU4-1", 
            "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", 
            "sequence": {
                "length": 345, 
                "sequence": "MLRPAGLWRLCRRPWAARVPAENLGRREVTSGVSPRGSTSPRTLNIFDRDLKRKQKNWAARQPEPTKFDYLKEEVGSRIADRVYDIPRNFPLALDLGCGRGYIAQYLNKETIGKFFQADIAENALKNSSETEIPTVSVLADEEFLPFKENTFDLVVSSLSLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCAWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPPGKKSQ"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2APY7/", 
                    "id": "A2APY7", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/11474", 
                    "id": "11474", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "NDUFAF5", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081369.2", 
        "ac": "NP_081369.2", 
        "name": "arginine-hydroxylase NDUFAF5, mitochondrial precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oxidoreductase activity", 
                        "id": "GO:0016491"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "methyltransferase activity", 
                        "id": "GO:0008168"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", 
                        "pmid": "18614015", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitochondrion", 
                        "id": "GO:0005739"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031314", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extrinsic component of mitochondrial inner membrane", 
                        "id": "GO:0031314"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitochondrial respiratory chain complex I assembly", 
                        "id": "GO:0032981"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "methylation", 
                        "id": "GO:0032259"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030961", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2APY7", 
                                "id": "A2APY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidyl-arginine hydroxylation", 
                        "id": "GO:0030961"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 267, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 265
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027384", 
            "id": "ENSMUSG00000027384", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/69487", 
            "id": "69487", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013216", 
            "id": "IPR013216", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", 
            "id": "IPR029063", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69487", 
            "id": "mmu:69487", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1916737", 
            "id": "1916737", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/IYFVGWK/", 
            "id": "IYFVGWK", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=691814at2759", 
            "id": "691814at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF08241", 
            "id": "PF08241", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2APY7", 
            "id": "PR_A2APY7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799198", 
            "id": "R-MMU-6799198", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081369", 
            "id": "NP_081369", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081369.2", 
            "id": "NP_081369.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7", 
            "id": "A2APY7", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7-1", 
            "id": "A2APY7-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7-2", 
            "id": "A2APY7-2", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "disease_id": "DOID:0060536", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:0060536", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "isolated mitochondrial respiratory chain complex I deficiency", 
                    "id": "DOID:0060536"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0060536", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "isolated NADH-coenzyme Q reductase deficiency", 
                    "id": "DOID:0060536"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0060536", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "isolated NADH-CoQ reductase deficiency", 
                    "id": "DOID:0060536"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0060536", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "isolated NADH-ubiquinone reductase deficiency", 
                    "id": "DOID:0060536"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:0060536", 
                "resource": "Disease Ontology", 
                "description": "A mitochondrial metabolism disease characterized by a wide range of manifestations including marked and often fatal lactic acidosis, cardiomyopathy, leukoencephalopathy, pure myopathy and hepatopathy with tubulopathy. Among the numerous clinical phenotypes observed are Leigh syndrome, Leber hereditary optic neuropathy and MELAS syndrome. It can have material basis in mutations in multiple different genes, both nuclear-encoded and mitochondrial-encoded.", 
                "name": "mitochondrial complex I deficiency", 
                "id": "DOID:0060536"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0060536#disease-associations", 
                    "id": "0060536", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 38405.0, 
        "chemical_mass": 38405.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7", 
            "name": "Ndufaf5", 
            "locus": {
                "end_pos": 140203689, 
                "strand": "+", 
                "start_pos": 140170649, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000027384", 
                        "id": "ENSMUSG00000027384", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "1.-.-.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.1.1.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Arginine-hydroxylase NDUFAF5, mitochondrial"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2APY7#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Putative methyltransferase NDUFAF5"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "arginine-hydroxylase NDUFAF5, mitochondrial precursor"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "probable methyltransferase C20orf7 homolog, mitochondrial; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; putative methyltransferase NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial; NADH dehydrogenase (ubiquinone) complex I, assembly factor 5"
        }
    ]
}