{ "uniprot_canonical_ac": "A2A472-1", "ptm_annotation": [], "sequence": { "header": "tr|A2A472-1|A2A472_MOUSE Isoform 1 of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1", "length": 547, "sequence": "MGGGGAGPPANRGPRVVGRLIKLLFLAFFSLSVLIMQQHLTEAVAGAFSRCLGFRGMRLRLLTRHWCIAGASLQKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCSLLPRDKSLYLT" }, "uniprot_id": "A2A473_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11812828", "type": "PubMed", "id": "11812828" } ], "title": "Gene expression in the developing mouse retina by EST sequencing and microarray analysis.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ], "authors": "Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14764631", "type": "PubMed", "id": "14764631" } ], "title": "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells.", "journal": "Endocrinology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ], "authors": "Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15226823", "type": "PubMed", "id": "15226823" } ], "title": "Genomic analysis of mouse retinal development.", "journal": "PLoS biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ], "authors": "Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15496829", "type": "PubMed", "id": "15496829" } ], "title": "Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database.", "journal": "Molecular vision", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ], "authors": "Liang S, Zhao S, Mu X, Thomas T, Klein WH", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30037996", "type": "PubMed", "id": "30037996" } ], "title": "Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ], "authors": "Sima J, Yan Z, Chen Y, Lehrmann E, Zhang Y, Nagaraja R, Wang W, Wang Z, Schlessinger D", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31152140", "type": "PubMed", "id": "31152140" } ], "title": "TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ], "authors": "Seo H, Chen J, Gonzalez-Avalos E, Samaniego-Castruita D, Das A, Wang YH, Lopez-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A", "date": "2019" } ], "uniprot_ac": "A2A472", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A472", "type": "synonym", "resource": "RefSeq", "name": "AI851523; AV026525; BI987407; Gcx1; RxHMG; RxHMG1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A472", "type": "synonym", "resource": "RefSeq", "name": "Tox2" }, { "url": "https://www.uniprot.org/uniprot/A2A472", "type": "recommended", "resource": "UniProtKB", "name": "Tox2" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A472#A2A472-1", "isoform_ac": "A2A472-1", "locus": { "end_pos": 163225363, "strand": "-", "start_pos": 163322777, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099110", "id": "ENSMUST00000099110", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000096710", "id": "ENSMUSP00000096710", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A472-1|A2A472_MOUSE Isoform 1 of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1", "length": 547, "sequence": "MGGGGAGPPANRGPRVVGRLIKLLFLAFFSLSVLIMQQHLTEAVAGAFSRCLGFRGMRLRLLTRHWCIAGASLQKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCSLLPRDKSLYLT" } }, { "url": "https://www.uniprot.org/uniprot/A2A472#A2A473-1", "isoform_ac": "A2A473-1", "locus": { "end_pos": 163203164, "strand": "-", "start_pos": 163322777, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000109428", "id": "ENSMUST00000109428", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000105055", "id": "ENSMUSP00000105055", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A473-1|A2A472_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1", "length": 505, "sequence": "MDVRLYPSAPAVGARPGAEPAGLAHLDYYHCGKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCSLLPRDKSLYLT" } }, { "url": "https://www.uniprot.org/uniprot/A2A472#A2A474-1", "isoform_ac": "A2A474-1", "locus": { "end_pos": 163204605, "strand": "-", "start_pos": 163276097, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000128999", "id": "ENSMUST00000128999", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122344", "id": "ENSMUSP00000122344", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A474-1|A2A472_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1", "length": 124, "sequence": "MLSGCCSSRASGRSLGLRGWASLQVHPQALRERLRPGALCSSPWSGRRGPRRPGRPGAEFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHG" } }, { "url": "https://www.uniprot.org/uniprot/A2A472#E9Q0B9-1", "isoform_ac": "E9Q0B9-1", "locus": { "end_pos": 163225468, "strand": "-", "start_pos": 163323007, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000165937", "id": "ENSMUST00000165937", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000126243", "id": "ENSMUSP00000126243", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9Q0B9-1|E9Q0B9_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1", "length": 522, "sequence": "MQQHLTEAVAGAFSRCLGFRGMRLRLLTRHWCIAGASLQKFDGDSAYVGMSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHGSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSVDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRGSPPPTTSPKNLQEPSAR" } }, { "url": "https://www.uniprot.org/uniprot/A2A472#F6XVL5-1", "isoform_ac": "F6XVL5-1", "locus": { "end_pos": 163320378, "strand": "-", "start_pos": 163323009, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000148599", "id": "ENSMUST00000148599", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118219", "id": "ENSMUSP00000118219", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6XVL5-1|F6XVL5_MOUSE Computationally mapped isoform of TOX high mobility group box family member 2 OS=Mus musculus OX=10090 GN=Tox2 PE=1 SV=1 CANONICAL=A2A472-1", "length": 169, "sequence": "XAMPGLASFLTPSDLQAFRSGASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPASMALQVQLAMSPSPPGPQDFPHISDFSSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRGSPPPTTSPKNLQEPSAR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269389", "resource": "KEGG Pathway", "id": "mmu:269389", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "annotation": "Identification and functional analysis of the rat Gcx1 ortholog.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "annotation": "Tox2(-/-) mice exhibited defective Tfh differentiation, and inhibition of both Tox2 and the related transcription factor Tox abolished Tfh differentiation. Thus, a Tox2-Bcl6 axis establishes a transcriptional feed-forward loop that promotes the Tfh program.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q76IQ7-1", "protein_name": "TOX high mobility group box family member 2", "sequence": { "length": 473, "sequence": "MSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGLRSGIAHSSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSTDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSAASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPAPMALQVQLAMSPSPPGPQDFPHISDFPSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRSSPPPTTSPKNLQEPSAR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13155", "id": "13155", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Tox2", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q96NM4-1", "protein_name": "TOX high mobility group box family member 2", "sequence": { "length": 488, "sequence": "MQQTRTEAVAGAFSRCLGFCGMRLGLLLLARHWCIAGVFPQKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLLPRDKSLYLT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13155", "id": "13155", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TOX2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "ac": "NP_001092269.1", "name": "TOX high mobility group box family member 2 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "chromatin DNA binding", "id": "GO:0031490" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001085", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription factor binding", "id": "GO:0001085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074607", "id": "ENSMUSG00000074607", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/269389", "id": "269389", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "id": "IPR009071", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "id": "IPR036910", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269389", "id": "mmu:269389", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:3611233", "id": "3611233", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/PPSKMIP/", "id": "PPSKMIP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=818359at2759", "id": "818359at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00505", "id": "PF00505", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269", "id": "NP_001092269", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092269.1", "id": "NP_001092269.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006499675", "id": "XP_006499675", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006499675.1", "id": "XP_006499675.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A472", "id": "A2A472", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A472-1", "id": "A2A472-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A473", "id": "A2A473", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A473-1", "id": "A2A473-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A474", "id": "A2A474", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A474-1", "id": "A2A474-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/E9Q0B9", "id": "E9Q0B9", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/E9Q0B9-1", "id": "E9Q0B9-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F6XVL5", "id": "F6XVL5", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F6XVL5-1", "id": "F6XVL5-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 57797.0, "chemical_mass": 57797.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A472", "name": "Tox2", "locus": { "end_pos": 163324170, "strand": "+", "start_pos": 163203125, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074607", "id": "ENSMUSG00000074607", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A472", "type": "synonym", "resource": "RefSeq", "name": "TOX high mobility group box family member 2 isoform 1" }, { "url": "https://www.uniprot.org/uniprot/A2A472#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "TOX high mobility group box family member 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A472", "type": "synonym", "resource": "RefSeq", "name": "granulosa cell HMG-box protein 1" } ] }