{ "uniprot_canonical_ac": "A2A432-1", "ptm_annotation": [ { "annotation": "Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q13620", "id": "Q13620", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A432-1|CUL4B_MOUSE Isoform 1 of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 970, "sequence": "MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" }, "uniprot_id": "CUL4B_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": "PubMed", "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16052071", "type": "PubMed", "id": "16052071" } ], "title": "Cloning and characterization of mouse cullin4B/E3 ubiquitin ligase.", "journal": "J. Biosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Kota S.K., Sastry K.S., Srinivas U.K., Tripathi R.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": "PubMed", "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PXY1", "id": "E9PXY1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/J3QJX0", "id": "J3QJX0", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17954973", "type": "PubMed", "id": "17954973" } ], "title": "Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.", "journal": "Journal of biosciences", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Tripathi R, Kota SK, Srinivas UK", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "type": "PubMed", "id": "21183079" } ], "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" }, { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2A432", "id": "A2A432", "database": "iPTMnet" } ], "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29106389", "type": "PubMed", "id": "29106389" } ], "title": "CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2.", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Qi M, Jiao M, Li X, Hu J, Wang L, Zou Y, Zhao M, Zhang R, Liu H, Mi J, Zhang L, Liu L, Gong Y, Han B", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30992047", "type": "PubMed", "id": "30992047" } ], "title": "Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.", "journal": "Epigenetics & chromatin", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Lin Y, Yu J, Wu J, Wang S, Zhang T", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31235785", "type": "PubMed", "id": "31235785" } ], "title": "Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells.", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Xu Z, Li L, Qian Y, Song Y, Qin L, Duan Y, Wang M, Li P, Jiang B, Ma C, Shao C, Gong Y", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31260508", "type": "PubMed", "id": "31260508" } ], "title": "Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31653699", "type": "PubMed", "id": "31653699" } ], "title": "Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARgamma for proteasomal degradation.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ], "authors": "Dou H, Duan Y, Zhang X, Yu Q, Di Q, Song Y, Li P, Gong Y", "date": "2019" } ], "uniprot_ac": "A2A432", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A432", "type": "synonym", "resource": "RefSeq", "name": "2700050M05Rik; AA409770; CUL-4B; mKIAA0695" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A432", "type": "synonym", "resource": "RefSeq", "name": "Cul4b" }, { "url": "https://www.uniprot.org/uniprot/A2A432", "type": "recommended", "resource": "UniProtKB", "name": "Cul4b" }, { "url": "https://www.uniprot.org/uniprot/A2A432", "type": "synonym", "resource": "UniProtKB", "name": "mKIAA0695" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A432#A2A432-1", "isoform_ac": "A2A432-1", "locus": { "end_pos": 38533636, "strand": "+", "start_pos": 38572464, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000050083", "id": "ENSMUST00000050083", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000059276", "id": "ENSMUSP00000059276", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A432-1|CUL4B_MOUSE Isoform 1 of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 970, "sequence": "MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A432#A2A432-2", "isoform_ac": "A2A432-2", "locus": {}, "sequence": { "header": "sp|A2A432-2|CUL4B_MOUSE Isoform 2 of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 941, "sequence": "MSRSTRSKERRENDTDSEDNSSETSNQERRRCRQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A432#E9PXY1-1", "isoform_ac": "E9PXY1-1", "locus": { "end_pos": 38533636, "strand": "+", "start_pos": 38564221, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000016681", "id": "ENSMUST00000016681", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000016681", "id": "ENSMUSP00000016681", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PXY1-1|CUL4B_MOUSE Computationally mapped isoform of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=2 CANONICAL=A2A432-1", "length": 896, "sequence": "MFPTGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" } }, { "url": "https://www.uniprot.org/uniprot/A2A432#J3QJX0-1", "isoform_ac": "J3QJX0-1", "locus": { "end_pos": 38545600, "strand": "+", "start_pos": 38564221, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000147129", "id": "ENSMUST00000147129", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000136083", "id": "ENSMUSP00000136083", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|J3QJX0-1|J3QJX0_MOUSE Computationally mapped isoform of Cullin-4B OS=Mus musculus OX=10090 GN=Cul4b PE=1 SV=1 CANONICAL=A2A432-1", "length": 552, "sequence": "MFPTGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGIDTKMAEESSSSSSSSSPTAATSQQQQQQQLKTKSILISSVASVHHANGLAKSSTAVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSHKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIVFLHFS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72584", "resource": "KEGG Pathway", "id": "mmu:72584", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-110314", "description": "Recognition of DNA damage by PCNA-containing replication complex", "resource": "Reactome", "id": "R-MMU-110314", "name": "Recognition of DNA damage by PCNA-containing replication complex" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696394", "description": "DNA Damage Recognition in GG-NER", "resource": "Reactome", "id": "R-MMU-5696394", "name": "DNA Damage Recognition in GG-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696395", "description": "Formation of Incision Complex in GG-NER", "resource": "Reactome", "id": "R-MMU-5696395", "name": "Formation of Incision Complex in GG-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696400", "description": "Dual Incision in GG-NER", "resource": "Reactome", "id": "R-MMU-5696400", "name": "Dual Incision in GG-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6781823", "description": "Formation of TC-NER Pre-Incision Complex", "resource": "Reactome", "id": "R-MMU-6781823", "name": "Formation of TC-NER Pre-Incision Complex" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6782135", "description": "Dual incision in TC-NER", "resource": "Reactome", "id": "R-MMU-6782135", "name": "Dual incision in TC-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6782210", "description": "Gap-filling DNA repair synthesis and ligation in TC-NER", "resource": "Reactome", "id": "R-MMU-6782210", "name": "Gap-filling DNA repair synthesis and ligation in TC-NER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "description": "Neddylation", "resource": "Reactome", "id": "R-MMU-8951664", "name": "Neddylation" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "Aryl hydrocarbon receptor (AhR) functions as a substrate receptor for Cullin 4b (Cul4b)-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) degradation in mouse 3T3-L1 cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "CUL4B level mediates HOX gene expression via histone H2A ubiquitination. Aberrant CUL4B-mediated H2AK119ub1 level may be a risk factor for neural tube defects. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A432#function", "annotation": "Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (By similarity). With CUL4A, contributes to ribosome biogenesis (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432#function", "id": "A2A432", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "Demonstrate that the enhanced growth and metastasis of transplanted tumor cells in hematopoietic or myeloid cell-specific Cul4b knockout recipient mice is mediated by increased production of IL-6 in myeloid-derived suppressive cells", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "High CUL4B expression promotes gastric cancer invasion and metastasis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "Plays a conserved role in the regulation of beta-catenin levels.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "Study in Cul4b knockout mice showed that the loss of embryonic Cul4b affects the growth of the inner cell mass in vitro and delays epiblast development during the gastrulation period at E6.5~E7.5 in vivo, as highlighted by the absence of the epiblastic transcription factor Brachyury from E6.5~E7.5. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "annotation": "The cloning and expression of amino and carboxy-terminal halves of cullin4B in mouse PCC4 cells is reported.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103612.1", "id": "NP_001103612.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZK73-1", "protein_name": "Cullin 4B (Predicted)", "sequence": { "length": 971, "sequence": "MSRSTKSRERRENDANSEDNSSETSNQERRRCLQGPPRPPYPPLLPPVFPPPTPPPQVRRTRGLQDLGAMKSVCPGTSGFSSPNPSAASAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSSNSSNEREDFDSTSSSSTPPQPRDSASPSTSSFCLGVPVATSSHVPIQKKLRFEDTLEFVGFDTKMAEESSSSSSSSSPTAATSQQQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLNMLSDLQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVLLQHWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" }, "evidence": [ { "url": 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"MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2660", "id": 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"name": "SCF ubiquitin ligase complex", "id": "GO:0019005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031461", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "cullin-RING ubiquitin ligase complex", "id": "GO:0031461" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031465", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "Cul4B-RING E3 ubiquitin ligase complex", "id": "GO:0031465" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "pmid": "26711351", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "ribosome biogenesis", "id": "GO:0042254" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "pmid": "18602923", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": 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"", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A432", "id": "A2A432", "database": "UniProtKB" } ], "name": "histone H2A monoubiquitination", "id": "GO:0035518" } ], "total": 14, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 104, "annotation": "n_glycosylation_sequon", "start_pos": 102 }, { "end_pos": 119, "annotation": "n_glycosylation_sequon", "start_pos": 117 }, { "end_pos": 126, "annotation": "n_glycosylation_sequon", "start_pos": 124 }, { "end_pos": 15, "annotation": "n_glycosylation_sequon", "start_pos": 13 }, { "end_pos": 22, "annotation": "n_glycosylation_sequon", "start_pos": 20 }, { "end_pos": 270, "annotation": "n_glycosylation_sequon", "start_pos": 268 }, { "end_pos": 288, "annotation": "n_glycosylation_sequon", "start_pos": 286 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031095", "id": "ENSMUSG00000031095", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/72584", 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An abnormal gait, tremor, decreased fine motor coordination and impaired speech are also present. The syndrome has been described in six boys from three generations of the same family. Transmission is X-linked and the causative gene has been localised to the q24-q25 region of the X chromosome.", "name": "X-linked intellectual disability, Cabezas type", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "syndromic X-linked intellectual disability Cabezas type", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "Cabezas syndrome; syndromic X-linked mental retardation 15", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "mental retardation, X-linked, with short stature", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "mental retardation, X-linked, syndromic, Cabezas type", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "MRSS", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "Cabezas syndrome", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "X-linked mental retardation with short stature", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "intellectual disability, X-linked, syndromic 15", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "MRXSC", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "mental retardation, X-linked, syndromic, Cabezas type; MRXSC", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "Cabezas type of X-linked syndromic intellectual disability", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "X-linked mental retardation with short stature, hypogonadism, and abnormal gait", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "MRXS15", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "mental retardation, X-linked, with short stature, hypogonadism, and abnormal Gait", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "Cul4B-related X-linked intellectual disability", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "mental retardation, X-linked, syndromic 15", "id": "MONDO:0010306" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010306", "resource": "MONDO", "description": "", "name": "mental retardation, X-linked, syndromic 15 (Cabezas type)", "id": "MONDO:0010306" }, { "url": "https://www.omim.org/entry/300354", "resource": "MIM", "description": "Mental retardation, X-linked, syndromic, 15", "name": "Mental retardation, X-linked, syndromic, 15", "id": "MIM:300354" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:0060822", "resource": "Disease Ontology", "description": "A syndromic X-linked intellectual disability characterized by intellectual deficit, muscle wasting, short stature, hypogonadism, and bnormal gait, with variable occurrence of prominent lower lip, kyphosis, joint hyperextensibility, tremor, decreased fine motor coordination and impaired speech that has_material_basis_in mutation in the CUL4B gene on chromosome Xq23.", "name": "syndromic X-linked intellectual disability Cabezas type", "id": "DOID:0060822" }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0060822#disease-associations", "id": "0060822", "database": "Alliance of Genome Resources" } ] }, { "disease_id": "DOID:1059", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:1059", "resource": "Disease Ontology", "description": "", "name": "MENTAL RETARDATION, AUTOSOMAL RECESSIVE 15", "id": "DOID:1059" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:1059", "resource": "Disease Ontology", "description": "A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.", "name": "intellectual disability", "id": "DOID:1059" }, "evidence": [ { "url": 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