{ "uniprot_canonical_ac": "A0PJX4-1", "ptm_annotation": [], "sequence": { "header": "sp|A0PJX4-1|SHSA3_HUMAN Isoform 1 of Protein shisa-3 homolog OS=Homo sapiens OX=9606 GN=SHISA3 PE=1 SV=1 CANONICAL=A0PJX4-1", "length": 238, "sequence": "MRALLALCLLLGWLRWGPAGAQQSGEYCHGWVDVQGNYHEGFQCPEDFDTLDATICCGSCALRYCCAAADARLEQGGCTNDRRELEHPGITAQPVYVPFLIVGSIFIAFIILGSVVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSPRAPSRQSSTATSSSSTGGSIRRFSFARAEPGCLVPSPPPPYTTSHSIHLAQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" }, "uniprot_id": "SHSA3_HUMAN", "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17481602", "type": "PubMed", "id": "17481602" } ], "title": "Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings.", "journal": "Developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Furushima K, Yamamoto A, Nagano T, Shibata M, Miyachi H, Abe T, Ohshima N, Kiyonari H, Aizawa S", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22120523", "type": "PubMed", "id": "22120523" } ], "title": "Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors.", "journal": "Cellular signalling", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Pei J, Grishin NV", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25036006", "type": "PubMed", "id": "25036006" } ], "title": "Shisa3 is associated with prolonged survival through promoting beta-catenin degradation in lung cancer.", "journal": "American journal of respiratory and critical care medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan S, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25968618", "type": "PubMed", "id": "25968618" } ], "title": "DNA Hypermethylation of SHISA3 in Colorectal Cancer: An Independent Predictor of Poor Prognosis.", "journal": "Annals of surgical oncology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Tsai MH, Chen WC, Yu SL, Chen CC, Jao TM, Huang CY, Tzeng ST, Yen SJ, Yang YC", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28299336", "type": "PubMed", "id": "28299336" } ], "title": "SHISA3 Promoter Methylation Is a Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma.", "journal": "BioMed research international", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Shen Z, Zhou C, Li J, Ye D, Deng H, Cao B, Hao W, Lin L, Zhang Y", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30573520", "type": "PubMed", "id": "30573520" } ], "title": "Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability.", "journal": "Cancer research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Zhang J, Li YQ, Guo R, Wang YQ, Zhang PP, Tang XR, Wen X, Hong XH, Lei Y, He QM, Yang XJ, Sun Y, Ma J, Liu N", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31801598", "type": "PubMed", "id": "31801598" } ], "title": "Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties.", "journal": "Journal of experimental & clinical cancer research : CR", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Si J, Ma Y, Bi JW, Xiong Y, Lv C, Li S, Wu N, Yang Y", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/32692756", "type": "PubMed", "id": "32692756" } ], "title": "SHISA3, an antagonist of the Wnt/beta-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ], "authors": "Shahzad N, Munir T, Javed M, Tasneem F, Aslam B, Ali M, Mutahir Z, Akhtar Ali M, Umer M, Ahmad M, Farooq K, Hassan U, Mustafa T, Anjum RS, Shakoori AR", "date": "2020" } ], "uniprot_ac": "A0PJX4", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0PJX4", "type": "synonym", "resource": "RefSeq", "name": "SHISA3" }, { "url": "https://www.uniprot.org/uniprot/A0PJX4", "type": "recommended", "resource": "UniProtKB", "name": "SHISA3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0PJX4", "type": "synonym", "resource": "RefSeq", "name": "hShisa3" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4#A0PJX4-1", "isoform_ac": "A0PJX4-1", "locus": { "end_pos": 42398057, "strand": "-", "start_pos": 42401448, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000319234", "id": "ENST00000319234", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000326445", "id": "ENSP00000326445", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0PJX4-1|SHSA3_HUMAN Isoform 1 of Protein shisa-3 homolog OS=Homo sapiens OX=9606 GN=SHISA3 PE=1 SV=1 CANONICAL=A0PJX4-1", "length": 238, "sequence": "MRALLALCLLLGWLRWGPAGAQQSGEYCHGWVDVQGNYHEGFQCPEDFDTLDATICCGSCALRYCCAAADARLEQGGCTNDRRELEHPGITAQPVYVPFLIVGSIFIAFIILGSVVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSPRAPSRQSSTATSSSSTGGSIRRFSFARAEPGCLVPSPPPPYTTSHSIHLAQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:152573", "resource": "KEGG Pathway", "id": "hsa:152573", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "Down-regulation of SHISA3 expression was associated with colorectal cancer.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "For TKI-resistant PC9/ER tumors in nod-scid mice, overexpressed shisa3 had a significant inhibitory effect. In addition, we verified that shisa3 inhibited EGFR-TKI resistance by interacting with FGFR1/3 to regulate AKT/mTOR signaling. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "Low Shisa3 expression is associated with Nasopharyngeal Carcinoma Metastasis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A0PJX4#function", "annotation": "Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0PJX4#function", "id": "A0PJX4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "SHISA3 promoter hypermethylation might increase the risk of LSCC through regulation of gene expression and is a potential diagnostic and prognostic biomarker for laryngeal squamous cell carcinoma", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "annotation": "SHISA3, an antagonist of the Wnt/beta-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B5DF81-1", "protein_name": "Similar to MGC68837 protein (Predicted)", "sequence": { "length": 238, "sequence": "MGALLALCLLVGLLRWGPAGAQQPGEYCHGWVDAQGNYHEGFQCPEDFDTQDATICCGSCALRYCCAAADARLEQGGCTNDRGELEHPGITAQPVYVPFLIVGSIFIAFIILGSLVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSLRTASRQSSTATSSSSTGGSVRRFSFARAEPNCLVPSSPPPYTTGHTIHLTQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/47831", "id": "47831", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0PJX4/", "id": "A0PJX4", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Shisa3", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q3UPR0-1", "protein_name": "Protein shisa-3 homolog", "sequence": { "length": 238, "sequence": "MGALLAFCLLVGLLRWGPAGAQQPGEYCHGWVDAQGNYHEGFQCPEDFDTQDATICCGSCALRYCCAAADARLEQGGCTNDRGELEHPGITAQPVYVPFLIVGSIFIAFIILGSLVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSLRAASRQSSTATSSSSTGGSVRRFSFARAEPSCLVPSSPPPYTTGHTIHLTQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/47831", "id": "47831", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0PJX4/", "id": "A0PJX4", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Shisa3", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.2%).", "sequence_org": "W", "start_pos": 13, "alt_nt": "T", "chr_id": "4", "subjects_positive": "3", "chr_pos": "42400112", "disease": [ { "disease_id": "DOID:9256", "synonyms": [ { "url": "https://monarchinitiative.org/disease/MONDO:0023113", "resource": "MONDO", "description": "Familial colon cancer is a cluster of colon cancer within a family. Most cases ofcolon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes ( mutations ) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories.", "name": "familial colorectal cancer", "id": "MONDO:0023113" }, { "url": "https://monarchinitiative.org/disease/MONDO:0023113", "resource": "MONDO", "description": "", "name": "hereditary colorectal cancer", "id": "MONDO:0023113" }, { "url": "https://monarchinitiative.org/disease/MONDO:0023113", "resource": "MONDO", "description": "", "name": "colorectal cancer, familial", "id": "MONDO:0023113" }, { "url": "https://www.omim.org/entry/114500", "resource": "MIM", "description": "Colorectal cancer", "name": "Colorectal cancer", "id": "MIM:114500" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:9256", "resource": "Disease Ontology", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum.", "name": "colorectal cancer", "id": "DOID:9256" } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0PJX4", "id": "A0PJX4", "database": "BioMuta" } ], "glycoeffect": [], "frequency": "1.2", "sequence_mut": "C", "subjects_tested": "254", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "end_pos": 13, "minor_allelic_frequency": "", "ref_nt": "G" }, { "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. 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"https://www.nextprot.org/entry/NX_A0PJX4", "id": "NX_A0PJX4", "database": "neXtProt" }, { "url": "https://omabrowser.org/oma/group/PYFGYPL/", "id": "PYFGYPL", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1325567at2759", "id": "1325567at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31395", "id": "PTHR31395", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF13908", "id": "PF13908", "database": "Pfam" }, { "url": "https://pharos.nih.gov/targets/A0PJX4", "id": "A0PJX4", "database": "PHAROS" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A0PJX4", "id": "PR_A0PJX4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974", "id": "NP_001073974", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073974.1", "id": "NP_001073974.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0PJX4", "id": "A0PJX4", "database": "UniProtKB" }, { 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