{
    "uniprot_canonical_ac": "A0A1B0GS75-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A1B0GS75-1|A0A1B0GS75_MOUSE Isoform 1 of Interferon-induced transmembrane protein 6  OS=Mus musculus OX=10090 GN=Ifitm6 PE=3 SV=1 CANONICAL=A0A1B0GS75-1", 
        "length": 124, 
        "sequence": "MAVICSFLWPWSEASQPHKNMVKRDPDSAPVPSTVVCINSDVIQPDHITWSTFNTVFMNGCCLGFIAYIYSVKSRDRKMVGDMTGAQSHASTAKILNILALVISLIFYIMLIVLYSFNLLGNQR"
    }, 
    "uniprot_id": "A0A1B0GS75_MOUSE", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                    "id": "A0A1B0GS75", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12659663", 
                    "type": "PubMed", 
                    "id": "12659663"
                }
            ], 
            "title": "The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice.", 
            "journal": "BMC developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
                    "id": "NP_001028804.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lange UC, Saitou M, Western PS, Barton SC, Surani MA", 
            "date": "2003"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18505827", 
                    "type": "PubMed", 
                    "id": "18505827"
                }
            ], 
            "title": "Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.", 
            "journal": "Molecular and cellular biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
                    "id": "NP_001028804.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A, Surani MA", 
            "date": "2008"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20064371", 
                    "type": "PubMed", 
                    "id": "20064371"
                }
            ], 
            "title": "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.", 
            "journal": "Cell", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
                    "id": "NP_001028804.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22363774", 
                    "type": "PubMed", 
                    "id": "22363774"
                }
            ], 
            "title": "The dispanins: a novel gene family of ancient origin that contains 14 human members.", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
                    "id": "NP_001028804.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sallman Almen M, Bringeland N, Fredriksson R, Schioth HB", 
            "date": "2012"
        }
    ], 
    "uniprot_ac": "A0A1B0GS75", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GS75", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "A330075D07; Dspa2f; Fgls5; fra; fragilis5"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GS75", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ifitm6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ifitm6"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75#A0A1B0GS75-1", 
            "isoform_ac": "A0A1B0GS75-1", 
            "locus": {
                "end_pos": 141016007, 
                "strand": "+", 
                "start_pos": 141017423, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000211330", 
                        "id": "ENSMUST00000211330", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147821", 
                        "id": "ENSMUSP00000147821", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A1B0GS75-1|A0A1B0GS75_MOUSE Isoform 1 of Interferon-induced transmembrane protein 6  OS=Mus musculus OX=10090 GN=Ifitm6 PE=3 SV=1 CANONICAL=A0A1B0GS75-1", 
                "length": 124, 
                "sequence": "MAVICSFLWPWSEASQPHKNMVKRDPDSAPVPSTVVCINSDVIQPDHITWSTFNTVFMNGCCLGFIAYIYSVKSRDRKMVGDMTGAQSHASTAKILNILALVISLIFYIMLIVLYSFNLLGNQR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75#Q3SXF0-1", 
            "isoform_ac": "Q3SXF0-1", 
            "locus": {
                "end_pos": 141016007, 
                "strand": "+", 
                "start_pos": 141016858, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000209328", 
                        "id": "ENSMUST00000209328", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147357", 
                        "id": "ENSMUSP00000147357", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|Q3SXF0-1|Q3SXF0_MOUSE Computationally mapped isoform of Interferon-induced transmembrane protein 6  OS=Mus musculus OX=10090 GN=Ifitm6 PE=2 SV=1 CANONICAL=A0A1B0GS75-1", 
                "length": 104, 
                "sequence": "MVKRDPDSAPVPSTVVCINSDVIQPDHITWSTFNTVFMNGCCLGFIAYIYSVKSRDRKMVGDMTGAQSHASTAKILNILALVISLIFYIMLIVLYSFNLLGNQR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213002", 
            "resource": "KEGG Pathway", 
            "id": "mmu:213002", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-198933", 
            "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", 
            "resource": "Reactome", 
            "id": "R-MMU-198933", 
            "name": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
            "annotation": "The increase in IFITM6 expression may be involved in macrophage functions of tumor-bearing mice.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
                    "id": "NP_001028804.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
        "ac": "NP_001028804.1", 
        "name": "interferon induced transmembrane protein 6", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to virus", 
                        "id": "GO:0051607"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of viral genome replication", 
                        "id": "GO:0045071"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060337", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "type I interferon signaling pathway", 
                        "id": "GO:0060337"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034341", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to interferon-gamma", 
                        "id": "GO:0034341"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035455", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to interferon-alpha", 
                        "id": "GO:0035455"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035456", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to interferon-beta", 
                        "id": "GO:0035456"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046597", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
                                "id": "A0A1B0GS75", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of viral entry into host cell", 
                        "id": "GO:0046597"
                    }
                ], 
                "total": 7, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000059108", 
            "id": "ENSMUSG00000059108", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/213002", 
            "id": "213002", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007593", 
            "id": "IPR007593", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213002", 
            "id": "mmu:213002", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2686976", 
            "id": "2686976", 
            "database": "MGI"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1555189at2759", 
            "id": "1555189at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF04505", 
            "id": "PF04505", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-198933", 
            "id": "R-MMU-198933", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804", 
            "id": "NP_001028804", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028804.1", 
            "id": "NP_001028804.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
            "id": "A0A1B0GS75", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75-1", 
            "id": "A0A1B0GS75-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/Q3SXF0", 
            "id": "Q3SXF0", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/Q3SXF0-1", 
            "id": "Q3SXF0-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 13875.0, 
        "chemical_mass": 13875.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75", 
            "name": "Ifitm6", 
            "locus": {
                "end_pos": 141015699, 
                "strand": "-", 
                "start_pos": 141017924, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000059108", 
                        "id": "ENSMUSG00000059108", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A1B0GS75#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Interferon-induced transmembrane protein 6"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GS75", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "fragilis 5"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GS75", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "interferon induced transmembrane protein 6"
        }
    ]
}