{ "uniprot_canonical_ac": "A2AL36-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AL36-1|CNTRL_MOUSE Isoform 1 of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1", "length": 2334, "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH" }, "uniprot_id": "", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10688839", "type": "PubMed", "id": "10688839" } ], "title": "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33).", "journal": "Blood", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36", "database": "UniProtKB" } ], "authors": "Rattner J.B., Birnbaum D., Dastugue N., Guasch G., Mack G.J., Pebusque M.-J., Popovici C.", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "type": "PubMed", "id": "21183079" } ], "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36", "database": "UniProtKB" }, { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AL36", "id": "A2AL36", "database": "iPTMnet" } ], "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23777766", "type": "PubMed", "id": "23777766" } ], "title": "Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.", "journal": "Blood", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "id": "NP_036148.2", "database": "RefSeq" } ], "authors": "Ren M, Qin H, Kitamura E, Cowell JK", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25220058", "type": "PubMed", "id": "25220058" } ], "title": "A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.", "journal": "Current biology : CB", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "id": "NP_036148.2", "database": "RefSeq" } ], "authors": "Chen CT, Hehnly H, Yu Q, Farkas D, Zheng G, Redick SD, Hung HF, Samtani R, Jurczyk A, Akbarian S, Wise C, Jackson A, Bober M, Guo Y, Lo C, Doxsey S", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27002738", "type": "PubMed", "id": "27002738" } ], "title": "Genetic link between renal birth defects and congenital heart disease.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "id": "NP_036148.2", "database": "RefSeq" } ], "authors": "San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ", "date": "2016" } ], "uniprot_ac": "A2AL36", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AL36", "type": "synonym", "resource": "RefSeq", "name": "6720467O09Rik; AA968343; b2b1468.1Clo; b2b1468C; b2b1468Clo; Cep; Cep1; Cep11; Cep110; IB3/; IB3/5; Ma2; Ma2a8" }, { "url": "https://www.uniprot.org/uniprot/A2AL36", "type": "synonym", "resource": "UniProtKB", "name": "Cep110" }, { "url": "https://www.uniprot.org/uniprot/A2AL36", "type": "synonym", "resource": "UniProtKB", "name": "Cep1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AL36", "type": "synonym", "resource": "RefSeq", "name": "Cntrl" }, { "url": "https://www.uniprot.org/uniprot/A2AL36", "type": "recommended", "resource": "UniProtKB", "name": "Cntrl" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AL36#A0A0G2JE96-1", "isoform_ac": "A0A0G2JE96-1", "locus": { "end_pos": 35133964, "strand": "-", "start_pos": 35137679, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000150807", "id": "ENSMUST00000150807", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142683", "id": "ENSMUSP00000142683", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JE96-1|A0A0G2JE96_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=4 CANONICAL=A2AL36-1", "length": 139, "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVN" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#A0A0G2JFA2-1", "isoform_ac": "A0A0G2JFA2-1", "locus": { "end_pos": 35160308, "strand": "-", "start_pos": 35161929, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124081", "id": "ENSMUST00000124081", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000143087", "id": "ENSMUSP00000143087", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JFA2-1|A0A0G2JFA2_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1", "length": 71, "sequence": "DAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEE" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#A0A0J9YTY9-1", "isoform_ac": "A0A0J9YTY9-1", "locus": { "end_pos": 35145096, "strand": "-", "start_pos": 35147459, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000201787", "id": "ENSMUST00000201787", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000143914", "id": "ENSMUSP00000143914", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YTY9-1|A0A0J9YTY9_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1", "length": 122, "sequence": "QLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEVGTQVSQDVLISTVSE" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#A2AL36-1", "isoform_ac": "A2AL36-1", "locus": { "end_pos": 35111586, "strand": "-", "start_pos": 35178092, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028237", "id": "ENSMUST00000028237", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028237", "id": "ENSMUSP00000028237", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AL36-1|CNTRL_MOUSE Isoform 1 of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1", "length": 2334, "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#A2AL36-2", "isoform_ac": "A2AL36-2", "locus": { "end_pos": 35111586, "strand": "-", "start_pos": 35129839, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028235", "id": "ENSMUST00000028235", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028235", "id": "ENSMUSP00000028235", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AL36-2|CNTRL_MOUSE Isoform 2 of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1", "length": 559, "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHVSKMGNLD" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#A2AS42-1", "isoform_ac": "A2AS42-1", "locus": { "end_pos": 35133964, "strand": "-", "start_pos": 35147459, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113033", "id": "ENSMUST00000113033", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108656", "id": "ENSMUSP00000108656", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AS42-1|A2AS42_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1", "length": 481, "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEVGTQVSQDVLISTVSE" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#E9Q9E7-1", "isoform_ac": "E9Q9E7-1", "locus": { "end_pos": 35133964, "strand": "-", "start_pos": 35178092, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113037", "id": "ENSMUST00000113037", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108660", "id": "ENSMUSP00000108660", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9Q9E7-1|E9Q9E7_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1", "length": 1780, "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#F6QP53-1", "isoform_ac": "F6QP53-1", "locus": { "end_pos": 35127381, "strand": "-", "start_pos": 35147460, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000123884", "id": "ENSMUST00000123884", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119760", "id": "ENSMUSP00000119760", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6QP53-1|F6QP53_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=1 CANONICAL=A2AL36-1", "length": 635, "sequence": "XETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEVGTQVSQDVLISTVSE" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#R4GML3-1", "isoform_ac": "R4GML3-1", "locus": { "end_pos": 35111586, "strand": "-", "start_pos": 35178092, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113032", "id": "ENSMUST00000113032", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108655", "id": "ENSMUSP00000108655", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|R4GML3-1|R4GML3_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1", "length": 2333, "sequence": "MKKGSERRLSKAKMPLSSHFPGPSSLRSSMRSRSLSPLIGSETQPLHPGGQWPAQAELTDESTVPLEPQQRKGAESYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIVKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLVLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKNQDKLNKSLKEEAMLQKQSCEELESDLSTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKYPDESPYIGKSRYKRNMFATETYIVSDAQAVQIRKMVPEGGQLRHEHTPPRVQAPPDLQLEDTEKKISAAQTRLSELHHEIETAEQKVLRATQEFKQLEEAIQQKKISEAEKDLLLKQLSGRLQHLNRLRQEALDLEIQMEKQRKEIAEKHEEINTVQLATDSLDPKDPKHSHMKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAQHSEDHHLQVLRESETLLQAKRAELETLKSQVTSQQQELAVLDSELGHRREELLLLQDSLAQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISEKKTQLALIQQEMEKEEKNLQVVLQQLSRHKTELKNVADILQLETSELQGLKLQHDQKVVELEKAQVDVLEEKLELENLQQATQQQRRELERQRQLLERDRRETERVRAESQALQSCVECLSKEKEDLQGQCESWEKKSSHAQRVLAATEESNKMEQSNLGKLELSVRKLRQELEQLSQDKLALHSEVAEVQQQLQGKQEAINSLQEELDSTQDHLDLAKQDLIHTTKCQNELLNEQTQLQEDISKWMARLESCQKETETKEQQVQQLQDEIRESKLRLDQQEMMFQKLQKEREREEQKFEAGKVTLEQQQRQLEKELTDQKSRLKQLLTDVSAAEGRLGTLQEEERRIEGLERMLSQAKQQLSEREQQLMAKSGELLALQKEADDMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELSQMQQEYLELKKQVANQKDLERRQMEVSDAMRTLKSEVKDEIRTSLRNLNQFLPELPADLASILERNENLRELESLKENFPFTTKERIFEEKSNFPQVHIMDEHWRGEALRQRLRRHEDQLKAQLRHCMSKQAEVLIKGKQQTEGTLHSLRRQVDALGELVTSTSTDSASSPSLPSLVEDSQHGHSQSSFQVLQVPLEEPNSYRH" } }, { "url": "https://www.uniprot.org/uniprot/A2AL36#R4GML4-1", "isoform_ac": "R4GML4-1", "locus": { "end_pos": 35133964, "strand": "-", "start_pos": 35160635, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113034", "id": "ENSMUST00000113034", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000108657", "id": "ENSMUSP00000108657", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|R4GML4-1|R4GML4_MOUSE Computationally mapped isoform of Centriolin OS=Mus musculus OX=10090 GN=Cntrl PE=1 SV=2 CANONICAL=A2AL36-1", "length": 987, "sequence": "MKAQKRGKEQQLDIMNRQYTQLESRLDEILCRIAKETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLQDEKETLLQRLTEVQQEKEELELIAMDAENMRKELAELESALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELEKLLRRTQLEQSVLQTELEKERESLRDALGKAQSSEEKQQENNELRTQLKQLQDDNSLLKKQLKEFQNHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFRQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKKREDARSQEQFLGLDEELKSLKKAVAASDKLAAAELTIAKDQLKSLHGTVVRINQERAEELQEAERFSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENADLGAKGANSQLLEIEALNEAMAKQRAEITRLRDVLNLTGAGTKGGIENVLEEIAELRHAVSAQNEYISSMADPFRRQGWWYFMPPAPSSKVSSHSSQATKDSGLGLKYTASTPLRKPQPGQQEEKDSSGPLPASGYWVYSPIRSTLHKSFSKREDADSGGDSQEESGLDDQEEPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPNSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLVPAGVQHCNIPEHHNLENEVSRLEDIMQHLKSKQREERRQKASTQHSEEEVDGLHRDIDDLLQEKKELELEVEELHRTIERHQQRKDFIDGHVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAENELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLN" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2565942", "description": "Regulation of PLK1 Activity at G2/M Transition", "resource": "Reactome", "id": "R-MMU-2565942", "name": "Regulation of PLK1 Activity at G2/M Transition" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "description": "Loss of Nlp from mitotic centrosomes", "resource": "Reactome", "id": "R-MMU-380259", "name": "Loss of Nlp from mitotic centrosomes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380270", "description": "Recruitment of mitotic centrosome proteins and complexes", "resource": "Reactome", "id": "R-MMU-380270", "name": "Recruitment of mitotic centrosome proteins and complexes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380284", "description": "Loss of proteins required for interphase microtubule organization from the centrosome", "resource": "Reactome", "id": "R-MMU-380284", "name": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380320", "description": "Recruitment of NuMA to mitotic centrosomes", "resource": "Reactome", "id": "R-MMU-380320", "name": "Recruitment of NuMA to mitotic centrosomes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620912", "description": "Anchoring of the basal body to the plasma membrane", "resource": "Reactome", "id": "R-MMU-5620912", "name": "Anchoring of the basal body to the plasma membrane" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "description": "AURKA Activation by TPX2", "resource": "Reactome", "id": "R-MMU-8854518", "name": "AURKA Activation by TPX2" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "annotation": "CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "id": "NP_036148.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "annotation": "Centriolin depletion affects spindle size and peripheral spindle migration in oocytes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "id": "NP_036148.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AL36#function", "annotation": "Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AL36#function", "id": "A2AL36", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4A619-1", "protein_name": "Centriolin", "sequence": { "length": 2336, "sequence": "MKKGSERKLSKAKMPVSSHFPGPSSLRSSMRSRSLSPLIGSETPPFHPGGQCPAQAELTDENTMPLESQQHKGADPYVGVRYITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCVKLEVLNLSYNLIAKIEKVDKLLRLRELNLSYNKISKIEGLENMCNLQKLNLAGNEIEHIPGWFSKKLKSLRVLNLKGNKISSLQDVSKLKPLQDLTSLTLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFSLEEIERLEKDLEKKTVETEELKNKQTKFLEEIKHQDKLNKSLKEEAMLQKQSCEELESDLNTKKELLKQKTVELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEMDKSPDESPYIGKSRYKRNMFATETYIVSDAQAVQVRKMVPDGGQLRHEHAPRAQAPPDVQLEDTGKQIVAAQTRLSELHHEIEAAEQKVLRATQEFKQLEEAIRQKKISEAEKDLLLKQLSGRLRHLNKLRQEALDLEAQLEKQRKEIAEKHEEINSAQLATDLLDSKDPKQSHMKAQKRGKEQQLDIMNKQYTQLESRLDEILCRIATETEEIKDLEQQLTDGQIAANEALKKDLEGVISGLQEYLGTIKGQAAQAQNECRKLQDEKETLLQRLTEVKQEKDELEIVAMDAENMRKELAELENALQEQHEVNASLQQAQGDLSAYETELETQLKLKDAETSQLKQELENLVRRTQLEQSVLQTELEKERQSLRDALGKAQSSEEKQQENSELRAQLKQLQDDNSLLKKQLKDFQSHLNHVVDGLIHPEEVAARVDELRKRLKLGAGEMRIHSPSDVLGKSLADLQKQFSEILARSQWEKEEAQVRERKLHEEMALQQEKLANGQEEFKQACERALEARIKFDKRQHNARIQQLENEIHYLQENLKSMEKIQGLTDLQLQEADEEKERILAQLQELEKKKRREDARSQEQFLGLDTELKSLKKAVAASDKLAAAELTIAKEQLKSLHGTVMRINQERAEELQEAERSSREAMQAAKDLSRAEAEIELLQHLLREREGQFRDEMENAHVGSKGANLQLLEIEALKEAMAKQRAEITRLRDVLNLTGTGKKGGIENVVEEIAELRHAVSAQNEYISSMADPVQRQGCWYFMPPPPSSKVSSHSSQATKDSGLGLKCTASTPLRSQQAGQQEEKGSSGPLPASGYWVYSPIRSTPHKSFSKREDADNGGDSQEESGLDDQEDPPFVPPPGYIMYTVLPDGSPVPQGVALYAPSPPLPHSSHPLTPGTVVYGPPPAGAPIIYGPPPANFAVPLISMGVQHCNIPEHRDLENEVSRLEDITHHLKSKHQEERWLKTSRQHPEKEVEELHRNIDDLVQEKKELELEVEELHRTVERHQQRRDFIDGNVENLMTELEIEKSLKHHEDIVDEIECLEKTLLKRRSELREADRLLAEAESELACTKEKTKSAVEKFTDAKRNLLQTESDAEALEKRAQETALNLVKAEQQLRLLQADAEDLEQHKIKQEEILKEINKVVAAKDADFQCLNEKKEKLTEELQSLQRDIKAAEVNEDHHLQVLKESESLLQAKRAELETLKSQVTSQQQELAVLDSQLGHRREELLLLQDSLTQAKADLQEALTLGETEVAEKCSHIREVKSLLEELSFQKGELNVHISERRTQLTLIKQEIEKEEENLEVVLQQLSKHKTELKNVADILQLETNELQSLKLQHDQKVVELEKTQVDLLEGKLELESLQQTAQQQRRELERQRQLLERDRRETERVRAETQALQSCIECLNKEKEHLQEQCESWEKKSSHAKRVLAATEESNNTEQSKLGQLEVSVRKLQQELELLSQDKLALHSDSAQEQQQLQDKREALNSLQKELENTQDHLNLAKQDLMHTTKCQSALLSEQAQLQKDVSQWTARLESCQKETETKEQQLQELQDEIRESKLQLDQQEMVFQKLQKERESEEQKLVASIVSLEQQQGQLERELMDQKSKLEWLLTDVSAAEGRLRTLQKEERCTESLEKMLSQAKQQLSEREQQLMEKSGDLLALQKEADGMRADFSLLRNQFLTERKKAEKQVAGLKEALKIQRSQLEKNLLEQKQENSCMQKEMATIELVAQDNHERARRLMKELRQMQQEYLELKKQVANQKDFERRQMEVSNAMRTLKSEVKDEIRTSLRNLNQFLPDLPADLTAILERDDNLRELESVKENFPFTTNERIFEEKSNFPQVHIMDEHRRGEALRERLRHREDHLKAQLRDSMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSVDSAPSPSLSHLESSLVEDSQHGHSQSSFQVLQVPSEPNIYRH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/38260", "id": "38260", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Cntrl", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q7Z7A1-1", "protein_name": "Centriolin", "sequence": { "length": 2325, "sequence": "MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETLPFHSGGQWCEQVEIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRRGYWYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYWVYSPIRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGMALYAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQEKNASAR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/38260", "id": "38260", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "CNTRL", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036148.2", "ac": "NP_036148.2", "name": "centriolin isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AL36", "id": "A2AL36", "database": "UniProtKB" } ], "name": "cytoskeletal protein binding", "id": "GO:0008092" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "pmid": "", "evidence": [ { "url": 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"resource": "MONDO", "description": "Progressive tubulointerstitial nephritis inherited in an autosomal recessive manner. It is caused by mutations in the NPHP1 gene. Patients present with anemia, polyuria, and polydipsia during childhood. 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