{
    "uniprot_canonical_ac": "A6H687-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A6H687-1|SAC31_MOUSE Isoform 1 of SAC3 domain-containing protein 1  OS=Mus musculus OX=10090 GN=Sac3d1 PE=1 SV=1 CANONICAL=A6H687-1", 
        "length": 427, 
        "sequence": "MGRFKGENRSQARWIMGGVSKGRGSGKSRKPRQAAFGQTGARVCPSSPQQDAVPRFRWPGDAECASSTHTPTMSGCKLPMGLCPDMCPAAERARRERERRLHRLEVEPGGRGNAPRADPKRTVKEYSRPAAGKPRPPPSLLRPPPVLLATVRYLAGEVAGRGDVSCAEVASFVADRLRAVRLDLSLQGVDDADAATVLEAALATLLAVVARVRPEETRGAADPVLLQTQVQEGFGSLRRCYARGKGPYPRQAAFQGLFLLYNLGSVEALQEVLQLPAALRACPPLQAALAVDAAFREDNHARLFRLLRTLPYLQSCAVQEHIGYARRKALARLSRALSTPKGQTLPLDFIEHFLALDGLQEARDLCQAHGLTLDKDRVVFLRGQYSEEGLPPPGAYHILVGNKLQGHTLEDVVMAEEGDIHRPGSAA"
    }, 
    "uniprot_id": "SAC31_MOUSE", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H687", 
                    "id": "A6H687", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15322101", 
                    "type": "PubMed", 
                    "id": "15322101"
                }
            ], 
            "title": "The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells.", 
            "journal": "J. Biol. Chem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H687", 
                    "id": "A6H687", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Xing Y., Kuwahara K., Yoshida M., Sakaguchi N., Takeya M., Shimasaki T., Khuda S.E.", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18838617", 
                    "type": "PubMed", 
                    "id": "18838617"
                }
            ], 
            "title": "SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription.", 
            "journal": "Blood", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598439.3", 
                    "id": "NP_598439.3", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Nakajima H, Tamura T, Ito M, Shibata F, Kuroda K, Fukuchi Y, Watanabe N, Kitamura T, Ikeda Y, Handa M", 
            "date": "2009"
        }
    ], 
    "uniprot_ac": "A6H687", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H687", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "2410004C24Rik; AU015683; Shd; shd1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H687", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Sac3d1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Sac3d1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Shd1"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H687#A6H687-1", 
            "isoform_ac": "A6H687-1", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A6H687-1|SAC31_MOUSE Isoform 1 of SAC3 domain-containing protein 1  OS=Mus musculus OX=10090 GN=Sac3d1 PE=1 SV=1 CANONICAL=A6H687-1", 
                "length": 427, 
                "sequence": "MGRFKGENRSQARWIMGGVSKGRGSGKSRKPRQAAFGQTGARVCPSSPQQDAVPRFRWPGDAECASSTHTPTMSGCKLPMGLCPDMCPAAERARRERERRLHRLEVEPGGRGNAPRADPKRTVKEYSRPAAGKPRPPPSLLRPPPVLLATVRYLAGEVAGRGDVSCAEVASFVADRLRAVRLDLSLQGVDDADAATVLEAALATLLAVVARVRPEETRGAADPVLLQTQVQEGFGSLRRCYARGKGPYPRQAAFQGLFLLYNLGSVEALQEVLQLPAALRACPPLQAALAVDAAFREDNHARLFRLLRTLPYLQSCAVQEHIGYARRKALARLSRALSTPKGQTLPLDFIEHFLALDGLQEARDLCQAHGLTLDKDRVVFLRGQYSEEGLPPPGAYHILVGNKLQGHTLEDVVMAEEGDIHRPGSAA"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687#G5E8Q7-1", 
            "isoform_ac": "G5E8Q7-1", 
            "locus": {
                "end_pos": 6116097, 
                "strand": "+", 
                "start_pos": 6118586, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000113533", 
                        "id": "ENSMUST00000113533", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000109161", 
                        "id": "ENSMUSP00000109161", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|G5E8Q7-1|G5E8Q7_MOUSE Computationally mapped isoform of SAC3 domain-containing protein 1  OS=Mus musculus OX=10090 GN=Sac3d1 PE=1 SV=1 CANONICAL=A6H687-1", 
                "length": 427, 
                "sequence": "MGRFKGENRSQARWIMGGVSKGRGSGKSRKPRQAAFGQTGARVCPSSPRQDAVPRFRWPGDAECASSTHTPTMSGCKLPMGLCPDMCPAAERARRERERRLHRLEVEPGGRGNAPRADPKRTVKEYSRPAAGKPRPPPSLLRPPPVLLATVRYLAGEVAGRGDVSCAEVASFVADRLRAVRLDLSLQGVDDADAATVLEAALATLLAVVARVRPEETRGAADPVLLQTQVQEGFGSLRRCYARGKGPYPRQAAFQGLFLLYNLGSVEALQEVLQLPAALRACPPLQAALAVDAAFREDNHARLFRLLRTLPYLQSCAVQEHIGYARRKALARLSRALSTPKGQTLPLDFIEHFLALDGLQEARDLCQAHGLTLDKDRVVFLRGQYSEEGLPPPGAYHILVGNKLQGHTLEDVVMAEEGDIHRPGSAA"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66406", 
            "resource": "KEGG Pathway", 
            "id": "mmu:66406", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H687#function", 
            "annotation": "Involved in centrosome duplication and mitotic progression.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H687#function", 
                    "id": "A6H687", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598439.3", 
            "annotation": "SHD1 is a novel cytokine-inducible negative feedback regulator of STAT5a.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598439.3", 
                    "id": "NP_598439.3", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A6NKF1-1", 
            "protein_name": "SAC3 domain-containing protein 1", 
            "sequence": {
                "length": 404, 
                "sequence": "MAGRRAQTGSAPPRPAAPHPRPASRAFPQHCRPRDAERPPSPRSPLMPGCELPVGTCPDMCPAAERAQREREHRLHRLEVVPGCRQDPPRADPQRAVKEYSRPAAGKPRPPPSQLRPPSVLLATVRYLAGEVAESADIARAEVASFVADRLRAVLLDLALQGAGDAEAAVVLEAALATLLTVVARLGPDAARGPADPVLLQAQVQEGFGSLRRCYARGAGPHPRQPAFQGLFLLYNLGSVEALHEVLQLPAALRACPPLRKALAVDAAFREGNAARLFRLLQTLPYLPSCAVQCHVGHARREALARFARAFSTPKGQTLPLGFMVNLLALDGLREARDLCQAHGLPLDGEERVVFLRGRYVEEGLPPASTCKVLVESKLRGRTLEEVVMAEEEDEGTDRPGSPA"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/40867", 
                    "id": "40867", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "SAC3D1", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598439.3", 
        "ac": "NP_598439.3", 
        "name": "SAC3 domain-containing protein 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "18838617", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", 
                        "pmid": "15322101", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "centrosome", 
                        "id": "GO:0005813"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", 
                        "pmid": "15322101", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "spindle", 
                        "id": "GO:0005819"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", 
                        "pmid": "15322101", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "microtubule cytoskeleton", 
                        "id": "GO:0015630"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 5, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", 
                        "pmid": "18838617", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of immune response", 
                        "id": "GO:0050776"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298", 
                        "pmid": "15322101", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "centrosome duplication", 
                        "id": "GO:0051298"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046426", 
                        "pmid": "18838617", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of receptor signaling pathway via JAK-STAT", 
                        "id": "GO:0046426"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", 
                        "pmid": "15322101", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "spindle assembly", 
                        "id": "GO:0051225"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H687", 
                                "id": "A6H687", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell division", 
                        "id": "GO:0051301"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 10, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 8
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024790", 
            "id": "ENSMUSG00000024790", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/66406", 
            "id": "66406", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000717", 
            "id": "IPR000717", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005062", 
            "id": "IPR005062", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66406", 
            "id": "mmu:66406", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1913656", 
            "id": "1913656", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/CALHRHL/", 
            "id": "CALHRHL", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1410585at2759", 
            "id": "1410585at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03399", 
            "id": "PF03399", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A6H687", 
            "id": "PR_A6H687", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598439", 
            "id": "NP_598439", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598439.3", 
            "id": "NP_598439.3", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687", 
            "id": "A6H687", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687-1", 
            "id": "A6H687-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/G5E8Q7", 
            "id": "G5E8Q7", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/G5E8Q7-1", 
            "id": "G5E8Q7-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "comment": "Phosphoserine", 
            "kinase_gene_name": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H687", 
                    "id": "A6H687", 
                    "database": "UniProtKB"
                }
            ], 
            "start_pos": 425, 
            "end_pos": 425, 
            "kinase_uniprot_canonical_ac": ""
        }
    ], 
    "mass": {
        "monoisotopic_mass": 46384.0, 
        "chemical_mass": 46384.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H687", 
            "name": "Sac3d1", 
            "locus": {
                "end_pos": 6116004, 
                "strand": "-", 
                "start_pos": 6118586, 
                "chromosome": "19", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000024790", 
                        "id": "ENSMUSG00000024790", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H687", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "SAC3 domain-containing protein 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "SAC3 domain-containing protein 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H687#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "SAC3 homology domain-containing protein 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H687", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Sac3 homology domain 1; SAC3 homology domain-containing protein 1"
        }
    ]
}