{ "uniprot_canonical_ac": "A3KGF7-1", "ptm_annotation": [], "sequence": { "header": "sp|A3KGF7-1|PLCB2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 1181, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL" }, "uniprot_id": "PLCB2_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [ { "gene_name": "Plch1", "uniprot_ac": "A0A096MJW8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJW8", "id": "A0A096MJW8", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJW8", "id": "A0A096MJW8", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plch2", "uniprot_ac": "A2AP18", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb2", "uniprot_ac": "A3KGF7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcd3", "uniprot_ac": "D4A978", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4A978", "id": "D4A978", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4A978", "id": "D4A978", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plch2", "uniprot_ac": "D4AAX6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4AAX6", "id": "D4AAX6", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4AAX6", "id": "D4AAX6", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcl2", "uniprot_ac": "F1M324", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1M324", "id": "F1M324", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1M324", "id": "F1M324", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCH2", "uniprot_ac": "O75038", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O75038", "id": "O75038", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O75038", "id": "O75038", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb2", "uniprot_ac": "O89040", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O89040", "id": "O89040", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O89040", "id": "O89040", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcg1", "uniprot_ac": "P10686", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P10686", "id": "P10686", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P10686", "id": "P10686", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb1", "uniprot_ac": "P10687", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P10687", "id": "P10687", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P10687", "id": "P10687", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcd1", "uniprot_ac": "P10688", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P10688", "id": "P10688", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P10688", "id": "P10688", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCG2", "uniprot_ac": "P16885", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P16885", "id": "P16885", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P16885", "id": "P16885", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCG1", "uniprot_ac": "P19174", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P19174", "id": "P19174", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P19174", "id": "P19174", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcg2", "uniprot_ac": "P24135", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P24135", "id": "P24135", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P24135", "id": "P24135", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCD1", "uniprot_ac": "P51178", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P51178", "id": "P51178", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P51178", "id": "P51178", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb3", "uniprot_ac": "P51432", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P51432", "id": "P51432", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P51432", "id": "P51432", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCB2", "uniprot_ac": "Q00722", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q00722", "id": "Q00722", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q00722", "id": "Q00722", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCB3", "uniprot_ac": "Q01970", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q01970", "id": "Q01970", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q01970", "id": "Q01970", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCL1", "uniprot_ac": "Q15111", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q15111", "id": "Q15111", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q15111", "id": "Q15111", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCB4", "uniprot_ac": "Q15147", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q15147", "id": "Q15147", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q15147", "id": "Q15147", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plch1", "uniprot_ac": "Q4KWH5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q4KWH5", "id": "Q4KWH5", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q4KWH5", "id": "Q4KWH5", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCH1", "uniprot_ac": "Q4KWH8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q4KWH8", "id": "Q4KWH8", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q4KWH8", "id": "Q4KWH8", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcz1", "uniprot_ac": "Q5FX52", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5FX52", "id": "Q5FX52", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q5FX52", "id": "Q5FX52", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcg1", "uniprot_ac": "Q62077", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q62077", "id": "Q62077", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q62077", "id": "Q62077", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcl1", "uniprot_ac": "Q62688", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q62688", "id": "Q62688", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q62688", "id": "Q62688", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcd4", "uniprot_ac": "Q62711", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q62711", "id": "Q62711", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q62711", "id": "Q62711", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Gdpd5", "uniprot_ac": "Q640M6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q640M6", "id": "Q640M6", "database": "UniProtKB" } ], "ec_number": "3.1.4.2", "activity": "sn-glycero-3-phosphocholine + H(2)O = choline + sn-glycerol 3-phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q640M6", "id": "Q640M6", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." } ] }, { "gene_name": "PLCZ1", "uniprot_ac": "Q86YW0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q86YW0", "id": "Q86YW0", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q86YW0", "id": "Q86YW0", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcg2", "uniprot_ac": "Q8CIH5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CIH5", "id": "Q8CIH5", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CIH5", "id": "Q8CIH5", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcd3", "uniprot_ac": "Q8K2J0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K2J0", "id": "Q8K2J0", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K2J0", "id": "Q8K2J0", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcd4", "uniprot_ac": "Q8K3R3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K3R3", "id": "Q8K3R3", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K3R3", "id": "Q8K3R3", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcz1", "uniprot_ac": "Q8K4D7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4D7", "id": "Q8K4D7", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4D7", "id": "Q8K4D7", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plce1", "uniprot_ac": "Q8K4S1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4S1", "id": "Q8K4S1", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4S1", "id": "Q8K4S1", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCD3", "uniprot_ac": "Q8N3E9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8N3E9", "id": "Q8N3E9", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8N3E9", "id": "Q8N3E9", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcd1", "uniprot_ac": "Q8R3B1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8R3B1", "id": "Q8R3B1", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8R3B1", "id": "Q8R3B1", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "GDPD5", "uniprot_ac": "Q8WTR4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WTR4", "id": "Q8WTR4", "database": "UniProtKB" } ], "ec_number": "3.1.4.2", "activity": "sn-glycero-3-phosphocholine + H(2)O = choline + sn-glycerol 3-phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WTR4", "id": "Q8WTR4", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." } ] }, { "gene_name": "Plcb4", "uniprot_ac": "Q91UZ1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91UZ1", "id": "Q91UZ1", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91UZ1", "id": "Q91UZ1", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb3", "uniprot_ac": "Q99JE6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99JE6", "id": "Q99JE6", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99JE6", "id": "Q99JE6", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plce1", "uniprot_ac": "Q99P84", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99P84", "id": "Q99P84", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99P84", "id": "Q99P84", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCD4", "uniprot_ac": "Q9BRC7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BRC7", "id": "Q9BRC7", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BRC7", "id": "Q9BRC7", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCB1", "uniprot_ac": "Q9NQ66", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9NQ66", "id": "Q9NQ66", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9NQ66", "id": "Q9NQ66", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCE1", "uniprot_ac": "Q9P212", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9P212", "id": "Q9P212", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9P212", "id": "Q9P212", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb4", "uniprot_ac": "Q9QW07", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9QW07", "id": "Q9QW07", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9QW07", "id": "Q9QW07", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "PLCL2", "uniprot_ac": "Q9UPR0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UPR0", "id": "Q9UPR0", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UPR0", "id": "Q9UPR0", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] }, { "gene_name": "Plcb1", "uniprot_ac": "Q9Z1B3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z1B3", "id": "Q9Z1B3", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z1B3", "id": "Q9Z1B3", "database": "UniProtKB" } ], "ec_number": "3.1.4.11", "activity": "" } ] } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2033248", "type": "PubMed", "id": "2033248" } ], "title": "Expression of phospholipase C isozymes by murine B lymphocytes.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Hempel WM, DeFranco AL", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30691513", "type": "PubMed", "id": "30691513" } ], "title": "TrkB expression and dependence divides gustatory neurons into three subpopulations.", "journal": "Neural development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Rios-Pilier J, Krimm RF", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30765691", "type": "PubMed", "id": "30765691" } ], "title": "PLCbeta2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Wang L, Zhou Y, Chen Z, Sun L, Wu J, Li H, Liu F, Wang F, Yang C, Yang J, Leng Q, Zhang Q, Xu A, Shen L, Sun J, Wu D, Fang C, Lu H, Yan D, Ge B", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31268747", "type": "PubMed", "id": "31268747" } ], "title": "Phospholipase C-beta1 potentiates glucose-stimulated insulin secretion.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Hwang HJ, Yang YR, Kim HY, Choi Y, Park KS, Lee H, Ma JS, Yamamoto M, Kim J, Chae YC, Choi JH, Cocco L, Berggren PO, Jang HJ, Suh PG", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31980480", "type": "PubMed", "id": "31980480" } ], "title": "The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.", "journal": "ImmunoHorizons", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Howitt MR, Cao YG, Gologorsky MB, Li JA, Haber AL, Biton M, Lang J, Michaud M, Regev A, Garrett WS", "date": "2020" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/32294408", "type": "PubMed", "id": "32294408" } ], "title": "Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.", "journal": "Immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin O, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Gunther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schutz B, Boehm U, Zufall F, Bufe B, Kummer W", "date": "2020" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8672127", "type": "PubMed", "id": "8672127" } ], "title": "Genetic mapping of the human and mouse phospholipase C genes.", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Lyu MS, Park DJ, Rhee SG, Kozak CA", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8739298", "type": "PubMed", "id": "8739298" } ], "title": "Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.", "journal": "Acta histochemica", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Martelli AM, Lach S, Grill V, Gilmour RS, Cocco L, Narducci P, Bareggi R", "date": "1996" } ], "uniprot_ac": "A3KGF7", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGF7", "type": "synonym", "resource": "RefSeq", "name": "AI550384; B230205M18Rik; B230399N12" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGF7", "type": "synonym", "resource": "RefSeq", "name": "Plcb2" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7", "type": "recommended", "resource": "UniProtKB", "name": "Plcb2" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/33179", "id": "33179", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "input_participant_list": [], "enzyme_list": [ "P10686-1", "P10688-1", "A0A096MJW8-1", "Q9QW07-1", "Q62711-1", "D4AAX6-1", "Q62688-1", "D4A978-1", "O89040-1", "P10687-1", "Q99JE6-1", "Q99P84-1", "P24135-1", "Q5FX52-1", "F1M324-1", "Q9NQ66-1", "Q9UPR0-1", "P19174-1", "P16885-1", "Q8WTR4-1", "Q8N3E9-1", "O75038-1", "Q9BRC7-1", "Q86YW0-1", "Q15111-1", "Q4KWH8-1", "P51178-1", "Q9P212-1", "Q01970-1", "Q15147-1", "Q00722-1", "Q8K2J0-1", "P51432-1", "Q62077-1", "Q8K4D7-1", "Q91UZ1-1", "A2AP18-1", "Q640M6-1", "Q8K4S1-1", "Q4KWH5-1", "Q9Z1B3-1", "A3KGF7-1", "Q8CIH5-1", "Q8K3R3-1", "Q8R3B1-1" ], "id": "33179", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/43484", "id": "43484", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "input_participant_list": [], "enzyme_list": [ "O89040-1", "P10688-1", "Q62711-1", "Q99JE6-1", "Q9QW07-1", "P10686-1", "Q9BRC7-1", "P19174-1", "P51178-1", "Q01970-1", "Q15147-1", "Q00722-1", "P51432-1", "A3KGF7-1", "Q62077-1", "Q8K3R3-1", "Q8R3B1-1" ], "id": "43484", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-111879", "id": "R-MMU-111879", "database": "Reactome" } ], "name": "PIP2 hydrolysis", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [ "R-ALL-179856" ], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q91UZ1-1" ], "id": "R-MMU-111879", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112037", "id": "R-MMU-112037", "database": "Reactome" } ], "name": "Inactivation of PLC beta", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q91UZ1-1" ], "id": "R-MMU-112037", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-114688", "id": "R-MMU-114688", "database": "Reactome" } ], "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1", "Q91UZ1-1" ], "id": "R-MMU-114688", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855177", "id": "R-MMU-1855177", "database": "Reactome" } ], "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "Q8K4D7-1", "P51432-1", "Q91UZ1-1" ], "id": "R-MMU-1855177", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-398040", "id": "R-MMU-398040", "database": "Reactome" } ], "name": "Gbeta:gamma activation of PLC beta", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "id": "R-MMU-398040", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-398193", "id": "R-MMU-398193", "database": "Reactome" } ], "name": "PLC beta-mediated PIP2 hydrolysis", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "id": "R-MMU-398193", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399998", "id": "R-MMU-399998", "database": "Reactome" } ], "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "id": "R-MMU-399998", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500717", "id": "R-MMU-500717", "database": "Reactome" } ], "name": "Activation of GRIK3 homomer", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "Q9Z1B3-1", "A3KGF7-1", "P51432-1" ], "id": "R-MMU-500717", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-1", "isoform_ac": "A3KGF7-1", "locus": { "end_pos": 118709002, "strand": "+", "start_pos": 118728321, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000102524", "id": "ENSMUST00000102524", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000099583", "id": "ENSMUSP00000099583", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGF7-1|PLCB2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 1181, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-2", "isoform_ac": "A3KGF7-2", "locus": {}, "sequence": { "header": "sp|A3KGF7-2|PLCB2_MOUSE Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 679, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITARPRADKWLGGLGS" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-3", "isoform_ac": "A3KGF7-3", "locus": {}, "sequence": { "header": "sp|A3KGF7-3|PLCB2_MOUSE Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 702, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITARPRADKWLGGLGS" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-4", "isoform_ac": "A3KGF7-4", "locus": {}, "sequence": { "header": "sp|A3KGF7-4|PLCB2_MOUSE Isoform 4 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 633, "sequence": "MEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMGKNTSKTREPSPGPLTTSPEPSPGPCIPRCPPSEPSSGPCLSDPYSSLDKEL" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#E9PYI3-1", "isoform_ac": "E9PYI3-1", "locus": { "end_pos": 118709002, "strand": "+", "start_pos": 118728321, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000159756", "id": "ENSMUST00000159756", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124364", "id": "ENSMUSP00000124364", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PYI3-1|E9PYI3_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 1158, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18796", "resource": "KEGG Pathway", "id": "mmu:18796", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112043", "description": "PLC beta mediated events", "resource": "Reactome", "id": "R-MMU-112043", "name": "PLC beta mediated events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "description": "Synthesis of IP3 and IP4 in the cytosol", "resource": "Reactome", "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399997", "description": "Acetylcholine regulates insulin secretion", "resource": "Reactome", "id": "R-MMU-399997", "name": "Acetylcholine regulates insulin secretion" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4086398", "description": "Ca2+ pathway", "resource": "Reactome", "id": "R-MMU-4086398", "name": "Ca2+ pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416476", "description": "G alpha (q) signalling events", "resource": "Reactome", "id": "R-MMU-416476", "name": "G alpha (q) signalling events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418217", "description": "G beta:gamma signalling through PLC beta", "resource": "Reactome", "id": "R-MMU-418217", "name": "G beta:gamma signalling through PLC beta" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-434316", "description": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "resource": "Reactome", "id": "R-MMU-434316", "name": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500657", "description": "Presynaptic function of Kainate receptors", "resource": "Reactome", "id": "R-MMU-500657", "name": "Presynaptic function of Kainate receptors" } ], "reaction_participants": [ { "crossref": [ { "url": "", "id": "C04637", "database": "COMPOUND" }, { "url": "", "id": "18348", "database": "ChEBI" }, { "url": "", "id": "18348", "database": "ChEBI" }, { "url": "", "id": "C04637", "database": "COMPOUND" }, { "url": "", "id": "18348", "database": "ChEBI" }, { "url": "", "id": "C04637", "database": "COMPOUND" } ], "participant_name": "PI(4,5)P2 [plasma membrane]", "participant_id": "R-ALL-179856" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "annotation": "Results show that phospholipase C beta 2 (PLCbeta2) inhibits the virus-induced expression of pro-inflammatory cytokines by interacting with and inhibiting transforming growth factor-beta-activated kinase 1 (TAK1) activation. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#function", "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7#function", "id": "A3KGF7", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/E9PYI3#function", "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PYI3#function", "id": "E9PYI3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O89040-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "sequence": { "length": 1183, "sequence": "MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20957", "id": "20957", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Plcb2", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q00722-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "sequence": { "length": 1185, "sequence": "MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A3KGF7/", "id": "A3KGF7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/20957", "id": "20957", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PLCB2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "ac": "NP_001277719.1", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": 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