{ "uniprot_canonical_ac": "A2TJV2-1", "ptm_annotation": [ { "annotation": "Palmitoylated on Cys-728 and Cys-730 and prenylated on Cys-731; which is required for membrane association.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2TJV2-1|PALM3_MOUSE Isoform 1 of Paralemmin-3 OS=Mus musculus OX=10090 GN=Palm3 PE=1 SV=1 CANONICAL=A2TJV2-1", "length": 734, "sequence": "MALQTPVLSPATPTVMAESALYRQRLEVIAEKRRLQEEIGAARRELEEEKLRVERLKRKSLRERWLMDGAAEGPERPEEPASKDPQSPEGQAQARIRNLEDSLFSLQSQLQLLQSASTGAQHRPAGRPAWRREGPRPLSQSAMEAAPTAPTDVDKRTSLPDAPVGMSPESPSDPREESIAVLPASRPSTEAIGTSSEANGPCPGHSPLPEQLSLGVSSVTKAKGDGAVEVVWAGLRATENSATGPTDVELEAKVEEVVLEAIGARQGTSSPELPTWVKEGRGVVEVVWEGLGGRDLDVTGESGRDAEATHTSSRRLQEQFEAETCRKEEGASRDSLEGVGQGGPGVEEGSFIWVERVALSEDWEEILMEGLEAPQGAGSAGEPEALIGAQPRGGEASWEVEKREVEKVEGIEEKGRAEKLGAEREDGVAVLPDETQGREENEAEKVERKDSEGPFPAEIATDEEKWEVKTTEGEESLEVEKGGEAEPVTTEKPLVTEKKPEGSLETERKGSEMPLDQEKDGEGSLDRESKTTEILLDGEIGDKSSLDETKGSKKLLDEKTGGEGSLDEEAEGSKKLLDREADGIEPFSEVDKTSGAKDDVSPEEQGKANEGAEFQAEDASPPGATVCVQDEPRSEEQGQQEPEKQEGLVEGAASKPEPCTEREGPPGDATLLLAETPAPEQPVESQPLLHQEASSTNPGDHPAPTYAPAQQLELAEAKEASGPKQKTCQCCVVM" }, "uniprot_id": "", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11478809", "type": "PubMed", "id": "11478809" } ], "title": "The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative.", "journal": "Biochem. Biophys. Res. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "authors": "Copeland N.G., Gilbert D.J., Jenkins N.A., Kilimann M.W., Hu B.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "type": "PubMed", "id": "21183079" } ], "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "evidence": [ { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2TJV2", "id": "A2TJV2", "database": "iPTMnet" } ], "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26772416", "type": "PubMed", "id": "26772416" } ], "title": "Silencing of Paralemmin-3 Protects Mice from lipopolysaccharide-induced acute lung injury.", "journal": "Peptides", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083153.1", "id": "NP_083153.1", "database": "RefSeq" } ], "authors": "Li S, Guo L, Zhao Y, Qian P, Lv X, Qian L, Wang Q, Qian G, Yao W, Wu X", "date": "2016" } ], "uniprot_ac": "A2TJV2", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2TJV2", "type": "synonym", "resource": "RefSeq", "name": "4432412L15Rik; AL024300" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2TJV2", "type": "synonym", "resource": "RefSeq", "name": "Palm3" }, { "url": "https://www.uniprot.org/uniprot/A2TJV2", "type": "recommended", "resource": "UniProtKB", "name": "Palm3" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2#A2TJV2-1", "isoform_ac": "A2TJV2-1", "locus": { "end_pos": 84021488, "strand": "-", "start_pos": 84030062, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000055077", "id": "ENSMUST00000055077", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000051396", "id": "ENSMUSP00000051396", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2TJV2-1|PALM3_MOUSE Isoform 1 of Paralemmin-3 OS=Mus musculus OX=10090 GN=Palm3 PE=1 SV=1 CANONICAL=A2TJV2-1", "length": 734, "sequence": "MALQTPVLSPATPTVMAESALYRQRLEVIAEKRRLQEEIGAARRELEEEKLRVERLKRKSLRERWLMDGAAEGPERPEEPASKDPQSPEGQAQARIRNLEDSLFSLQSQLQLLQSASTGAQHRPAGRPAWRREGPRPLSQSAMEAAPTAPTDVDKRTSLPDAPVGMSPESPSDPREESIAVLPASRPSTEAIGTSSEANGPCPGHSPLPEQLSLGVSSVTKAKGDGAVEVVWAGLRATENSATGPTDVELEAKVEEVVLEAIGARQGTSSPELPTWVKEGRGVVEVVWEGLGGRDLDVTGESGRDAEATHTSSRRLQEQFEAETCRKEEGASRDSLEGVGQGGPGVEEGSFIWVERVALSEDWEEILMEGLEAPQGAGSAGEPEALIGAQPRGGEASWEVEKREVEKVEGIEEKGRAEKLGAEREDGVAVLPDETQGREENEAEKVERKDSEGPFPAEIATDEEKWEVKTTEGEESLEVEKGGEAEPVTTEKPLVTEKKPEGSLETERKGSEMPLDQEKDGEGSLDRESKTTEILLDGEIGDKSSLDETKGSKKLLDEKTGGEGSLDEEAEGSKKLLDREADGIEPFSEVDKTSGAKDDVSPEEQGKANEGAEFQAEDASPPGATVCVQDEPRSEEQGQQEPEKQEGLVEGAASKPEPCTEREGPPGDATLLLAETPAPEQPVESQPLLHQEASSTNPGDHPAPTYAPAQQLELAEAKEASGPKQKTCQCCVVM" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:74337", "resource": "KEGG Pathway", "id": "mmu:74337", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2#function", "annotation": "ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2#function", "id": "A2TJV2", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083153.1", "annotation": "PALM3 contributes to the development of acute lung injury in mice challenged with lipopolysaccharide.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083153.1", "id": "NP_083153.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A6NDB9-1", "protein_name": "Paralemmin-3", "sequence": { "length": 673, "sequence": "MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQKTCQCCAVM" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/53493", "id": "53493", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PALM3", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4A1J3-1", "protein_name": "Paralemmin 3", "sequence": { "length": 733, "sequence": "MALQTPVLSPATPTVMAESALYRQRLEVIAEKRRLQEEIGAARRELEEEKFRVERLKRKSLRERWLMDGAAEGPERQEDPASKDPESPEGQAQARIRNLEDSLFSLQSQLQLLQSASTGAQHRPAGRPAWRREGPRPLSQPAMDTGPTGPTDVDKRTSLPDAPVGISSESPSDPREESIGVLPALRPSPEAIGTSSEANGPCPGHSSLPEQLSLGVSSVTKAKGDGVVEVVWAGLRATENSATGPTGVELEAKVEEVVLEAIGARQGTSSPDLPTWVKEGRGVVEVVWEGLGGRDLDVTEESGSGAEAMHTGTPRLQEQFESETCRKEEGASRDSLEGVGQGGPGAEEGSFIWVEKVALSEDWEEILMEGLEAPPEAGSARGPEALMGAQPRGDESSWEVEKREVEKMEGREEKGRAEKLGAELEDGAAVLPDATQGGEESEAEKIERKDGEGPFPEEIATDEEKWEVKEKKDEEPLEVEKGGEEEPPTIEKPLVAEKEAEGSPETEKKGNETPLGQEKDGEGSLDRESKTEILLDGETGGESSLDETKGSKKLLDEETGGEGSLDEATKGSKKLLDGEAGGSELFSEVEKTSGAKDDVSPEEQGKSNEGADFQAEEASQPGATLCVQEEPRSEEQGLQDPEKQESPVEEATRKPQPCTESEGPPEDATPLLAETPAPEQPVESQPLLRQEVSSTNPGDHPAPTYAPAPQLELAEVKEASGPKQKTCQCCVVM" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/53493", "id": "53493", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2TJV2/", "id": "A2TJV2", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Palm3", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083153.1", "ac": "NP_083153.1", "name": "paralemmin-3", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001960", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "negative regulation of cytokine-mediated signaling pathway", "id": "GO:0001960" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "response to lipopolysaccharide", "id": "GO:0032496" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008063", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "name": "Toll signaling pathway", "id": "GO:0008063" } ], "total": 3, "name": "Biological Process" } ] }, "site_annotation": [], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000047986", "id": "ENSMUSG00000047986", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/74337", "id": "74337", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024149", "id": "IPR024149", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:74337", "id": "mmu:74337", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1921587", "id": "1921587", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/DWEELLM/", "id": "DWEELLM", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=979127at2759", "id": "979127at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47528", "id": "PTHR47528", "database": "PANTHER" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2TJV2", "id": "PR_A2TJV2", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083153", "id": "NP_083153", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083153.1", "id": "NP_083153.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2TJV2-1", "id": "A2TJV2-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "start_pos": 139, "end_pos": 139, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "start_pos": 158, "end_pos": 158, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 167, "end_pos": 167, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "start_pos": 170, "end_pos": 170, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "start_pos": 172, "end_pos": 172, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 270, "end_pos": 270, "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "comment": "Phosphothreonine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "start_pos": 311, "end_pos": 311, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 332, "end_pos": 332, "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 332, "end_pos": 332, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 335, "end_pos": 335, "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 335, "end_pos": 335, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 451, "end_pos": 451, "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 451, "end_pos": 451, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 601, "end_pos": 601, "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": 601, "end_pos": 601, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "id": "A2TJV2", "database": "UniProtKB" } ], "start_pos": 721, "end_pos": 721, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 78788.0, "chemical_mass": 78788.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2", "name": "Palm3", "locus": { "end_pos": 84030295, "strand": "+", "start_pos": 84021471, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000047986", "id": "ENSMUSG00000047986", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2TJV2#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Paralemmin-3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2TJV2", "type": "synonym", "resource": "RefSeq", "name": "paralemmin-3" } ] }