{
    "uniprot_canonical_ac": "A2RRU2-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2RRU2-1|A2RRU2_RAT Isoform 1 of Transmembrane protein 127  OS=Rattus norvegicus OX=10116 GN=Tmem127 PE=2 SV=1 CANONICAL=A2RRU2-1", 
        "length": 238, 
        "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP"
    }, 
    "uniprot_id": "A2RRU2_RAT", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                    "id": "A2RRU2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20154675", 
                    "type": "PubMed", 
                    "id": "20154675"
                }
            ], 
            "title": "Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.", 
            "journal": "Nature genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", 
                    "id": "NP_001094448.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24334765", 
                    "type": "PubMed", 
                    "id": "24334765"
                }
            ], 
            "title": "The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function.", 
            "journal": "Human molecular genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", 
                    "id": "NP_001094448.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Qin Y, Deng Y, Ricketts CJ, Srikantan S, Wang E, Maher ER, Dahia PL", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A2RRU2", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "RGD1309744"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RGD1309744"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tmem127"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tmem127"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_26229"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2#A2RRU2-1", 
            "isoform_ac": "A2RRU2-1", 
            "locus": {
                "end_pos": 119678179, 
                "strand": "-", 
                "start_pos": 119686931, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000031577", 
                        "id": "ENSRNOT00000031577", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000030631", 
                        "id": "ENSRNOP00000030631", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2RRU2-1|A2RRU2_RAT Isoform 1 of Transmembrane protein 127  OS=Rattus norvegicus OX=10116 GN=Tmem127 PE=2 SV=1 CANONICAL=A2RRU2-1", 
                "length": 238, 
                "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311405", 
            "resource": "KEGG Pathway", 
            "id": "rno:311405", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "O75204-1", 
            "protein_name": "Transmembrane protein 127", 
            "sequence": {
                "length": 238, 
                "sequence": "MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEPYPAEYEVINQFQPPPAYTP"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/9877", 
                    "id": "9877", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "TMEM127", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q8BGP5-1", 
            "protein_name": "Transmembrane protein 127", 
            "sequence": {
                "length": 238, 
                "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVNPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/9877", 
                    "id": "9877", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Tmem127", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", 
        "ac": "NP_001094448.1", 
        "name": "transmembrane protein 127", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017137", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Rab GTPase binding", 
                        "id": "GO:0017137"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane", 
                        "id": "GO:0016020"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "early endosome", 
                        "id": "GO:0005769"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 5, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell population proliferation", 
                        "id": "GO:0008285"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endosome organization", 
                        "id": "GO:0007032"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of TOR signaling", 
                        "id": "GO:0032007"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RRU2", 
                                "id": "A2RRU2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of TOR signaling", 
                        "id": "GO:0032006"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022727", 
            "id": "ENSRNOG00000022727", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/311405", 
            "id": "311405", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033331", 
            "id": "IPR033331", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311405", 
            "id": "rno:311405", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/QPSWFRI/", 
            "id": "QPSWFRI", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1422066at2759", 
            "id": "1422066at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28358", 
            "id": "PTHR28358", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2RRU2", 
            "id": "PR_A2RRU2", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448", 
            "id": "NP_001094448", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", 
            "id": "NP_001094448.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309744", 
            "id": "1309744", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2", 
            "id": "A2RRU2", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2-1", 
            "id": "A2RRU2-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "disease_id": "DOID:0050771", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:0050771", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "phaeochromocytoma", 
                    "id": "DOID:0050771"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008233", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "phaeochromocytoma", 
                    "id": "MONDO:0008233"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008233", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pheochromocytoma", 
                    "id": "MONDO:0008233"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008233", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pheochromocytoma, susceptibility to", 
                    "id": "MONDO:0008233"
                }, 
                {
                    "url": "https://www.omim.org/entry/171300", 
                    "resource": "MIM", 
                    "description": "Pheochromocytoma", 
                    "name": "Pheochromocytoma", 
                    "id": "MIM:171300"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:0050771", 
                "resource": "Disease Ontology", 
                "description": "An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure.", 
                "name": "pheochromocytoma", 
                "id": "DOID:0050771"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0050771#disease-associations", 
                    "id": "0050771", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 25858.0, 
        "chemical_mass": 25858.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2", 
            "name": "Tmem127", 
            "locus": {
                "end_pos": 119690366, 
                "strand": "+", 
                "start_pos": 119677575, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000022727", 
                        "id": "ENSRNOG00000022727", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RCG26229, isoform CRA_a"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RRU2#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Transmembrane protein 127"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "transmembrane protein 127"
        }
    ]
}