{
    "uniprot_canonical_ac": "A2ATD1-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2ATD1-1|ISM1_MOUSE Isoform 1 of Isthmin-1  OS=Mus musculus OX=10090 GN=Ism1 PE=1 SV=1 CANONICAL=A2ATD1-1", 
        "length": 454, 
        "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
    }, 
    "uniprot_id": "", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12128218", 
                    "type": "PubMed", 
                    "id": "12128218"
                }
            ], 
            "title": "Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer.", 
            "journal": "Mech. Dev.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kim J.I., De Robertis E.M., Li S.-Y., Brechner M., Martinez S.L., Pera E.M., Wessely O.", 
            "date": "2002"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19874420", 
                    "type": "PubMed", 
                    "id": "19874420"
                }
            ], 
            "title": "Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.", 
            "journal": "J. Cell. Mol. Med.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Wang J., Wang Z., Yang H., Zhang Y., Irwan I.D., Ge R., Xiang W., Ke Z., Cheng G.H., Kini R.M., Potturi P., Sulochana K.N., Zhuo L.", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20637190", 
                    "type": "PubMed", 
                    "id": "20637190"
                }
            ], 
            "title": "O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.", 
            "journal": "Developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24956034", 
                    "type": "PubMed", 
                    "id": "24956034"
                }
            ], 
            "title": "Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells.", 
            "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Valle-Rios R, Maravillas-Montero JL, Burkhardt AM, Martinez C, Buhren BA, Homey B, Gerber PA, Robinson O, Hevezi P, Zlotnik A", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A2ATD1", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "5430433G21Rik; Ism"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ism1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ism1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Ism"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#A2ATD1-1", 
            "isoform_ac": "A2ATD1-1", 
            "locus": {
                "end_pos": 139678670, 
                "strand": "-", 
                "start_pos": 139757491, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000099307", 
                        "id": "ENSMUST00000099307", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000096910", 
                        "id": "ENSMUSP00000096910", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2ATD1-1|ISM1_MOUSE Isoform 1 of Isthmin-1  OS=Mus musculus OX=10090 GN=Ism1 PE=1 SV=1 CANONICAL=A2ATD1-1", 
                "length": 454, 
                "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#V9GXR4-1", 
            "isoform_ac": "V9GXR4-1", 
            "locus": {
                "end_pos": 139678670, 
                "strand": "-", 
                "start_pos": 139757491, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000184404", 
                        "id": "ENSMUST00000184404", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000139280", 
                        "id": "ENSMUSP00000139280", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|V9GXR4-1|V9GXR4_MOUSE Computationally mapped isoform of Isthmin-1  OS=Mus musculus OX=10090 GN=Ism1 PE=3 SV=1 CANONICAL=A2ATD1-1", 
                "length": 461, 
                "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNVSGSQLQNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319909", 
            "resource": "KEGG Pathway", 
            "id": "mmu:319909", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#function", 
            "annotation": "Acts as an angiogenesis inhibitor.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ATD1#function", 
                    "id": "A2ATD1", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
            "annotation": "Given that ISM1 has been reported to have anti-angiogenic properties, these observations suggest that ISM1 is a mediator of lymphocyte effector functions and may participate in both innate and acquired immune responses.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
            "annotation": "ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
            "annotation": "ISM1 transcripts are found in tissues as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
            "annotation": "Results demonstrate that Isthmin is a novel endogenous angiogenesis inhibitor with functions likely in physiological as well as pathological angiogenesis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
                    "id": "NP_001263418.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "B1AKI9-1", 
            "protein_name": "Isthmin-1", 
            "sequence": {
                "length": 464, 
                "sequence": "MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETSFSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/19061", 
                    "id": "19061", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "ISM1", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
        "ac": "NP_001263418.1", 
        "name": "isthmin-1 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                                "id": "A2ATD1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016525", 
                        "pmid": "19874420", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ATD1", 
                                "id": "A2ATD1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of angiogenesis", 
                        "id": "GO:0016525"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "site_annotation": [
        {
            "end_pos": 277, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 275
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074766", 
            "id": "ENSMUSG00000074766", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/319909", 
            "id": "319909", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", 
            "id": "IPR000884", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005533", 
            "id": "IPR005533", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", 
            "id": "IPR036383", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042413", 
            "id": "IPR042413", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319909", 
            "id": "mmu:319909", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2442963", 
            "id": "2442963", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/EGDWSNW/", 
            "id": "EGDWSNW", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=876510at2759", 
            "id": "876510at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10239", 
            "id": "PTHR10239", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00090", 
            "id": "PF00090", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03782", 
            "id": "PF03782", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2ATD1", 
            "id": "PR_A2ATD1", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418", 
            "id": "NP_001263418", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263418.1", 
            "id": "NP_001263418.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "id": "A2ATD1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1-1", 
            "id": "A2ATD1-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/V9GXR4", 
            "id": "V9GXR4", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/V9GXR4-1", 
            "id": "V9GXR4-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 51145.0, 
        "chemical_mass": 51145.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1", 
            "name": "Ism1", 
            "locus": {
                "end_pos": 139758581, 
                "strand": "+", 
                "start_pos": 139678178, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074766", 
                        "id": "ENSMUSG00000074766", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ATD1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Isthmin-1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "isthmin 1 homolog"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ATD1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "isthmin-1 precursor"
        }
    ]
}