The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AP18#A0A087WSR3-1", "isoform_ac": "A0A087WSR3-1", "locus": { "end_pos": 154986165, "strand": "+", "start_pos": 155054578, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000186598", "id": "ENSMUST00000186598", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141152", "id": "ENSMUSP00000141152", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WSR3-1|A0A087WSR3_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 493, "sequence": "MDSSIGPASLPEDPGPDLGSRWLFLSANVLPVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTGKACRSAASHALYTWHA" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-1", "isoform_ac": "A2AP18-1", "locus": { "end_pos": 154983665, "strand": "+", "start_pos": 155010984, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105631", "id": "ENSMUST00000105631", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101256", "id": "ENSMUSP00000101256", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AP18-1|PLCH2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1501, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-2", "isoform_ac": "A2AP18-2", "locus": {}, "sequence": { "header": "sp|A2AP18-2|PLCH2_MOUSE Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1238, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLRREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-3", "isoform_ac": "A2AP18-3", "locus": {}, "sequence": { "header": "sp|A2AP18-3|PLCH2_MOUSE Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1252, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTGKACRSAASHALYTWHA" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-4", "isoform_ac": "A2AP18-4", "locus": { "end_pos": 154983665, "strand": "+", "start_pos": 155042996, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000135665", "id": "ENSMUST00000135665", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118292", "id": "ENSMUSP00000118292", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AP18-4|PLCH2_MOUSE Isoform 4 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1396, "sequence": "MDAGAAPQKHMERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-5", "isoform_ac": "A2AP18-5", "locus": { "end_pos": 154998165, "strand": "+", "start_pos": 155010984, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000145662", "id": "ENSMUST00000145662", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119864", "id": "ENSMUSP00000119864", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AP18-5|PLCH2_MOUSE Isoform 5 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 599, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDVSGSPGSACREPGVGPQHPRPILSTKGIYLPQRERGQGVRDKDRRWRVREKGKGTREGARGICPGGRGDKGLPLDREETDRQTWPIGKWWFTNVKK" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A6PWW4-1", "isoform_ac": "A6PWW4-1", "locus": { "end_pos": 155009079, "strand": "+", "start_pos": 155019025, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000126098", "id": "ENSMUST00000126098", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115440", "id": "ENSMUSP00000115440", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A6PWW4-1|A6PWW4_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=4 SV=8 CANONICAL=A2AP18-1", "length": 57, "sequence": "MPTLQEGSEVLFCRVRCSCPAATVPDFKSNPGDVWRRVERCMSAMQEGTQMVKLRGS" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#F6UKG4-1", "isoform_ac": "F6UKG4-1", "locus": { "end_pos": 155007073, "strand": "+", "start_pos": 155054578, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000131173", "id": "ENSMUST00000131173", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118629", "id": "ENSMUSP00000118629", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6UKG4-1|F6UKG4_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 111, "sequence": "MDSSIGPASLPEDPGPDLGSRWLFLSANVLPVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNC" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#F7C3A0-1", "isoform_ac": "F7C3A0-1", "locus": { "end_pos": 154985385, "strand": "+", "start_pos": 155010984, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000139976", "id": "ENSMUST00000139976", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122704", "id": "ENSMUSP00000122704", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7C3A0-1|F7C3A0_MOUSE Computationally mapped isoform of Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1238, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#F7C512-1", "isoform_ac": "F7C512-1", "locus": { "end_pos": 154985383, "strand": "+", "start_pos": 154989791, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124517", "id": "ENSMUST00000124517", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122139", "id": "ENSMUSP00000122139", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7C512-1|F7C512_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 199, "sequence": "XEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#H3BIW6-1", "isoform_ac": "H3BIW6-1", "locus": { "end_pos": 154985385, "strand": "+", "start_pos": 155019242, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000176194", "id": "ENSMUST00000176194", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134750", "id": "ENSMUSP00000134750", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BIW6-1|H3BIW6_MOUSE Computationally mapped isoform of Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 1137, "sequence": "MEEPGPPGGLSQDQVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#H3BK11-1", "isoform_ac": "H3BK11-1", "locus": { "end_pos": 154983663, "strand": "+", "start_pos": 155007007, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000175982", "id": "ENSMUST00000175982", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000135209", "id": "ENSMUSP00000135209", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BK11-1|H3BK11_MOUSE Computationally mapped isoform of Phosphoinositide phospholipase C OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 1250, "sequence": "XARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269615", "resource": "KEGG Pathway", "id": "mmu:269615", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "description": "Synthesis of IP3 and IP4 in the cytosol", "resource": "Reactome", "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "Molecular cloning of PLC-eta1 and PLC-eta2.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "annotation": "Molecular cloning of PLC-eta1 and PLC-eta2.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "id": "NP_780765.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "annotation": "PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "id": "NP_780765.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "annotation": "PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "id": "NP_780765.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "The molecular cloning and sequencing of phospholipase C eta2 are reported.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "annotation": "The molecular cloning and sequencing of phospholipase C eta2 are reported.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "id": "NP_780765.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AP18#function", "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18#function", "id": "A2AP18", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "annotation": "The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "id": "NP_780765.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O75038-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "sequence": { "length": 1416, "sequence": "MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/85172", "id": "85172", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PLCH2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "ac": "NP_780765.2", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "pmid": "15899900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phospholipase C activity", "id": "GO:0004629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phospholipase C activity", "id": "GO:0004629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "15899900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "pmid": "15899900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol metabolic process", "id": "GO:0046488" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "lipid catabolic process", "id": "GO:0016042" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" } ], "total": 4, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 1239, "annotation": "n_glycosylation_sequon", "start_pos": 1237 }, { "end_pos": 20, "annotation": "n_glycosylation_sequon", "start_pos": 18 }, { "end_pos": 370, "annotation": "n_glycosylation_sequon", "start_pos": 368 }, { "end_pos": 383, "annotation": "n_glycosylation_sequon", "start_pos": 381 }, { "end_pos": 552, "annotation": "n_glycosylation_sequon", "start_pos": 550 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029055", "id": "ENSMUSG00000029055", "database": "Bgee" }, { "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.11&UniProtAcc=A2AP18", "id": "3.1.4.11", "database": "BRENDA" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/269615", "id": "269615", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AP18*", "id": "A2AP18", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "id": "IPR000008", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "id": "IPR000909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "id": "IPR001192", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "id": "IPR001711", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "id": "IPR002048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "id": "IPR011992", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "id": "IPR015359", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "id": "IPR017946", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "id": "IPR018247", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028393", "id": "IPR028393", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "id": "IPR035892", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269615", "id": "mmu:269615", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2443078", "id": "2443078", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/SMQRSVT/", "id": "SMQRSVT", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=368239at2759", "id": "368239at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "id": "PTHR10336", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF166", "id": "PTHR10336:SF166", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00168", "id": "PF00168", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00387", "id": "PF00387", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00388", "id": "PF00388", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09279", "id": "PF09279", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16457", "id": "PF16457", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AP18", "id": "PR_A2AP18", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "id": "R-MMU-1855204", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831", "id": "NP_001106831", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765", "id": "NP_780765", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780765.2", "id": "NP_780765.2", "database": "RefSeq" }, { "url": "https://www.rhea-db.org/rhea/33179", "id": "33179", "database": "Rhea" }, { "url": "https://www.uniprot.org/uniprot/A0A087WSR3", "id": "A0A087WSR3", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A087WSR3-1", "id": "A0A087WSR3-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AP18-1", "id": "A2AP18-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AP18-2", "id": "A2AP18-2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AP18-3", "id": "A2AP18-3", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AP18-4", "id": "A2AP18-4", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AP18-5", "id": "A2AP18-5", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A6PWW4", "id": "A6PWW4", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A6PWW4-1", "id": "A6PWW4-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F6UKG4", "id": "F6UKG4", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F6UKG4-1", "id": "F6UKG4-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/F7C3A0", "id": "F7C3A0", "database": "UniProtKB" }, { 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"UniProtKB", "name": "Phospholipase C-eta-2" }, { "url": "https://www.uniprot.org/uniprot/A2AP18#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Phospholipase C-like protein 4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AP18", "type": "synonym", "resource": "RefSeq", "name": "phospholipase C-like protein 4; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2" } ] }