{ "uniprot_canonical_ac": "A2ALS5-1", "ptm_annotation": [], "sequence": { "header": "sp|A2ALS5-1|RPGP1_MOUSE Isoform 1 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1", "length": 663, "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC" }, "uniprot_id": "", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12082090", "type": "PubMed", "id": "12082090" } ], "title": "MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ], "authors": "Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12172908", "type": "PubMed", "id": "12172908" } ], "title": "Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).", "journal": "Acta neuropathologica", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ], "authors": "Kehrer-Sawatzki H, Wilda M, Braun VM, Richter HP, Hameister H", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12873387", "type": "PubMed", "id": "12873387" } ], "title": "Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.", "journal": "Neuron", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ], "authors": "Morozov A, Muzzio IA, Bourtchouladze R, Van-Strien N, Lapidus K, Yin D, Winder DG, Adams JP, Sweatt JD, Kandel ER", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14643017", "type": "PubMed", "id": "14643017" } ], "title": "Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons.", "journal": "Brain research. Developmental brain research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ], "authors": "Bithell A, Alberta J, Hornby F, Stiles CD, Williams BP", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19218462", "type": "PubMed", "id": "19218462" } ], "title": "Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" }, { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5", "id": "A2ALS5", "database": "iPTMnet" } ], "authors": "Greengard P., Nairn A.C., Zhou M.M., McAvoy T.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "type": "PubMed", "id": "21183079" } ], "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "evidence": [ { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2ALS5", "id": "A2ALS5", "database": "iPTMnet" } ], "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22522171", "type": "PubMed", "id": "22522171" } ], "title": "Id proteins synchronize stemness and anchorage to the niche of neural stem cells.", "journal": "Nature cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ], "authors": "Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24642466", "type": "PubMed", "id": "24642466" } ], "title": "Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ], "authors": "Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24803656", "type": "PubMed", "id": "24803656" } ], "title": "The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.", "journal": "Development (Cambridge, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ], "authors": "Le Borgne M, Chartier N, Buchet-Poyau K, Destaing O, Faurobert E, Thibert C, Rouault JP, Courchet J, Negre D, Bouvard D, Albiges-Rizo C, Rousseaux S, Khochbin S, Segretain D, Crepieux P, Guillou F, Durand P, Perrard MH, Billaud M", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26371508", "type": "PubMed", "id": "26371508" } ], "title": "The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ], "authors": "Bebee TW, Park JW, Sheridan KI, Warzecha CC, Cieply BW, Rohacek AM, Xing Y, Carstens RP", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8978063", "type": "PubMed", "id": "8978063" } ], "title": "Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.", "journal": "Genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ], "authors": "Gould KA, Luongo C, Moser AR, McNeley MK, Borenstein N, Shedlovsky A, Dove WF, Hong K, Dietrich WF, Lander ES", "date": "1996" } ], "uniprot_ac": "A2ALS5", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ALS5", "type": "synonym", "resource": "RefSeq", "name": "1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; G; Gap; Rap; Rap1ga1; Rap1GAP1" }, { "url": "https://www.uniprot.org/uniprot/A2ALS5", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa0474" }, { "url": "https://www.uniprot.org/uniprot/A2ALS5", "type": "synonym", "resource": "UniProtKB", "name": "Rap1ga1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ALS5", "type": "synonym", "resource": "RefSeq", "name": "Rap1gap" }, { "url": "https://www.uniprot.org/uniprot/A2ALS5", "type": "recommended", "resource": "UniProtKB", "name": "Rap1gap" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS2-1", "isoform_ac": "A2ALS2-1", "locus": { "end_pos": 137681712, "strand": "-", "start_pos": 137715789, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000152567", "id": "ENSMUST00000152567", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115391", "id": "ENSMUSP00000115391", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALS2-1|A2ALS2_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=1 CANONICAL=A2ALS5-1", "length": 165, "sequence": "MSGRKRSFTFGAYGGRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLV" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS3-1", "isoform_ac": "A2ALS3-1", "locus": { "end_pos": 137681712, "strand": "-", "start_pos": 137717954, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000150928", "id": "ENSMUST00000150928", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000123561", "id": "ENSMUSP00000123561", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALS3-1|A2ALS3_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=8 CANONICAL=A2ALS5-1", "length": 240, "sequence": "MSGRKRSFTFGAYGGVDKSFSLRQSVWRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTG" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS4-1", "isoform_ac": "A2ALS4-1", "locus": { "end_pos": 137681712, "strand": "-", "start_pos": 137728561, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105835", "id": "ENSMUST00000105835", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101461", "id": "ENSMUSP00000101461", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALS4-1|A2ALS4_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=1 CANONICAL=A2ALS5-1", "length": 729, "sequence": "MSGRKRSFTFGAYGGVDKSFSLRQSVWRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLHMAGRQREHHERGQLPSEVAPSCPPSQASHGHPTQTSASRGTLRVPRSRSNWKHLSSTHPRWAASCHLISRRD" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-1", "isoform_ac": "A2ALS5-1", "locus": {}, "sequence": { "header": "sp|A2ALS5-1|RPGP1_MOUSE Isoform 1 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1", "length": 663, "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-2", "isoform_ac": "A2ALS5-2", "locus": { "end_pos": 137681712, "strand": "-", "start_pos": 137728533, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000047243", "id": "ENSMUST00000047243", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000042473", "id": "ENSMUSP00000042473", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ALS5-2|RPGP1_MOUSE Isoform 2 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1", "length": 727, "sequence": "MSGRKRSFTFGAYGGVDKSFSLRQSVWRSDGQKQSFPQALNLLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-3", "isoform_ac": "A2ALS5-3", "locus": { "end_pos": 137707586, "strand": "-", "start_pos": 137728533, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000097837", "id": "ENSMUST00000097837", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095448", "id": "ENSMUSP00000095448", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ALS5-3|RPGP1_MOUSE Isoform 3 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1", "length": 694, "sequence": "MAQPRPPAPHGRPRRGSLPAGAGWQNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTPQMGC" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS5-4", "isoform_ac": "A2ALS5-4", "locus": {}, "sequence": { "header": "sp|A2ALS5-4|RPGP1_MOUSE Isoform 4 of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=2 CANONICAL=A2ALS5-1", "length": 665, "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLHMAGRQREHHERGQLPSEVAPSCPPSQASHGHPTQTSASRGTLRVPRSRSNWKHLSSTHPRWAASCHLISRRD" } }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#A2ALS7-1", "isoform_ac": "A2ALS7-1", "locus": { "end_pos": 137718872, "strand": "-", "start_pos": 137728357, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000141306", "id": "ENSMUST00000141306", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122315", "id": "ENSMUSP00000122315", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALS7-1|A2ALS7_MOUSE Computationally mapped isoform of Rap1 GTPase-activating protein 1 OS=Mus musculus OX=10090 GN=Rap1gap PE=1 SV=1 CANONICAL=A2ALS5-1", "length": 405, "sequence": "QLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGLESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDVGKSGDPACPEIKIQLETSEQHTP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110351", "resource": "KEGG Pathway", "id": "mmu:110351", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-392517", "description": "Rap1 signalling", "resource": "Reactome", "id": "R-MMU-392517", "name": "Rap1 signalling" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8853659", "description": "RET signaling", "resource": "Reactome", "id": "R-MMU-8853659", "name": "RET signaling" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "annotation": "ERK activation by cAMP does not require RAP1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "annotation": "ERK activation by cAMP does not require RAP1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "annotation": "Evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "annotation": "Evidence of differential Krit1 and Rap1A expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1, not restricted to vascular endothelial cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "annotation": "Expression studies show that mr-gef is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "annotation": "Expression studies show that mr-gef is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2ALS5#function", "annotation": "GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5#function", "id": "A2ALS5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "annotation": "Increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "annotation": "Increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "annotation": "Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "id": "NP_001074624.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "annotation": "Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LV89-1", "protein_name": "Rap1 GTPase-activating protein", "sequence": { "length": 753, "sequence": "MSGRKRSFTFGAYGGVDKSFSPRQSVWRSDGQKHSFPQTLNVLLVDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEISSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGMESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQLETSEQHTPQMGC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2163", "id": "2163", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Rap1gap", "tax_id": 10116 }, { "uniprot_canonical_ac": "P47736-1", "protein_name": "Rap1 GTPase-activating protein 1", "sequence": { "length": 663, "sequence": "MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTNHEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQSSPEMPTTKNRAETAAQRAEALKDFSRSSSSASSFASVVEETEGVDGEDTGLESVSSSGTPHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHPDAGKLGDPACPEIKIQLEASEQHMPQLGC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/2163", "id": "2163", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "RAP1GAP", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074624.1", "ac": "NP_001074624.1", "name": "rap1 GTPase-activating protein 1 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030695", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "GTPase regulator activity", "id": "GO:0030695" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017016", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "Ras GTPase binding", "id": "GO:0017016" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "early endosome", "id": "GO:0005769" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "regulation of small GTPase mediated signal transduction", "id": "GO:0051056" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022409", "pmid": "24803656", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "positive regulation of cell-cell adhesion", "id": "GO:0022409" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "pmid": "24803656", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "positive regulation of phagocytosis", "id": "GO:0050766" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903697", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "negative regulation of microvillus assembly", "id": "GO:1903697" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "regulation of GTPase activity", "id": "GO:0043087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "positive regulation of GTPase activity", "id": "GO:0043547" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "negative regulation of neuron differentiation", "id": "GO:0045665" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904425", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "negative regulation of GTP binding", "id": "GO:1904425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904442", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "negative regulation of thyroid gland epithelial cell proliferation", "id": "GO:1904442" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990792", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" } ], "name": "cellular response to glial cell derived neurotrophic factor", "id": "GO:1990792" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 422, "annotation": "n_glycosylation_sequon", "start_pos": 420 }, { "end_pos": 538, "annotation": "n_glycosylation_sequon", "start_pos": 536 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041351", "id": "ENSMUSG00000041351", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/110351", "id": "110351", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ALS5*", "id": "A2ALS5", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000331", "id": "IPR000331", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003109", "id": "IPR003109", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035974", "id": "IPR035974", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110351", "id": "mmu:110351", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:109338", "id": "109338", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/XESVSSS/", 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"https://www.ncbi.nlm.nih.gov/protein/NP_001243147.1", "id": "NP_001243147.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2ALS2", "id": "A2ALS2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS2-1", "id": "A2ALS2-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS3", "id": "A2ALS3", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS3-1", "id": "A2ALS3-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS4", "id": "A2ALS4", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS4-1", "id": "A2ALS4-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS5", "id": "A2ALS5", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS5-1", "id": "A2ALS5-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALS5-2", "id": "A2ALS5-2", "database": "UniProtKB" }, { "url": 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