{ "uniprot_canonical_ac": "A2AKK5-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AKK5-1|ACNT1_MOUSE Isoform 1 of Acyl-coenzyme A amino acid N-acyltransferase 1 OS=Mus musculus OX=10090 GN=Acnat1 PE=1 SV=1 CANONICAL=A2AKK5-1", "length": 416, "sequence": "MMIKLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQAFYKTNEAGEVDLEKTPALGGDYVGVHPMGLFFSLKPKKAFHRLMKKDVMNSPFCICLDLYDSVNWLETVRIPSKASQRVQRWFVGPGVKREQIQEGRVRGALFLPPGKGPFPGIIDLFGVIGGLVEFRASLLASHGFAVLALAYFAYKDLPEKLQEVDLEYFEEAANFLLSHPKIQQPGIGVISTSKGAEIGLAMACYLKQVIATVCINGATTTTAVPLRYQDLVVTPIQQALERMEVHVSGAVCFRHTTQYLQNKNILPVEKAQGKILFIVGENDELLDSKLHAQRAMDRLRRHGRSSGRMLAYPGAGHLIEPPYSPLCFASWQPVLGRPMCFGGDLMAHAAAQEHSWREIQKFFRKHLLQSGSKL" }, "uniprot_id": "A2AKK6_MOUSE", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [ { "gene_name": "Acnat1", "uniprot_ac": "A2AKK5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "ec_number": "2.3.1.-", "activity": "" } ] } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16916647", "type": "PubMed", "id": "16916647" } ], "title": "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158037.1", "id": "NP_001158037.1", "database": "RefSeq" } ], "authors": "Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17116739", "type": "PubMed", "id": "17116739" } ], "title": "A peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids.", "journal": "FASEB J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158037.1", "id": "NP_001158037.1", "database": "RefSeq" } ], "authors": "Alexson S.E.H., Hunt M.C., Andersson U., O'Byrne J., O'Shea E.M., Reilly S.-J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18538142", "type": "PubMed", "id": "18538142" } ], "title": "Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism.", "journal": "Progress in lipid research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158037.1", "id": "NP_001158037.1", "database": "RefSeq" } ], "authors": "Hunt MC, Alexson SE", "date": "2008" } ], "uniprot_ac": "A2AKK5", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AKK5", "type": "synonym", "resource": "RefSeq", "name": "AI132189" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AKK5", "type": "synonym", "resource": "RefSeq", "name": "Acnat1" }, { "url": "https://www.uniprot.org/uniprot/A2AKK5", "type": "recommended", "resource": "UniProtKB", "name": "Acnat1" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/50100", "id": "50100", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine", "input_participant_list": [], "enzyme_list": [ "A2AKK5-1" ], "id": "50100", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/50104", "id": "50104", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine", "input_participant_list": [], "enzyme_list": [ "A2AKK5-1" ], "id": "50104", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/50108", "id": "50108", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine", "input_participant_list": [], "enzyme_list": [ "A2AKK5-1" ], "id": "50108", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/50112", "id": "50112", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine", "input_participant_list": [], "enzyme_list": [ "A2AKK5-1" ], "id": "50112", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/50116", "id": "50116", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine", "input_participant_list": [], "enzyme_list": [ "A2AKK5-1" ], "id": "50116", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/50120", "id": "50120", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine", "input_participant_list": [], "enzyme_list": [ "A2AKK5-1" ], "id": "50120", "summary": "" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5#A2AKK5-1", "isoform_ac": "A2AKK5-1", "locus": { "end_pos": 49447332, "strand": "+", "start_pos": 49451109, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000095086", "id": "ENSMUST00000095086", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000092702", "id": "ENSMUSP00000092702", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AKK5-1|ACNT1_MOUSE Isoform 1 of Acyl-coenzyme A amino acid N-acyltransferase 1 OS=Mus musculus OX=10090 GN=Acnat1 PE=1 SV=1 CANONICAL=A2AKK5-1", "length": 416, "sequence": "MMIKLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQAFYKTNEAGEVDLEKTPALGGDYVGVHPMGLFFSLKPKKAFHRLMKKDVMNSPFCICLDLYDSVNWLETVRIPSKASQRVQRWFVGPGVKREQIQEGRVRGALFLPPGKGPFPGIIDLFGVIGGLVEFRASLLASHGFAVLALAYFAYKDLPEKLQEVDLEYFEEAANFLLSHPKIQQPGIGVISTSKGAEIGLAMACYLKQVIATVCINGATTTTAVPLRYQDLVVTPIQQALERMEVHVSGAVCFRHTTQYLQNKNILPVEKAQGKILFIVGENDELLDSKLHAQRAMDRLRRHGRSSGRMLAYPGAGHLIEPPYSPLCFASWQPVLGRPMCFGGDLMAHAAAQEHSWREIQKFFRKHLLQSGSKL" } }, { "url": "https://www.uniprot.org/uniprot/A2AKK5#A2AKK5-2", "isoform_ac": "A2AKK5-2", "locus": { "end_pos": 49447332, "strand": "+", "start_pos": 49451109, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107697", "id": "ENSMUST00000107697", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103325", "id": "ENSMUSP00000103325", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AKK5-2|ACNT1_MOUSE Isoform 2 of Acyl-coenzyme A amino acid N-acyltransferase 1 OS=Mus musculus OX=10090 GN=Acnat1 PE=1 SV=1 CANONICAL=A2AKK5-1", "length": 398, "sequence": "MMIKLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQAFYKTNEAGEVDLEKTPALGGDYVGVHPMGLFFSLKPKKAFHRLMKKDVMNSPFCICLDLYDSVNWLETVRIPSKASQRVQRWFVGPGVKREQIQEGRVRGALFLPPVEFRASLLASHGFAVLALAYFAYKDLPEKLQEVDLEYFEEAANFLLSHPKIQQPGIGVISTSKGAEIGLAMACYLKQVIATVCINGATTTTAVPLRYQDLVVTPIQQALERMEVHVSGAVCFRHTTQYLQNKNILPVEKAQGKILFIVGENDELLDSKLHAQRAMDRLRRHGRSSGRMLAYPGAGHLIEPPYSPLCFASWQPVLGRPMCFGGDLMAHAAAQEHSWREIQKFFRKHLLQSGSKL" } }, { "url": "https://www.uniprot.org/uniprot/A2AKK5#A2AKK6-1", "isoform_ac": "A2AKK6-1", "locus": { "end_pos": 49450966, "strand": "+", "start_pos": 49451109, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000135976", "id": "ENSMUST00000135976", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121168", "id": "ENSMUSP00000121168", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AKK6-1|ACNT1_MOUSE Computationally mapped isoform of Acyl-coenzyme A amino acid N-acyltransferase 1 OS=Mus musculus OX=10090 GN=Acnat1 PE=1 SV=1 CANONICAL=A2AKK5-1", "length": 48, "sequence": "MMIKLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230161", "resource": "KEGG Pathway", "id": "mmu:230161", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5#function", "annotation": "Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine (PubMed:17116739). Shows no conjugation activity in the presence of glycine (PubMed:17116739).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5#function", "id": "A2AKK5", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K2H6-1", "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 1", "sequence": { "length": 419, "sequence": "IMLQLIATPSNALADEPVSIRAIGLPPSQIVTITATVKDEKENLFQSKAFYKANEAGEVDLEQASALGGDYVGVHPMGLFCCLKPKRAFQRLIKKDVMNSPLCICLDLYDSVCWLETVRIPPKASQIVHRWFAGPGVKREQIREGRVRGALFLPPGKGPFPGIIDLFGSIGGLVEFRASLLASRGFAVLALAYFAYEDLPKELLEEDLDYFEEAANFLLAHPKIQQPGIGVISVSKGAEIGLAMACYLKQVAATVCINGPSVVFDVPLRYGDLVVTPILLASELMQVHPSGAVRFRHCSVPQNKLNSQKILPVEKAQGKILFIVGENDESLASKLHAQRAMDRLRSHGRSSGRMLAYPGAGHLIEPPYSPFCFASWHSVLGKPLLWGGDPIAHAAAQVHSWGEIQKFFRQHLLQSGGKL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AKK5/", "id": "A2AKK5", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Acnat1", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5FVR5-1", "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 2", "sequence": { "length": 418, "sequence": "MLQLIATPSNALADEPVSIRAIGLPPSQIVTITATVKDEKENLFQSKAFYKANEAGEVDLEQASALGGDYVGVHPMGLFCCLKPKRAFQRLIKKDVMNSPLCICLDLYDSVCWLETVRIPPKASQIVHRWFAGPGVKREQIREGRVRGALFLPPGKGPFPGIIDLFGSIGGLVEFRASLLASRGFAVLALAYFAYEDLPKVLLEEDLDYFEEAANFLLAHPKIQQPGIGVISVSKGAEIGLAMACYLKQVVATVCINGPSAIFDFPLKYRDLVVTPMRLAFEKIQFHGSGAACFRHCWDPQNMLNPPKILPVEKAQGKILFIVGENDQCLASKLHAQRAMDRLRSHGRSSGRMLAYPGAGHLIEPPYSPFCFACWDSVLGKPMLWGGDPIAHAAAQVHSWREIQKFFRQHLLQSGGKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28287", "id": "28287", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Acnat2", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8BGG9-1", "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 2", "sequence": { "length": 420, "sequence": "MMIQLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQAFYKTNEAGEVDLEKTPALGGDYVGVHPMGLFFSLKPKKAFHRLMKKDVMNSPLCICLDLYDSVNWLETVRIPSKASQRVQRWFVGPGVKREQIQEGRVRGALFLPPGKGPFPGIIDLFGLIGGLVEFRASLLASHGFAVLALAYFAYEDLPEKPQEVDLEYFEEAANFLLSHPKIQQPGIGVISTSKGAEIGLAMACYLKQVIATVCINGPTTITIFPLRYQDLVMTPIHPALERIQVHDSGALLFRYTTQYLHNKLNSQNILPVEKAQGKILFIVGENDECLDSKLHAQKAMDRLQRHGRSSGRMLAYPGAGHLIEPPYSPVCFVAWFPVLGQPMCFGGDLMAHAAAQEHSWREIQKFFRKHLLQSGSKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28287", "id": "28287", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Acnat2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158037.1", "ac": "NP_001158037.1", "name": "acyl-coenzyme A amino acid N-acyltransferase 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047617", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "name": "acyl-CoA hydrolase activity", "id": "GO:0047617" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016410", "pmid": "17116739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "name": "N-acyltransferase activity", "id": "GO:0016410" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "pmid": "17116739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "name": "peroxisome", "id": "GO:0005777" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "pmid": "17116739", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "name": "fatty acid metabolic process", "id": "GO:0006631" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006637", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "name": "acyl-CoA metabolic process", "id": "GO:0006637" } ], "total": 2, "name": "Biological Process" } ] }, "site_annotation": [], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070985", "id": "ENSMUSG00000070985", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/230161", "id": "230161", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006862", "id": "IPR006862", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014940", "id": "IPR014940", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016662", "id": "IPR016662", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "id": "IPR029058", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042490", "id": "IPR042490", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230161", "id": "mmu:230161", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2140197", "id": "2140197", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/WITLDLY/", "id": "WITLDLY", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1260385at2759", "id": "1260385at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF04775", "id": "PF04775", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08840", "id": "PF08840", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AKK5", "id": "PR_A2AKK5", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158037", "id": "NP_001158037", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158037.1", "id": "NP_001158037.1", "database": "RefSeq" }, { "url": "https://www.rhea-db.org/rhea/50100", "id": "50100", "database": "Rhea" }, { "url": "https://www.rhea-db.org/rhea/50104", "id": "50104", "database": "Rhea" }, { "url": "https://www.rhea-db.org/rhea/50108", "id": "50108", "database": "Rhea" }, { "url": "https://www.rhea-db.org/rhea/50112", "id": "50112", "database": "Rhea" }, { "url": "https://www.rhea-db.org/rhea/50116", "id": "50116", "database": "Rhea" }, { "url": "https://www.rhea-db.org/rhea/50120", "id": "50120", "database": "Rhea" }, { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AKK5-1", "id": "A2AKK5-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AKK5-2", "id": "A2AKK5-2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AKK6", "id": "A2AKK6", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AKK6-1", "id": "A2AKK6-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "start_pos": 125, "end_pos": 125, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "comment": "Phosphoserine", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "id": "A2AKK5", "database": "UniProtKB" } ], "start_pos": 414, "end_pos": 414, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 46071.0, "chemical_mass": 46071.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5", "name": "Acnat1", "locus": { "end_pos": 49447105, "strand": "-", "start_pos": 49473912, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000070985", "id": "ENSMUSG00000070985", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AKK5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.3.1.-" }, { "url": "https://www.uniprot.org/uniprot/A2AKK5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Acyl-coenzyme A amino acid N-acyltransferase 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AKK5", "type": "synonym", "resource": "RefSeq", "name": "acyl-coenzyme A amino acid N-acyltransferase 1" } ] }