{ "uniprot_canonical_ac": "A2AAY5-1", "ptm_annotation": [ { "annotation": "Phosphorylated in SRC-transformed cells.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144821", "id": "19144821", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AAY5-1|SPD2B_MOUSE Isoform 1 of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1", "length": 908, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" }, "uniprot_id": "", "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15592455", "type": "PubMed", "id": "15592455" } ], "title": "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.", "journal": "Nat. Biotechnol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5", "id": "A2AAY5", "database": "iPTMnet" } ], "authors": "Rush J., Zhang H., Comb M.J., Goss V.L., Guo A., Lee K.A., Moritz A., Polakiewicz R.D., Spek E.J., Zha X.-M., Zha X.M.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18959745", "type": "PubMed", "id": "18959745" } ], "title": "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.", "journal": "FEBS J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Eguchi T., Osada S., Imagawa M., Nishizuka M., Hishida T.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "type": "PubMed", "id": "19144319" } ], "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5", "id": "A2AAY5", "database": "iPTMnet" } ], "authors": "Thibault P., Trost M., Desjardins M., Courcelles M., English L., Lemieux S.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144821", "type": "PubMed", "id": "19144821" } ], "title": "The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.", "journal": "Mol. Biol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" }, { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5", "id": "A2AAY5", "database": "iPTMnet" } ], "authors": "Courtneidge S.A., Pass I., Buschman M.D., Cejudo-Martin P., Bromann P.A., Wen F.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19233245", "type": "PubMed", "id": "19233245" } ], "title": "The role of C/EBPdelta in the early stages of adipogenesis.", "journal": "Biochimie", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Hishida T, Nishizuka M, Osada S, Imagawa M", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19669234", "type": "PubMed", "id": "19669234" } ], "title": "The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.", "journal": "Mamm. Genome", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Mao M., Chang B., Johnson K.R., Zheng Q.Y., Donahue L.R., Thedens D.R., Harris B.S., Anderson M.G.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19755710", "type": "PubMed", "id": "19755710" } ], "title": "Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.", "journal": "Sci. Signal.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "authors": "Bokoch G.M., Fowler B., Courtneidge S.A., Gianni D., Diaz B., Taulet N.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20137777", "type": "PubMed", "id": "20137777" } ], "title": "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.", "journal": "Am. J. Hum. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Megarbane A., Veltman J.A., van Bokhoven H., de Brouwer A., Alanay Y., Albrecht B., Ben-Neriah Z., Courtneidge S.A., Iqbal Z., van Beusekom E., Hennekam R., van der Zwaag B., Ruiz-Lozano P., Millan J.L., Artuso R., Hamel B., Amenduni M., Cejudo-Martin P., Lindsey J.D., Oudakker A., Scimia M.C., Weinreb R.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "type": "PubMed", "id": "21183079" } ], "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "evidence": [ { "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/A2AAY5", "id": "A2AAY5", "database": "iPTMnet" } ], "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27711054", "type": "PubMed", "id": "27711054" } ], "title": "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Dulk M, Kudlik G, Fekete A, Ernszt D, Kvell K, Pongracz JE, Mero BL, Szeder B, Radnai L, Geiszt M, Csecsy DE, Kovacs T, Uher F, Lanyi A, Vas V, Buday L", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27802184", "type": "PubMed", "id": "27802184" } ], "title": "The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.", "journal": "Oncotarget", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31387265", "type": "PubMed", "id": "31387265" } ], "title": "Analysis of Tks4 Knockout Mice Suggests a Role for Tks4 in Adipose Tissue Homeostasis in the Context of Beigeing.", "journal": "Cells", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Vas V, Hahner T, Kudlik G, Ernszt D, Kvell K, Kuti D, Kovacs KJ, Tovari J, Trexler M, Mero BL, Szeder B, Koprivanacz K, Buday L", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31591456", "type": "PubMed", "id": "31591456" } ], "title": "Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Mehes E, Barath M, Gulyas M, Bugyik E, Geiszt M, Szoor A, Lanyi A, Czirok A", "date": "2019" } ], "uniprot_ac": "A2AAY5", "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "type": "synonym", "resource": "UniProtKB", "name": "Fad49" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AAY5", "type": "synonym", "resource": "RefSeq", "name": "Fad4; fad49; G431001E03Rik; Tks; Tks4; TSK4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AAY5", "type": "synonym", "resource": "RefSeq", "name": "Sh3pxd2b" }, { "url": "https://www.uniprot.org/uniprot/A2AAY5", "type": "recommended", "resource": "UniProtKB", "name": "Sh3pxd2b" }, { "url": "https://www.uniprot.org/uniprot/A2AAY5", "type": "synonym", "resource": "UniProtKB", "name": "Tks4" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5#A0A5F8MPP7-1", "isoform_ac": "A0A5F8MPP7-1", "locus": { "end_pos": 32347894, "strand": "-", "start_pos": 32423558, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000239041", "id": "ENSMUST00000239041", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000158896", "id": "ENSMUSP00000158896", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A5F8MPP7-1|A0A5F8MPP7_MOUSE Computationally mapped isoform of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1", "length": 936, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYCSLPRSVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" } }, { "url": "https://www.uniprot.org/uniprot/A2AAY5#A2AAY5-1", "isoform_ac": "A2AAY5-1", "locus": { "end_pos": 32347894, "strand": "-", "start_pos": 32423558, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000038753", "id": "ENSMUST00000038753", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000044276", "id": "ENSMUSP00000044276", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AAY5-1|SPD2B_MOUSE Isoform 1 of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1", "length": 908, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268396", "resource": "KEGG Pathway", "id": "mmu:268396", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5#function", "annotation": "Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5#function", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Beigeing process was more robust in the WAT of Tks4-KO mice compared to the wild-type animals. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4. Erratum:[Sci Rep. 2020 Jul 20;10(1):12293. PMID: 32686692] Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Induction of the fad49 gene was observed in adipocyte differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3 cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "SH3PXD2B is a podosomal-adaptor protein required for postnatal growth and development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Silencing of C/EBPdelta impaired the expression of factor for adipocyte differentiation (fad) 49, which is up-regulated and plays a crucial role early in adipogenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "These findings establish a role for TKS4 in Frank-Ter Haar syndrome and embryonic development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Tks4 has a role in the formation and function of podosomes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Together, these results establish a novel function for Tks4 in the regulation of mesenchymal stromal cells differentiation. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A1X283-1", "protein_name": "SH3 and PX domain-containing protein 2B", "sequence": { "length": 911, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AAY5/", "id": "A2AAY5", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/27952", "id": "27952", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SH3PXD2B", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZAF9-1", "protein_name": "SH3 and PX domains 2B", "sequence": { "length": 804, "sequence": "ALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGVVVEVIQKNLEGWWKIRFQGKEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDLDGVSRQQNAVGREKELLNNQRDGRFEGRLAPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGEAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPHRGSSPKPPGVILPMIPAKHAPLARDSKKPEPKPDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELPEEKVEPNPQNLFLKSRPQVRPKPTPSPKTEPAQGEDQVDIYNLRSKLRPAKSQEKALLDGESHHAAGGHDTALGRSFLPGEGPGRGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGSQREESRAIPASGRALLVPPKAKPFLSNSSVGQDDIRGKGGLGPRIAGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCRVLSGAPSWEGWIPSNYLRKKP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AAY5/", "id": "A2AAY5", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Sh3pxd2b", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006514775.1", "ac": "XP_006514775.1", "name": "SH3 and PX domain-containing protein 2B isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "name": "phosphatidylinositol binding", "id": "GO:0035091" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "pmid": "18959745", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314" }, { 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