The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [ "R-ALL-215075" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211924", "id": "R-MMU-211924", "database": "Reactome" } ], "name": "CYP4B1 12-hydroxylates ARA", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A2A974-1", "Q91WL5-1", "O88833-1", "Q64462-1", "Q9EP75-1" ], "id": "R-MMU-211924", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [ "R-ALL-216612" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211962", "id": "R-MMU-211962", "database": "Reactome" } ], "name": "CYP4F11 16-hydroxylates 3OH-PALM", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [ "R-ALL-216621" ], "enzyme_list": [ "A2A974-1", "Q91WL5-1", "O88833-1", "Q64462-1", "Q9EP75-1" ], "id": "R-MMU-211962", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [ "R-ALL-571314" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-215526", "id": "R-MMU-215526", "database": "Reactome" } ], "name": "CYP4F3 20-hydroxylates LTB4", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [ "R-ALL-215557" ], "enzyme_list": [ "A2A974-1", "Q91WL5-1", "O88833-1", "Q64462-1", "Q9EP75-1" ], "id": "R-MMU-215526", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [ "R-ALL-2142740" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2161745", "id": "R-MMU-2161745", "database": "Reactome" } ], "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A2A974-1", "Q91WL5-1", "O88833-1", "Q64462-1", "Q9EP75-1" ], "id": "R-MMU-2161745", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [ "R-ALL-2161582" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2161792", "id": "R-MMU-2161792", "database": "Reactome" } ], "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A2A974-1", "Q91WL5-1", "O88833-1", "Q64462-1", "Q9EP75-1" ], "id": "R-MMU-2161792", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [ "R-ALL-42373" ], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76466", "id": "R-MMU-76466", "database": "Reactome" } ], "name": "CYP4A11 12-hydroxylates DDCX", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [ "R-ALL-33549" ], "enzyme_list": [ "A2A974-1", "Q91WL5-1", "O88833-1", "Q64462-1", "Q9EP75-1" ], "id": "R-MMU-76466", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A974#A2A974-1", "isoform_ac": "A2A974-1", "locus": { "end_pos": 115411683, "strand": "-", "start_pos": 115438222, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000094887", "id": "ENSMUST00000094887", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000092487", "id": "ENSMUSP00000092487", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A974-1|CP4CB_MOUSE Isoform 1 of Cytochrome P450 4A12B OS=Mus musculus OX=10090 GN=Cyp4a12b PE=1 SV=1 CANONICAL=A2A974-1", "length": 508, "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:13118", "resource": "KEGG Pathway", "id": "mmu:13118", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211935", "description": "Fatty acids", "resource": "Reactome", "id": "R-MMU-211935", "name": "Fatty acids" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211958", "description": "Miscellaneous substrates", "resource": "Reactome", "id": "R-MMU-211958", "name": "Miscellaneous substrates" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211979", "description": "Eicosanoids", "resource": "Reactome", "id": "R-MMU-211979", "name": "Eicosanoids" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142691", "description": "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "resource": "Reactome", "id": "R-MMU-2142691", "name": "Synthesis of Leukotrienes (LT) and Eoxins (EX)" } ], "reaction_participants": [ { "crossref": [ { "url": "", "id": "63979", "database": "ChEBI" }, { "url": "", "id": "000033985160", "database": "ZINC" }, { "url": "", "id": "HMDB0012641", "database": "HMDB Metabolite" }, { "url": "", "id": "HMDB0012641", "database": "HMDB Metabolite" }, { "url": "", "id": "63979", "database": "ChEBI" }, { "url": "", "id": "000033985160", "database": "ZINC" }, { "url": "", "id": "63979", "database": "ChEBI" }, { "url": "", "id": "000033985160", "database": "ZINC" }, { "url": "", "id": "HMDB0012641", "database": "HMDB Metabolite" } ], "participant_name": "20cho-LTB4 [cytosol]", "participant_id": "R-ALL-2142740" }, { "crossref": [ { "url": "", "id": "000033838754", "database": "ZINC" }, { "url": "", "id": "19138", "database": "ChEBI" }, { "url": "", "id": "000033838755", "database": "ZINC" }, { "url": "", "id": "000033838754", "database": "ZINC" }, { "url": "", "id": "000033838755", "database": "ZINC" }, { "url": "", "id": "19138", "database": "ChEBI" }, { "url": "", "id": "000033838754", "database": "ZINC" }, { "url": "", "id": "000033838755", "database": "ZINC" }, { "url": "", "id": "19138", "database": "ChEBI" } ], "participant_name": "12-HETE [endoplasmic reticulum lumen]", "participant_id": "R-ALL-215075" }, { "crossref": [ { "url": "", "id": "15647", "database": "ChEBI" }, { "url": "", "id": "C02165", "database": "COMPOUND" }, { "url": "", "id": "000004623738", "database": "ZINC" }, { "url": "", "id": "HMDB0002995", "database": "HMDB Metabolite" }, { "url": "", "id": "15647", "database": "ChEBI" }, { "url": "", "id": "C02165", "database": "COMPOUND" }, { "url": "", "id": "000004623738", "database": "ZINC" }, { "url": "", "id": "HMDB0002995", "database": "HMDB Metabolite" }, { "url": "", "id": "15647", "database": "ChEBI" }, { "url": "", "id": "C02165", "database": "COMPOUND" }, { "url": "", "id": "000004623738", "database": "ZINC" }, { "url": "", "id": "HMDB0002995", "database": "HMDB Metabolite" } ], "participant_name": "LTB4 [endoplasmic reticulum lumen]", "participant_id": "R-ALL-215557" }, { "crossref": [ { "url": "", "id": "HMDB0006059", "database": "HMDB Metabolite" }, { "url": "", "id": "27562", "database": "ChEBI" }, { "url": "", "id": "C05950", "database": "COMPOUND" }, { "url": "", "id": "000004632132", "database": "ZINC" }, { "url": "", "id": "C05950", "database": "COMPOUND" }, { "url": "", "id": "000004632132", "database": "ZINC" }, { "url": "", "id": "HMDB0006059", "database": "HMDB Metabolite" }, { "url": "", "id": "27562", "database": "ChEBI" }, { "url": "", "id": "HMDB0006059", "database": "HMDB Metabolite" }, { "url": "", "id": "27562", "database": "ChEBI" }, { "url": "", "id": "000004632132", "database": "ZINC" }, { "url": "", "id": "C05950", "database": "COMPOUND" } ], "participant_name": "20cooh-LTB4 [cytosol]", "participant_id": "R-ALL-2161582" }, { "crossref": [ { "url": "", "id": "15646", "database": "ChEBI" }, { "url": "", "id": "C04853", "database": "COMPOUND" }, { "url": "", "id": "000004629872", "database": "ZINC" }, { "url": "", "id": "HMDB0001509", "database": "HMDB Metabolite" }, { "url": "", "id": "C04853", "database": "COMPOUND" }, { "url": "", "id": "HMDB0001509", "database": "HMDB Metabolite" }, { "url": "", "id": "15646", "database": "ChEBI" }, { "url": "", "id": "000004629872", "database": "ZINC" }, { "url": "", "id": "15646", "database": "ChEBI" }, { "url": "", "id": "C04853", "database": "COMPOUND" }, { "url": "", "id": "000004629872", "database": "ZINC" }, { "url": "", "id": "HMDB0001509", "database": "HMDB Metabolite" } ], "participant_name": "20OH-LTB4 [cytosol]", "participant_id": "R-ALL-2161636" }, { "crossref": [ { "url": "", "id": "63904", "database": "ChEBI" }, { "url": "", "id": "000087528734", "database": "ZINC" }, { "url": "", "id": "000087528731", "database": "ZINC" }, { "url": "", "id": "63904", "database": "ChEBI" }, { "url": "", "id": "000087528734", "database": "ZINC" }, { "url": "", "id": "000087528731", "database": "ZINC" }, { "url": "", "id": "63904", "database": "ChEBI" }, { "url": "", "id": "000087528734", "database": "ZINC" }, { "url": "", "id": "000087528731", "database": "ZINC" } ], "participant_name": "3,16DOH-PALM [endoplasmic reticulum lumen]", "participant_id": "R-ALL-216612" }, { "crossref": [ { "url": "", "id": "37248", "database": "ChEBI" }, { "url": "", "id": "HMDB0061658", "database": "HMDB Metabolite" }, { "url": "", "id": "000032838984", "database": "ZINC" }, { "url": "", "id": "000032838986", "database": "ZINC" }, { "url": "", "id": "37248", "database": "ChEBI" }, { "url": "", "id": "HMDB0061658", "database": "HMDB Metabolite" }, { "url": "", "id": "000032838984", "database": "ZINC" }, { "url": "", "id": "000032838986", "database": "ZINC" }, { "url": "", "id": "37248", "database": "ChEBI" }, { "url": "", "id": "HMDB0061658", "database": "HMDB Metabolite" }, { "url": "", "id": "000032838984", "database": "ZINC" }, { "url": "", "id": "000032838986", "database": "ZINC" } ], "participant_name": "3OH-PALM [endoplasmic reticulum lumen]", "participant_id": "R-ALL-216621" }, { "crossref": [ { "url": "", "id": "15647", "database": "ChEBI" }, { "url": "", "id": "C02165", "database": "COMPOUND" }, { "url": "", "id": "000004623738", "database": "ZINC" }, { "url": "", "id": "HMDB0002995", "database": "HMDB Metabolite" }, { "url": "", "id": "15647", "database": "ChEBI" }, { "url": "", "id": "C02165", "database": "COMPOUND" }, { "url": "", "id": "000004623738", "database": "ZINC" }, { "url": "", "id": "HMDB0002995", "database": "HMDB Metabolite" }, { "url": "", "id": "15647", "database": "ChEBI" }, { "url": "", "id": "C02165", "database": "COMPOUND" }, { "url": "", "id": "000004623738", "database": "ZINC" }, { "url": "", "id": "HMDB0002995", "database": "HMDB Metabolite" } ], "participant_name": "LTB4 [cytosol]", "participant_id": "R-ALL-266056" }, { "crossref": [ { "url": "", "id": "30805", "database": "ChEBI" }, { "url": "", "id": "HMDB0000638", "database": "HMDB Metabolite" }, { "url": "", "id": "8145220", "database": "PubChem Substance" }, { "url": "", "id": "C02679", "database": "COMPOUND" }, { "url": "", "id": "000001529498", "database": "ZINC" }, { "url": "", "id": "30805", "database": "ChEBI" }, { "url": "", "id": "HMDB0000638", "database": "HMDB Metabolite" }, { "url": "", "id": "8145220", "database": "PubChem Substance" }, { "url": "", "id": "C02679", "database": "COMPOUND" }, { "url": "", "id": "000001529498", "database": "ZINC" }, { "url": "", "id": "30805", "database": "ChEBI" }, { "url": "", "id": "HMDB0000638", "database": "HMDB Metabolite" }, { "url": "", "id": "8145220", "database": "PubChem Substance" }, { "url": "", "id": "C02679", "database": "COMPOUND" }, { "url": "", "id": "000001529498", "database": "ZINC" } ], "participant_name": "DDCX [endoplasmic reticulum lumen]", "participant_id": "R-ALL-33549" }, { "crossref": [ { "url": "", "id": "HMDB0002059", "database": "HMDB Metabolite" }, { "url": "", "id": "000001531061", "database": "ZINC" }, { "url": "", "id": "39567", "database": "ChEBI" }, { "url": "", "id": "C08317", "database": "COMPOUND" }, { "url": "", "id": "8148189", "database": "PubChem Substance" }, { "url": "", "id": "000001531061", "database": "ZINC" }, { "url": "", "id": "HMDB0002059", "database": "HMDB Metabolite" }, { "url": "", "id": "8148189", "database": "PubChem Substance" }, { "url": "", "id": "C08317", "database": "COMPOUND" }, { "url": "", "id": "39567", "database": "ChEBI" }, { "url": "", "id": "39567", "database": "ChEBI" }, { "url": "", "id": "C08317", "database": "COMPOUND" }, { "url": "", "id": "8148189", "database": "PubChem Substance" }, { "url": "", "id": "000001531061", "database": "ZINC" }, { "url": "", "id": "HMDB0002059", "database": "HMDB Metabolite" } ], "participant_name": "12OH-DDCX [endoplasmic reticulum lumen]", "participant_id": "R-ALL-42373" }, { "crossref": [ { "url": "", "id": "000004629872", "database": "ZINC" }, { "url": "", "id": "15646", "database": "ChEBI" }, { "url": "", "id": "HMDB0001509", "database": "HMDB Metabolite" }, { "url": "", "id": "C04853", "database": "COMPOUND" }, { "url": "", "id": "000004629872", "database": "ZINC" }, { "url": "", "id": "15646", "database": "ChEBI" }, { "url": "", "id": "HMDB0001509", "database": "HMDB Metabolite" }, { "url": "", "id": "C04853", "database": "COMPOUND" }, { "url": "", "id": "HMDB0001509", "database": "HMDB Metabolite" }, { "url": "", "id": "C04853", "database": "COMPOUND" }, { "url": "", "id": "15646", "database": "ChEBI" }, { "url": "", "id": "000004629872", "database": "ZINC" } ], "participant_name": "20OH-LTB4 [endoplasmic reticulum lumen]", "participant_id": "R-ALL-571314" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "annotation": "'...Cyp4a12...is expressed in mouse lung... may be upregulated by...clofibrate and... cytokine IL-1Beta...IL-1Beta has been...associated with asthma...data raise the question...whether CYP4A expression could be altered in asthmatic conditions' p. 184-5", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "id": "NP_758510.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A974#function", "annotation": "A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:17112342). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:17112342). Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoc acid (EPA). Catalyzes the epoxidation of the last double bond of EPA with no preferred stereoselectivity, producing both (R,S) and (S,R) stereoisomers (PubMed:17112342). Can also catalyze the omega-1 and omega-2 oxidation of fatty acids with lower efficiency (PubMed:17112342).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974#function", "id": "A2A974", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P24464-1", "protein_name": "Cytochrome P450 4A12", "sequence": { "length": 508, "sequence": "MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134044", "id": "134044", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Cyp4a12", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5TCH4-1", "protein_name": "Cytochrome P450 4A22", "sequence": { "length": 519, "sequence": "MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134044", "id": "134044", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "CYP4A22", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q91WL5-1", "protein_name": "Cytochrome P450 4A12A", "sequence": { "length": 508, "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134044", "id": "134044", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Cyp4a12a", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758510.2", "ac": "NP_758510.2", "name": "cytochrome P450 4A12B precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052869", "pmid": "17112342", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "arachidonic acid omega-hydroxylase activity", "id": "GO:0052869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018685", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "alkane 1-monooxygenase activity", "id": "GO:0018685" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008391", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "arachidonic acid monooxygenase activity", "id": "GO:0008391" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "aromatase activity", "id": "GO:0070330" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "heme binding", "id": "GO:0020037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "monooxygenase activity", "id": "GO:0004497" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102116", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "laurate hydroxylase activity", "id": "GO:0102116" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0103002", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "16-hydroxypalmitate dehydrogenase activity", "id": "GO:0103002" } ], "total": 9, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097267", "pmid": "17112342", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "omega-hydroxylase P450 pathway", "id": "GO:0097267" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046456", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "icosanoid biosynthetic process", "id": "GO:0046456" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "kidney development", "id": "GO:0001822" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043651", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "linoleic acid metabolic process", "id": "GO:0043651" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019369", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "arachidonic acid metabolic process", "id": "GO:0019369" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048252", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A974", "id": "A2A974", "database": "UniProtKB" } ], "name": "lauric acid metabolic process", "id": "GO:0048252" } ], "total": 6, "name": "Biological Process" } ] }, "site_annotation": [], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078597", "id": 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"description": "", "name": "Polycystic Kidney Disease, Infantile, Type I", "id": "DOID:0110861" }, { "url": "http://disease-ontology.org/term/DOID:0110861", "resource": "Disease Ontology", "description": "", "name": "Pkhd1", "id": "DOID:0110861" }, { "url": "http://disease-ontology.org/term/DOID:0110861", "resource": "Disease Ontology", "description": "", "name": "Polycystic Kidney and Hepatic Disease 1", "id": "DOID:0110861" }, { "url": "http://disease-ontology.org/term/DOID:0110861", "resource": "Disease Ontology", "description": "", "name": "Arpkd", "id": "DOID:0110861" }, { "url": "https://monarchinitiative.org/disease/MONDO:0033004", "resource": "MONDO", "description": "A autosomal dominant polycystic kidney disease that has_material_basis_in mutation in the PKD4 gene.", "name": "polycystic kidney disease 4", "id": "MONDO:0033004" }, { "url": "https://monarchinitiative.org/disease/MONDO:0033004", "resource": "MONDO", "description": "", "name": "polycystic kidney disease 4 with or 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"name": "polycystic kidney disease, infantile, type 1", "id": "MONDO:0033004" }, { "url": "https://monarchinitiative.org/disease/MONDO:0033004", "resource": "MONDO", "description": "", "name": "hepatic fibrosis, congenital", "id": "MONDO:0033004" }, { "url": "https://monarchinitiative.org/disease/MONDO:0033004", "resource": "MONDO", "description": "", "name": "polycystic kidney disease 4", "id": "MONDO:0033004" }, { "url": "https://monarchinitiative.org/disease/MONDO:0033004", "resource": "MONDO", "description": "", "name": "polycystic kidney disease, autosomal recessive", "id": "MONDO:0033004" }, { "url": "https://www.omim.org/entry/263200", "resource": "MIM", "description": "Polycystic kidney disease 4, with or without polycystic liver disease", "name": "Polycystic kidney disease 4, with or without polycystic liver disease", "id": "MIM:263200" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:0110861", "resource": "Disease Ontology", "description": "A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal recessive fashion.", "name": "autosomal recessive polycystic kidney disease", "id": "DOID:0110861" }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0110861#disease-associations", "id": "0110861", "database": "Alliance of Genome Resources" } ] }, { "disease_id": "DOID:10763", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "description": "", "name": "HTN", "id": "DOID:10763" }, { "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "description": "", "name": "hyperpiesia", "id": "DOID:10763" }, { "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "description": "", "name": "vascular hypertensive disorder", "id": "DOID:10763" }, { "url": 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