{ "uniprot_canonical_ac": "A2A8L5-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A8L5-1|PTPRF_MOUSE Isoform 1 of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1898, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" }, "uniprot_id": "F6Y3V0_MOUSE", "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly", "reported.uniprotkb_gly", "reported_with_glycan.glyconnect" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "reaction_enzymes": [ { "gene_name": "Ptprj", "uniprot_ac": "A0A0G2JXZ9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JXZ9", "id": "A0A0G2JXZ9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JXZ9", "id": "A0A0G2JXZ9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Eya3", "uniprot_ac": "A0A0G2JZ01", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JZ01", "id": "A0A0G2JZ01", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn14", "uniprot_ac": "A0A0G2K2N0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2N0", "id": "A0A0G2K2N0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2N0", "id": "A0A0G2K2N0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprb", "uniprot_ac": "A0A0G2K2W0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2W0", "id": "A0A0G2K2W0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K2W0", "id": "A0A0G2K2W0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp3", "uniprot_ac": "A0A0G2K3I9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K3I9", "id": "A0A0G2K3I9", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K3I9", "id": "A0A0G2K3I9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K3I9", "id": "A0A0G2K3I9", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K3I9", "id": "A0A0G2K3I9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprh", "uniprot_ac": "A0A0G2K754", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K754", "id": "A0A0G2K754", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K754", "id": "A0A0G2K754", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp13", "uniprot_ac": "A0A0G2K9N1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1", "id": "A0A0G2K9N1", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1", "id": "A0A0G2K9N1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1", "id": "A0A0G2K9N1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1", "id": "A0A0G2K9N1", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Ptpn20", "uniprot_ac": "A1L1L3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L3", "id": "A1L1L3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1L3", "id": "A1L1L3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprf", "uniprot_ac": "A2A8L5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn3", "uniprot_ac": "A2ALK8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "CDC14C", "uniprot_ac": "A4D256", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4D256", "id": "A4D256", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4D256", "id": "A4D256", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4D256", "id": "A4D256", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4D256", "id": "A4D256", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprk", "uniprot_ac": "A5I9F0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PGP", "uniprot_ac": "A6NDG6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6NDG6", "id": "A6NDG6", "database": "UniProtKB" } ], "ec_number": "3.1.3.21", "activity": "Glycerol 1-phosphate + H(2)O = glycerol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6NDG6", "id": "A6NDG6", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6NDG6", "id": "A6NDG6", "database": "UniProtKB" } ], "ec_number": "3.1.3.21", "activity": "" } ] }, { "gene_name": "Ptprs", "uniprot_ac": "B0V2N1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B0V2N1", "id": "B0V2N1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B0V2N1", "id": "B0V2N1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpru", "uniprot_ac": "B1AUH1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B1AUH1", "id": "B1AUH1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B1AUH1", "id": "B1AUH1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpre", "uniprot_ac": "B2GV87", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2GV87", "id": "B2GV87", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2GV87", "id": "B2GV87", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprb", "uniprot_ac": "B2RU80", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RU80", "id": "B2RU80", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RU80", "id": "B2RU80", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Cdkn3", "uniprot_ac": "B2RZ50", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RZ50", "id": "B2RZ50", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RZ50", "id": "B2RZ50", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RZ50", "id": "B2RZ50", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B2RZ50", "id": "B2RZ50", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "EPM2A", "uniprot_ac": "B3EWF7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B3EWF7", "id": "B3EWF7", "database": "UniProtKB" } ], "ec_number": "3.1.3.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B3EWF7", "id": "B3EWF7", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B3EWF7", "id": "B3EWF7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B3EWF7", "id": "B3EWF7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B3EWF7", "id": "B3EWF7", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Dusp15", "uniprot_ac": "B4F7B7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B4F7B7", "id": "B4F7B7", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B4F7B7", "id": "B4F7B7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B4F7B7", "id": "B4F7B7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B4F7B7", "id": "B4F7B7", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Ptprz1", "uniprot_ac": "B9EKR1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B9EKR1", "id": "B9EKR1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B9EKR1", "id": "B9EKR1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Pgp", "uniprot_ac": "D3ZDK7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDK7", "id": "D3ZDK7", "database": "UniProtKB" } ], "ec_number": "3.1.3.21", "activity": "Glycerol 1-phosphate + H(2)O = glycerol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDK7", "id": "D3ZDK7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDK7", "id": "D3ZDK7", "database": "UniProtKB" } ], "ec_number": "3.1.3.21", "activity": "" } ] }, { "gene_name": "Dusp8", "uniprot_ac": "D3ZNK9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZNK9", "id": "D3ZNK9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZNK9", "id": "D3ZNK9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Eya1", "uniprot_ac": "D3ZVI5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZVI5", "id": "D3ZVI5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZVI5", "id": "D3ZVI5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Cdc25c", "uniprot_ac": "D4ADT2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4ADT2", "id": "D4ADT2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4ADT2", "id": "D4ADT2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Eya2", "uniprot_ac": "E9PTJ3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PTJ3", "id": "E9PTJ3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PTJ3", "id": "E9PTJ3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprh", "uniprot_ac": "E9Q0N2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9Q0N2", "id": "E9Q0N2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9Q0N2", "id": "E9Q0N2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpro", "uniprot_ac": "E9Q612", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9Q612", "id": "E9Q612", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9Q612", "id": "E9Q612", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprg", "uniprot_ac": "F1LP13", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LP13", "id": "F1LP13", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LP13", "id": "F1LP13", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprm", "uniprot_ac": "F1LPJ1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LPJ1", "id": "F1LPJ1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LPJ1", "id": "F1LPJ1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn3", "uniprot_ac": "F1LQQ5", "activity": [ { 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"ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LXJ9", "id": "F1LXJ9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpru", "uniprot_ac": "F1MAG7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1MAG7", "id": "F1MAG7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1MAG7", "id": "F1MAG7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn4", "uniprot_ac": "G3V6B9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V6B9", "id": "G3V6B9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V6B9", "id": "G3V6B9", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn12", "uniprot_ac": "G3V7Q4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V7Q4", "id": "G3V7Q4", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V7Q4", "id": "G3V7Q4", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn13", "uniprot_ac": "G3V9S3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V9S3", "id": "G3V9S3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V9S3", "id": "G3V9S3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "LOC108348179", "uniprot_ac": "M0R587", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R587", "id": "M0R587", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R587", "id": "M0R587", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R587", "id": "M0R587", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R587", "id": "M0R587", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Ptprd", "uniprot_ac": "M0RB22", "activity": [ { "evidence": [ { "url": 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"evidence": [ { "url": "https://www.uniprot.org/uniprot/O09112", "id": "O09112", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O09112", "id": "O09112", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O09112", "id": "O09112", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O09112", "id": "O09112", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PTPRT", "uniprot_ac": "O14522", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O14522", "id": "O14522", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O14522", "id": "O14522", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn9", "uniprot_ac": "O35239", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O35239", "id": "O35239", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O35239", "id": "O35239", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp5", "uniprot_ac": "O54838", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O54838", "id": "O54838", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": 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"database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptp4a2", "uniprot_ac": "O70274", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O70274", "id": "O70274", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O70274", "id": "O70274", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DNAJC6", "uniprot_ac": "O75061", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O75061", "id": "O75061", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O75061", "id": "O75061", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PTP4A3", "uniprot_ac": "O75365", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O75365", "id": "O75365", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O75365", "id": "O75365", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptprq", "uniprot_ac": "O88488", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O88488", "id": "O88488", "database": "UniProtKB" } ], "ec_number": "3.1.3.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O88488", "id": "O88488", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O88488", "id": "O88488", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptpn23", "uniprot_ac": "O88902", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O88902", "id": "O88902", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O88902", "id": "O88902", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DUSP14", "uniprot_ac": "O95147", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O95147", "id": "O95147", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O95147", "id": "O95147", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": 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"evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BFV3", "id": "Q8BFV3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ubash3b", "uniprot_ac": "Q8BGG7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BGG7", "id": "Q8BGG7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BGG7", "id": "Q8BGG7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp29", "uniprot_ac": "Q8BK84", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BK84", "id": "Q8BK84", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BK84", "id": "Q8BK84", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BK84", "id": "Q8BK84", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BK84", "id": "Q8BK84", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp28", "uniprot_ac": "Q8BTR5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BTR5", "id": "Q8BTR5", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BTR5", "id": "Q8BTR5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BTR5", "id": "Q8BTR5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BTR5", "id": "Q8BTR5", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Ptpn7", "uniprot_ac": "Q8BUM3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BUM3", "id": "Q8BUM3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BUM3", "id": "Q8BUM3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Tns2", "uniprot_ac": "Q8CGB6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CGB6", "id": "Q8CGB6", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CGB6", "id": "Q8CGB6", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Pgp", "uniprot_ac": "Q8CHP8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CHP8", "id": "Q8CHP8", "database": "UniProtKB" } ], "ec_number": "3.1.3.21", "activity": "Glycerol 1-phosphate + H(2)O = glycerol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CHP8", "id": "Q8CHP8", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CHP8", "id": "Q8CHP8", "database": "UniProtKB" } ], "ec_number": "3.1.3.21", "activity": "" } ] }, { "gene_name": "Mtmr3", "uniprot_ac": "Q8K296", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K296", "id": "Q8K296", "database": "UniProtKB" } ], "ec_number": "3.1.3.64", "activity": "1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K296", "id": "Q8K296", "database": "UniProtKB" } ], "ec_number": "3.1.3.64", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K296", "id": "Q8K296", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K296", "id": "Q8K296", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K296", "id": "Q8K296", "database": "UniProtKB" } ], "ec_number": "3.1.3.95", "activity": "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate." } ] }, { "gene_name": "Ssh3", "uniprot_ac": "Q8K330", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K330", "id": "Q8K330", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K330", "id": "Q8K330", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K330", "id": "Q8K330", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K330", "id": "Q8K330", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp19", "uniprot_ac": "Q8K4T5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4T5", "id": "Q8K4T5", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4T5", "id": "Q8K4T5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4T5", "id": "Q8K4T5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8K4T5", "id": "Q8K4T5", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "DUSP18", "uniprot_ac": "Q8NEJ0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8NEJ0", "id": "Q8NEJ0", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8NEJ0", "id": "Q8NEJ0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8NEJ0", "id": "Q8NEJ0", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8NEJ0", "id": "Q8NEJ0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp15", "uniprot_ac": "Q8R4V2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8R4V2", "id": "Q8R4V2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8R4V2", "id": "Q8R4V2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8R4V2", "id": "Q8R4V2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8R4V2", "id": "Q8R4V2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "SSH3", "uniprot_ac": "Q8TE77", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8TE77", "id": "Q8TE77", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8TE77", "id": "Q8TE77", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8TE77", "id": "Q8TE77", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8TE77", "id": "Q8TE77", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "UBASH3B", "uniprot_ac": "Q8TF42", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8TF42", "id": "Q8TF42", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8TF42", "id": "Q8TF42", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp18", "uniprot_ac": "Q8VE01", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8VE01", "id": "Q8VE01", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": 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H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WTR2", "id": "Q8WTR2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WTR2", "id": "Q8WTR2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "PTPMT1", "uniprot_ac": "Q8WUK0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WUK0", "id": "Q8WUK0", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WUK0", "id": "Q8WUK0", "database": "UniProtKB" } ], "ec_number": "3.1.3.27", "activity": "Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WUK0", "id": "Q8WUK0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WUK0", "id": "Q8WUK0", "database": "UniProtKB" } ], "ec_number": "3.1.3.27", "activity": "" } ] }, { "gene_name": "SSH1", "uniprot_ac": "Q8WYL5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WYL5", "id": "Q8WYL5", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WYL5", "id": "Q8WYL5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WYL5", "id": "Q8WYL5", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8WYL5", "id": "Q8WYL5", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Epm2a", "uniprot_ac": "Q91XQ2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XQ2", "id": "Q91XQ2", "database": "UniProtKB" } ], "ec_number": "3.1.3.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XQ2", "id": "Q91XQ2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XQ2", "id": "Q91XQ2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XQ2", "id": "Q91XQ2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XQ2", "id": "Q91XQ2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Mtmr4", "uniprot_ac": "Q91XS1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XS1", "id": "Q91XS1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91XS1", "id": "Q91XS1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp7", "uniprot_ac": "Q91Z46", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91Z46", "id": "Q91Z46", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91Z46", "id": "Q91Z46", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91Z46", "id": "Q91Z46", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91Z46", "id": "Q91Z46", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "PTPRU", "uniprot_ac": "Q92729", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92729", "id": "Q92729", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92729", "id": "Q92729", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PTPRN2", "uniprot_ac": "Q92932", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92932", "id": "Q92932", "database": "UniProtKB" } ], "ec_number": "3.1.3.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92932", "id": "Q92932", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92932", "id": "Q92932", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PTP4A1", "uniprot_ac": "Q93096", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q93096", "id": "Q93096", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q93096", "id": "Q93096", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "EYA1", "uniprot_ac": "Q99502", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99502", "id": "Q99502", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99502", "id": "Q99502", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99502", "id": "Q99502", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99502", "id": "Q99502", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "EYA3", "uniprot_ac": "Q99504", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99504", "id": "Q99504", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99504", "id": "Q99504", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PTPN18", "uniprot_ac": "Q99952", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99952", "id": "Q99952", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99952", "id": "Q99952", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DUSP9", "uniprot_ac": "Q99956", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99956", "id": "Q99956", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99956", "id": "Q99956", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99956", "id": "Q99956", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99956", "id": "Q99956", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Ptprt", "uniprot_ac": "Q99M80", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99M80", "id": "Q99M80", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99M80", "id": "Q99M80", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp22", "uniprot_ac": "Q99N11", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99N11", "id": "Q99N11", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99N11", "id": "Q99N11", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99N11", "id": "Q99N11", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99N11", "id": "Q99N11", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DUSP26", "uniprot_ac": "Q9BV47", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BV47", "id": "Q9BV47", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BV47", "id": "Q9BV47", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BV47", "id": "Q9BV47", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BV47", "id": "Q9BV47", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DUSP23", "uniprot_ac": "Q9BVJ7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BVJ7", "id": "Q9BVJ7", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BVJ7", "id": "Q9BVJ7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BVJ7", "id": "Q9BVJ7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BVJ7", "id": "Q9BVJ7", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "DUSP16", "uniprot_ac": "Q9BY84", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BY84", "id": "Q9BY84", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BY84", "id": "Q9BY84", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BY84", "id": "Q9BY84", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9BY84", "id": "Q9BY84", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Dusp12", "uniprot_ac": "Q9D0T2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D0T2", "id": "Q9D0T2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D0T2", "id": "Q9D0T2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D0T2", "id": "Q9D0T2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D0T2", "id": "Q9D0T2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Acp1", "uniprot_ac": "Q9D358", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D358", "id": "Q9D358", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "A phosphate monoester + H(2)O = an alcohol + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D358", "id": "Q9D358", "database": "UniProtKB" } ], "ec_number": "3.1.3.2", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D358", "id": "Q9D358", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D358", "id": "Q9D358", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Ptp4a3", "uniprot_ac": "Q9D658", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D658", "id": "Q9D658", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D658", "id": "Q9D658", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp26", "uniprot_ac": "Q9D700", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D700", "id": "Q9D700", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D700", "id": "Q9D700", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D700", "id": "Q9D700", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D700", "id": "Q9D700", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp3", "uniprot_ac": "Q9D7X3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D7X3", "id": "Q9D7X3", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D7X3", "id": "Q9D7X3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D7X3", "id": "Q9D7X3", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D7X3", "id": "Q9D7X3", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Mdp1", "uniprot_ac": "Q9D967", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D967", "id": "Q9D967", "database": "UniProtKB" } ], "ec_number": "3.1.3.-", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D967", "id": "Q9D967", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D967", "id": "Q9D967", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp21", "uniprot_ac": "Q9D9D8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D9D8", "id": "Q9D9D8", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D9D8", "id": "Q9D9D8", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D9D8", "id": "Q9D9D8", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9D9D8", "id": "Q9D9D8", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" } ] }, { "gene_name": "Dusp6", "uniprot_ac": "Q9DBB1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBB1", "id": "Q9DBB1", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBB1", "id": "Q9DBB1", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBB1", "id": "Q9DBB1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9DBB1", "id": "Q9DBB1", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "Dusp10", "uniprot_ac": "Q9ESS0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9ESS0", "id": "Q9ESS0", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9ESS0", "id": "Q9ESS0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9ESS0", "id": "Q9ESS0", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9ESS0", "id": "Q9ESS0", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DUSP15", "uniprot_ac": "Q9H1R2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H1R2", "id": "Q9H1R2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H1R2", "id": "Q9H1R2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H1R2", "id": "Q9H1R2", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H1R2", "id": "Q9H1R2", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "PTPN23", "uniprot_ac": "Q9H3S7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H3S7", "id": "Q9H3S7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H3S7", "id": "Q9H3S7", "database": "UniProtKB" } ], "ec_number": "3.1.3.48", "activity": "" } ] }, { "gene_name": "DUSP21", "uniprot_ac": "Q9H596", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H596", "id": "Q9H596", "database": "UniProtKB" } ], "ec_number": "3.1.3.16", "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H596", "id": "Q9H596", "database": "UniProtKB" } ], 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"activity": "" } ] } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11241288", "type": "PubMed", "id": "11241288" } ], "title": "Within the hemopoietic system, LAR phosphatase is a T cell lineage-specific adhesion receptor-like protein whose phosphatase activity appears dispensable for T cell development, repertoire selection and function.", "journal": "Eur. J. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "authors": "Rolink A.G., Kisielow P., Hendriks W.J.A.J., Jankowski A., Terszowski G.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1454056", "type": "PubMed", "id": "1454056" } ], "title": "Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.", "journal": "Molecular biology reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Schepens J, Zeeuwen P, Wieringa B, Hendriks W", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1655529", "type": "PubMed", "id": "1655529" } ], "title": "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase.", "journal": "FEBS letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Gebbink MF, van Etten I, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Geurts van Kessel A, Moolenaar WH", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19349973", "type": "PubMed", "id": "19349973" } ], "title": "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.", "journal": "Nat. Biotechnol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "authors": "Aebersold R., Bausch-Fluck D., Bibel M., Henderson C., O'Brien R., Schiess R., Watts J.D., Wollscheid B.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21402080", "type": "PubMed", "id": "21402080" } ], "title": "The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation.", "journal": "J. Mol. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "authors": "Bouyain S., Hammel M., Biersmith B.H., Geisbrecht E.R.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27074791", "type": "PubMed", "id": "27074791" } ], "title": "Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.", "journal": "Molecular & cellular proteomics : MCP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Sarhan AR, Patel TR, Creese AJ, Tomlinson MG, Hellberg C, Heath JK, Hotchin NA, Cunningham DL", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27352860", "type": "PubMed", "id": "27352860" } ], "title": "LAR protein tyrosine phosphatase regulates focal adhesions through CDK1.", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Sarhan AR, Patel TR, Cowell AR, Tomlinson MG, Hellberg C, Heath JK, Cunningham DL, Hotchin NA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28637841", "type": "PubMed", "id": "28637841" } ], "title": "Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2972792", "type": "PubMed", "id": "2972792" } ], "title": "A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.", "journal": "The Journal of experimental medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Streuli M, Krueger NX, Hall LR, Schlossman SF, Saito H", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "type": "PubMed", "id": "30899004" } ], "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2669", "id": "2669", "database": "GlyConnect" } ], "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31985401", "type": "PubMed", "id": "31985401" } ], "title": "LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Sclip A, Sudhof TC", "date": "2020" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7604039", "type": "PubMed", "id": "7604039" } ], "title": "Capturing genes encoding membrane and secreted proteins important for mouse development.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Skarnes WC, Moss JE, Hurtley SM, Beddington RS", "date": "1995" } ], "uniprot_ac": "A2A8L5", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8L5", "type": "synonym", "resource": "RefSeq", "name": "AA591035; LAR; LARS; RP; RPTP-LAR" }, { "url": "https://www.uniprot.org/uniprot/A2A8L5", "type": "synonym", "resource": "UniProtKB", "name": "Lar" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8L5", "type": "synonym", "resource": "RefSeq", "name": "Ptprf" }, { "url": "https://www.uniprot.org/uniprot/A2A8L5", "type": "recommended", "resource": "UniProtKB", "name": "Ptprf" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/10684", "id": "10684", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate", "input_participant_list": [], "enzyme_list": [ "Q9JIM4-1", "A0A0G2K2W0-1", "Q03348-1", "F1LX86-1", "Q64605-1", "Q62656-1", "E9PTJ3-1", "Q64612-1", "A0A0G2JZ01-1", "G3V7Q4-1", "Q5M863-1", "D3ZNK9-1", "P41498-1", "P48965-1", "A5I9F0-1", "A0A0G2JXZ9-1", "P81718-1", "M0RB22-1", "O54838-1", "F1LQQ5-1", "Q64604-1", "A1L1L3-1", "B2GV87-1", "O88488-1", "O88902-1", "P04157-1", "P35233-1", "P35234-1", "P48966-1", "Q63475-1", "Q78EG7-1", "A0A0G2K3I9-1", "O08617-1", "Q6P9X4-1", "B4F7B7-1", "Q5FVI9-1", "Q91XQ2-1", "B2RZ50-1", "D3ZDK7-1", "P20417-1", "P49445-1", "Q5XIS1-1", "Q62728-1", "Q641Z2-1", "M0R587-1", "P0C595-1", "Q62767-1", "Q63340-1", "Q64346-1", "Q64623-1", "Q6AXW7-1", "F1LP13-1", "A0A0G2K9N1-1", "Q5PQT2-1", "O54857-1", "P41499-2", "D3ZVI5-1", "A0A0G2K754-1", "F1LXJ9-1", "F1MAG7-1", "P0C089-1", "Q62797-1", "G3V6B9-1", "A0A0G2K2N0-1", "Q2YDV1-1", "F1LPJ1-1", "G3V9S3-1", "D4ADT2-1", "Q9UMZ3-1", "O95147-1", "P28562-1", "Q9BVJ7-1", "Q9H1R2-1", "Q05923-1", "Q9NYA4-1", "Q05209-1", "Q8WUK0-1", "Q9H3S7-1", "P08575-3", "P23470-1", "P23471-1", "Q76I76-1", "Q8TE77-1", "O75365-1", "P56180-1", "P17706-1", "O75061-1", "A6NDG6-1", "Q06124-2", "O95677-1", "P10586-1", "Q99502-1", "Q99504-1", "Q15262-1", "P23468-1", "P26045-1", "P30305-1", "A4D256-1", "O60729-1", "Q9UNH5-1", "Q13202-1", "Q8WTR2-1", "Q9BV47-1", "Q9BY84-1", "Q16829-1", "Q9UNI6-1", "P51452-1", "Q16690-1", "Q4G0W2-1", "Q9NRW4-1", "Q13115-1", "Q16828-1", "Q99956-1", "Q9H596-1", "P30307-1", "Q13615-1", "Q15678-1", "Q99952-1", "P23467-1", "P28827-1", "P35236-1", "P43378-1", "P60484-1", "Q12913-1", "Q13332-1", "Q16827-1", "Q9HD43-1", "Q16825-1", "Q12974-1", "Q8TF42-1", "Q16667-1", "Q9UII6-1", "Q8NEJ0-1", "Q86V88-1", "P30304-1", "P29350-1", "P54829-1", "P18031-1", "P18433-5", "P23469-1", "P29074-1", "Q15256-1", "O14522-3", "Q92729-1", "Q92932-1", "Q8WYL5-1", "P24666-1", "Q12923-1", "Q9Y6W6-1", "O00167-1", "Q9Y2R2-1", "B3EWF7-1", "Q4JDL3-1", "Q93096-1", "Q68J44-1", "Q63HR2-1", "Q80TZ3-1", "Q6PFY9-1", "Q8K4T5-1", "Q8R4V2-1", "Q9D0T2-1", "Q9ESS0-1", "Q99N11-1", "Q9JLY7-1", "O09112-1", "Q05922-1", "Q8BTR5-1", "Q9D7X3-1", "Q9DBB1-1", "P97767-1", "Q9Z191-1", "O08575-1", "Q9D967-1", "P30306-1", "P48967-1", "Q91XS1-1", "A2ALK8-1", "B0V2N1-1", "B2RU80-1", "E9Q612-1", "O35239-1", "O55082-1", "P28828-1", "P35831-1", "P49446-1", "P70289-1", "Q05909-1", "Q06180-1", "Q62130-1", "Q62132-1", "Q62136-1", "Q64455-1", "Q64487-4", "Q66GT5-1", "Q99M80-1", "P06800-4", "P0C5E4-1", "P35821-1", "Q61152-1", "Q64512-1", "Q76I79-1", "Q8BK84-1", "Q9D358-1", "P18052-1", "Q9D9D8-1", "A2A8L5-1", "P48964-1", "Q9D700-1", "Q9QYJ7-1", "Q8BFV3-1", "Q91Z46-1", "B9EKR1-1", "E9Q0N2-1", "P54830-1", "P80560-1", "P35235-2", "Q6PB44-1", "Q8BUM3-1", "B1AUH1-1", "P35822-1", "Q8BGG7-1", "Q6GQT0-1", "Q810P3-1", "Q8VE01-1", "P29351-1", "Q9WU22-1", "Q8K330-1", "Q5SW75-1", "Q63739-1", "O70274-1", "Q9D658-1", "P97480-1", "P28563-1", "Q6NT99-1", "O08586-1", "Q9WUA5-1", "Q8K296-1", "Q8CHP8-1", "P29352-1", "Q1HL35-1", "Q8CGB6-1", "Q7TNL7-1" ], "id": "10684", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-388824", "id": "R-MMU-388824", "database": "Reactome" } ], "name": "PTPRF, PTPRS, PTPRD bind Liprins", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "B0V2N1-1", "Q64487-4", "A2A8L5-1" ], "id": "R-MMU-388824", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798258", "id": "R-MMU-6798258", "database": "Reactome" } ], "name": "PRTPRF, PTPRS, PTPRD bind LRRC4B", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "B0V2N1-1", "Q64487-4", "A2A8L5-1" ], "id": "R-MMU-6798258", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8855648", "id": "R-MMU-8855648", "database": "Reactome" } ], "name": "SALM3 binds LAR-RPTP", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "B0V2N1-1", "Q64487-4", "A2A8L5-1" ], "id": "R-MMU-8855648", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5#A0A1Y7VNR5-1", "isoform_ac": "A0A1Y7VNR5-1", "locus": { "end_pos": 118236373, "strand": "+", "start_pos": 118277439, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000222620", "id": "ENSMUST00000222620", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152568", "id": "ENSMUSP00000152568", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VNR5-1|A0A1Y7VNR5_MOUSE Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 363, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGGSPIRGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAA" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#A2A8L5-1", "isoform_ac": "A2A8L5-1", "locus": { "end_pos": 118209824, "strand": "+", "start_pos": 118277439, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000049074", "id": "ENSMUST00000049074", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000039368", "id": "ENSMUSP00000039368", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A8L5-1|PTPRF_MOUSE Isoform 1 of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1898, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#F6S1X8-1", "isoform_ac": "F6S1X8-1", "locus": { "end_pos": 118209822, "strand": "+", "start_pos": 118236016, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124758", "id": "ENSMUST00000124758", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119954", "id": "ENSMUSP00000119954", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6S1X8-1|PTPRF_MOUSE Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1332, "sequence": "XSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSMPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#F6Y3V0-1", "isoform_ac": "F6Y3V0-1", "locus": { "end_pos": 118209822, "strand": "+", "start_pos": 118236445, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000150096", "id": "ENSMUST00000150096", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117313", "id": "ENSMUSP00000117313", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Y3V0-1|F6Y3V0_MOUSE Computationally mapped isoform of Protein-tyrosine-phosphatase OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1291, "sequence": "XSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSMPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:19268", "resource": "KEGG Pathway", "id": "mmu:19268", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-388844", "description": "Receptor-type tyrosine-protein phosphatases", "resource": "Reactome", "id": "R-MMU-388844", "name": "Receptor-type tyrosine-protein phosphatases" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8849932", "description": "Synaptic adhesion-like molecules", "resource": "Reactome", "id": "R-MMU-8849932", "name": "Synaptic adhesion-like molecules" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "annotation": "Loss of LAR activity resulted in reduced activity of CDK1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#function", "annotation": "Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5#function", "id": "A2A8L5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "annotation": "Study has identified LAR as a regulator of key signaling pathways, including mTOR and JNK, and has significantly expanded the number of proteins regulated downstream of LAR phosphatase activity.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "annotation": "We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P10586-1", "protein_name": "Receptor-type tyrosine-protein phosphatase F", "sequence": { "length": 1907, "sequence": "MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20623", "id": "20623", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A8L5/", "id": "A2A8L5", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PTPRF", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q64604-1", "protein_name": "Protein-tyrosine-phosphatase", "sequence": { "length": 1898, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEACTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDAPSGFPQNLRVTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDINSQHELQNVTGDVHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGTSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDELPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRIATVVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLAGSKARASRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20623", "id": "20623", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ptprf", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NDT->DDT).", "alt_nt": "null", "chr_id": "4", "ref_nt": "C", "chr_pos": "118225931T>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs241328477", "id": "rs241328477", "database": "dbSNP" }, { "url": "https://www.ensembl.org/id/rs241328477", "id": "rs241328477", "database": "ENSEMBL" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "sequence_mut": "D", "start_pos": 960, "keywords": [ "ebi", "germline" ], "end_pos": 960, "minor_allelic_frequency": "" } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "ac": "NP_035343.2", "name": "receptor-type tyrosine-protein phosphatase F precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "pmid": "23791195", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "protein-containing complex binding", "id": "GO:0044877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004721", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "phosphoprotein phosphatase activity", "id": "GO:0004721" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035373", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "chondroitin sulfate proteoglycan binding", "id": "GO:0035373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042301", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "phosphate ion binding", "id": "GO:0042301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "insulin receptor binding", "id": "GO:0005158" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "heparin binding", "id": "GO:0008201" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "cell adhesion molecule binding", "id": "GO:0050839" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "receptor tyrosine kinase binding", "id": "GO:0030971" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005001", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "transmembrane receptor protein tyrosine phosphatase activity", "id": "GO:0005001" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "pmid": "11438588", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "excitatory synapse", "id": "GO:0060076" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099061", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "integral component of postsynaptic density membrane", "id": "GO:0099061" } ], "total": 11, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048679", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "regulation of axon regeneration", "id": "GO:0048679" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031102", "pmid": "11438588", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": 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"name": "3.1.3.48" }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "LAR" }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Leukocyte common antigen related" }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Protein-tyrosine-phosphatase" }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Receptor-type tyrosine-protein phosphatase F" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8L5", "type": "synonym", "resource": "RefSeq", "name": "leukocyte antigen-related (LAR) PTP receptor; Receptor-type tyrosine-protein phosphatase F; leukocyte common antigen related" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8L5", "type": "synonym", "resource": "RefSeq", "name": "receptor-type tyrosine-protein phosphatase F precursor" } ] }