{ "uniprot_canonical_ac": "A0A0G2KA94-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KA94-1|A0A0G2KA94_RAT Isoform 1 of Tyrosine-protein kinase OS=Rattus norvegicus OX=10116 GN=Tec PE=1 SV=1 CANONICAL=A0A0G2KA94-1", "length": 674, "sequence": "MGLVSACQTPGSAVWPALSPVLCQHALGQESRDLQWQEKEQQKTEMNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR" }, "uniprot_id": "", "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "reaction_enzymes": [ { "gene_name": "Dyrk4", "uniprot_ac": "A0A0G2JU41", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JU41", "id": "A0A0G2JU41", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JU41", "id": "A0A0G2JU41", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Flt3", "uniprot_ac": "A0A0G2JW59", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JW59", "id": "A0A0G2JW59", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JW59", "id": "A0A0G2JW59", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Ephb2", "uniprot_ac": "A0A0G2JY48", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JY48", "id": "A0A0G2JY48", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JY48", "id": "A0A0G2JY48", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Btk", "uniprot_ac": "A0A0G2K134", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K134", "id": "A0A0G2K134", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K134", "id": "A0A0G2K134", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Fgfr3", "uniprot_ac": "A0A0G2K210", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K210", "id": "A0A0G2K210", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K210", "id": "A0A0G2K210", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Tec", "uniprot_ac": "A0A0G2KA94", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Dyrk1b", "uniprot_ac": "A0A0G2KAP6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP6", "id": "A0A0G2KAP6", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP6", "id": "A0A0G2KAP6", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Zap70", "uniprot_ac": "A0A0R4J8U1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1", "id": "A0A0R4J8U1", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1", "id": "A0A0R4J8U1", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Tie1", "uniprot_ac": "B5DFD6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B5DFD6", "id": "B5DFD6", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/B5DFD6", "id": "B5DFD6", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Epha2", "uniprot_ac": "D3ZBN3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZBN3", "id": "D3ZBN3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZBN3", "id": "D3ZBN3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Tek", "uniprot_ac": "D3ZCD0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZCD0", "id": "D3ZCD0", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZCD0", "id": "D3ZCD0", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Tyk2", "uniprot_ac": "D3ZD03", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZD03", "id": "D3ZD03", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZD03", "id": "D3ZD03", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Epha1", "uniprot_ac": "D3ZDH4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDH4", "id": "D3ZDH4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDH4", "id": "D3ZDH4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Ptk6", "uniprot_ac": "D3ZDS3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDS3", "id": "D3ZDS3", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZDS3", "id": "D3ZDS3", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Ephb3", "uniprot_ac": "D3ZH39", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZH39", "id": "D3ZH39", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZH39", "id": "D3ZH39", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Mst1r", "uniprot_ac": "D3ZYM4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZYM4", "id": "D3ZYM4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZYM4", "id": "D3ZYM4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Epha4", "uniprot_ac": "D3ZZK3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZZK3", "id": "D3ZZK3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D3ZZK3", "id": "D3ZZK3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Fes", "uniprot_ac": "D4A584", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4A584", "id": "D4A584", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4A584", "id": "D4A584", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Itk", "uniprot_ac": "D4A7W7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4A7W7", "id": "D4A7W7", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4A7W7", "id": "D4A7W7", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Wee2", "uniprot_ac": "D4ADZ5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4ADZ5", "id": "D4ADZ5", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/D4ADZ5", "id": "D4ADZ5", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Axl", "uniprot_ac": "E9PSY0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PSY0", "id": "E9PSY0", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PSY0", "id": "E9PSY0", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Abl1", "uniprot_ac": "E9PT20", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PT20", "id": "E9PT20", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/E9PT20", "id": "E9PT20", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Yes1", "uniprot_ac": "F1LM93", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LM93", "id": "F1LM93", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LM93", "id": "F1LM93", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "", "uniprot_ac": "F1LQK6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LQK6", "id": "F1LQK6", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LQK6", "id": "F1LQK6", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Alk", "uniprot_ac": "F1LRZ0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LRZ0", "id": "F1LRZ0", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LRZ0", "id": "F1LRZ0", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Fgfr2", "uniprot_ac": "F1LSG7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LSG7", "id": "F1LSG7", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LSG7", "id": "F1LSG7", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Bmx", "uniprot_ac": "F1LVI0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LVI0", "id": "F1LVI0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1LVI0", "id": "F1LVI0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Ltk", "uniprot_ac": "F1M0B3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1M0B3", "id": "F1M0B3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1M0B3", "id": "F1M0B3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Abl2", "uniprot_ac": "F1M0N1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1M0N1", "id": "F1M0N1", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F1M0N1", "id": "F1M0N1", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Ddr2", "uniprot_ac": "F7EVN7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F7EVN7", "id": "F7EVN7", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/F7EVN7", "id": "F7EVN7", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Egfr", "uniprot_ac": "G3V6K6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V6K6", "id": "G3V6K6", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V6K6", "id": "G3V6K6", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Ret", "uniprot_ac": "G3V9H8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V9H8", "id": "G3V9H8", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V9H8", "id": "G3V9H8", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Jak1", "uniprot_ac": "G3V9W2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V9W2", "id": "G3V9W2", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/G3V9W2", "id": "G3V9W2", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "", "uniprot_ac": "M0R4N8", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R4N8", "id": "M0R4N8", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0R4N8", "id": "M0R4N8", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Ephb4", "uniprot_ac": "M0RDA4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0RDA4", "id": "M0RDA4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0RDA4", "id": "M0RDA4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "", "uniprot_ac": "M0RE12", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0RE12", "id": "M0RE12", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/M0RE12", "id": "M0RE12", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Epha3", "uniprot_ac": "O08680", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O08680", "id": "O08680", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/O08680", "id": "O08680", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Kdr", 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O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P22518", "id": "P22518", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "FGFR3", "uniprot_ac": "P22607", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P22607", "id": "P22607", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P22607", "id": "P22607", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "JAK1", "uniprot_ac": "P23458", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P23458", "id": "P23458", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": 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ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P35739", "id": "P35739", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Ttk", "uniprot_ac": "P35761", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P35761", "id": "P35761", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P35761", "id": "P35761", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "FLT4", "uniprot_ac": "P35916", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/P35916", "id": "P35916", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ 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"2.7.10.2", "activity": "" } ] }, { "gene_name": "Wee2", "uniprot_ac": "Q66JT0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q66JT0", "id": "Q66JT0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q66JT0", "id": "Q66JT0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "STYK1", "uniprot_ac": "Q6J9G0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6J9G0", "id": "Q6J9G0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6J9G0", "id": "Q6J9G0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Styk1", "uniprot_ac": "Q6J9G1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6J9G1", "id": "Q6J9G1", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6J9G1", "id": "Q6J9G1", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Fgr", "uniprot_ac": "Q6P6U0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6P6U0", "id": "Q6P6U0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6P6U0", "id": "Q6P6U0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Ntrk3", "uniprot_ac": "Q6VNS1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6VNS1", "id": "Q6VNS1", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6VNS1", "id": "Q6VNS1", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Dstyk", "uniprot_ac": "Q6XUX1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6XUX1", "id": "Q6XUX1", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6XUX1", "id": "Q6XUX1", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Dstyk", "uniprot_ac": "Q6XUX2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6XUX2", "id": "Q6XUX2", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6XUX2", "id": "Q6XUX2", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "DSTYK", "uniprot_ac": "Q6XUX3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6XUX3", "id": "Q6XUX3", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q6XUX3", "id": "Q6XUX3", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Ros1", "uniprot_ac": "Q78DX7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q78DX7", "id": "Q78DX7", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q78DX7", "id": "Q78DX7", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Dyrk4", "uniprot_ac": "Q8BI55", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BI55", "id": "Q8BI55", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BI55", "id": "Q8BI55", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Epha10", "uniprot_ac": "Q8BYG9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BYG9", "id": "Q8BYG9", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8BYG9", "id": "Q8BYG9", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Ephb1", "uniprot_ac": "Q8CBF3", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CBF3", "id": "Q8CBF3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CBF3", "id": "Q8CBF3", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Map2k7", "uniprot_ac": "Q8CE90", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CE90", "id": "Q8CE90", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8CE90", "id": "Q8CE90", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "" } ] }, { "gene_name": "Tesk2", "uniprot_ac": "Q8VCT9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8VCT9", "id": "Q8VCT9", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q8VCT9", "id": "Q8VCT9", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Chek1", "uniprot_ac": "Q91ZN7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91ZN7", "id": "Q91ZN7", "database": "UniProtKB" } ], "ec_number": "2.4.99.18", "activity": "Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91ZN7", "id": "Q91ZN7", "database": "UniProtKB" } ], "ec_number": "2.4.99.18", "activity": "" }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91ZN7", "id": "Q91ZN7", "database": "UniProtKB" } ], "ec_number": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91ZN7", "id": "Q91ZN7", "database": "UniProtKB" } ], "ec_number": "2.7.11.1", "activity": "" } ] }, { "gene_name": "Flt4", "uniprot_ac": "Q91ZT1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91ZT1", "id": "Q91ZT1", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q91ZT1", "id": "Q91ZT1", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Frk", "uniprot_ac": "Q922K9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q922K9", "id": "Q922K9", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q922K9", "id": "Q922K9", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Dyrk3", "uniprot_ac": "Q922Y0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q922Y0", "id": "Q922Y0", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q922Y0", "id": "Q922Y0", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Tesk2", "uniprot_ac": "Q924U5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q924U5", "id": "Q924U5", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q924U5", "id": "Q924U5", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "DYRK2", "uniprot_ac": "Q92630", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92630", "id": "Q92630", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q92630", "id": "Q92630", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "PBK", "uniprot_ac": "Q96KB5", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q96KB5", "id": "Q96KB5", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q96KB5", "id": "Q96KB5", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "" } ] }, { "gene_name": "TESK2", "uniprot_ac": "Q96S53", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q96S53", "id": "Q96S53", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q96S53", "id": "Q96S53", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Tnk1", "uniprot_ac": "Q99ML2", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99ML2", "id": "Q99ML2", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q99ML2", "id": "Q99ML2", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "SRMS", "uniprot_ac": "Q9H3Y6", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H3Y6", "id": "Q9H3Y6", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9H3Y6", "id": "Q9H3Y6", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "CLK4", "uniprot_ac": "Q9HAZ1", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9HAZ1", "id": "Q9HAZ1", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9HAZ1", "id": "Q9HAZ1", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Pbk", "uniprot_ac": "Q9JJ78", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JJ78", "id": "Q9JJ78", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9JJ78", "id": "Q9JJ78", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "" } ] }, { "gene_name": "DYRK4", "uniprot_ac": "Q9NR20", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9NR20", "id": "Q9NR20", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9NR20", "id": "Q9NR20", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Ptk2b", "uniprot_ac": "Q9QVP9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9QVP9", "id": "Q9QVP9", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9QVP9", "id": "Q9QVP9", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Tyk2", "uniprot_ac": "Q9R117", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9R117", "id": "Q9R117", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9R117", "id": "Q9R117", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "EPHA6", "uniprot_ac": "Q9UF33", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UF33", "id": "Q9UF33", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UF33", "id": "Q9UF33", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "BAZ1B", "uniprot_ac": "Q9UIG0", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UIG0", "id": "Q9UIG0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UIG0", "id": "Q9UIG0", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "ALK", "uniprot_ac": "Q9UM73", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UM73", "id": "Q9UM73", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9UM73", "id": "Q9UM73", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Insrr", "uniprot_ac": "Q9WTL4", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WTL4", "id": "Q9WTL4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WTL4", "id": "Q9WTL4", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Src", "uniprot_ac": "Q9WUD9", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WUD9", "id": "Q9WUD9", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WUD9", "id": "Q9WUD9", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] }, { "gene_name": "Map2k5", "uniprot_ac": "Q9WVS7", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WVS7", "id": "Q9WVS7", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9WVS7", "id": "Q9WVS7", "database": "UniProtKB" } ], "ec_number": "2.7.12.2", "activity": "" } ] }, { "gene_name": "DYRK1B", "uniprot_ac": "Q9Y463", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y463", "id": "Q9Y463", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Y463", "id": "Q9Y463", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Ror2", "uniprot_ac": "Q9Z138", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z138", "id": "Q9Z138", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z138", "id": "Q9Z138", "database": "UniProtKB" } ], "ec_number": "2.7.10.1", "activity": "" } ] }, { "gene_name": "Dyrk1b", "uniprot_ac": "Q9Z188", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z188", "id": "Q9Z188", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z188", "id": "Q9Z188", "database": "UniProtKB" } ], "ec_number": "2.7.12.1", "activity": "" } ] }, { "gene_name": "Baz1b", "uniprot_ac": "Q9Z277", "activity": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z277", "id": "Q9Z277", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate." }, { "evidence": [ { "url": "https://www.uniprot.org/uniprot/Q9Z277", "id": "Q9Z277", "database": "UniProtKB" } ], "ec_number": "2.7.10.2", "activity": "" } ] } ], "publication": [], "uniprot_ac": "A0A0G2KA94", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KA94", "type": "synonym", "resource": "RefSeq", "name": "Tec" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "type": "recommended", "resource": "UniProtKB", "name": "Tec" } ], "reactions": [ { "output_participant_list": [], "evidence": [ { "url": "https://www.rhea-db.org/rhea/10596", "id": "10596", "database": "Rhea" } ], "name": "", "cellular_location": "plasma membrane", "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "input_participant_list": [], "enzyme_list": [ "Q63117-1", "Q63604-1", "Q6XUX2-1", "P36506-1", "Q63272-1", "F1LSG7-1", "M0RDA4-1", "F1LM93-1", "Q04589-1", "Q62956-1", "F1M0N1-1", "G3V6K6-1", "Q64725-1", "P53767-1", "P15127-1", "P97523-1", "A0A0G2K210-1", "F1LVI0-1", "M0RE12-1", "A0A0G2JY48-1", "A0A0R4J8U1-1", "E9PSY0-1", "E9PT20-1", "P54757-1", "O08680-1", "Q00495-1", "A0A0G2JU41-1", "Q4V8A3-1", "Q63470-1", "Q924U5-1", "F1LRZ0-1", "P29321-1", "P20786-1", "A0A0G2K134-1", "P55146-1", "P06494-1", "D4A584-1", "Q91ZT1-1", "D3ZH39-1", "Q4KM97-1", "Q5FVG7-1", "O35346-1", "Q63474-1", "P09215-1", "Q07014-1", "O08775-1", "P24062-1", "Q64716-1", "P35739-1", "P57760-1", "Q63132-1", "Q9WUD9-1", "P09759-1", "P32577-1", "P54758-1", "P54759-1", "P70600-1", "Q03351-1", "Q62662-1", "Q62799-1", "Q62844-1", "Q63184-1", "G3V9H8-1", "Q05030-1", "Q62689-1", "Q63802-1", "D4ADZ5-1", "P09760-1", "Q01621-1", "Q498D6-1", "Q6P6U0-1", "Q01986-1", "Q4KSH7-1", "Q62862-1", "Q63572-1", "P41243-1", "P50545-1", "P57097-1", "Q62838-1", "Q5U2X5-1", "A0A0G2JW59-1", "D3ZBN3-1", "A0A0G2KA94-1", "D3ZYM4-1", "D3ZD03-1", "M0R4N8-1", "B5DFD6-1", "Q501W1-1", "A0A0G2KAP6-1", "F7EVN7-1", "F1M0B3-1", "Q63116-1", "D4A7W7-1", "F1LQK6-1", "G3V9W2-1", "D3ZZK3-1", "D3ZDS3-1", "D3ZDH4-1", "D3ZCD0-1", "Q06187-1", "Q9UF33-1", "Q9UIG0-1", "P51813-1", "P54753-1", "P54762-1", "P21709-1", "Q5JZY3-1", "Q05655-1", "P16234-1", "Q504Y2-1", "Q13470-1", "P29597-1", "P07947-1", "P54756-1", "Q12866-1", "Q06418-1", "Q05397-1", "Q13627-1", "Q07912-1", "P42681-1", "P17948-1", "P08631-1", "P42679-1", "P07333-1", "Q6XUX3-1", "P06239-1", "P21802-1", "P07332-1", "P04626-1", "Q15303-1", "P00533-1", "P11362-1", "Q9Y463-1", "Q9NR20-1", "P00519-1", "P19525-1", "P42685-1", "P08069-1", "P52333-1", "O60674-1", "P43405-1", "Q08881-1", "P08581-1", "Q16288-1", "O43353-1", "P08922-1", "Q04912-1", "Q01974-1", "P34925-1", "Q6J9G0-1", "O75716-1", "P42680-1", "P30291-1", "P42684-1", "Q9UM73-1", "Q08345-1", "P29322-1", "P54760-1", "Q15375-1", "P21860-1", "P29320-1", "P54764-1", "P06241-1", "P14616-1", "P29376-1", "P45985-1", "P07949-1", "P12931-1", "P35590-1", "P30530-1", "P35968-1", "P49760-1", "P49761-4", "Q92630-1", "P29323-1", "P16591-1", "Q14680-1", "P36507-1", "Q02750-1", "O15146-1", "P04629-1", "Q96KB5-1", "P0C1S8-1", "P09769-1", "P10721-1", "P51451-1", "P46734-1", "P52564-1", "P49759-1", "Q9HAZ1-1", "Q16832-1", "O43781-1", "P29317-1", "Q14289-1", "P22455-1", "P36888-1", "P22607-1", "P06213-1", "P23458-1", "P07948-1", "Q13163-1", "O14733-1", "Q16620-1", "P09619-1", "Q13882-1", "Q9H3Y6-1", "Q15569-1", "Q96S53-1", "Q02763-1", "P35916-2", "P43403-1", "P41240-1", "P33981-1", "Q9Z277-1", "P97504-1", "P16277-1", "Q01279-1", "Q62413-1", "Q8BYG9-1", "Q03963-1", "O09127-1", "P54761-1", "Q61772-1", "P39688-1", "P16879-1", "Q61846-1", "Q61006-1", "Q6VNS1-1", "Q5RJI4-1", "Q64434-1", "Q62190-1", "Q01887-1", "Q62270-1", "P08923-1", "Q9WVS7-1", "Q9JJ78-1", "P21803-1", "Q4JIM5-1", "Q60629-1", "Q61851-1", "P06240-1", "P16092-1", "P41242-1", "Q02858-1", "Q61527-1", "O35491-1", "O35492-1", "O35493-1", "Q5U4C9-1", "P35969-1", "P05622-1", "P54754-1", "Q61214-1", "P35991-1", "P41241-1", "Q03146-1", "P29319-1", "P54763-3", "Q03137-1", "Q03145-1", "Q60750-1", "P70424-1", "Q61526-1", "P70451-1", "P14234-1", "Q922K9-1", "Q00342-1", "Q62137-1", "Q9WTL4-1", "P15208-1", "Q03526-1", "Q62120-1", "P28867-1", "Q60805-1", "Q3UFB7-1", "P15209-1", "P05480-1", "P35917-1", "P97793-1", "P09581-1", "Q62371-1", "Q9QVP9-1", "P48025-1", "P16056-1", "P26618-1", "Q78DX7-1", "Q9Z138-1", "O88697-1", "Q6J9G1-1", "Q99ML2-1", "Q9R117-1", "P43404-1", "O54967-1", "P00520-1", "Q8CBF3-1", "P34152-3", "Q03142-1", "P08103-1", "Q60751-1", "P05532-1", "P35546-1", "P58801-1", "P24604-1", "Q06806-1", "Q00993-1", "P55144-1", "Q9Z188-1", "P22518-1", "Q6XUX1-1", "Q8BI55-1", "Q922Y0-1", "P25911-1", "O09110-1", "P70236-1", "Q63932-1", "Q8CE90-1", "O70146-1", "Q8VCT9-1", "P35918-1", "P47810-1", "Q66JT0-1", "Q04736-1", "P52332-1", "P31938-1", "P47809-1", "P42682-1", "P35761-1" ], "id": "10596", "summary": "" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-205328", "id": "R-RNO-205328", "database": "Reactome" } ], "name": "Interaction of other tyrosine kinases with p-KIT", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A0A0G2KA94-1", "Q63116-1", "D4A584-1", "P09760-1", "Q91ZN7-1" ], "id": "R-RNO-205328", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2730833", "id": "R-RNO-2730833", "database": "Reactome" } ], "name": "Phosphorylation of TEC kinases by p-SYK", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "P24135-1", "P10686-1", "A0A0G2KA94-1", "Q07014-1", "Q64725-1", "Q501W1-1", "A0A0G2K134-1", "D4A7W7-1" ], "id": "R-RNO-2730833", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2730847", "id": "R-RNO-2730847", "database": "Reactome" } ], "name": "Hydrolysis of PIP2 by PLCG", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "P24135-1", "P10686-1", "A0A0G2KA94-1", "Q501W1-1", "A0A0G2K134-1", "D4A7W7-1" ], "id": "R-RNO-2730847", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2730858", "id": "R-RNO-2730858", "database": "Reactome" } ], "name": "Autophosphorylation of BTK/ITK", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "P24135-1", "P10686-1", "A0A0G2KA94-1", "Q501W1-1", "A0A0G2K134-1", "D4A7W7-1" ], "id": "R-RNO-2730858", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "output_participant_list": [], "evidence": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-879914", "id": "R-RNO-879914", "database": "Reactome" } ], "name": "IL3 stimulation induces Vav binding to Tec kinase", "cellular_location": "plasma membrane", "equation": "", "input_participant_list": [], "enzyme_list": [ "A0A0G2KA94-1" ], "id": "R-RNO-879914", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94#A0A0G2KA94-1", "isoform_ac": "A0A0G2KA94-1", "locus": { "end_pos": 37919199, "strand": "-", "start_pos": 38027371, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000088441", "id": "ENSRNOT00000088441", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075313", "id": "ENSRNOP00000075313", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KA94-1|A0A0G2KA94_RAT Isoform 1 of Tyrosine-protein kinase OS=Rattus norvegicus OX=10116 GN=Tec PE=1 SV=1 CANONICAL=A0A0G2KA94-1", "length": 674, "sequence": "MGLVSACQTPGSAVWPALSPVLCQHALGQESRDLQWQEKEQQKTEMNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94#B2RYC7-1", "isoform_ac": "B2RYC7-1", "locus": { "end_pos": 37962848, "strand": "-", "start_pos": 38027371, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000003125", "id": "ENSRNOT00000003125", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000003125", "id": "ENSRNOP00000003125", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B2RYC7-1|A0A0G2KA94_RAT Computationally mapped isoform of Tyrosine-protein kinase OS=Rattus norvegicus OX=10116 GN=Tec PE=1 SV=1 CANONICAL=A0A0G2KA94-1", "length": 629, "sequence": "MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGRAEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECEETFGR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:84492", "resource": "KEGG Pathway", "id": "rno:84492", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1433557", "description": "Signaling by SCF-KIT", "resource": "Reactome", "id": "R-RNO-1433557", "name": "Signaling by SCF-KIT" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "description": "FCERI mediated Ca+2 mobilization", "resource": "Reactome", "id": "R-RNO-2871809", "name": "FCERI mediated Ca+2 mobilization" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-512988", "description": "Interleukin-3, Interleukin-5 and GM-CSF signaling", "resource": "Reactome", "id": "R-RNO-512988", "name": "Interleukin-3, Interleukin-5 and GM-CSF signaling" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445884.1", "annotation": "TEC promotes hepatocyte proliferation and regeneration and is involved in Hepatocyte Growth Factor-induced Erk signaling pathway.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445884.1", "id": "NP_445884.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P24604-1", "protein_name": "Tyrosine-protein kinase Tec", "sequence": { "length": 630, "sequence": "MNFNTILEEILIKRSQQKKKTSLLNYKERLCVLPKSVLSYYEGRAEKKYRKGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDANTLYIFAPSPQSRDRWVKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHRPKLATKYLYEVMLRCWQERPEGRPSLEDLLRTIDELVECEETFGR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/1302", "id": "1302", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Tec", "tax_id": 10090 }, { "uniprot_canonical_ac": "P42680-1", "protein_name": "Tyrosine-protein kinase Tec", "sequence": { "length": 631, "sequence": "MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/1302", "id": "1302", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TEC", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445884.1", "ac": "NP_445884.1", "name": "tyrosine-protein kinase Tec", "summary": "protein-tyrosine kinase; may play a role in early response phase of liver regeneration [RGD, Feb 2006]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004715", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "non-membrane spanning protein tyrosine kinase activity", "id": "GO:0004715" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "cell-cell junction", "id": "GO:0005911" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "T cell receptor signaling pathway", "id": "GO:0050852" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "adaptive immune response", "id": "GO:0002250" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042246", "pmid": "11097837", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "tissue regeneration", "id": "GO:0042246" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010543", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "regulation of platelet activation", "id": "GO:0010543" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "integrin-mediated signaling pathway", "id": "GO:0007229" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018108", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "peptidyl-tyrosine phosphorylation", "id": "GO:0018108" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038083", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "peptidyl-tyrosine autophosphorylation", "id": "GO:0038083" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050731", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "positive regulation of peptidyl-tyrosine phosphorylation", "id": "GO:0050731" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" } ], "name": "B cell receptor signaling pathway", "id": "GO:0050853" } ], "total": 10, "name": "Biological Process" } ] }, "site_annotation": [ { "end_pos": 257, "annotation": "n_glycosylation_sequon", "start_pos": 255 }, { "end_pos": 298, "annotation": "n_glycosylation_sequon", "start_pos": 296 }, { "end_pos": 583, "annotation": "n_glycosylation_sequon", "start_pos": 581 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002278", "id": "ENSRNOG00000002278", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11905", "id": "cd11905", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/84492", "id": "84492", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "id": "IPR000980", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "id": "IPR001245", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "id": "IPR001452", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001562", "id": "IPR001562", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "id": "IPR008266", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "id": "IPR017441", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "id": "IPR020635", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035572", "id": "IPR035572", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "id": "IPR036028", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "id": "IPR036860", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:84492", "id": "rno:84492", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/NDIHWWK/", "id": "NDIHWWK", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1047190at2759", "id": "1047190at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00017", "id": "PF00017", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00018", "id": "PF00018", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00169", "id": "PF00169", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00779", "id": "PF00779", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07714", "id": "PF07714", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1433557", "id": "R-RNO-1433557", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2871809", "id": "R-RNO-2871809", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-512988", "id": "R-RNO-512988", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445884", "id": "NP_445884", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445884.1", "id": "NP_445884.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620973", "id": "620973", "database": "RGD" }, { "url": "https://www.rhea-db.org/rhea/10596", "id": "10596", "database": "Rhea" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "id": "A0A0G2KA94", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94-1", "id": "A0A0G2KA94-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/B2RYC7", "id": "B2RYC7", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/B2RYC7-1", "id": "B2RYC7-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 78291.0, "chemical_mass": 78291.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94", "name": "Tec", "locus": { "end_pos": 38027925, "strand": "+", "start_pos": 37918652, "chromosome": "14", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000002278", "id": "ENSRNOG00000002278", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.7.10.2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA94#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Tyrosine-protein kinase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KA94", "type": "synonym", "resource": "RefSeq", "name": "cytoplasmic tyrosine kinase, Dscr28C related" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KA94", "type": "synonym", "resource": "RefSeq", "name": "tyrosine-protein kinase Tec" } ] }