{
    "uniprot_canonical_ac": "A0A0G2JVC1-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0G2JVC1-1|A0A0G2JVC1_RAT Isoform 1 of E3 ubiquitin-protein ligase Mdm2  OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1", 
        "length": 483, 
        "sequence": "MCNTNMSVSTEGAAGTSQIPASEQETLVRPKPLLLKLLKSVGAQKDIYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN"
    }, 
    "uniprot_id": "A0A0G2JVC1_RAT", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "reaction_enzymes": [
        {
            "gene_name": "Mdm2", 
            "uniprot_ac": "A0A0G2JVC1", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                            "id": "A0A0G2JVC1", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.3.2.27", 
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                            "id": "A0A0G2JVC1", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.3.2.27", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Trim27", 
            "uniprot_ac": "B5DFI5", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/B5DFI5", 
                            "id": "B5DFI5", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.3.2.27", 
                    "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/B5DFI5", 
                            "id": "B5DFI5", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.3.2.27", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Atm", 
            "uniprot_ac": "D4ACL8", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/D4ACL8", 
                            "id": "D4ACL8", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/D4ACL8", 
                            "id": "D4ACL8", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Pten", 
            "uniprot_ac": "O54857", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O54857", 
                            "id": "O54857", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.67", 
                    "activity": "Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O54857", 
                            "id": "O54857", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.16", 
                    "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O54857", 
                            "id": "O54857", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.48", 
                    "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O54857", 
                            "id": "O54857", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.67", 
                    "activity": ""
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O54857", 
                            "id": "O54857", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.48", 
                    "activity": ""
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/O54857", 
                            "id": "O54857", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.16", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Camk2b", 
            "uniprot_ac": "P08413", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P08413", 
                            "id": "P08413", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P08413", 
                            "id": "P08413", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Camk2a", 
            "uniprot_ac": "P11275", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P11275", 
                            "id": "P11275", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P11275", 
                            "id": "P11275", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Camk2g", 
            "uniprot_ac": "P11730", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P11730", 
                            "id": "P11730", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P11730", 
                            "id": "P11730", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Camk2d", 
            "uniprot_ac": "P15791", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P15791", 
                            "id": "P15791", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P15791", 
                            "id": "P15791", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.17", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Cdk1", 
            "uniprot_ac": "P39951", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P39951", 
                            "id": "P39951", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.22", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P39951", 
                            "id": "P39951", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.23", 
                    "activity": "ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P39951", 
                            "id": "P39951", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.23", 
                    "activity": ""
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P39951", 
                            "id": "P39951", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.22", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Akt1", 
            "uniprot_ac": "P47196", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P47196", 
                            "id": "P47196", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P47196", 
                            "id": "P47196", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Akt2", 
            "uniprot_ac": "P47197", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P47197", 
                            "id": "P47197", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P47197", 
                            "id": "P47197", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Nup98", 
            "uniprot_ac": "P49793", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P49793", 
                            "id": "P49793", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.4.21.-", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ppp2cb", 
            "uniprot_ac": "P62716", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P62716", 
                            "id": "P62716", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.16", 
                    "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P62716", 
                            "id": "P62716", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.16", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ube2i", 
            "uniprot_ac": "P63281", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P63281", 
                            "id": "P63281", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.3.2.-", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Ppp2ca", 
            "uniprot_ac": "P63331", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P63331", 
                            "id": "P63331", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.16", 
                    "activity": "[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/P63331", 
                            "id": "P63331", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.1.3.16", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Sgk1", 
            "uniprot_ac": "Q06226", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q06226", 
                            "id": "Q06226", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q06226", 
                            "id": "Q06226", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Usp7", 
            "uniprot_ac": "Q4VSI4", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q4VSI4", 
                            "id": "Q4VSI4", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.4.19.12", 
                    "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q4VSI4", 
                            "id": "Q4VSI4", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "3.4.19.12", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Akt3", 
            "uniprot_ac": "Q63484", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q63484", 
                            "id": "Q63484", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q63484", 
                            "id": "Q63484", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.1", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Cdk2", 
            "uniprot_ac": "Q63699", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q63699", 
                            "id": "Q63699", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.22", 
                    "activity": "ATP + a protein = ADP + a phosphoprotein."
                }, 
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q63699", 
                            "id": "Q63699", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.7.11.22", 
                    "activity": ""
                }
            ]
        }, 
        {
            "gene_name": "Pias2", 
            "uniprot_ac": "Q6AZ28", 
            "activity": [
                {
                    "evidence": [
                        {
                            "url": "https://www.uniprot.org/uniprot/Q6AZ28", 
                            "id": "Q6AZ28", 
                            "database": "UniProtKB"
                        }
                    ], 
                    "ec_number": "2.3.2.-", 
                    "activity": ""
                }
            ]
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
                    "type": "PubMed", 
                    "id": "22673903"
                }
            ], 
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.uniprot.org/uniprot/D3ZVH5", 
                    "id": "D3ZVH5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/30001240", 
                    "type": "PubMed", 
                    "id": "30001240"
                }
            ], 
            "title": "Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis.", 
            "journal": "The American journal of surgical pathology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "He X, Pang Z, Zhang X, Lan T, Chen H, Chen M, Yang H, Huang J, Chen Y, Zhang Z, Jing W, Peng R, Zhang H", 
            "date": "2018"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/30360646", 
                    "type": "PubMed", 
                    "id": "30360646"
                }
            ], 
            "title": "Hyperglycaemia correlates with skeletal muscle capillary regression and is associated with alterations in the murine double minute-2/forkhead box O1/thrombospondin-1 pathway in type 1 diabetic BioBreeding rats.", 
            "journal": "Diabetes & vascular disease research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Aiken J, Mandel ER, Riddell MC, Birot O", 
            "date": "2019"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/31973811", 
                    "type": "PubMed", 
                    "id": "31973811"
                }
            ], 
            "title": "Tempo-spatial alternative polyadenylation analysis reveals that 3' UTR lengthening of Mdm2 regulates p53 expression and cellular senescence in aged rat testis.", 
            "journal": "Biochemical and biophysical research communications", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang L, Chen M, Fu H, Ni T, Wei G", 
            "date": "2020"
        }
    ], 
    "uniprot_ac": "A0A0G2JVC1", 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Mdm2_predicted"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Mdm2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Mdm2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_48669"
        }
    ], 
    "reactions": [
        {
            "output_participant_list": [
                "R-RNO-198638"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198599", 
                    "id": "R-RNO-198599", 
                    "database": "Reactome"
                }
            ], 
            "name": "AKT phosphorylates MDM2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [
                "R-RNO-198644"
            ], 
            "enzyme_list": [
                "P47196-1", 
                "A0A0G2JVC1-1", 
                "P47197-1", 
                "Q63484-1"
            ], 
            "id": "R-RNO-198599", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3000434", 
                    "id": "R-RNO-3000434", 
                    "database": "Reactome"
                }
            ], 
            "name": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1", 
                "B5DFI5-1", 
                "P63281-1", 
                "Q6AZ28-1"
            ], 
            "id": "R-RNO-3000434", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-3215278", 
                "R-RNO-3222068"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3215295", 
                    "id": "R-RNO-3215295", 
                    "database": "Reactome"
                }
            ], 
            "name": "USP7 deubiquitinates MDM2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q4VSI4-1", 
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-3215295", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3222072", 
                    "id": "R-RNO-3222072", 
                    "database": "Reactome"
                }
            ], 
            "name": "DAXX binds Ub-MDM2 and USP7", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q4VSI4-1", 
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-3222072", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349426", 
                    "id": "R-RNO-349426", 
                    "database": "Reactome"
                }
            ], 
            "name": "Phosphorylation of MDM4 by CHEK2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-349426", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-349455", 
                    "id": "R-RNO-349455", 
                    "database": "Reactome"
                }
            ], 
            "name": "Phosphorylation of MDM4 by ATM", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1", 
                "D4ACL8-1"
            ], 
            "id": "R-RNO-349455", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-3006691", 
                "R-RNO-375977", 
                "R-RNO-381669", 
                "R-RNO-416333"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416320", 
                    "id": "R-RNO-416320", 
                    "database": "Reactome"
                }
            ], 
            "name": "Trafficking of GluR1-containing  AMPA receptors", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [
                "R-RNO-3006692", 
                "R-RNO-392241", 
                "R-RNO-416331", 
                "R-RNO-416332"
            ], 
            "enzyme_list": [
                "P08413-1", 
                "P11275-1", 
                "P11730-1", 
                "P15791-1", 
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-416320", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5228523", 
                    "id": "R-RNO-5228523", 
                    "database": "Reactome"
                }
            ], 
            "name": "RANBP2 SUMOylates MDM2 with SUMO1", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1", 
                "P49793-1", 
                "P63281-1"
            ], 
            "id": "R-RNO-5228523", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5633460", 
                    "id": "R-RNO-5633460", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 binds TP53", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-5633460", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689950", 
                    "id": "R-RNO-5689950", 
                    "database": "Reactome"
                }
            ], 
            "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q4VSI4-1", 
                "A0A0G2JVC1-1", 
                "O54857-1"
            ], 
            "id": "R-RNO-5689950", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-6792489"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6792863", 
                    "id": "R-RNO-6792863", 
                    "database": "Reactome"
                }
            ], 
            "name": "PP2A-PP2R5C dephosphorylates MDM2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "P63331-1", 
                "A0A0G2JVC1-1", 
                "P62716-1"
            ], 
            "id": "R-RNO-6792863", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6792871", 
                    "id": "R-RNO-6792871", 
                    "database": "Reactome"
                }
            ], 
            "name": "CCNG1 recruits PP2A-PPP2R5C to MDM2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "P63331-1", 
                "A0A0G2JVC1-1", 
                "P62716-1"
            ], 
            "id": "R-RNO-6792871", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-6792862"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6793661", 
                    "id": "R-RNO-6793661", 
                    "database": "Reactome"
                }
            ], 
            "name": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [
                "R-RNO-6793669"
            ], 
            "enzyme_list": [
                "Q63699-1", 
                "A0A0G2JVC1-1", 
                "P39951-1"
            ], 
            "id": "R-RNO-6793661", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6793666", 
                    "id": "R-RNO-6793666", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 translocates to the nucleus", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6793666", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6795460", 
                    "id": "R-RNO-6795460", 
                    "database": "Reactome"
                }
            ], 
            "name": "SGK1 phosphorylates MDM2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "Q06226-1", 
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6795460", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6795667", 
                    "id": "R-RNO-6795667", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 translocates to the cytosol", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [
                "R-RNO-69486"
            ], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6795667", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-6798383"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798373", 
                    "id": "R-RNO-6798373", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 ubiquitinates DYRK2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6798373", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-6804247"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804253", 
                    "id": "R-RNO-6804253", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 ubiquitinates JMY", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [
                "R-RNO-6804234"
            ], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6804253", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804724", 
                    "id": "R-RNO-6804724", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 ubiquitinates phosphorylated MDM4", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6804724", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804741", 
                    "id": "R-RNO-6804741", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 forms homo- or heterodimers", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1", 
                "D4ACL8-1"
            ], 
            "id": "R-RNO-6804741", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804879", 
                    "id": "R-RNO-6804879", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 ubiquitinates TP53", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6804879", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804942", 
                    "id": "R-RNO-6804942", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 homodimers auto-ubiquitinate", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-6804942", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [
                "R-RNO-6804954"
            ], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804955", 
                    "id": "R-RNO-6804955", 
                    "database": "Reactome"
                }
            ], 
            "name": "ATM phosphorylates MDM2", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1", 
                "D4ACL8-1"
            ], 
            "id": "R-RNO-6804955", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8952371", 
                    "id": "R-RNO-8952371", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 binds RUNX3", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-8952371", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }, 
        {
            "output_participant_list": [], 
            "evidence": [
                {
                    "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8952382", 
                    "id": "R-RNO-8952382", 
                    "database": "Reactome"
                }
            ], 
            "name": "MDM2 polyubiquitinates RUNX3", 
            "cellular_location": "plasma membrane", 
            "equation": "", 
            "input_participant_list": [], 
            "enzyme_list": [
                "A0A0G2JVC1-1"
            ], 
            "id": "R-RNO-8952382", 
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#A0A0G2JVC1-1", 
            "isoform_ac": "A0A0G2JVC1-1", 
            "locus": {
                "end_pos": 60720300, 
                "strand": "+", 
                "start_pos": 60742415, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000086116", 
                        "id": "ENSRNOT00000086116", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069425", 
                        "id": "ENSRNOP00000069425", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JVC1-1|A0A0G2JVC1_RAT Isoform 1 of E3 ubiquitin-protein ligase Mdm2  OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1", 
                "length": 483, 
                "sequence": "MCNTNMSVSTEGAAGTSQIPASEQETLVRPKPLLLKLLKSVGAQKDIYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#D3ZVH5-1", 
            "isoform_ac": "D3ZVH5-1", 
            "locus": {
                "end_pos": 60720300, 
                "strand": "+", 
                "start_pos": 60742415, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000066767", 
                        "id": "ENSRNOT00000066767", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000063449", 
                        "id": "ENSRNOP00000063449", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|D3ZVH5-1|D3ZVH5_RAT Computationally mapped isoform of E3 ubiquitin-protein ligase Mdm2  OS=Rattus norvegicus OX=10116 GN=Mdm2 PE=1 SV=1 CANONICAL=A0A0G2JVC1-1", 
                "length": 458, 
                "sequence": "MCNTNMSVSTEGAAGTSQIPASEQETLIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVVVSQQDSGTSPSESRCQPEGGSDLKDPVQASQEEKPSSSDVVSRPSTSSRRRAISETEENTDELPGERQRKRHRALSFDESLGLCVLREICCERSSSSEATDTPSHQDLDDGVSDHSADCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQAGESDADSFEGDPEISLADYWKCTSCNEMNPPLPSHCNRCWTLRENWLPDDKGKDKVEISEKAKLESSDQAEEGLDVPDGKKVTEDDAKESSAEDSEEKVAQMLLSQESDDYSQPSTSSSIVYSSQESGKELKEDTQDKEESMESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314856", 
            "resource": "KEGG Pathway", 
            "id": "rno:314856", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198323", 
            "description": "AKT phosphorylates targets in the cytosol", 
            "resource": "Reactome", 
            "id": "R-RNO-198323", 
            "name": "AKT phosphorylates targets in the cytosol"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559580", 
            "description": "Oxidative Stress Induced Senescence", 
            "resource": "Reactome", 
            "id": "R-RNO-2559580", 
            "name": "Oxidative Stress Induced Senescence"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2559585", 
            "description": "Oncogene Induced Senescence", 
            "resource": "Reactome", 
            "id": "R-RNO-2559585", 
            "name": "Oncogene Induced Senescence"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3232142", 
            "description": "SUMOylation of ubiquitinylation proteins", 
            "resource": "Reactome", 
            "id": "R-RNO-3232142", 
            "name": "SUMOylation of ubiquitinylation proteins"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399719", 
            "description": "Trafficking of AMPA receptors", 
            "resource": "Reactome", 
            "id": "R-RNO-399719", 
            "name": "Trafficking of AMPA receptors"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5689880", 
            "description": "Ub-specific processing proteases", 
            "resource": "Reactome", 
            "id": "R-RNO-5689880", 
            "name": "Ub-specific processing proteases"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804756", 
            "description": "Regulation of TP53 Activity through Phosphorylation", 
            "resource": "Reactome", 
            "id": "R-RNO-6804756", 
            "name": "Regulation of TP53 Activity through Phosphorylation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804757", 
            "description": "Regulation of TP53 Degradation", 
            "resource": "Reactome", 
            "id": "R-RNO-6804757", 
            "name": "Regulation of TP53 Degradation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6804760", 
            "description": "Regulation of TP53 Activity through Methylation", 
            "resource": "Reactome", 
            "id": "R-RNO-6804760", 
            "name": "Regulation of TP53 Activity through Methylation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69541", 
            "description": "Stabilization of p53", 
            "resource": "Reactome", 
            "id": "R-RNO-69541", 
            "name": "Stabilization of p53"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8941858", 
            "description": "Regulation of RUNX3 expression and activity", 
            "resource": "Reactome", 
            "id": "R-RNO-8941858", 
            "name": "Regulation of RUNX3 expression and activity"
        }
    ], 
    "reaction_participants": [
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "ENSRNOG00000006304", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241445.1", 
                    "database": "RefSeq"
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                {
                    "url": "", 
                    "id": "XP_006241444.1", 
                    "database": "RefSeq"
                }, 
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                    "url": "", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000069425", 
                    "database": "Ensembl"
                }, 
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                    "url": "", 
                    "id": "1305332", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000086116", 
                    "database": "Ensembl"
                }
            ], 
            "participant_name": "phospho-Mdm2 [cytosol]", 
            "participant_id": "R-RNO-198638"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241445.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000069425", 
                    "database": "Ensembl"
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                {
                    "url": "", 
                    "id": "XP_006241444.1", 
                    "database": "RefSeq"
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                {
                    "url": "", 
                    "id": "ENSRNOT00000086116", 
                    "database": "Ensembl"
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                    "url": "", 
                    "id": "ENSRNOG00000006304", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "1305332", 
                    "database": "RGD"
                }
            ], 
            "participant_name": "Mdm2 [cytosol]", 
            "participant_id": "R-RNO-198644"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "ENSRNOG00000011852", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "1560646", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "D4A5I9", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000016428", 
                    "database": "Ensembl"
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                {
                    "url": "", 
                    "id": "ENSRNOP00000016428", 
                    "database": "Ensembl"
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            ], 
            "participant_name": "Myo6 [plasma membrane]", 
            "participant_id": "R-RNO-3006691"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "D4A5I9", 
                    "database": "UniProt"
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                {
                    "url": "", 
                    "id": "ENSRNOG00000011852", 
                    "database": "Ensembl"
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                {
                    "url": "", 
                    "id": "ENSRNOT00000016428", 
                    "database": "Ensembl"
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                {
                    "url": "", 
                    "id": "1560646", 
                    "database": "RGD"
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                {
                    "url": "", 
                    "id": "ENSRNOP00000016428", 
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                }
            ], 
            "participant_name": "Myo6 [cytosol]", 
            "participant_id": "R-RNO-3006692"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "NP_001019961.1", 
                    "database": "RefSeq"
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                {
                    "url": "", 
                    "id": "1306915", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "Q4VSI4", 
                    "database": "PRO"
                }, 
                {
                    "url": "", 
                    "id": "Q4VSI4", 
                    "database": "UniProt"
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            ], 
            "participant_name": "Usp7 [nucleoplasm]", 
            "participant_id": "R-RNO-3215278"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "621227", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "Q8VIB2", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "Q8VIB2", 
                    "database": "PRO"
                }
            ], 
            "participant_name": "Daxx [nucleoplasm]", 
            "participant_id": "R-RNO-3222068"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "2AWU", 
                    "database": "PDB"
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                {
                    "url": "", 
                    "id": "Q62696", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "3UAT", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2I0I", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2AWX", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "1RSO", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "NP_036920.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "2I0L", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2505", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "1ZOK", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2AWW", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2G2L", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "Q62696", 
                    "database": "PRO"
                }
            ], 
            "participant_name": "Dlg1 [plasma membrane]", 
            "participant_id": "R-RNO-375977"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "P24587", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "620829", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "P24587", 
                    "database": "PRO"
                }
            ], 
            "participant_name": "Akap5 [plasma membrane]", 
            "participant_id": "R-RNO-381669"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "Q9WTP0", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "71087", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "Q9WTP0", 
                    "database": "PRO"
                }, 
                {
                    "url": "", 
                    "id": "NP_742087.1", 
                    "database": "RefSeq"
                }
            ], 
            "participant_name": "Epb41l1 [cytosol]", 
            "participant_id": "R-RNO-392241"
        }, 
        {
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                    "url": "", 
                    "id": "P24587", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "P24587", 
                    "database": "PRO"
                }, 
                {
                    "url": "", 
                    "id": "620829", 
                    "database": "RGD"
                }
            ], 
            "participant_name": "Akap5 [cytosol]", 
            "participant_id": "R-RNO-416331"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "Q62696", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "2AWW", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2AWX", 
                    "database": "PDB"
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                {
                    "url": "", 
                    "id": "2505", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "2AWU", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "Q62696", 
                    "database": "PRO"
                }, 
                {
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                    "id": "1RSO", 
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                    "id": "2I0L", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "3UAT", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2G2L", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "2I0I", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "1ZOK", 
                    "database": "PDB"
                }, 
                {
                    "url": "", 
                    "id": "NP_036920.1", 
                    "database": "RefSeq"
                }
            ], 
            "participant_name": "Dlg1 [cytosol]", 
            "participant_id": "R-RNO-416332"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "NP_742087.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "71087", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "Q9WTP0", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "Q9WTP0", 
                    "database": "PRO"
                }
            ], 
            "participant_name": "Epb41l1 [plasma membrane]", 
            "participant_id": "R-RNO-416333"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "ENSRNOT00000065633", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000003256", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "P39950", 
                    "database": "PRO"
                }, 
                {
                    "url": "", 
                    "id": "P39950", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000063905", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "NP_037055.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "2295", 
                    "database": "RGD"
                }
            ], 
            "participant_name": "Ccng1 [nucleoplasm]", 
            "participant_id": "R-RNO-6792489"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "ENSRNOG00000006304", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241445.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241444.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000069425", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "1305332", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000086116", 
                    "database": "Ensembl"
                }
            ], 
            "participant_name": "phospho-Mdm2 [nucleoplasm]", 
            "participant_id": "R-RNO-6792862"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241445.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000069425", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241444.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000086116", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000006304", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "1305332", 
                    "database": "RGD"
                }
            ], 
            "participant_name": "phospho-Mdm2 [nucleoplasm]", 
            "participant_id": "R-RNO-6793669"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "XP_006241453.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000010283", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "NP_001101570.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "F1LYY7", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000010283", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "XP_017450342.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "1312039", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000007821", 
                    "database": "Ensembl"
                }
            ], 
            "participant_name": "Dyrk2 [nucleoplasm]", 
            "participant_id": "R-RNO-6798383"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "M0R8J3", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "1585601", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000065789", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000050343", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000075286", 
                    "database": "Ensembl"
                }
            ], 
            "participant_name": "Jmy [nucleoplasm]", 
            "participant_id": "R-RNO-6804234"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "1585601", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000050343", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "M0R8J3", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000065789", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000075286", 
                    "database": "Ensembl"
                }
            ], 
            "participant_name": "Jmy [nucleoplasm]", 
            "participant_id": "R-RNO-6804247"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "XP_006241444.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241445.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000006304", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000086116", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "1305332", 
                    "database": "RGD"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000069425", 
                    "database": "Ensembl"
                }
            ], 
            "participant_name": "phospho-Mdm2 [nucleoplasm]", 
            "participant_id": "R-RNO-6804954"
        }, 
        {
            "crossref": [
                {
                    "url": "", 
                    "id": "A0A0G2JVC1", 
                    "database": "UniProt"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241445.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOP00000069425", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "XP_006241444.1", 
                    "database": "RefSeq"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOT00000086116", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "ENSRNOG00000006304", 
                    "database": "Ensembl"
                }, 
                {
                    "url": "", 
                    "id": "1305332", 
                    "database": "RGD"
                }
            ], 
            "participant_name": "Mdm2 [nucleoplasm]", 
            "participant_id": "R-RNO-69486"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
            "annotation": "LncRNA UCA1 protects cardiomyocytes against hypoxia/reoxygenation induced apoptosis through inhibiting miR-143/MDM2/p53 axis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
            "annotation": "Murine double minute-2-forkhead box O1-thrombospondin-1 pathway plays an important role in angio-regulation of the skeletal muscle in the pathophysiological context of type 1 diabetes.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
            "annotation": "Only MDM2/FRS2 low-grade osteosarcoma was dedifferentiated parosteal osteosarcoma", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
            "annotation": "Tempo-spatial alternative polyadenylation analysis reveals that 3' UTR lengthening of Mdm2 regulates p53 expression and cellular senescence in aged rat testis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
            "annotation": "The results indicate that the miR-188-3p-MDM2-p53 axis may have a critical role in sevoflurane-induced cognitive dysfunction.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101569.1", 
                    "id": "NP_001101569.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "P23804-1", 
            "protein_name": "E3 ubiquitin-protein ligase Mdm2", 
            "sequence": {
                "length": 489, 
                "sequence": "MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/1793", 
                    "id": "1793", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2JVC1/", 
                    "id": "A0A0G2JVC1", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Mdm2", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q00987-1", 
            "protein_name": "Double minute 2 protein", 
            "sequence": {
                "length": 491, 
                "sequence": "MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/1793", 
                    "id": "1793", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "MDM2", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241444.1", 
        "ac": "XP_006241444.1", 
        "name": "E3 ubiquitin-protein ligase Mdm2 isoform X2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", 
                        "pmid": "16330492", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-protein transferase activity", 
                        "id": "GO:0004842"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", 
                        "pmid": "16330492", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "p53 binding", 
                        "id": "GO:0002039"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", 
                        "pmid": "23941874", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "p53 binding", 
                        "id": "GO:0002039"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "zinc ion binding", 
                        "id": "GO:0008270"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008097", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "5S rRNA binding", 
                        "id": "GO:0008097"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042975", 
                        "pmid": "19103650", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peroxisome proliferator activated receptor binding", 
                        "id": "GO:0042975"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033612", 
                        "pmid": "26228571", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "receptor serine/threonine kinase binding", 
                        "id": "GO:0033612"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "enzyme binding", 
                        "id": "GO:0019899"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein domain specific binding", 
                        "id": "GO:0019904"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ribonucleoprotein complex binding", 
                        "id": "GO:0043021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin protein ligase binding", 
                        "id": "GO:0031625"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin protein ligase activity", 
                        "id": "GO:0061630"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047485", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein N-terminus binding", 
                        "id": "GO:0047485"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "scaffold protein binding", 
                        "id": "GO:0097110"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin binding", 
                        "id": "GO:0043130"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019789", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "SUMO transferase activity", 
                        "id": "GO:0019789"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097718", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "disordered domain specific binding", 
                        "id": "GO:0097718"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ligase activity", 
                        "id": "GO:0016874"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061663", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "NEDD8 ligase activity", 
                        "id": "GO:0061663"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", 
                        "pmid": "14642282", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin protein ligase activity", 
                        "id": "GO:0061630"
                    }
                ], 
                "total": 21, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "17107963", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "19819240", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "14642282", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleolus", 
                        "id": "GO:0005730"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", 
                        "pmid": "14642282", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "synapse", 
                        "id": "GO:0045202"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
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                        "id": "GO:0016604"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
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            }, 
            {
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                        "pmid": "19103650", 
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                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", 
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                            {
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                                "id": "A0A0G2JVC1", 
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", 
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                                "id": "A0A0G2JVC1", 
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                        "name": "response to toxic substance", 
                        "id": "GO:0009636"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", 
                        "pmid": "17905399", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to toxic substance", 
                        "id": "GO:0009636"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010039", 
                        "pmid": "20019189", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to iron ion", 
                        "id": "GO:0010039"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010955", 
                        "pmid": "19638633", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "negative regulation of protein processing", 
                        "id": "GO:0010955"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription by RNA polymerase II", 
                        "id": "GO:0000122"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001974", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "blood vessel remodeling", 
                        "id": "GO:0001974"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006977", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest", 
                        "id": "GO:0006977"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "blood vessel development", 
                        "id": "GO:0001568"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003203", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "endocardial cushion morphogenesis", 
                        "id": "GO:0003203"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003281", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003181", 
                        "pmid": "", 
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                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "atrioventricular valve morphogenesis", 
                        "id": "GO:0003181"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0006511"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002027", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of heart rate", 
                        "id": "GO:0002027"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003283", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "atrial septum development", 
                        "id": "GO:0003283"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007089", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "traversing start control point of mitotic cell cycle", 
                        "id": "GO:0007089"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription by RNA polymerase II", 
                        "id": "GO:0006357"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042493", 
                        "pmid": "19136059", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to drug", 
                        "id": "GO:0042493"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", 
                        "pmid": "17881359", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of apoptotic process", 
                        "id": "GO:0043066"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154", 
                        "pmid": "19850968", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        "name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process", 
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                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", 
                        "pmid": "19103650", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "negative regulation of transcription, DNA-templated", 
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046827", 
                        "pmid": "17881359", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
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                        "name": "positive regulation of protein export from nucleus", 
                        "id": "GO:0046827"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977", 
                        "pmid": "23051735", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of neuron projection development", 
                        "id": "GO:0010977"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043278", 
                        "pmid": "14625023", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to morphine", 
                        "id": "GO:0043278"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048545", 
                        "pmid": "17000718", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to steroid hormone", 
                        "id": "GO:0048545"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", 
                        "pmid": "16091747", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "cellular response to growth factor stimulus", 
                        "id": "GO:0071363"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042220", 
                        "pmid": "14625023", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "response to cocaine", 
                        "id": "GO:0042220"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301", 
                        "pmid": "19638633", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to hydrogen peroxide", 
                        "id": "GO:0070301"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071312", 
                        "pmid": "19136059", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to alkaloid", 
                        "id": "GO:0071312"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904707", 
                        "pmid": "21498419", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
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                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", 
                        "pmid": "16330492", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein ubiquitination", 
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                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071310", 
                        "pmid": "19950214", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to organic substance", 
                        "id": "GO:0071310"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071375", 
                        "pmid": "19850968", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to peptide hormone stimulus", 
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071407", 
                        "pmid": "19819240", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to organic cyclic compound", 
                        "id": "GO:0071407"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904754", 
                        "pmid": "21498419", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of vascular associated smooth muscle cell migration", 
                        "id": "GO:1904754"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071236", 
                        "pmid": "18469520", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "cellular response to antibiotic", 
                        "id": "GO:0071236"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071391", 
                        "pmid": "14667141", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to estrogen stimulus", 
                        "id": "GO:0071391"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045472", 
                        "pmid": "16790648", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to ether", 
                        "id": "GO:0045472"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032026", 
                        "pmid": "15165363", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to magnesium ion", 
                        "id": "GO:0032026"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071494", 
                        "pmid": "14558917", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to UV-C", 
                        "id": "GO:0071494"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990785", 
                        "pmid": "23174211", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to water-immersion restraint stress", 
                        "id": "GO:1990785"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071301", 
                        "pmid": "15656374", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to vitamin B1", 
                        "id": "GO:0071301"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904404", 
                        "pmid": "18045764", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to formaldehyde", 
                        "id": "GO:1904404"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003170", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "heart valve development", 
                        "id": "GO:0003170"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "heart development", 
                        "id": "GO:0007507"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045931", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of mitotic cell cycle", 
                        "id": "GO:0045931"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990000", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "amyloid fibril formation", 
                        "id": "GO:1990000"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to hypoxia", 
                        "id": "GO:0071456"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "establishment of protein localization", 
                        "id": "GO:0045184"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051149", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of muscle cell differentiation", 
                        "id": "GO:0051149"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046677", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to antibiotic", 
                        "id": "GO:0046677"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034504", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein localization to nucleus", 
                        "id": "GO:0034504"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045787", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cell cycle", 
                        "id": "GO:0045787"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0032436"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of gene expression", 
                        "id": "GO:0010468"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein autoubiquitination", 
                        "id": "GO:0051865"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902254", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", 
                        "id": "GO:1902254"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018205", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidyl-lysine modification", 
                        "id": "GO:0018205"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein destabilization", 
                        "id": "GO:0031648"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteolysis involved in cellular protein catabolic process", 
                        "id": "GO:0051603"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043518", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of DNA damage response, signal transduction by p53 class mediator", 
                        "id": "GO:0043518"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071480", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to gamma radiation", 
                        "id": "GO:0071480"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060411", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cardiac septum morphogenesis", 
                        "id": "GO:0060411"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042176", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of protein catabolic process", 
                        "id": "GO:0042176"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071157", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell cycle arrest", 
                        "id": "GO:0071157"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", 
                        "pmid": "", 
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                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein-containing complex assembly", 
                        "id": "GO:0065003"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072717", 
                        "pmid": "", 
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                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to actinomycin D", 
                        "id": "GO:0072717"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901797", 
                        "pmid": "", 
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                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of signal transduction by p53 class mediator", 
                        "id": "GO:1901797"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", 
                        "pmid": "14642282", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
                                "id": "A0A0G2JVC1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein ubiquitination", 
                        "id": "GO:0016567"
                    }
                ], 
                "total": 71, 
                "name": "Biological Process"
            }
        ]
    }, 
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        {
            "end_pos": 7, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 5
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    ], 
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            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006304", 
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            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16783", 
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            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", 
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        {
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            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016495", 
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028340", 
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036443", 
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036885", 
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        {
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        {
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        {
            "url": "https://omabrowser.org/oma/group/ADYWKCS/", 
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            "database": "OMA"
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        {
            "url": "http://www.orthodb.org/?query=1329283at2759", 
            "id": "1329283at2759", 
            "database": "OrthoDB"
        }, 
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            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13844:SF15", 
            "id": "PTHR13844:SF15", 
            "database": "PANTHER"
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        {
            "url": "http://pfam.xfam.org/family/PF00641", 
            "id": "PF00641", 
            "database": "Pfam"
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        {
            "url": "http://pfam.xfam.org/family/PF02201", 
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            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-198323", 
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            "database": "Reactome"
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            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305332", 
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            "database": "RGD"
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            "id": "D3ZVH5-1", 
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    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
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                    "url": "http://disease-ontology.org/term/DOID:0050625", 
                    "resource": "Disease Ontology", 
                    "description": "", 
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                    "id": "DOID:0050625"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0050625", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "tumor of the extrahepatic bile duct", 
                    "id": "DOID:0050625"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0050625", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "neoplasm of extrahepatic bile ducts", 
                    "id": "DOID:0050625"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:0050625", 
                "resource": "Disease Ontology", 
                "description": "A hepatobiliary benign neoplasm located_in the biliary tract.", 
                "name": "biliary tract benign neoplasm", 
                "id": "DOID:0050625"
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            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0050625#disease-associations", 
                    "id": "0050625", 
                    "database": "Alliance of Genome Resources"
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                {
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                    "resource": "Disease Ontology", 
                    "description": "", 
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                    "id": "DOID:11054"
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                {
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                    "resource": "MONDO", 
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                    "name": "urinary bladder cancer", 
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                {
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                    "resource": "MONDO", 
                    "description": "", 
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                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
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                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant tumor, urinary bladder", 
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                {
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                    "resource": "MONDO", 
                    "description": "", 
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                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant urinary bladder tumor", 
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                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant neoplasm of the urinary bladder", 
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                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "bladder cancer", 
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                {
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                    "resource": "MONDO", 
                    "description": "", 
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                }, 
                {
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                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant urinary bladder neoplasm", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant neoplasm, bladder", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "urinary bladder malignant tumor", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant bladder tumor", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant neoplasm, urinary bladder", 
                    "id": "MONDO:0001187"
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                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "urinary bladder cancer", 
                    "id": "MONDO:0001187"
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                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant tumor of the bladder", 
                    "id": "MONDO:0001187"
                }, 
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                    "resource": "MONDO", 
                    "description": "", 
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                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "tumor of the bladder", 
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                }, 
                {
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                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant neoplasm of urinary bladder", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant neoplasm of bladder", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "cancer of urinary bladder", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "malignant tumor of urinary bladder", 
                    "id": "MONDO:0001187"
                }, 
                {
                    "url": "https://www.omim.org/entry/109800", 
                    "resource": "MIM", 
                    "description": "Bladder cancer", 
                    "name": "Bladder cancer", 
                    "id": "MIM:109800"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:11054", 
                "resource": "Disease Ontology", 
                "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder.", 
                "name": "urinary bladder cancer", 
                "id": "DOID:11054"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/11054#disease-associations", 
                    "id": "11054", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:1115", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:1115", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "tumor of soft tissue and skeleton", 
                    "id": "DOID:1115"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1115", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "connective and soft tissue neoplasm", 
                    "id": "DOID:1115"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:1115", 
                "resource": "Disease Ontology", 
                "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm.", 
                "name": "sarcoma", 
                "id": "DOID:1115"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1115#disease-associations", 
                    "id": "1115", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:1612", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:1612", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "malignant tumor of the breast", 
                    "id": "DOID:1612"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1612", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "primary breast cancer", 
                    "id": "DOID:1612"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1612", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "breast tumor", 
                    "id": "DOID:1612"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1612", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "mammary tumor", 
                    "id": "DOID:1612"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1612", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "mammary cancer", 
                    "id": "DOID:1612"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1612", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "malignant neoplasm of breast", 
                    "id": "DOID:1612"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma.", 
                    "name": "hereditary breast carcinoma", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial cancer of the breast", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial cancer of breast", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial breast cancer", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "breast cancer, familial Male", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "breast cancer, familial", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial breast carcinoma", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hereditary breast cancer", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0016419", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hereditary breast carcinoma", 
                    "id": "MONDO:0016419"
                }, 
                {
                    "url": "https://www.omim.org/entry/114480", 
                    "resource": "MIM", 
                    "description": "Breast cancer", 
                    "name": "Breast cancer", 
                    "id": "MIM:114480"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:1612", 
                "resource": "Disease Ontology", 
                "description": "A thoracic cancer that originates in the mammary gland.", 
                "name": "breast cancer", 
                "id": "DOID:1612"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1612#disease-associations", 
                    "id": "1612", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:1697", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:1697", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "ichthyoses", 
                    "id": "DOID:1697"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1697", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "non-syndromic ichthyosis", 
                    "id": "DOID:1697"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:1697", 
                "resource": "Disease Ontology", 
                "description": "A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed.", 
                "name": "ichthyosis", 
                "id": "DOID:1697"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1697#disease-associations", 
                    "id": "1697", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:2055", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:2055", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "traumatic neurosis", 
                    "id": "DOID:2055"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:2055", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "PTSD", 
                    "id": "DOID:2055"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:2055", 
                "resource": "Disease Ontology", 
                "description": "An anxiety disorder which results from a traumatic experience that results in psychological trauma.", 
                "name": "post-traumatic stress disorder", 
                "id": "DOID:2055"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/2055#disease-associations", 
                    "id": "2055", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:224", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Transient cerebral ischaemia", 
                    "id": "DOID:224"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "TRANSIENT ISCHEMIC ATTACK", 
                    "id": "DOID:224"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "TIA - Transient ischaemic attack", 
                    "id": "DOID:224"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "transient ischemic attack", 
                    "id": "DOID:224"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Transient cerebral ischemia", 
                    "id": "DOID:224"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Transient ischemic attacks", 
                    "id": "DOID:224"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:224", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "TIA", 
                    "id": "DOID:224"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:224", 
                "resource": "Disease Ontology", 
                "description": "A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death.", 
                "name": "transient cerebral ischemia", 
                "id": "DOID:224"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/224#disease-associations", 
                    "id": "224", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:3068", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:3068", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "adult glioblastoma multiforme", 
                    "id": "DOID:3068"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3068", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "GBM", 
                    "id": "DOID:3068"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3068", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "glioblastoma multiforme", 
                    "id": "DOID:3068"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3068", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "spongioblastoma multiforme", 
                    "id": "DOID:3068"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3068", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "primary glioblastoma multiforme", 
                    "id": "DOID:3068"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3068", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "grade IV adult Astrocytic tumor", 
                    "id": "DOID:3068"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:3068", 
                "resource": "Disease Ontology", 
                "description": "An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.", 
                "name": "glioblastoma", 
                "id": "DOID:3068"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/3068#disease-associations", 
                    "id": "3068", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:3587", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:3587", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "pancreatic duct cancer", 
                    "id": "DOID:3587"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3587", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "malignant neoplasm of duct of Wirsung", 
                    "id": "DOID:3587"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:3587", 
                "resource": "Disease Ontology", 
                "description": "A pancreatic carcinoma located_in the pancreatic duct.", 
                "name": "pancreatic ductal carcinoma", 
                "id": "DOID:3587"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/3587#disease-associations", 
                    "id": "3587", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:3669", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:3669", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Intermittent claudication", 
                    "id": "DOID:3669"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:3669", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Charcot's syndrome", 
                    "id": "DOID:3669"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:3669", 
                "resource": "Disease Ontology", 
                "description": "", 
                "name": "intermittent claudication", 
                "id": "DOID:3669"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/3669#disease-associations", 
                    "id": "3669", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:409", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:409", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "hepatic disorder", 
                    "id": "DOID:409"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:409", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "disorder of liver", 
                    "id": "DOID:409"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:409", 
                "resource": "Disease Ontology", 
                "description": "", 
                "name": "liver disease", 
                "id": "DOID:409"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/409#disease-associations", 
                    "id": "409", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:4947", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:4947", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "cholangiosarcoma", 
                    "id": "DOID:4947"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:4947", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "adult primary cholangiocellular carcinoma", 
                    "id": "DOID:4947"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:4947", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "adult primary Cholangiocarcinoma", 
                    "id": "DOID:4947"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:4947", 
                "resource": "Disease Ontology", 
                "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells.", 
                "name": "cholangiocarcinoma", 
                "id": "DOID:4947"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/4947#disease-associations", 
                    "id": "4947", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:4989", 
            "synonyms": [
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas.", 
                    "name": "hereditary chronic pancreatitis", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hereditary chronic pancreatitis", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "autosomal dominant hereditary pancreatitis", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, chronic", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, chronic, protection against, included", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, calcific, included", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Hp", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, chronic pancreatitis, chronic, susceptibility to, included", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial pancreatitis", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, calcific", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, hereditary", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "PCTT", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "HPC", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hereditary pancreatitis", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, chronic, protection against", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, hereditary; PCTT", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "pancreatitis, chronic, susceptibility to", 
                    "id": "MONDO:0008185"
                }, 
                {
                    "url": "https://www.omim.org/entry/167800", 
                    "resource": "MIM", 
                    "description": "Pancreatitis, hereditary", 
                    "name": "Pancreatitis, hereditary", 
                    "id": "MIM:167800"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:4989", 
                "resource": "Disease Ontology", 
                "description": "", 
                "name": "pancreatitis", 
                "id": "DOID:4989"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/4989#disease-associations", 
                    "id": "4989", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:684", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:684", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Hepatoma", 
                    "id": "DOID:684"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.", 
                    "name": "hepatocellular carcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "primary carcinoma of the liver cells", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "liver carcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hepatoblastoma caused by somatic mutation", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hepatoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "liver cell cancer (hepatocellular carcinoma)", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hepatocellular adenocarcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "carcinoma, hepatocellular, malignant", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "adult primary hepatocellular carcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hepatoblastoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "adult hepatoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "carcinoma of liver cells", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "liver and intrahepatic bile duct carcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "HCC", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hepatocellular cancer", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hepatocellular carcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "carcinoma of the liver cells", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "primary carcinoma of liver cells", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "carcinoma of liver", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "liver cancer", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "liver cell carcinoma", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007256", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "cancer, hepatocellular", 
                    "id": "MONDO:0007256"
                }, 
                {
                    "url": "https://www.omim.org/entry/114550", 
                    "resource": "MIM", 
                    "description": "Hepatocellular carcinoma", 
                    "name": "Hepatocellular carcinoma", 
                    "id": "MIM:114550"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:684", 
                "resource": "Disease Ontology", 
                "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.", 
                "name": "hepatocellular carcinoma", 
                "id": "DOID:684"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/684#disease-associations", 
                    "id": "684", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:8552", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "CML", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Myeloid Leukemia, chronic", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "chronic myelogenous leukemia", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "chronic myeloid leukaemia", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "CML - chronic Myelogenous Leukemia", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "chronic myelogenous leukaemia", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "chronic granulocytic leukaemia", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:8552", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "chronic granulocytic leukemia", 
                    "id": "DOID:8552"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.", 
                    "name": "chronic myelogenous leukemia, BCR-ABL1 positive", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "CML", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hematopoeitic - chronic myelocytic leukemia (CML)", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "BCR-ABL Positive chronic myelogenous leukemia", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic myelocytic leukemia", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, chronic myelogenous", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "myeloid leukemia, chronic", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic myelogenous leukemia", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, chronic myeloid; CML", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic myelogenous leukemia, BCR-ABL1 Positive", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "CML - chronic myelogenous leukemia", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic myelogenous leukemia (CML)", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic myelogenous leukemias", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic myeloid leukemia", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, chronic myeloid", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, chronic myeloid, atypical", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011996", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "chronic granulocytic leukemia", 
                    "id": "MONDO:0011996"
                }, 
                {
                    "url": "https://www.omim.org/entry/608232", 
                    "resource": "MIM", 
                    "description": "Leukemia, chronic myeloid, atypical", 
                    "name": "Leukemia, chronic myeloid, atypical", 
                    "id": "MIM:608232"
                }
            ], 
            "recommended_name": {
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                "resource": "Disease Ontology", 
                "description": "A myeloid leukemia that is characterized by over production of white blood cells.", 
                "name": "chronic myeloid leukemia", 
                "id": "DOID:8552"
            }, 
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                {
                    "url": "https://www.alliancegenome.org/gene/8552#disease-associations", 
                    "id": "8552", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
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                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "acute myeloblastic leukaemia", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "acute myelogenous leukaemia", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "acute myeloblastic leukemia", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "acute myelogenous leukemia", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "AML - acute Myeloid Leukemia", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "acute myeloid leukaemia", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:9119", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Leukemia, Myelocytic, acute", 
                    "id": "DOID:9119"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections.", 
                    "name": "acute myeloid leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, acute myeloid; AML", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "AML", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute granulocytic leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hematopoeitic - acute Myleogenous leukemia (AML)", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute myelocytic leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute Nonlymphocytic leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute myeloid leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute nonlymphocytic leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute myelogenous leukemias", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "myeloid leukemia, acute", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, acute myelogenous", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, acute myeloid, susceptibility to", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute myeloid leukemia (AML)", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute myeloblastic leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute non lymphoblastic leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "ANLL", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "acute myelogenous leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, myelocytic, acute", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "leukemia, acute myeloid", 
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                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0018874", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "AML - acute myeloid leukemia", 
                    "id": "MONDO:0018874"
                }, 
                {
                    "url": "https://www.omim.org/entry/601626", 
                    "resource": "MIM", 
                    "description": "Leukemia, acute myelogenous", 
                    "name": "Leukemia, acute myelogenous", 
                    "id": "MIM:601626"
                }
            ], 
            "recommended_name": {
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                "resource": "Disease Ontology", 
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                "name": "acute myeloid leukemia", 
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            }, 
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                    "url": "https://www.alliancegenome.org/gene/9119#disease-associations", 
                    "id": "9119", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:9286", 
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                {
                    "url": "http://disease-ontology.org/term/DOID:9286", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Mentulagra", 
                    "id": "DOID:9286"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:9286", 
                "resource": "Disease Ontology", 
                "description": "A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.", 
                "name": "priapism", 
                "id": "DOID:9286"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/9286#disease-associations", 
                    "id": "9286", 
                    "database": "Alliance of Genome Resources"
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    "phosphorylation": [], 
    "mass": {
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        "chemical_mass": 53902.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1", 
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                "strand": "-", 
                "start_pos": 60743328, 
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                        "id": "ENSRNOG00000006304", 
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    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.3.2.27"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC1", 
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            "resource": "RefSeq", 
            "name": "E3 ubiquitin-protein ligase Mdm2 isoform X2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "E3 ubiquitin-protein ligase Mdm2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC1#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "E3 ubiquitin-protein ligase Mdm2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "double minute 2; Mdm2 p53 binding protein homolog; p53 E3 ubiquitin protein ligase; MDM2 oncogene, E3 ubiquitin protein ligase; MDM2 proto-oncogene, E3 ubiquitin protein ligase; transformed mouse 3T3 cell double minute 2"
        }
    ]
}