{
    "uniprot_canonical_ac": "A0A0G2JSV6-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0G2JSV6-1|A0A0G2JSV6_RAT Isoform 1 of Globin c2  OS=Rattus norvegicus OX=10116 GN=Hba-a2 PE=1 SV=1 CANONICAL=A0A0G2JSV6-1", 
        "length": 142, 
        "sequence": "MVLSAADKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR"
    }, 
    "uniprot_id": "", 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                    "id": "A0A0G2JSV6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "reaction_enzymes": [], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20458337", 
                    "type": "PubMed", 
                    "id": "20458337"
                }
            ], 
            "title": "MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.", 
            "journal": "Immunology and cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21805676", 
                    "type": "PubMed", 
                    "id": "21805676"
                }
            ], 
            "title": "Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection.", 
            "journal": "Proteomics. Clinical applications", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Fornander L, Ghafouri B, Kihlstrom E, Akerlind B, Schon T, Tagesson C, Lindahl M", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22516433", 
                    "type": "PubMed", 
                    "id": "22516433"
                }
            ], 
            "title": "Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.", 
            "journal": "Journal of proteomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23012479", 
                    "type": "PubMed", 
                    "id": "23012479"
                }
            ], 
            "title": "Impact of lactobacilli on orally acquired listeriosis.", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/4044827", 
                    "type": "PubMed", 
                    "id": "4044827"
                }
            ], 
            "title": "Compensatory increase in alpha 1-globin gene expression in individuals heterozygous for the alpha-thalassemia-2 deletion.", 
            "journal": "The Journal of clinical investigation", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Liebhaber SA, Cash FE, Main DM", 
            "date": "1985"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/6490612", 
                    "type": "PubMed", 
                    "id": "6490612"
                }
            ], 
            "title": "Initiation codon mutation as a cause of alpha thalassemia.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Pirastu M, Saglio G, Chang JC, Cao A, Kan YW", 
            "date": "1984"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8706699", 
                    "type": "PubMed", 
                    "id": "8706699"
                }
            ], 
            "title": "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.", 
            "journal": "European journal of biochemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
                    "id": "NP_001007723.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A", 
            "date": "1996"
        }
    ], 
    "uniprot_ac": "A0A0G2JSV6", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Glnc2; Glnc3; Hba-a1; Hba1; Hba2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Glnc2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Hba-a2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Hba-a2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Hba2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_34342"
        }
    ], 
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    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6#A0A0G2JSV6-1", 
            "isoform_ac": "A0A0G2JSV6-1", 
            "locus": {
                "end_pos": 15589449, 
                "strand": "+", 
                "start_pos": 15590174, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000048977", 
                        "id": "ENSRNOT00000048977", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000044081", 
                        "id": "ENSRNOP00000044081", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JSV6-1|A0A0G2JSV6_RAT Isoform 1 of Globin c2  OS=Rattus norvegicus OX=10116 GN=Hba-a2 PE=1 SV=1 CANONICAL=A0A0G2JSV6-1", 
                "length": 142, 
                "sequence": "MVLSAADKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360504", 
            "resource": "KEGG Pathway", 
            "id": "rno:360504", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1237044", 
            "description": "Erythrocytes take up carbon dioxide and release oxygen", 
            "resource": "Reactome", 
            "id": "R-RNO-1237044", 
            "name": "Erythrocytes take up carbon dioxide and release oxygen"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1247673", 
            "description": "Erythrocytes take up oxygen and release carbon dioxide", 
            "resource": "Reactome", 
            "id": "R-RNO-1247673", 
            "name": "Erythrocytes take up oxygen and release carbon dioxide"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2168880", 
            "description": "Scavenging of heme from plasma", 
            "resource": "Reactome", 
            "id": "R-RNO-2168880", 
            "name": "Scavenging of heme from plasma"
        }
    ], 
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        {
            "uniprot_canonical_ac": "P01946-1", 
            "protein_name": "Hemoglobin subunit alpha-1/2", 
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                "length": 142, 
                "sequence": "MVLSADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/133979", 
                    "id": "133979", 
                    "database": "MGI"
                }
            ], 
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            "organism": "Rattus norvegicus", 
            "gene_name": "Hba1", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
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        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
        "ac": "NP_001007723.1", 
        "name": "hemoglobin alpha, adult chain 2", 
        "summary": ""
    }, 
    "go_annotation": {
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            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043177", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "organic acid binding", 
                        "id": "GO:0043177"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
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                        "id": "GO:0020037"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oxygen binding", 
                        "id": "GO:0019825"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oxygen carrier activity", 
                        "id": "GO:0005344"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "iron ion binding", 
                        "id": "GO:0005506"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
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                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
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                        "id": "GO:0005833"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031838", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "haptoglobin-hemoglobin complex", 
                        "id": "GO:0031838"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosolic small ribosomal subunit", 
                        "id": "GO:0022627"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032355", 
                        "pmid": "20534718", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to estradiol", 
                        "id": "GO:0032355"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "in utero embryonic development", 
                        "id": "GO:0001701"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to bacterium", 
                        "id": "GO:0009617"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042542", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "response to hydrogen peroxide", 
                        "id": "GO:0042542"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010942", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cell death", 
                        "id": "GO:0010942"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "hydrogen peroxide catabolic process", 
                        "id": "GO:0042744"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "erythrocyte development", 
                        "id": "GO:0048821"
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                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098869", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
                                "id": "A0A0G2JSV6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular oxidant detoxification", 
                        "id": "GO:0098869"
                    }
                ], 
                "total": 8, 
                "name": "Biological Process"
            }
        ]
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    "pro_annotation": [], 
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            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000047321", 
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            "database": "Bgee"
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            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08927", 
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            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012292", 
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            "url": "https://omabrowser.org/oma/group/FHHFDLS/", 
            "id": "FHHFDLS", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1398217at2759", 
            "id": "1398217at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00042", 
            "id": "PF00042", 
            "database": "Pfam"
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        {
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            "id": "R-RNO-1237044", 
            "database": "Reactome"
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            "database": "Reactome"
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            "id": "R-RNO-2168880", 
            "database": "Reactome"
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        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723", 
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            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723.1", 
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            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359364", 
            "id": "1359364", 
            "database": "RGD"
        }, 
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            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
            "id": "A0A0G2JSV6", 
            "database": "UniProtKB"
        }, 
        {
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            "id": "A0A0G2JSV6-1", 
            "database": "UniProtKB"
        }
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    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
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            "disease_id": "DOID:0110031", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:0110031", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "alpha thalassemia, haemoglobin H type", 
                    "id": "DOID:0110031"
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                {
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                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "alpha thalassemia, hemoglobin H type", 
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                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0110031", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "HBH", 
                    "id": "DOID:0110031"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0110031", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "alpha-thalassemia intermedia", 
                    "id": "DOID:0110031"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0110031", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "hemoglobin H disease, deletional", 
                    "id": "DOID:0110031"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0110031", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "haemoglobin H disease, deletional", 
                    "id": "DOID:0110031"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0110031", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "haemoglobin H disease", 
                    "id": "DOID:0110031"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "Hemoglobin H (HbH) disease is a moderate to severe form of alpha-thalassemia (see this term) characterized by pronounced microcytic hypochromic hemolytic anemia.", 
                    "name": "hemoglobin H disease", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "alpha thalassemia, hemoglobin H type", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Alpha-thalassemia, Hemoglobin H type", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "HbH", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hemoglobin H disease", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "HbH disease", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Alpha-thalassemia intermedia", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "alpha-thalassemia intermedia", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Hemoglobin H disease, Nondeletional", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Hemoglobin H disease, Deletional", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "HEMOGLOBIN H disease; HbH", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0013512", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "hemoglobin H disease, deletional", 
                    "id": "MONDO:0013512"
                }, 
                {
                    "url": "https://www.omim.org/entry/613978", 
                    "resource": "MIM", 
                    "description": "Hemoglobin H disease", 
                    "name": "Hemoglobin H disease", 
                    "id": "MIM:613978"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:0110031", 
                "resource": "Disease Ontology", 
                "description": "An alpha thalassemia that has_material_basis_in contiguous gene deletion of the hemoglobin alpha-1 (HBA1) and alpha-2 (HBA2) genes on one chromosome 16, and a defect, deletional or nondeletional, in either HBA1 or HBA2 on the other.", 
                "name": "hemoglobin H disease", 
                "id": "DOID:0110031"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0110031#disease-associations", 
                    "id": "0110031", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:0111363", 
            "synonyms": [
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007705", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Heinz body anemia", 
                    "id": "MONDO:0007705"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0007705", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Heinz body anemias", 
                    "id": "MONDO:0007705"
                }, 
                {
                    "url": "https://www.omim.org/entry/140700", 
                    "resource": "MIM", 
                    "description": "Heinz body anemias", 
                    "name": "Heinz body anemias", 
                    "id": "MIM:140700"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:0111363", 
                "resource": "Disease Ontology", 
                "description": "A congenital nonspherocytic hemolytic anemia characterized by nonspherocytic hemolytic anemia of Dacie type I with Heinz bodies seen in erythrocytes after splenectomy that has_material_basis_in heterozygous mutation in HBA1, HBA2 or HBB on chromosome 11p15.4, 16p13.3, and 16p13.3, respectively.", 
                "name": "Heinz body anemia", 
                "id": "DOID:0111363"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0111363#disease-associations", 
                    "id": "0111363", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:0111631", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:0111631", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "ECYT7", 
                    "id": "DOID:0111631"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0111631", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "alpha-globin type erythrocytosis", 
                    "id": "DOID:0111631"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:0111631", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "alpha-globin type polycythemia", 
                    "id": "DOID:0111631"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0054802", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "erythrocytosis, familial, 7", 
                    "id": "MONDO:0054802"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0054802", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "erythrocytosis, Alpha-globin type", 
                    "id": "MONDO:0054802"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0054802", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "polycythemia, Alpha-globin type", 
                    "id": "MONDO:0054802"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0054802", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "ECYT7", 
                    "id": "MONDO:0054802"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0054802", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "erythrocytosis, FAMILIAL, 7; ECYT7", 
                    "id": "MONDO:0054802"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:0111631", 
                "resource": "Disease Ontology", 
                "description": "A primary polycythemia characterized by high oxygen affinity hemoglobin and compensatory polycythemia that has_material_basis_in heterozygous mutation in either HBA2 or HBA1 on chromosome 16p13.3.", 
                "name": "familial erythrocytosis 7", 
                "id": "DOID:0111631"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0111631#disease-associations", 
                    "id": "0111631", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:1099", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:1099", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "alpha-Thalassemia", 
                    "id": "DOID:1099"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1099", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "Alpha thalassaemia", 
                    "id": "DOID:1099"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011399", 
                    "resource": "MONDO", 
                    "description": "Alpha-thalassemia is an inherited hemoglobinopathy characterized by impaired synthesis of alpha-globin chains leading to a variable clinical picture depending on the number of affected alleles.", 
                    "name": "alpha thalassemia", 
                    "id": "MONDO:0011399"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011399", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "alpha-thalassemia", 
                    "id": "MONDO:0011399"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011399", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "A-thalassemia", 
                    "id": "MONDO:0011399"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011399", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "Alpha thalassaemia", 
                    "id": "MONDO:0011399"
                }, 
                {
                    "url": "https://www.omim.org/entry/604131", 
                    "resource": "MIM", 
                    "description": "Alpha-thalassemia", 
                    "name": "Alpha-thalassemia", 
                    "id": "MIM:604131"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:1099", 
                "resource": "Disease Ontology", 
                "description": "Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes.", 
                "name": "alpha thalassemia", 
                "id": "DOID:1099"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1099#disease-associations", 
                    "id": "1099", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 15285.0, 
        "chemical_mass": 15285.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6", 
            "name": "Hba-a2", 
            "locus": {
                "end_pos": 15589364, 
                "strand": "-", 
                "start_pos": 15590220, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000047321", 
                        "id": "ENSRNOG00000047321", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "2-alpha-1 globin; 2-alpha globin; hemoglobin alpha 2 chain; globin c2; globin c3; Hemoglobin subunit alpha-1/2; Alpha-1/2-globin; Hemoglobin alpha-1/2 chain; hemoglobin, alpha 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Globin c2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Hemoglobin alpha, adult chain 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JSV6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RCG34342, isoform CRA_a"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JSV6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "hemoglobin alpha, adult chain 2"
        }
    ]
}