{
    "record_id": "pmid.10409727", 
    "title": "Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.", 
    "mutagenesis": [
        {
            "sequence_org": "S", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/P03372", 
                    "id": "P03372", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14764652", 
                    "id": "14764652", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10409727", 
                    "id": "10409727", 
                    "database": "PubMed"
                }
            ], 
            "sequence_mut": "A", 
            "start_pos": 118, 
            "end_pos": 118, 
            "annotation": "Decreases phosphorylation and transactivation activity. Abolishes AF-1 transactivation. Insensitive to PPP5C inhibition of transactivation activity."
        }, 
        {
            "sequence_org": "S", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/P03372", 
                    "id": "P03372", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14764652", 
                    "id": "14764652", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10409727", 
                    "id": "10409727", 
                    "database": "PubMed"
                }
            ], 
            "sequence_mut": "E", 
            "start_pos": 118, 
            "end_pos": 118, 
            "annotation": "Enhances transactivation activity. Enhances interaction with DDX5. Insensitive to PPP5C inhibition of transactivation activity."
        }
    ], 
    "journal": "Mol. Cell. Biol.", 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "kinase_gene_name": "MAPK1", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10409727", 
                    "id": "10409727", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12093745", 
                    "id": "12093745", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9528769", 
                    "id": "9528769", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/7491495", 
                    "id": "7491495", 
                    "database": "PubMed"
                }, 
                {
                    "url": "http://phospho.elm.eu.org/byAccession/P03372.html", 
                    "id": "P03372", 
                    "database": "phospho.ELM"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15059947", 
                    "id": "15059947", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12466266", 
                    "id": "12466266", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17615152", 
                    "id": "17615152", 
                    "database": "PubMed"
                }
            ], 
            "start_pos": 118, 
            "end_pos": 118, 
            "kinase_uniprot_canonical_ac": "P28482-1"
        }
    ], 
    "referenced_glycans": [], 
    "authors": "Maruyama K., Kobayashi Y., Hashimoto S., Kato S., Goto M., Endoh H., Yanagisawa J., Masuhiro Y., Metzger D., Tai H.", 
    "date": "1999", 
    "referenced_proteins": [
        "P03372-1", 
        "P17844-1"
    ], 
    "abstract": ""
}