{ "uniprot_canonical_ac": "A5H2Z9-1", "ptm_annotation": [], "sequence": { "header": "tr|A5H2Z9-1|A5H2Z9_RAT Isoform 1 of Toll-like receptor 7 OS=Rattus norvegicus OX=10116 GN=Tlr7 PE=2 SV=1 CANONICAL=A5H2Z9-1", "length": 1050, "sequence": "MVFPMWTLKRQSFIFLNMILVSRVLGFRWYPKTLPCDVSLDSTNTHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFHRLKHLEELDLRCNCVPILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQDLPSSLQLLSLEANNIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTILPPNLLELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYFRYDEYARSCRFKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGNAIGQTLNGSELQPLRELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNSHYFQAEGITHMLNFTKKLRHLEKLMMNDNDISTSASRTMESESLRVLEFRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDEKVDVIILIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNALTTDNHVAYSQMFKETV" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008144", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "drug binding", "id": "GO:0008144" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038187", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "pattern recognition receptor activity", "id": "GO:0038187" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "transmembrane signaling receptor activity", "id": "GO:0004888" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "double-stranded RNA binding", "id": "GO:0003725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "single-stranded RNA binding", "id": "GO:0003727" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035197", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "siRNA binding", "id": "GO:0035197" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "receptor complex", "id": "GO:0043235" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "lysosome", "id": "GO:0005764" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032009", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "early phagosome", "id": "GO:0032009" } ], "total": 9, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001774", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "microglial cell activation", "id": "GO:0001774" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "immune response", "id": "GO:0006955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "I-kappaB kinase/NF-kappaB signaling", "id": "GO:0007249" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "toll-like receptor signaling pathway", "id": "GO:0002224" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032727", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-alpha production", "id": "GO:0032727" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "defense response to virus", "id": "GO:0051607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of NIK/NF-kappaB signaling", "id": "GO:1901224" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032722", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of chemokine production", "id": "GO:0032722" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-6 production", "id": "GO:0032755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-gamma production", "id": "GO:0032729" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "cellular response to mechanical stimulus", "id": "GO:0071260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032757", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-8 production", "id": "GO:0032757" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001932", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "regulation of protein phosphorylation", "id": "GO:0001932" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007252", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "I-kappaB phosphorylation", "id": "GO:0007252" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034154", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "toll-like receptor 7 signaling pathway", "id": "GO:0034154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002755", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "MyD88-dependent toll-like receptor signaling pathway", "id": "GO:0002755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-beta production", "id": "GO:0032728" } ], "total": 18, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12781911", "type": "PubMed", "id": "12781911" } ], "title": "Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections.", "journal": "Neuroscience letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Bottcher T, von Mering M, Ebert S, Meyding-Lamade U, Kuhnt U, Gerber J, Nau R", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14976261", "type": "PubMed", "id": "14976261" } ], "title": "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14976262", "type": "PubMed", "id": "14976262" } ], "title": "Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15723075", "type": "PubMed", "id": "15723075" } ], "title": "Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.", "journal": "Nature medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16111635", "type": "PubMed", "id": "16111635" } ], "title": "Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.", "journal": "Immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Kariko K, Buckstein M, Ni H, Weissman D", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25384124", "type": "PubMed", "id": "25384124" } ], "title": "Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats.", "journal": "Laboratory investigation; a journal of technical methods and pathology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Okazaki S, Nagoya S, Matsumoto H, Mizuo K, Sasaki M, Watanabe S, Yamashita T, Inoue H", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26363072", "type": "PubMed", "id": "26363072" } ], "title": "Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Feng Y, Chen H, Cai J, Zou L, Yan D, Xu G, Li D, Chao W", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26434622", "type": "PubMed", "id": "26434622" } ], "title": "The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons.", "journal": "Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Helley MP, Abate W, Jackson SK, Bennett JH, Thompson SW", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28665028", "type": "PubMed", "id": "28665028" } ], "title": "Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.", "journal": "Aging cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Lee EK, Chung KW, Kim YR, Ha S, Kim SD, Kim DH, Jung KJ, Lee B, Im E, Yu BP, Chung HY", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31647818", "type": "PubMed", "id": "31647818" } ], "title": "Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Alshammari TK, Alghamdi H, Green TA, Niazy A, Alkahdar L, Alrasheed N, Alhosaini K, Alswayyed M, Elango R, Laezza F, Alshammari MA, Yacoub H", "date": "2019" } ], "uniprot_ac": "A5H2Z9", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A5H2Z9", "type": "synonym", "resource": "RefSeq", "name": "RGD1563357" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5H2Z9", "type": "synonym", "resource": "RefSeq", "name": "Tlr7" }, { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "type": "recommended", "resource": "UniProtKB", "name": "Tlr7" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9#A5H2Z9-1", "isoform_ac": "A5H2Z9-1", "locus": { "end_pos": 28487420, "strand": "-", "start_pos": 28512039, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000005620", "id": "ENSRNOT00000005620", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000005620", "id": "ENSRNOP00000005620", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A5H2Z9-1|A5H2Z9_RAT Isoform 1 of Toll-like receptor 7 OS=Rattus norvegicus OX=10116 GN=Tlr7 PE=2 SV=1 CANONICAL=A5H2Z9-1", "length": 1050, "sequence": "MVFPMWTLKRQSFIFLNMILVSRVLGFRWYPKTLPCDVSLDSTNTHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFHRLKHLEELDLRCNCVPILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQDLPSSLQLLSLEANNIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTILPPNLLELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYFRYDEYARSCRFKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGNAIGQTLNGSELQPLRELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNSHYFQAEGITHMLNFTKKLRHLEKLMMNDNDISTSASRTMESESLRVLEFRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDEKVDVIILIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNALTTDNHVAYSQMFKETV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:317468", "resource": "KEGG Pathway", "id": "rno:317468", "name": "" }, { "reaction_list": [ "R-RNO-1678920", "R-RNO-1678921", "R-RNO-1678923", "R-RNO-1678944", "R-RNO-1678981", "R-RNO-1678998" ], "resource": "Reactome", "description": "Trafficking and processing of endosomal TLR", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", "id": "R-RNO-1679131", "name": "Trafficking and processing of endosomal TLR" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via MyD88-TLR7 signaling.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Evaluated (1) the incidence of ONFH in rats after the administration of TLR7 or TLR9 ligands together with methylprednisolone (MPSL) and (2) whether transcription factors contribute to the development of ONFH", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Fluoxetine treatment reversed depressive-like behaviour and molecularly modulated the expression of TLR7, suggesting that fluoxetine exerts antidepressant effects partially by modulating the TLR7 signaling pathway. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "This is the first quantitative description of toll-like receptors 4 and 7 expression within adult mammalian sensory ganglia in relation to functional neuronal phenotype.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P58681-1", "protein_name": "Toll-like receptor 7", "sequence": { "length": 1050, "sequence": "MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/75060", "id": "75060", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Tlr7", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9NYK1-1", "protein_name": "Toll-like receptor 7", "sequence": { "length": 1049, "sequence": "MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/75060", "id": "75060", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TLR7", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "ac": "NP_001091051.1", "name": "toll-like receptor 7", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 169, "annotation": "n_glycosylation_sequon", "start_pos": 167 }, { "end_pos": 192, "annotation": "n_glycosylation_sequon", "start_pos": 190 }, { "end_pos": 217, "annotation": "n_glycosylation_sequon", "start_pos": 215 }, { "end_pos": 277, "annotation": "n_glycosylation_sequon", "start_pos": 275 }, { "end_pos": 314, "annotation": "n_glycosylation_sequon", "start_pos": 312 }, { "end_pos": 397, "annotation": "n_glycosylation_sequon", "start_pos": 395 }, { "end_pos": 526, "annotation": "n_glycosylation_sequon", "start_pos": 524 }, { "end_pos": 537, "annotation": "n_glycosylation_sequon", "start_pos": 535 }, { "end_pos": 593, "annotation": "n_glycosylation_sequon", "start_pos": 591 }, { "end_pos": 68, "annotation": "n_glycosylation_sequon", "start_pos": 66 }, { "end_pos": 679, "annotation": "n_glycosylation_sequon", "start_pos": 677 }, { "end_pos": 71, "annotation": "n_glycosylation_sequon", "start_pos": 69 }, { "end_pos": 723, "annotation": "n_glycosylation_sequon", "start_pos": 721 }, { "end_pos": 802, "annotation": "n_glycosylation_sequon", "start_pos": 800 }, { "end_pos": 945, "annotation": "n_glycosylation_sequon", "start_pos": 943 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004249", "id": "ENSRNOG00000004249", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4105914", "id": "CHEMBL4105914", "database": "ChEMBL" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/317468", "id": "317468", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "id": "IPR000157", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "id": "IPR000483", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "id": "IPR003591", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026880", "id": "IPR026880", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "id": "IPR035897", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041283", "id": "IPR041283", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:317468", "id": 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"https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563357", "id": "1563357", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A5H2Z9-1", "id": "A5H2Z9-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "disease_id": "DOID:1273", "synonyms": [], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:1273", "resource": "Disease Ontology", "description": "A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.", "name": "respiratory syncytial virus infectious disease", "id": "DOID:1273" }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/1273#disease-associations", "id": "1273", "database": "Alliance of Genome Resources" } ] }, { "disease_id": "DOID:612", "synonyms": [ { "url": "http://disease-ontology.org/term/DOID:612", "resource": "Disease Ontology", "description": "", "name": "immune deficiency disorder", "id": "DOID:612" }, { "url": "http://disease-ontology.org/term/DOID:612", "resource": "Disease Ontology", "description": "", "name": "hypoimmunity", "id": "DOID:612" }, { "url": "http://disease-ontology.org/term/DOID:612", "resource": "Disease Ontology", "description": "", "name": "immunodeficiency syndrome", "id": "DOID:612" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010421", "resource": "MONDO", "description": "X-linked 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"id": "MONDO:0012836" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "An instance of systemic lupus erythematosus (disease) that is caused by an inherited modification of the individual's genome.", "name": "autosomal systemic lupus erythematosus", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "hereditary systemic lupus erythematosus (disease)", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "familial systemic lupus erythematosus", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "familial SLE", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "autosomal SLE", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus 16; SLEB16", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "SLEB16", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus type 16", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013743", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus 16", "id": "MONDO:0013743" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010433", "resource": "MONDO", "description": "", "name": "SLEB15", "id": "MONDO:0010433" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010433", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 15", "id": "MONDO:0010433" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010433", "resource": "MONDO", "description": "", "name": "SLEB15", "id": "MONDO:0010433" }, { "url": "https://monarchinitiative.org/disease/MONDO:0010433", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 15; SLEB15", "id": "MONDO:0010433" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.", "name": "systemic lupus erythematosus (disease)", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "Excess LMW-DNA", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "lupus erythematosus, systemic", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "SLE - lupus erythematosus, systemic", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "disseminated lupus erythematosus", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus; SLE", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "SLE", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007915", "resource": "MONDO", "description": "", "name": "Excess lymphocyte Low molecular weight DNA", "id": "MONDO:0007915" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012036", "resource": "MONDO", "description": "", "name": "SLEB4", "id": "MONDO:0012036" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012036", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 4", "id": "MONDO:0012036" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012036", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 4; SLEB4", "id": "MONDO:0012036" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012036", "resource": "MONDO", "description": "", "name": "SLEB4", "id": "MONDO:0012036" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012369", "resource": "MONDO", "description": "", "name": "SLEB6", "id": "MONDO:0012369" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012369", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 6", "id": "MONDO:0012369" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012369", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 6; SLEB6", "id": "MONDO:0012369" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012369", "resource": "MONDO", "description": "", "name": "SLEB6", "id": "MONDO:0012369" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012884", "resource": "MONDO", "description": "", "name": "SLEB13", "id": "MONDO:0012884" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012884", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 13", "id": "MONDO:0012884" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012884", "resource": "MONDO", "description": "", "name": "SLEB13", "id": "MONDO:0012884" }, { "url": "https://monarchinitiative.org/disease/MONDO:0012884", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 13; SLEB13", "id": "MONDO:0012884" }, { "url": "https://monarchinitiative.org/disease/MONDO:0011560", "resource": "MONDO", "description": "", "name": "SLEB3", "id": "MONDO:0011560" }, { "url": "https://monarchinitiative.org/disease/MONDO:0011560", "resource": "MONDO", "description": "", "name": "SLEB3", "id": "MONDO:0011560" }, { "url": "https://monarchinitiative.org/disease/MONDO:0011560", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 3; SLEB3", "id": "MONDO:0011560" }, { "url": "https://monarchinitiative.org/disease/MONDO:0011560", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 3", "id": "MONDO:0011560" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013152", "resource": "MONDO", "description": "", "name": "SLEB14", "id": "MONDO:0013152" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013152", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 14", "id": "MONDO:0013152" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013152", "resource": "MONDO", "description": "", "name": "SLEB14", "id": "MONDO:0013152" }, { "url": "https://monarchinitiative.org/disease/MONDO:0013152", "resource": "MONDO", "description": "", "name": "systemic lupus erythematosus, susceptibility to, 14; SLEB14", "id": "MONDO:0013152" }, { "url": "https://www.omim.org/entry/614420", "resource": "MIM", "description": "Systemic lupus erythematosus 16", "name": "Systemic lupus erythematosus 16", "id": "MIM:614420" }, { "url": "https://www.omim.org/entry/152700", "resource": "MIM", "description": "Systemic lupus erythematosus", "name": "Systemic lupus erythematosus", "id": "MIM:152700" }, { "url": "https://www.omim.org/entry/609939", "resource": "MIM", "description": "Systemic lupus erythematosus 6", "name": "Systemic lupus erythematosus 6", "id": "MIM:609939" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:9074", "resource": "Disease Ontology", "description": "A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.", "name": "systemic lupus erythematosus", "id": "DOID:9074" }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/9074#disease-associations", "id": "9074", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 121300.0, "chemical_mass": 121300.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "name": "Tlr7", "locus": { "end_pos": 28512957, "strand": "+", "start_pos": 28486869, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004249", "id": "ENSRNOG00000004249", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Toll-like receptor 7" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5H2Z9", "type": "synonym", "resource": "RefSeq", "name": "toll-like receptor 7" } ] }