{ "uniprot_canonical_ac": "A4L9P8-1", "ptm_annotation": [], "sequence": { "header": "sp|A4L9P8-1|CE295_RAT Isoform 1 of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=2 SV=2 CANONICAL=A4L9P8-1", "length": 2395, "sequence": "MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTSSSLSHLKEAVSGDETAKRNRSQCI" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "microtubule binding", "id": "GO:0008017" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990498", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "mitotic spindle microtubule", "id": "GO:1990498" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901985", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "positive regulation of protein acetylation", "id": "GO:1901985" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904951", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "positive regulation of establishment of protein localization", "id": "GO:1904951" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903724", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "positive regulation of centriole elongation", "id": "GO:1903724" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046599", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "regulation of centriole replication", "id": "GO:0046599" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "centriole replication", "id": "GO:0007099" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010825", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "name": "positive regulation of centrosome duplication", "id": "GO:0010825" } ], "total": 6, "name": "Biological Process" } ] }, "publication": [], "uniprot_ac": "A4L9P8", "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "type": "recommended", "resource": "UniProtKB", "name": "Cep295" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8#A0A0G2K417-1", "isoform_ac": "A0A0G2K417-1", "locus": { "end_pos": 13871415, "strand": "+", "start_pos": 13906355, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000078372", "id": "ENSRNOT00000078372", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072866", "id": "ENSRNOP00000072866", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K417-1|A0A0G2K417_RAT Computationally mapped isoform of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=4 SV=1 CANONICAL=A4L9P8-1", "length": 2342, "sequence": "MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHSLPALFLPKEIEHPFIPLPFAETKSKSICESYLSEKEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTKAVSGDETAKRNRSQCI" } }, { "url": "https://www.uniprot.org/uniprot/A4L9P8#A0A0G2K773-1", "isoform_ac": "A0A0G2K773-1", "locus": { "end_pos": 13871415, "strand": "+", "start_pos": 13909154, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083011", "id": "ENSRNOT00000083011", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074090", "id": "ENSRNOP00000074090", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K773-1|CE295_RAT Computationally mapped isoform of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=2 SV=1 CANONICAL=A4L9P8-1", "length": 2473, "sequence": "MTEVTRSGPWLSSRYPNGCWVTGRVQIPVCCEVRPHTLSDPLYLKYSEMKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHSLPALFLPKEIEHPFIPLPFAETKSKSICESYLSEKEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTKAVSGDETAKRNRSQCI" } }, { "url": "https://www.uniprot.org/uniprot/A4L9P8#A4L9P8-1", "isoform_ac": "A4L9P8-1", "locus": { "end_pos": 13871415, "strand": "+", "start_pos": 13906355, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000029634", "id": "ENSRNOT00000029634", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000029431", "id": "ENSRNOP00000029431", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4L9P8-1|CE295_RAT Isoform 1 of Centrosomal protein of 295 kDa OS=Rattus norvegicus OX=10116 GN=Cep295 PE=2 SV=2 CANONICAL=A4L9P8-1", "length": 2395, "sequence": "MKRKVMNGKLRLSPNEEAFILKEDYERRRKLRLLQVREQERGIAFQIREDIKQRRNQQVSHLAEELRAEWEEAQSQKIQNLEKLYLASLRHMGDGHQQAKENEPDLDALSRRAAERKTKAEARHKEALKAQKKQKEMLMKQKTRHIKARKEAVLVEKERSAKMARLPPPVPSPFENIDINRIPSLKTNRSTYHHISAFVSRQMGTKQPDAHLAAEEEARRVERLRKQAAQERMEQSERAHARGSQAMKKIHLAQNQERLMEELKQLQREDLACKRQTAAQMPSQLLELPYRRSEMKEDWQRELEFAFEDVYSADRKVKGNLILHLKPEPLPTMSDQLQDEELDLSMEQENEVPLATKTQQIPSRILLKRLLNKIRNQKSLWTIKSFSEDDNQVTASIISEIERKVPSTDSGTITTGETAVSFEQEQVMGSDRLMIESGPPSSEDKPLCYKSVTGKEQAMGVSPPATTVAQSSVLLHPQEEAARLRMSARHKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFQAQLEETRKQADHLEVRPAPVSHAMISDEERHRQMIRNYQYQLLQQNRLHKQTVETARKRLLEYQTVLKERCPSMSARSLIPDSVVSEPPQQAQKPAVASDYWDPSQRPKLSPSKYQPVQPSQIPALDQNHIQVPRQGHIPQRQGETARAKQSVESQERQWQFSQVETQQRDYEFIFKDSHSLSRTSSYVRPQTLQAAGEVSKPLRAIICQTSDSQQISSEDSENISSKPTEPSSSLPLMPECSSSSLSVKLESETIQKAFTTVNRSVISQMHGQPLSSSETGTTQQGDIRFLQGQLELQKKVLQERQEAQEKLLSCTQKELEEQTGIPVFFPSPVGNMFSSLPSASAESGNIQTSSTKSDATVSSDSMDNPYSQPISLRQTNLEFLQEQFSVEKDNLQARREAQEVSFTHTQSKLDKIVRSEQTGSSWPQLVALESFSSLTSADTQSRKIQKPPLPTNKKGLLPSQSEILSSQDGSSGFLQQTLPLQNTLKLLQEQLTIQRGMIQPRLNAQETLLLHKERCSVDSKAGPVNSLSSAVAQHSEAGPQSLQELYSSKKENTVLSSHLITPEVQEESHGSPQHSLPRQEHFASLQEQAHIQRVILGARKQIQEFAHKQNEFKKGLYSQQTGALSSPSQGTGWEISQESLSVRSDSTDPLSHFKIPGFQERLVRALQPTFPLRDNLQEHQEWVDPEKESFQFSPQTQENRSSQQTGFSSFTPSLRQPSCVSLPSVDSGITQHPLSTERDSKVTSSHLQIPELQHRLLKISQLIQPQQDSLKALQEQLATSRTIIHSRQEALEETLREWKEKIFPEQVGPFSPLMTQHSFASFPVSDIERAQELCSTNSEGAISSGYSEMLELPDRALGLSCTALPQQGNLTVHPGHLHAQTNSFHSTEKAQEKLVFPRPCKLEEISAEHSIQPPHDDLQALQQQLDVHREAIRSCQDIQEELLLQRLNKLEQRVSSKQISSSPLLSQVALPIANSEGTLQSSPAKNDDTEMLRSHSEYLNFSQPLQDNVTEQLDLEVVFHKELLLHKQKSQTKSESPEHAAPFNDAVIPRLQDRLLSYFQPALTQQDSMSPQKQLNLQREALYSRQKAQEELLVQRQTALQQQVQKHRETLKGFSNVSQTRAASGENDLEMQKTEQLTGWFPHIQGWPWGDSSQGSSSGDQPGAAAVHAEHSGESLGKELSGRASKPPVSKVKCVFDLNQHELSTIQEVESPTSGRTSMPGKAEFYRDRDPLRVSVSREQSYLGSPVAHDPFGCHQPSVQENSKSHDTAKAVKVKKSDIEDHALLSHAISEEEEEEEACTNLSPLMKPDDEVETQEISQELLSSMTVSTGSFLSYEITDLSLTDPESFSEQTEHQEQESSSKEEETGSLSCAVPSTQVTYQQQHSLGAHNSLLPTEEENASDQTHVHQIIDKDINEANLIPDKRDFQVPAVDLDFPELEHLFPHLHRQLFKPLEPHLDLDLSSPGTSQEDRDFYQQNSESSSEKHVKALSTSTLCFTALTAGSHSPNSRLNQQLDVNLAHATTEGSEQSFQQLLPEFSSQESQHTDLPSIYSIEARGTSQSMENQNYSEILQNKKKSIYFQPSTENLSPACSSSDTTLFDQLHPQHSTPCGSVSSEGSVKQLEGREEMLGFEELSRRAVPMSQRLTEDENVVLPINPYVGTVEMETSIQGSNSLSIQNEKPIQNVIKTETTKAVRNVCQLAQEEHMLKSESCPFRRPIPVWETETGYGIMEEPDLTLLSTSDISITDTDLANLTIEDNEAQCSQAGAVQPSSSVETTFCGAASEPWADQPTVASSAIPGSLGEAFMKRKKTFMERSYQRQREIWNKTPLPQAKVSKEKLSTSSSLSHLKEAVSGDETAKRNRSQCI" } } ], "pathway": [], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8#function", "annotation": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8#function", "id": "A4L9P8", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 1230, "annotation": "n_glycosylation_sequon", "start_pos": 1228 }, { "end_pos": 1400, "annotation": "n_glycosylation_sequon", "start_pos": 1398 }, { "end_pos": 1531, "annotation": "n_glycosylation_sequon", "start_pos": 1529 }, { "end_pos": 1539, "annotation": "n_glycosylation_sequon", "start_pos": 1537 }, { "end_pos": 1647, "annotation": "n_glycosylation_sequon", "start_pos": 1645 }, { "end_pos": 1832, "annotation": "n_glycosylation_sequon", "start_pos": 1830 }, { "end_pos": 190, "annotation": "n_glycosylation_sequon", "start_pos": 188 }, { "end_pos": 1930, "annotation": "n_glycosylation_sequon", "start_pos": 1928 }, { "end_pos": 2097, "annotation": "n_glycosylation_sequon", "start_pos": 2095 }, { "end_pos": 2117, "annotation": "n_glycosylation_sequon", "start_pos": 2115 }, { "end_pos": 2283, "annotation": "n_glycosylation_sequon", "start_pos": 2281 }, { "end_pos": 2356, "annotation": "n_glycosylation_sequon", "start_pos": 2354 }, { "end_pos": 2392, "annotation": "n_glycosylation_sequon", "start_pos": 2390 }, { "end_pos": 749, "annotation": "n_glycosylation_sequon", "start_pos": 747 }, { "end_pos": 789, "annotation": "n_glycosylation_sequon", "start_pos": 787 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010999", "id": "ENSRNOG00000010999", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029560", "id": "IPR029560", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/STYHHLC/", "id": "STYHHLC", "database": "OMA" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21553:SF25", "id": "PTHR21553:SF25", "database": "PANTHER" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A4L9P8", "id": "PR_A4L9P8", "database": "PRO" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311723", "id": "1311723", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K417", "id": "A0A0G2K417", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K417-1", "id": "A0A0G2K417-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K773", "id": "A0A0G2K773", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K773-1", "id": "A0A0G2K773-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A4L9P8-1", "id": "A4L9P8-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "start_pos": 13, "end_pos": 13, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "start_pos": 1565, "end_pos": 1565, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "id": "A4L9P8", "database": "UniProtKB" } ], "start_pos": 634, "end_pos": 634, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 269982.0, "chemical_mass": 269982.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8", "name": "Cep295", "locus": { "end_pos": 13871213, "strand": "-", "start_pos": 13909188, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000010999", "id": "ENSRNOG00000010999", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A4L9P8#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Centrosomal protein of 295 kDa" } ] }