{ "uniprot_canonical_ac": "A3KFU9-1", "ptm_annotation": [], "sequence": { "header": "sp|A3KFU9-1|DISP3_MOUSE Isoform 1 of Protein dispatched homolog 3 OS=Mus musculus OX=10090 GN=Disp3 PE=2 SV=1 CANONICAL=A3KFU9-1", "length": 1347, "sequence": "MDSEDDPLLQDVWLEEEQPEDEACRGIPGPGLQSGAQGCWRRWTLPSRPPTLGFWSTLGWAFTNPCCAGLVLFLGCSIPMVLSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNHSRPASRAPRSAPRDTVATQTSAANSSERRRREAPSPEGQVTNQSRARRGASRWDYSRTYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYMAPLESSCQNSCHQKCGRKSSLHFPGDLFTAPERAGGGPAQGPLPYLDDDIPLLNVEDEPASLELGDVSLVSVHCEGLQPTPDANSRGQLLAQLQELLHHWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRTETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRKWMVTALACDARRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRLCVAPPGCLLSSSPDGPTKGFFYVPSDKVPKARISATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGLNRTQQMDNHVIGDPGSVIYDSSFDLFKEIGHLCRLCKAIAGNSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVKEGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLRQQLQTFPEGSALHRGFQTCEHWKQIFMEIIGVQSALYGLVLSLLICVAAVAVFTTHVLLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPQLSQDPSSQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPGSFTRTRTSFLKALGAVLLAGALGLGACLVLLRSGYKIPLPSGATL" }, "uniprot_id": "DISP3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "nuclear membrane", "id": "GO:0031965" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle membrane", "id": "GO:0030659" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045834", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "positive regulation of lipid metabolic process", "id": "GO:0045834" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "cholesterol metabolic process", "id": "GO:0008203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "negative regulation of neuron differentiation", "id": "GO:0045665" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000179", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "name": "positive regulation of neural precursor cell proliferation", "id": "GO:2000179" } ], "total": 4, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19179482", "type": "PubMed", "id": "19179482" } ], "title": "DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.", "journal": "Mol. Endocrinol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" } ], "authors": "Bartunek P., Bendova Z., Corlett A., Pajer P., Zikova M.", "date": "2009" } ], "uniprot_ac": "A3KFU9", "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "type": "recommended", "resource": "UniProtKB", "name": "Disp3" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa1337" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9", "type": "synonym", "resource": "UniProtKB", "name": "Ptchd2" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9#A3KFU9-1", "isoform_ac": "A3KFU9-1", "locus": {}, "sequence": { "header": "sp|A3KFU9-1|DISP3_MOUSE Isoform 1 of Protein dispatched homolog 3 OS=Mus musculus OX=10090 GN=Disp3 PE=2 SV=1 CANONICAL=A3KFU9-1", "length": 1347, "sequence": "MDSEDDPLLQDVWLEEEQPEDEACRGIPGPGLQSGAQGCWRRWTLPSRPPTLGFWSTLGWAFTNPCCAGLVLFLGCSIPMVLSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNHSRPASRAPRSAPRDTVATQTSAANSSERRRREAPSPEGQVTNQSRARRGASRWDYSRTYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYMAPLESSCQNSCHQKCGRKSSLHFPGDLFTAPERAGGGPAQGPLPYLDDDIPLLNVEDEPASLELGDVSLVSVHCEGLQPTPDANSRGQLLAQLQELLHHWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRTETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRKWMVTALACDARRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRLCVAPPGCLLSSSPDGPTKGFFYVPSDKVPKARISATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGLNRTQQMDNHVIGDPGSVIYDSSFDLFKEIGHLCRLCKAIAGNSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVKEGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLRQQLQTFPEGSALHRGFQTCEHWKQIFMEIIGVQSALYGLVLSLLICVAAVAVFTTHVLLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPQLSQDPSSQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPGSFTRTRTSFLKALGAVLLAGALGLGACLVLLRSGYKIPLPSGATL" } }, { "url": "https://www.uniprot.org/uniprot/A3KFU9#A3KFU9-2", "isoform_ac": "A3KFU9-2", "locus": {}, "sequence": { "header": "sp|A3KFU9-2|DISP3_MOUSE Isoform 2 of Protein dispatched homolog 3 OS=Mus musculus OX=10090 GN=Disp3 PE=2 SV=1 CANONICAL=A3KFU9-1", "length": 839, "sequence": "MDSEDDPLLQDVWLEEEQPEDEACRGIPGPGLQSGAQGCWRRWTLPSRPPTLGFWSTLGWAFTNPCCAGLVLFLGCSIPMVLSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNHSRPASRAPRSAPRDTVATQTSAANSSERRRREAPSPEGQVTNQSRARRGASRWDYSRTYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYMAPLESSCQNSCHQKCGRKSSLHFPGDLFTAPERAGGGPAQGPLPYLDDDIPLLNVEDEPASLELGDVSLVSVHCEGLQPTPDANSRGQLLAQLQELLHHWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRTETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQGCFRRRAPPASGW" } }, { "url": "https://www.uniprot.org/uniprot/A3KFU9#A3KFU9-3", "isoform_ac": "A3KFU9-3", "locus": {}, "sequence": { "header": "sp|A3KFU9-3|DISP3_MOUSE Isoform 3 of Protein dispatched homolog 3 OS=Mus musculus OX=10090 GN=Disp3 PE=2 SV=1 CANONICAL=A3KFU9-1", "length": 826, "sequence": "MDSEDDPLLQDVWLEEEQPEDEACRGIPGPGLQSGAQGCWRRWTLPSRPPTLGFWSTLGWAFTNPCCAGLVLFLGCSIPMVLSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNHSRPASRAPRSAPRDTVATQTSAANSSERRRREAPSPEGQVTNQSRARRGASRWDYSRTYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYMAPLESSCQNSCHQKCGRKSSLHFPGDLFTAPERAGGGPAQGPLPYLDDDIPLLNVEDEPASLELGDVSLVSVHCEGLQPTPDANSRGQLLAQLQELLHHWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRTETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQ" } }, { "url": "https://www.uniprot.org/uniprot/A3KFU9#E9QL24-1", "isoform_ac": "E9QL24-1", "locus": { "end_pos": 148241259, "strand": "+", "start_pos": 148272401, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000047720", "id": "ENSMUST00000047720", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000038490", "id": "ENSMUSP00000038490", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9QL24-1|E9QL24_MOUSE Computationally mapped isoform of Protein dispatched homolog 3 OS=Mus musculus OX=10090 GN=Disp3 PE=4 SV=1 CANONICAL=A3KFU9-1", "length": 1347, "sequence": "MDSEDDPLLQDVWLEEEQPEDEACRGIPGPGLQSGAQGCWRRWTLPSRPPTLGFWSTLGWAFTNPCCAGLVLFLGCSIPMVLSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNHSRPASRAPRSAPRDTVATQTSAANSSERRRREAPSPEGQVTNQSRARRGASRWDYSRTYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYMAPLESSCQNSCHQKCGRKSSLHFPGDLFTAPERAGGGPAQGPLPYLDDDIPLLNVEDEPASLELGDVSLVSVHCEGLQPTPDANSRGQLLAQLQELLHHWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRTETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRKWMVTALACDARRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRLCVAPPGCLLSSSPDGPTKGFFYVPSDKVPKARISATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGLNRTQQMDNHVIGDPGSVIYDSSFDLFKEIGHLCRLCKAIAGNSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVKEGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLRQQLQTFPEGSALHRGFQTCEHWKQIFMEIIGVQSALYGLVLSLLICVAAVAVFTTHVLLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPQQAEDPSSQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPGSFTRTRTSFLKALGAVLLAGALGLGACLVLLRSGYKIPLPSGATL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:242748", "resource": "KEGG Pathway", "id": "mmu:242748", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9#function", "annotation": "Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9#function", "id": "A3KFU9", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZW02-1", "protein_name": "Dispatched RND transporter family member 3", "sequence": { "length": 1351, "sequence": "MDSEDDPLLQDVWLEEEQQEEETSDEACRAVPGPGLHSGAQGCWRRWTLPSRPPTLGFWSTLGWAFTNPCCAGLVLFLGCSIPMVLSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNHSRPASRAPRSDPRDTAATQRSATNTRERRRREAPPPEGQVANQSRARRGASRWDYSRTYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSVDNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTIQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVTCCWLAVLFTMPAALGLWSLYVAPLESSCQSSCHQKCGRKSSLHFPGDLFTAPERAGCGPAQGPLPYLDDDIPLLNVEDEPVSLELGDVSLVSVHCEGLQPTPDGNSRGQLLAQLQELLHRWVLWAAVKSRWVIVGLFASILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNVRTSLEKKKRGSGVSWASRPETTAQESMSTVYISKVKSKGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGDFTKKLTACMSTVGLLQAASPSRKWMVTALACDARRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRLCVAPPGCLLSSSPDGPTKGFFYVPSDRVPKARISATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGINRTQQMDNHVIGDPGSVIYDSSFDLFKEIGHLCRLCKAIAGNSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVKEGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLRQQLQTFPEGSALRRGFQTCEHWKQIFMEIIGVQSALYGLVLSLLICVAAVAVFTTHVLLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPQQAEDASSQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPGSFTRTRTSFLKALGAVLLAGALGLGTCLVLLRSGYKIPLPSGATL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/25712", "id": "25712", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Disp3", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9P2K9-1", "protein_name": "Protein dispatched homolog 3", "sequence": { "length": 1392, "sequence": "MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGFWSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQSGYKIPLPAGASL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/25712", "id": "25712", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "DISP3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076811.1", "ac": "NP_001076811.1", "name": "protein dispatched homolog 3", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 159, "annotation": "n_glycosylation_sequon", "start_pos": 157 }, { "end_pos": 184, "annotation": "n_glycosylation_sequon", "start_pos": 182 }, { "end_pos": 202, "annotation": "n_glycosylation_sequon", "start_pos": 200 }, { "end_pos": 732, "annotation": "n_glycosylation_sequon", "start_pos": 730 }, { "end_pos": 807, "annotation": "n_glycosylation_sequon", "start_pos": 805 }, { "end_pos": 978, "annotation": "n_glycosylation_sequon", "start_pos": 976 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041544", "id": "ENSMUSG00000041544", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/242748", "id": "242748", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", "id": "IPR000731", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003392", "id": "IPR003392", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042480", "id": "IPR042480", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:242748", "id": "mmu:242748", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2444403", "id": "2444403", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/EMGHLCK/", "id": "EMGHLCK", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=56949at2759", "id": "56949at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46687", "id": "PTHR46687", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02460", "id": "PF02460", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A3KFU9", "id": "PR_A3KFU9", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076811", "id": "NP_001076811", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076811.1", "id": "NP_001076811.1", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011248557", "id": "XP_011248557", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011248557.1", "id": "XP_011248557.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9", "id": "A3KFU9", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9-1", "id": "A3KFU9-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9-2", "id": "A3KFU9-2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9-3", "id": "A3KFU9-3", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/E9QL24", "id": "E9QL24", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/E9QL24-1", "id": "E9QL24-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 157, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9#ptm_processing", "id": "A3KFU9", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 157, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 976, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9#ptm_processing", "id": "A3KFU9", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 976, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 148446.0, "chemical_mass": 148446.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9", "name": "Disp3", "locus": { "end_pos": 148240264, "strand": "-", "start_pos": 148287965, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000041544", "id": "ENSMUSG00000041544", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A3KFU9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Patched domain-containing protein 2" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Protein dispatched homolog 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFU9", "type": "synonym", "resource": "RefSeq", "name": "RND-type protein RNDEu-2; patched domain-containing protein 2" }, { "url": "https://www.uniprot.org/uniprot/A3KFU9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RND-type protein RNDEu-2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KFU9", "type": "synonym", "resource": "RefSeq", "name": "protein dispatched homolog 3" } ] }