{ "uniprot_canonical_ac": "A2RRU4-1", "ptm_annotation": [ { "annotation": "Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP-SREBP complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBF2/SREBP2.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q6GQT6", "id": "Q6GQT6", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2RRU4-1|SCAP_RAT Isoform 1 of Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1 CANONICAL=A2RRU4-1", "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "pmid": "19158095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "protein-containing complex binding", "id": "GO:0044877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032934", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "sterol binding", "id": "GO:0032934" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "19158095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "19158095", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012507", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "ER to Golgi transport vesicle membrane", "id": "GO:0012507" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007568", "pmid": "16741953", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "aging", "id": "GO:0007568" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090110", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "COPII-coated vesicle cargo loading", "id": "GO:0090110" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "immune response", "id": "GO:0006955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "cholesterol metabolic process", "id": "GO:0008203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044255", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "cellular lipid metabolic process", "id": "GO:0044255" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "response to hypoxia", "id": "GO:0001666" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019217", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of fatty acid metabolic process", "id": "GO:0019217" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042304", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of fatty acid biosynthetic process", "id": "GO:0042304" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045540", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "regulation of cholesterol biosynthetic process", "id": "GO:0045540" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045542", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "positive regulation of cholesterol biosynthetic process", "id": "GO:0045542" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "response to insulin", "id": "GO:0032868" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032933", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "name": "SREBP signaling pathway", "id": "GO:0032933" } ], "total": 12, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11358865", "type": "PubMed", "id": "11358865" } ], "title": "SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11726962", "type": "PubMed", "id": "11726962" } ], "title": "A new feature on the cholesterol-lowering landscape.", "journal": "Nature medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Rader DJ", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12242332", "type": "PubMed", "id": "12242332" } ], "title": "Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Yabe D, Brown MS, Goldstein JL", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19158095", "type": "PubMed", "id": "19158095" } ], "title": "Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM 2nd, Siddiqi SA, Park EA, Raghow R, Elam MB", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19933148", "type": "PubMed", "id": "19933148" } ], "title": "Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Osborne TF, Espenshade PJ", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20973890", "type": "PubMed", "id": "20973890" } ], "title": "Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.", "journal": "Clinical & experimental ophthalmology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Chu Q, Zhang J, Wu Y, Zhang Y, Xu G, Li W, Xu GT", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22337502", "type": "PubMed", "id": "22337502" } ], "title": "Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.", "journal": "Glia", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ], "authors": "Verdier V, Csardi G, de Preux-Charles AS, Medard JJ, Smit AB, Verheijen MH, Bergmann S, Chrast R", "date": "2012" } ], "uniprot_ac": "A2RRU4", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU4", "type": "synonym", "resource": "RefSeq", "name": "Scap" }, { "url": "https://www.uniprot.org/uniprot/A2RRU4", "type": "recommended", "resource": "UniProtKB", "name": "Scap" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#A2RRU4-1", "isoform_ac": "A2RRU4-1", "locus": { "end_pos": 118596844, "strand": "-", "start_pos": 118628485, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000028295", "id": "ENSRNOT00000028295", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000028295", "id": "ENSRNOP00000028295", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RRU4-1|SCAP_RAT Isoform 1 of Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1 CANONICAL=A2RRU4-1", "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301024", "resource": "KEGG Pathway", "id": "rno:301024", "name": "" }, { "reaction_list": [ "R-RNO-1655831", "R-RNO-1655842", "R-RNO-1655851", "R-RNO-2065539", "R-RNO-2065549", "R-RNO-2065550" ], "resource": "Reactome", "description": "Regulation of cholesterol biosynthesis by SREBP (SREBF)", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "id": "R-RNO-1655829", "name": "Regulation of cholesterol biosynthesis by SREBP (SREBF)" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#function", "annotation": "Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#function", "id": "A2RRU4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "annotation": "Insulin selectively stimulates the processing of SREBP-1c in rat hepatocytes by enhancing the association between the SCAP-SREBP-1c complex and COPII proteins and subsequent ER to Golgi transport and proteolytic cleavage.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q12770-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "sequence": { "length": 1279, "sequence": "MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRNYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPERGGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLRLNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGIVLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDGGKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2RRU4/", "id": "A2RRU4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8160", "id": "8160", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SCAP", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6GQT6-1", "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "sequence": { "length": 1276, "sequence": "MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQQAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAGPAEGVHDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRSAWAPQEPLPAGLWESGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFETQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRVGCGRSRDSGYDFSRLVQRVYQEEGLAAMRMPALRPPSPGPPLPQASQEEGTAPEKGSPPLAWTPSTAGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSSVYSSSNTVTCHRTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLDDSCCLFTLKGHSGAITAVYIDQTMVLASGGQDGAICLWDVLTGSRVSQTFAHRGDVTSLTCTASCVISSGLDDFISIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2RRU4/", "id": "A2RRU4", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8160", "id": "8160", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Scap", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "ac": "NP_001094436.1", "name": "sterol regulatory element-binding protein cleavage-activating protein", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 1025, "annotation": "n_glycosylation_sequon", "start_pos": 1023 }, { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 }, { "end_pos": 592, "annotation": "n_glycosylation_sequon", "start_pos": 590 }, { "end_pos": 643, "annotation": "n_glycosylation_sequon", "start_pos": 641 }, { "end_pos": 881, "annotation": "n_glycosylation_sequon", "start_pos": 879 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020853", "id": "ENSRNOG00000020853", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/301024", "id": "301024", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", "id": "IPR000731", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030225", "id": "IPR030225", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301024", "id": "rno:301024", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/PIVADKC/", "id": "PIVADKC", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=523786at2759", "id": "523786at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46378", "id": "PTHR46378", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12349", "id": "PF12349", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2RRU4", "id": "PR_A2RRU4", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1655829", "id": "R-RNO-1655829", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436", "id": "NP_001094436", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094436.1", "id": "NP_001094436.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309378", "id": "1309378", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2RRU4-1", "id": "A2RRU4-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 263, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing", "id": "A2RRU4", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 263, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 590, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing", "id": "A2RRU4", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 590, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 641, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#ptm_processing", "id": "A2RRU4", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 641, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "start_pos": 821, "end_pos": 821, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "start_pos": 837, "end_pos": 837, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "start_pos": 843, "end_pos": 843, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "start_pos": 850, "end_pos": 850, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "start_pos": 905, "end_pos": 905, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "id": "A2RRU4", "database": "UniProtKB" } ], "start_pos": 934, "end_pos": 934, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 139499.0, "chemical_mass": 139499.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4", "name": "Scap", "locus": { "end_pos": 118628651, "strand": "+", "start_pos": 118570503, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020853", "id": "ENSRNOG00000020853", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2RRU4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "SCAP" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU4", "type": "synonym", "resource": "RefSeq", "name": "SREBP cleavage activating protein" }, { "url": "https://www.uniprot.org/uniprot/A2RRU4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "SREBP cleavage-activating protein" }, { "url": "https://www.uniprot.org/uniprot/A2RRU4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Sterol regulatory element-binding protein cleavage-activating protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU4", "type": "synonym", "resource": "RefSeq", "name": "sterol regulatory element-binding protein cleavage-activating protein" } ] }