{ "uniprot_canonical_ac": "A2AV25-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AV25-1|FBCD1_MOUSE Isoform 1 of Fibrinogen C domain-containing protein 1 OS=Mus musculus OX=10090 GN=Fibcd1 PE=2 SV=1 CANONICAL=A2AV25-1", "length": 459, "sequence": "MVHERWKTVGSASQLEDRPRDKPQRASCSYVLCTVLLSLAVLLAVAVTGVVLFLNHTHTPGTAPPPIVSTGTAGANSALVTVERADSSHLSLLIDPRCPDLTDSFARLEGIQASILRALSEHQAQPRLDGAPELLDALADQLPRLLTRASELQAECAGLRKGHSLLGQGLSTLQSEQGRLIQLLSESQGHMAHLVNSVSDVLEALQRERGLGRPRVKADLQRAPSRGARPRGCANGSRPRDCLDVLLSGQQDDGVYSIFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWEAYREGFGKLTGEHWLGLKRIHALTTQAAYELHVDLEDFDNGTAYAHYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "signaling receptor binding", "id": "GO:0005102" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "chitin binding", "id": "GO:0008061" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "collagen-containing extracellular matrix", "id": "GO:0062023" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" } ], "name": "cell adhesion", "id": "GO:0007155" } ], "total": 1, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31601676", "type": "PubMed", "id": "31601676" } ], "title": "Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.", "journal": "The Journal of experimental medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218.2", "id": "NP_849218.2", "database": "RefSeq" } ], "authors": "Moeller JB, Leonardi I, Schlosser A, Flamar AL, Bessman NJ, Putzel GG, Thomsen T, Hammond M, Jepsen CS, Skjodt K, Fuchtbauer EM, Farber DL, Sorensen GL, Iliev ID, Holmskov U, Artis D", "date": "2019" } ], "uniprot_ac": "A2AV25", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AV25", "type": "synonym", "resource": "RefSeq", "name": "AI448887" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AV25", "type": "synonym", "resource": "RefSeq", "name": "Fibcd1" }, { "url": "https://www.uniprot.org/uniprot/A2AV25", "type": "recommended", "resource": "UniProtKB", "name": "Fibcd1" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AV25#A2AV25-1", "isoform_ac": "A2AV25-1", "locus": { "end_pos": 31816441, "strand": "+", "start_pos": 31845782, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028188", "id": "ENSMUST00000028188", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028188", "id": "ENSMUSP00000028188", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AV25-1|FBCD1_MOUSE Isoform 1 of Fibrinogen C domain-containing protein 1 OS=Mus musculus OX=10090 GN=Fibcd1 PE=2 SV=1 CANONICAL=A2AV25-1", "length": 459, "sequence": "MVHERWKTVGSASQLEDRPRDKPQRASCSYVLCTVLLSLAVLLAVAVTGVVLFLNHTHTPGTAPPPIVSTGTAGANSALVTVERADSSHLSLLIDPRCPDLTDSFARLEGIQASILRALSEHQAQPRLDGAPELLDALADQLPRLLTRASELQAECAGLRKGHSLLGQGLSTLQSEQGRLIQLLSESQGHMAHLVNSVSDVLEALQRERGLGRPRVKADLQRAPSRGARPRGCANGSRPRDCLDVLLSGQQDDGVYSIFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWEAYREGFGKLTGEHWLGLKRIHALTTQAAYELHVDLEDFDNGTAYAHYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR" } }, { "url": "https://www.uniprot.org/uniprot/A2AV25#A2AV25-2", "isoform_ac": "A2AV25-2", "locus": {}, "sequence": { "header": "sp|A2AV25-2|FBCD1_MOUSE Isoform 2 of Fibrinogen C domain-containing protein 1 OS=Mus musculus OX=10090 GN=Fibcd1 PE=2 SV=1 CANONICAL=A2AV25-1", "length": 269, "sequence": "MAHLVNSVSDVLEALQRERGLGRPRVKADLQRAPSRGARPRGCANGSRPRDCLDVLLSGQQDDGVYSIFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWEAYREGFGKLTGEHWLGLKRIHALTTQAAYELHVDLEDFDNGTAYAHYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:98970", "resource": "KEGG Pathway", "id": "mmu:98970", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AV25#function", "annotation": "Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25#function", "id": "A2AV25", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218.2", "annotation": "These results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218.2", "id": "NP_849218.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4ADA1-1", "protein_name": "Fibrinogen C domain-containing 1-like 1", "sequence": { "length": 459, "sequence": "MVHERWKTVGGASQLEDRPRDKPQRAGCSYILCTVLLSLAVLLAVAVTGAVLFLNHAHAPGTAPPPIVSTGAAGANSALVTVERADSSHLSLLIDPRCPDLTDSFARLEGIQASILRTLSEHQAQPRLDGAPELLDALADQLPRLLARASELQAECAGLRKGHSLLGQGLSTLQSEQGRLIQLLSESQGHMAHLVNSVSDVLEALQRERGLGRPRVKADLQRAPSRGARPRGCANGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWEAYREGFGKLTGEHWLGLKRIHALTTQAAYELHVDLEDFDNGTAYAHYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGPHASYADGVEWSSWTGWQYSLKFSEMKIRPLREDR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/122246", "id": "122246", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AV25/", "id": "A2AV25", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Fibcd1", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8N539-1", "protein_name": "Fibrinogen C domain-containing protein 1", "sequence": { "length": 461, "sequence": "MVNDRWKTMGGAAQLEDRPRDKPQRPSCGYVLCTVLLALAVLLAVAVTGAVLFLNHAHAPGTAPPPVVSTGAASANSALVTVERADSSHLSILIDPRCPDLTDSFARLESAQASVLQALTEHQAQPRLVGDQEQELLDTLADQLPRLLARASELQTECMGLRKGHGTLGQGLSALQSEQGRLIQLLSESQGHMAHLVNSVSDILDALQRDRGLGRPRNKADLQRAPARGTRPRGCATGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWDAYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/122246", "id": "122246", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "FIBCD1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218.2", "ac": "NP_849218.2", "name": "fibrinogen C domain-containing protein 1", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 237, "annotation": "n_glycosylation_sequon", "start_pos": 235 }, { "end_pos": 340, "annotation": "n_glycosylation_sequon", "start_pos": 338 }, { "end_pos": 57, "annotation": "n_glycosylation_sequon", "start_pos": 55 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026841", "id": "ENSMUSG00000026841", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "id": "cd00087", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/98970", "id": "98970", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "id": "IPR002181", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014715", "id": "IPR014715", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "id": "IPR014716", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "id": "IPR020837", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "id": "IPR036056", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:98970", "id": "mmu:98970", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2138953", "id": "2138953", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/KKGHSAM/", "id": "KKGHSAM", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=523014at2759", "id": "523014at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00147", "id": "PF00147", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AV25", "id": "PR_A2AV25", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218", "id": "NP_849218", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849218.2", "id": "NP_849218.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AV25", "id": "A2AV25", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AV25-1", "id": "A2AV25-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AV25-2", "id": "A2AV25-2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 338, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AV25#ptm_processing", "id": "A2AV25", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 338, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 50602.0, "chemical_mass": 50602.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AV25", "name": "Fibcd1", "locus": { "end_pos": 31813290, "strand": "-", "start_pos": 31846005, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026841", "id": "ENSMUSG00000026841", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AV25#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Fibrinogen C domain-containing protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AV25", "type": "synonym", "resource": "RefSeq", "name": "fibrinogen C domain-containing protein 1" } ] }