{ "uniprot_canonical_ac": "A2ALK8-1", "ptm_annotation": [], "sequence": { "header": "sp|A2ALK8-1|PTN3_MOUSE Isoform 1 of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 913, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNHSPHRESLSENNPAQSCLTQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYCDKSDDGDGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQTEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVDGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQRLDPS" }, "uniprot_id": "", "enzyme_annotation": [ { "ec": "3.1.3.48", "activity": "" }, { "ec": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." } ], "glycation": [], "keywords": [ "enzyme" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoskeletal protein binding", "id": "GO:0008092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "phosphotyrosine residue binding", "id": "GO:0001784" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "ATPase binding", "id": "GO:0051117" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017080", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "sodium channel regulator activity", "id": "GO:0017080" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051045", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "negative regulation of membrane protein ectodomain proteolysis", "id": "GO:0051045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000649", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "regulation of sodium ion transmembrane transporter activity", "id": "GO:2000649" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045930", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "negative regulation of mitotic cell cycle", "id": "GO:0045930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006470", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "protein dephosphorylation", "id": "GO:0006470" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097421", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "liver regeneration", "id": "GO:0097421" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098902", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "name": "regulation of membrane depolarization during action potential", "id": "GO:0098902" } ], "total": 6, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11747609", "type": "PubMed", "id": "11747609" } ], "title": "Cloning, characterization, and genomic structure of the mouse Ikbkap gene.", "journal": "DNA and cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Cuajungco MP, Leyne M, Mull J, Gill SP, Gusella JF, Slaugenhaupt SA", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": "PubMed", "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17921143", "type": "PubMed", "id": "17921143" } ], "title": "Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Pilecka I, Patrignani C, Pescini R, Curchod ML, Perrin D, Xue Y, Yasenchak J, Clark A, Magnone MC, Zaratin P, Valenzuela D, Rommel C, Hooft van Huijsduijnen R", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19107198", "type": "PubMed", "id": "19107198" } ], "title": "The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Bauler TJ, Hendriks WJ, King PD", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22730326", "type": "PubMed", "id": "22730326" } ], "title": "p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8875997", "type": "PubMed", "id": "8875997" } ], "title": "Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Huang K, Sommers CL, Grinberg A, Kozak CA, Love PE", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9990064", "type": "PubMed", "id": "9990064" } ], "title": "Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ], "authors": "Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R", "date": "1999" } ], "uniprot_ac": "A2ALK8", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ALK8", "type": "synonym", "resource": "RefSeq", "name": "9530011I20Rik; PT; PTP-; PTP-H1; PTPCL" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ALK8", "type": "synonym", "resource": "RefSeq", "name": "Ptpn3" }, { "url": "https://www.uniprot.org/uniprot/A2ALK8", "type": "recommended", "resource": "UniProtKB", "name": "Ptpn3" } ], "reactions": [ { "source": "Reactome", "output_participant_list": [], "name": "PTPN3 dephosphorylates EPS15", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8867047", "cellular_location": "plasma membrane", "input_participant_list": [], "enzyme_list": [ "A2ALK8-1", "Q01279-1", "P22682-1" ], "id": "R-MMU-8867047", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "source": "Reactome", "output_participant_list": [], "name": "PTPN3 binds p-T183,Y185 MAPK12", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8867654", "cellular_location": "plasma membrane", "input_participant_list": [], "enzyme_list": [ "A2ALK8-1", "O08911-1" ], "id": "R-MMU-8867654", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "source": "Reactome", "output_participant_list": [ "R-MMU-171025", "R-MMU-8867650" ], "name": "PTPN3 dephosphorylates MAPK12", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8867658", "cellular_location": "plasma membrane", "input_participant_list": [], "enzyme_list": [ "A2ALK8-1", "O08911-1" ], "id": "R-MMU-8867658", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" }, { "source": "Reactome", "output_participant_list": [], "name": "MAPK12 phosphorylates PTPN3", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8868118", "cellular_location": "plasma membrane", "input_participant_list": [], "enzyme_list": [ "A2ALK8-1", "O08911-1" ], "id": "R-MMU-8868118", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp" } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALK8-1", "isoform_ac": "A2ALK8-1", "locus": { "end_pos": 57194288, "strand": "+", "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000075637", "id": "ENSMUST00000075637", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000075063", "id": "ENSMUSP00000075063", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ALK8-1|PTN3_MOUSE Isoform 1 of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 913, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDSEVSQNHSPHRESLSENNPAQSCLTQKSSSSVSPSSNAPGSCSPDGVDQRFLEDYHKVTKGGFVEDASQYYCDKSDDGDGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQTEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVDGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQRLDPS" } }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALK9-1", "isoform_ac": "A2ALK9-1", "locus": { "end_pos": 57245052, "strand": "+", "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153926", "id": "ENSMUST00000153926", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122490", "id": "ENSMUSP00000122490", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALK9-1|PTN3_MOUSE Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 229, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCTLHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHN" } }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALL0-1", "isoform_ac": "A2ALL0-1", "locus": { "end_pos": 57265058, "strand": "+", "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000130900", "id": "ENSMUST00000130900", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114805", "id": "ENSMUSP00000114805", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALL0-1|A2ALL0_MOUSE Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=1 SV=1 CANONICAL=A2ALK8-1", "length": 57, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDM" } }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#A2ALL1-1", "isoform_ac": "A2ALL1-1", "locus": { "end_pos": 57270050, "strand": "+", "start_pos": 57270160, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000151964", "id": "ENSMUST00000151964", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000120111", "id": "ENSMUSP00000120111", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ALL1-1|A2ALL1_MOUSE Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type 3 OS=Mus musculus OX=10090 GN=Ptpn3 PE=4 SV=1 CANONICAL=A2ALK8-1", "length": 37, "sequence": "MTSRLRALGGRINNTRTSELPKEKTRSEVICSIRFLD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:545622", "resource": "KEGG Pathway", "id": "mmu:545622", "name": "" }, { "reaction_list": [ "R-MMU-182969", "R-MMU-182986", "R-MMU-182988", "R-MMU-182990", "R-MMU-182993", "R-MMU-182994", "R-MMU-183002", "R-MMU-183036", "R-MMU-183051", "R-MMU-183052", "R-MMU-183055", "R-MMU-183058", "R-MMU-183067", "R-MMU-183072", "R-MMU-183084", "R-MMU-183089", "R-MMU-183094", "R-MMU-8864029", "R-MMU-8867041", "R-MMU-8867044", "R-MMU-8867047", "R-MMU-8951490" ], "resource": "Reactome", "description": "EGFR downregulation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-182971", "id": "R-MMU-182971", "name": "EGFR downregulation" }, { "reaction_list": [ "R-MMU-9635739", "R-MMU-9635743", "R-MMU-5674018", "R-MMU-5674019", "R-MMU-5674022", "R-MMU-5674140", "R-MMU-5675373", "R-MMU-5675376", "R-MMU-5675417", "R-MMU-5675431", "R-MMU-5675433", "R-MMU-8867654", "R-MMU-8867658", "R-MMU-8868118" ], "resource": "Reactome", "description": "Negative regulation of MAPK pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5675221", "id": "R-MMU-5675221", "name": "Negative regulation of MAPK pathway" } ], "reaction_participants": [ { "crossref": [ { "url": "", "id": "NP_038899.1", "database": "RefSeq" }, { "url": "", "id": "ENSMUST00000088827", "database": "Ensembl" }, { "url": "", "id": "ENSMUSG00000022610", "database": "Ensembl" }, { "url": "", "id": "1353438", "database": "MGI" }, { "url": "", "id": "ENSMUSP00000086207", "database": "Ensembl" }, { "url": "", "id": "O08911", "database": "UniProt" }, { "url": "", "id": "O08911", "database": "PRO" } ], "participant_name": "Mapk12 [cytosol]", "participant_id": "R-MMU-171025" }, { "crossref": [ { "url": "", "id": "3.1.3.48", "database": "IntEnz" }, { "url": "", "id": "ENSMUSG00000038764", "database": "Ensembl" }, { "url": "", "id": "XP_006538162.1", "database": "RefSeq" }, { "url": "", "id": "A2ALK8", "database": "PRO" }, { "url": "", "id": "NP_035337.2", "database": "RefSeq" }, { "url": "", "id": "105307", "database": "MGI" }, { "url": "", "id": "ENSMUSP00000075063", "database": "Ensembl" }, { "url": "", "id": "A2ALK8", "database": "UniProt" }, { "url": "", "id": "XP_006538163.1", "database": "RefSeq" }, { "url": "", "id": "ENSMUST00000075637", "database": "Ensembl" }, { "url": "", "id": "XP_006538161.1", "database": "RefSeq" } ], "participant_name": "Ptpn3 [cytosol]", "participant_id": "R-MMU-8867650" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#function", "annotation": "May act at junctions between the membrane and the cytoskeleton.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#function", "id": "A2ALK8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "annotation": "P38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "annotation": "PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "annotation": "PTPN3 and PTPN4 are dispensable for TCR signal transduction.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LQQ5-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type", "sequence": { "length": 1018, "sequence": "MGRKVQSERRKAGVGGGGRGRLERRPLGALKALGRANLPGVLGPAKEPRDSQLSHGAAGVGATPNSATEPPSKARCHFRFVVRQALAIPRHAIPESQAHSYSAAVMTSRLRALGGRINNIRTSELPKEKTRSEVTCSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGLPCILHFRVRYFIPDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHIGDFNSSIHHPGYLADSQFIPDQNDDFLSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKNVLSQYWTLGSRNPKKSVNNQYCKKVIGGMVWNPVMRRSLSVERLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLSPKDSDSEVSQNHSPHRGSLSENNPAQSCLTQKSSSSVSPCSNAPGSFSPDGVDQQFLEDYHKVTKGGSIEEASQYYCDKNDDGDGYLVLIRITPDKEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPEAMFPACPEGGDSLEGSMELLKKGLESGTVLIQFEQLYRKKPGLAVTFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPDIMDHGIFHIQCQAEDCTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLRVGGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQTLDPS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2ALK8/", "id": "A2ALK8", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/74451", "id": "74451", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ptpn3", "tax_id": 10116 }, { "uniprot_canonical_ac": "P26045-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 3", "sequence": { "length": 913, "sequence": "MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2ALK8/", "id": "A2ALK8", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/74451", "id": "74451", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PTPN3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "ac": "NP_035337.2", "name": "tyrosine-protein phosphatase non-receptor type 3", "summary": "" }, "reaction_enzymes": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "activity": "", "gene_name": "Ptpn3", "uniprot_ac": "A2ALK8", "ec_number": "3.1.3.48" }, { "url": "https://www.uniprot.org/uniprot/O08911", "activity": "", "gene_name": "Mapk12", "uniprot_ac": "O08911", "ec_number": "2.7.11.24" }, { "url": "https://www.uniprot.org/uniprot/P22682", "activity": "", "gene_name": "Cbl", "uniprot_ac": "P22682", "ec_number": "2.3.2.27" }, { "url": "https://www.uniprot.org/uniprot/Q01279", "activity": "", "gene_name": "Egfr", "uniprot_ac": "Q01279", "ec_number": "2.7.10.1" } ], "site_annotation": [ { "end_pos": 15, "annotation": "n_glycosylation_sequon", "start_pos": 13 }, { "end_pos": 164, "annotation": "n_glycosylation_sequon", "start_pos": 162 }, { "end_pos": 434, "annotation": "n_glycosylation_sequon", "start_pos": 432 }, { "end_pos": 699, "annotation": "n_glycosylation_sequon", "start_pos": 697 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038764", "id": "ENSMUSG00000038764", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13189", "id": "cd13189", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "id": "cd14473", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/545622", "id": "545622", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ALK8*", "id": "A2ALK8", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000242", "id": "IPR000242", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "id": "IPR000299", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "id": "IPR000387", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000798", "id": "IPR000798", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "id": "IPR001478", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "id": "IPR003595", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR012151", "id": "IPR012151", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "id": "IPR014352", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "id": "IPR016130", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018979", "id": "IPR018979", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018980", "id": "IPR018980", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019747", "id": "IPR019747", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "id": "IPR019748", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "id": "IPR019749", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "id": "IPR029021", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "id": "IPR029071", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "id": "IPR035963", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "id": "IPR036034", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041783", "id": "IPR041783", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:545622", "id": "mmu:545622", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:105307", "id": "105307", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/EHHSFFQ/", "id": "EHHSFFQ", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=96595at2759", "id": "96595at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00102", "id": "PF00102", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00373", "id": "PF00373", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00595", "id": "PF00595", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09379", "id": "PF09379", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09380", "id": "PF09380", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2ALK8", "id": "PR_A2ALK8", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-182971", "id": "R-MMU-182971", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5675221", "id": "R-MMU-5675221", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337", "id": "NP_035337", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035337.2", "id": "NP_035337.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALK8-1", "id": "A2ALK8-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALK9", "id": "A2ALK9", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALK9-1", "id": "A2ALK9-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALL0", "id": "A2ALL0", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALL0-1", "id": "A2ALL0-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALL1", "id": "A2ALL1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2ALL1-1", "id": "A2ALL1-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "start_pos": 357, "end_pos": 357, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "start_pos": 359, "end_pos": 359, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "start_pos": 367, "end_pos": 367, "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "start_pos": 376, "end_pos": 376, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "start_pos": 381, "end_pos": 381, "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "id": "A2ALK8", "database": "UniProtKB" } ], "start_pos": 425, "end_pos": 425, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 103896.0, "chemical_mass": 103896.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8", "name": "Ptpn3", "locus": { "end_pos": 57190841, "strand": "-", "start_pos": 57301837, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038764", "id": "ENSMUSG00000038764", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2ALK8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "3.1.3.48" }, { "url": "https://www.uniprot.org/uniprot/A2ALK8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Tyrosine-protein phosphatase non-receptor type 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ALK8", "type": "synonym", "resource": "RefSeq", "name": "protein-tyrosine phosphatase H1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ALK8", "type": "synonym", "resource": "RefSeq", "name": "tyrosine-protein phosphatase non-receptor type 3" } ] }