{
    "uniprot_canonical_ac": "A2AIW0-1", 
    "ptm_annotation": [
        {
            "annotation": "Phosphorylated.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q96C92", 
                    "id": "Q96C92", 
                    "database": "PubMed"
                }
            ]
        }
    ], 
    "sequence": {
        "header": "sp|A2AIW0-1|ENTR1_MOUSE Isoform 1 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
        "length": 432, 
        "sequence": "MSGYARRQGAPPLSRTRSLVVPDAPAFYERRSCLPQLDCERPHGGDLHPHLFGFRPTFMCYVPSPVLASVGDTGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS"
    }, 
    "uniprot_id": "", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endosome", 
                        "id": "GO:0005768"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "early endosome", 
                        "id": "GO:0005769"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "centrosome", 
                        "id": "GO:0005813"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "recycling endosome", 
                        "id": "GO:0055037"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "midbody", 
                        "id": "GO:0030496"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ciliary basal body", 
                        "id": "GO:0036064"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "retromer complex", 
                        "id": "GO:0030904"
                    }
                ], 
                "total": 7, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein transport", 
                        "id": "GO:0015031"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell division", 
                        "id": "GO:0051301"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell cycle", 
                        "id": "GO:0007049"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990126", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "retrograde transport, endosome to plasma membrane", 
                        "id": "GO:1990126"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell projection organization", 
                        "id": "GO:0030030"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903566", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of protein localization to cilium", 
                        "id": "GO:1903566"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of cytokinesis", 
                        "id": "GO:0032465"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045724", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                                "id": "A2AIW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cilium assembly", 
                        "id": "GO:0045724"
                    }
                ], 
                "total": 8, 
                "name": "Biological Process"
            }
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16332174", 
                    "type": "PubMed", 
                    "id": "16332174"
                }
            ], 
            "title": "Serologically defined colon cancer antigen 3 is necessary for the presentation of TNF receptor 1 on cell surface.", 
            "journal": "DNA Cell Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Gudkov A.V., Neznanov N., Angres B., Neznanova L.", 
            "date": "2005"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27373827", 
                    "type": "PubMed", 
                    "id": "27373827"
                }
            ], 
            "title": "Interaction of serologically defined colon cancer antigen-3 with Arf6 and its predominant expression in the mouse testis.", 
            "journal": "Biochemical and biophysical research communications", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
                    "id": "NP_001078876.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sakagami H, Hara Y, Fukaya M", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27767179", 
                    "type": "PubMed", 
                    "id": "27767179"
                }
            ], 
            "title": "The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.", 
            "journal": "Scientific reports", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
                    "id": "NP_001078876.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yu F, Sharma S, Skowronek A, Erdmann KS", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A2AIW0", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "C330016H24Rik; C630038K21Rik; Sdcca; Sdccag3"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Entr1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Entr1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Sdccag3"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW0-1", 
            "isoform_ac": "A2AIW0-1", 
            "locus": {
                "end_pos": 26383601, 
                "strand": "+", 
                "start_pos": 26389218, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000114102", 
                        "id": "ENSMUST00000114102", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000109737", 
                        "id": "ENSMUSP00000109737", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AIW0-1|ENTR1_MOUSE Isoform 1 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 432, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDAPAFYERRSCLPQLDCERPHGGDLHPHLFGFRPTFMCYVPSPVLASVGDTGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW0-2", 
            "isoform_ac": "A2AIW0-2", 
            "locus": {
                "end_pos": 26383601, 
                "strand": "+", 
                "start_pos": 26389218, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000028293", 
                        "id": "ENSMUST00000028293", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000028293", 
                        "id": "ENSMUSP00000028293", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AIW0-2|ENTR1_MOUSE Isoform 2 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 382, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW0-3", 
            "isoform_ac": "A2AIW0-3", 
            "locus": {
                "end_pos": 26383601, 
                "strand": "+", 
                "start_pos": 26389218, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000077983", 
                        "id": "ENSMUST00000077983", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000077133", 
                        "id": "ENSMUSP00000077133", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AIW0-3|ENTR1_MOUSE Isoform 3 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 359, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW0-4", 
            "isoform_ac": "A2AIW0-4", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2AIW0-4|ENTR1_MOUSE Isoform 4 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 374, 
                "sequence": "MCYVPSPVLASVGDTGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW0-5", 
            "isoform_ac": "A2AIW0-5", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2AIW0-5|ENTR1_MOUSE Isoform 5 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 307, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDAPAFYERRSCLPQLDCERPHGGDLHPHLFGFRPTFMCYVPSPVLASVGDTGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEAVSEGSVAPNTAELCCGEELQSSTSWVAWAQCHGQGS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW0-6", 
            "isoform_ac": "A2AIW0-6", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2AIW0-6|ENTR1_MOUSE Isoform 6 of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 93, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDGFGYGKGKCTNQGPSGAPETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKVHLGSCQW"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW3-1", 
            "isoform_ac": "A2AIW3-1", 
            "locus": {
                "end_pos": 26383601, 
                "strand": "+", 
                "start_pos": 26389218, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000114100", 
                        "id": "ENSMUST00000114100", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000109735", 
                        "id": "ENSMUSP00000109735", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2AIW3-1|ENTR1_MOUSE Computationally mapped isoform of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=1 SV=1 CANONICAL=A2AIW0-1", 
                "length": 409, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDAPAFYERRSCLPQLDCERPHGGDLHPHLFGFRPTFMCYVPSPVLASVGDTGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSPPCDTYLSFFSNSSELACPESLPPWTLSDTDSRISPASPAGSPNADFAAHEESLGDRHLRTLQISYEALKDENSKLRRKLNEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVLKLKQEINLLQAQLSNLRRENEALRSGQGASLSVVKQNTDVALQNLHLVMNSAHASIKQLVSGADTLNLVAEILKSIDRISEVKDEVDS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#A2AIW4-1", 
            "isoform_ac": "A2AIW4-1", 
            "locus": {
                "end_pos": 26387105, 
                "strand": "+", 
                "start_pos": 26388694, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000139738", 
                        "id": "ENSMUST00000139738", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000121256", 
                        "id": "ENSMUSP00000121256", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2AIW4-1|A2AIW4_MOUSE Computationally mapped isoform of Endosome-associated-trafficking regulator 1  OS=Mus musculus OX=10090 GN=Entr1 PE=3 SV=1 CANONICAL=A2AIW0-1", 
                "length": 144, 
                "sequence": "SSLRRQLSSPRLSGSQASAVFTSLDKRCSHKACCDHGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTTTSRIYPKEASRHPLGLEHSSPASQLMGYGLESQQPFFEDPTRASNLEEDEDDGWNITYLPSAVDQTHSSRDTQDSP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68112", 
            "resource": "KEGG Pathway", 
            "id": "mmu:68112", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#function", 
            "annotation": "Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (PubMed:16332174).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0#function", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#function", 
            "annotation": "May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (PubMed:16332174). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0#function", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
            "annotation": "SDCCAG3 has a role in ciliogenesis and in localization of cargo to primary cilia Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
                    "id": "NP_001078876.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
            "annotation": "These findings suggest that SDCCAG3 might function in endosomal trafficking downstream of Arf6.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
                    "id": "NP_001078876.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1LMK3-1", 
            "protein_name": "Endosome-associated-trafficking regulator 1", 
            "sequence": {
                "length": 432, 
                "sequence": "MSGYARRQGAPPLSRTRSLVVPDAPAFYERRSCLPQLDCERPHGGDLHPQFFGFRPTFMCYVPSPVLASVGDTDFGYGKGKCTKQGPSGAHETRFGGDKLEDLEEANPFSFKEFLKTKNLSLSKEDTATSRIYPKEASRHPLGLDHNSPVSQPMGYGLEYQQPFFEDPTRASNLEEDEEDGWSRAYLPSAVEQTHSTRATQNSSPCGTYLSFFSNASELAGPESLPPWTLSDTDSRLSPASPAGNPNVDFAAHEESLGDRHLRTLQLSYEALKDENSKLRRKLSEVQSFSETQTEMVRTLERKLEAKMIKEESDFHDLESVVQQVEQNLELMTKRAVKAENHVMKLKQEVNLLQAQLSNFKRENEALRSGQGASLTVVKQNTDVALQNLHVVMNSAHASIKQLVSGAETLNLVAEILKSIDRITEVKDEADS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/74578", 
                    "id": "74578", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Entr1", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q96C92-1", 
            "protein_name": "Endosome-associated-trafficking regulator 1", 
            "sequence": {
                "length": 435, 
                "sequence": "MSGYQRRPGATPLSRARSLAIPDAPAFYERRSCLPQLNCERPHGRDLDSPFFGIRPAFMCYVPSPVLASVGDTDFGYGKGKCSKQSPSGAHGTHFGDDRFEDLEEANPFSFREFLKTKNLGLSKEDPASRIYAKEASRHSLGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWSGAYLPSAIEQTHPERVPAGTSPCSTYLSFFSTPSELAGPESLPSWALSDTDSRVSPASPAGSPSADFAVHGESLGDRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLVAEILKSIDRISEVKDEEEDS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/74578", 
                    "id": "74578", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "ENTR1", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
        "ac": "NP_001078876.1", 
        "name": "endosome-associated-trafficking regulator 1 isoform 3", 
        "summary": ""
    }, 
    "reaction_enzymes": [], 
    "site_annotation": [
        {
            "end_pos": 121, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 119
        }, 
        {
            "end_pos": 185, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 183
        }, 
        {
            "end_pos": 217, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 215
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026927", 
            "id": "ENSMUSG00000026927", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/68112", 
            "id": "68112", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026757", 
            "id": "IPR026757", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68112", 
            "id": "mmu:68112", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1915362", 
            "id": "1915362", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LEYPQPF/", 
            "id": "LEYPQPF", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1429935at2759", 
            "id": "1429935at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31259", 
            "id": "PTHR31259", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2AIW0", 
            "id": "PR_A2AIW0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876", 
            "id": "NP_001078876", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078876.1", 
            "id": "NP_001078876.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006498325", 
            "id": "XP_006498325", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006498325.1", 
            "id": "XP_006498325.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0", 
            "id": "A2AIW0", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0-1", 
            "id": "A2AIW0-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0-2", 
            "id": "A2AIW0-2", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0-3", 
            "id": "A2AIW0-3", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0-4", 
            "id": "A2AIW0-4", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0-5", 
            "id": "A2AIW0-5", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0-6", 
            "id": "A2AIW0-6", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW3", 
            "id": "A2AIW3", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW3-1", 
            "id": "A2AIW3-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW4", 
            "id": "A2AIW4", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW4-1", 
            "id": "A2AIW4-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "kinase_gene_name": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ], 
            "start_pos": 148, 
            "end_pos": 148, 
            "kinase_uniprot_canonical_ac": ""
        }, 
        {
            "residue": "Ser", 
            "kinase_gene_name": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ], 
            "start_pos": 18, 
            "end_pos": 18, 
            "kinase_uniprot_canonical_ac": ""
        }, 
        {
            "residue": "Ser", 
            "kinase_gene_name": "Atxn7l3b", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", 
                    "id": "21183079", 
                    "database": "PubMed"
                }
            ], 
            "start_pos": 241, 
            "end_pos": 241, 
            "kinase_uniprot_canonical_ac": "Q3UD01-1"
        }, 
        {
            "residue": "Ser", 
            "kinase_gene_name": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ], 
            "start_pos": 241, 
            "end_pos": 241, 
            "kinase_uniprot_canonical_ac": ""
        }, 
        {
            "residue": "Ser", 
            "kinase_gene_name": "Atxn7l3b", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", 
                    "id": "21183079", 
                    "database": "PubMed"
                }
            ], 
            "start_pos": 245, 
            "end_pos": 245, 
            "kinase_uniprot_canonical_ac": "Q3UD01-1"
        }, 
        {
            "residue": "Ser", 
            "kinase_gene_name": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AIW0", 
                    "id": "A2AIW0", 
                    "database": "UniProtKB"
                }
            ], 
            "start_pos": 245, 
            "end_pos": 245, 
            "kinase_uniprot_canonical_ac": ""
        }
    ], 
    "mass": {
        "monoisotopic_mass": 48025.0, 
        "chemical_mass": 48025.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0", 
            "name": "Entr1", 
            "locus": {
                "end_pos": 26382802, 
                "strand": "-", 
                "start_pos": 26389316, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000026927", 
                        "id": "ENSMUSG00000026927", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Endosome-associated-trafficking regulator 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AIW0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Serologically defined colon cancer antigen 3"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "endosome-associated-trafficking regulator 1 isoform 3"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "endosome-associated-trafficking regulator 1 isoform X2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "serologically defined colon cancer antigen 3 homolog"
        }
    ]
}