{ "uniprot_canonical_ac": "A2AH22-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AH22-1|AMRA1_MOUSE Isoform 1 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1300, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" }, "uniprot_id": "AMRA1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "GTPase binding", "id": "GO:0051020" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "17589504", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21753002", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "pmid": "22493499", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "phagocytic vesicle", "id": "GO:0045335" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "pmid": "24089209", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagosome", "id": "GO:0005776" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "pmid": "17589504", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "pmid": "17589504", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "pmid": "17589504", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagy", "id": "GO:0006914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021915", "pmid": "17589504", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "neural tube development", "id": "GO:0021915" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagosome assembly", "id": "GO:0000045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "positive regulation of autophagy", "id": "GO:0010508" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009267", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "cellular response to starvation", "id": "GO:0009267" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "autophagy of mitochondrion", "id": "GO:0000422" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000423", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "mitophagy", "id": "GO:0000423" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010667", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "negative regulation of cardiac muscle cell apoptotic process", "id": "GO:0010667" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043552", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "positive regulation of phosphatidylinositol 3-kinase activity", "id": "GO:0043552" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098780", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "name": "response to mitochondrial depolarisation", "id": "GO:0098780" } ], "total": 13, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": "PubMed", "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17589504", "type": "PubMed", "id": "17589504" } ], "title": "Ambra1 regulates autophagy and development of the nervous system.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Cecconi F., Piacentini M., Chowdhury K., Corazzari M., Di Bartolomeo S., Fuoco C., Giunta L., Gruss P., Maria Fimia G., Nardacci R., Romagnoli A., Schwartz P., Stoykova A., Ucar A.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17603510", "type": "PubMed", "id": "17603510" } ], "title": "Autophagy: a new regulator of development.", "journal": "Nat. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "authors": "Le Bot N.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21753002", "type": "PubMed", "id": "21753002" } ], "title": "Parkin interacts with Ambra1 to induce mitophagy.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24089209", "type": "PubMed", "id": "24089209" } ], "title": "Functional interaction between autophagy and ciliogenesis.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "authors": "Codogno P., Patel B., Beau I., Cuervo A.M., Diaz-Carretero A., Orhon I., Pampliega O., Satir B.H., Satir P., Sridhar S.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24129315", "type": "PubMed", "id": "24129315" } ], "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Wang Y., Zhou J., Comb M.J., Guo A., Lee K.A., Aguiar M., Bedford M.T., Gu H., Jia X., Kornhauser J., Mulhern D., Ren J., Silva J.C., Vemulapalli V., Yang V.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30532260", "type": "PubMed", "id": "30532260" } ], "title": "Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Coccurello R, Nazio F, Rossi C, De Angelis F, Vacca V, Giacovazzo G, Procacci P, Magnaghi V, Ciavardelli D, Marinelli S", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30546041", "type": "PubMed", "id": "30546041" } ], "title": "GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition.", "journal": "Cell death & disease", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Zhao SJ, Kong FQ, Cai W, Xu T, Zhou ZM, Wang ZB, Xu AD, Yang YQ, Chen J, Tang PY, Wang Q, Cheng L, Luo YJ, Zhou Z, Li LW, Huang YF, Zhao X, Yin GY, Xue MX, Fan J", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30614598", "type": "PubMed", "id": "30614598" } ], "title": "Mitsugumin 53 promotes mitochondrial autophagy through regulating Ambra1 expression in C2C12 myoblast cells.", "journal": "Cell biology international", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Lijie G, Yueyue Z, Nan Z, Ling W, Xuan W, Weijie Y", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31123703", "type": "PubMed", "id": "31123703" } ], "title": "Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.", "journal": "Science advances", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ], "authors": "Di Rienzo M, Antonioli M, Fusco C, Liu Y, Mari M, Orhon I, Refolo G, Germani F, Corazzari M, Romagnoli A, Ciccosanti F, Mandriani B, Pellico MT, De La Torre R, Ding H, Dentice M, Neri M, Ferlini A, Reggiori F, Kulesz-Martin M, Piacentini M, Merla G, Fimia GM", "date": "2019" } ], "uniprot_ac": "A2AH22", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AH22", "type": "synonym", "resource": "RefSeq", "name": "2310079H06Rik; A130023A14; AA474864; AV021921; D030051N19Rik; mKIAA1736" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AH22", "type": "synonym", "resource": "RefSeq", "name": "Ambra1" }, { "url": "https://www.uniprot.org/uniprot/A2AH22", "type": "recommended", "resource": "UniProtKB", "name": "Ambra1" }, { "url": "https://www.uniprot.org/uniprot/A2AH22", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa1736" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-1", "isoform_ac": "A2AH22-1", "locus": { "end_pos": 91766566, "strand": "-", "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045705", "id": "ENSMUST00000045705", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000049258", "id": "ENSMUSP00000049258", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-1|AMRA1_MOUSE Isoform 1 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1300, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-2", "isoform_ac": "A2AH22-2", "locus": { "end_pos": 91766566, "strand": "-", "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099712", "id": "ENSMUST00000099712", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097299", "id": "ENSMUSP00000097299", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-2|AMRA1_MOUSE Isoform 2 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1209, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-3", "isoform_ac": "A2AH22-3", "locus": {}, "sequence": { "header": "sp|A2AH22-3|AMRA1_MOUSE Isoform 3 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 781, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-4", "isoform_ac": "A2AH22-4", "locus": {}, "sequence": { "header": "sp|A2AH22-4|AMRA1_MOUSE Isoform 4 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 752, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-5", "isoform_ac": "A2AH22-5", "locus": {}, "sequence": { "header": "sp|A2AH22-5|AMRA1_MOUSE Isoform 5 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 896, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHQRSTSLK" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-6", "isoform_ac": "A2AH22-6", "locus": { "end_pos": 91766566, "strand": "-", "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000111316", "id": "ENSMUST00000111316", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106948", "id": "ENSMUSP00000106948", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-6|AMRA1_MOUSE Isoform 6 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1240, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } }, { "url": "https://www.uniprot.org/uniprot/A2AH22#A2AH22-7", "isoform_ac": "A2AH22-7", "locus": { "end_pos": 91766566, "strand": "-", "start_pos": 91917820, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045699", "id": "ENSMUST00000045699", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000048898", "id": "ENSMUSP00000048898", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AH22-7|AMRA1_MOUSE Isoform 7 of Activating molecule in BECN1-regulated autophagy protein 1 OS=Mus musculus OX=10090 GN=Ambra1 PE=1 SV=1 CANONICAL=A2AH22-1", "length": 1180, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHLPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPSSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLSETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGAASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLPSEPGQLAERALSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDGSNRGEAAGPSGEPQNR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228361", "resource": "KEGG Pathway", "id": "mmu:228361", "name": "" }, { "reaction_list": [ "R-MMU-1632843", "R-MMU-1632857", "R-MMU-5665868", "R-MMU-5672008", "R-MMU-5672010", "R-MMU-5672011", "R-MMU-5672012", "R-MMU-5672017", "R-MMU-5672817", "R-MMU-5673768", "R-MMU-5675790", "R-MMU-5675868", "R-MMU-5676229", "R-MMU-5678313", "R-MMU-5678315", "R-MMU-5678490", "R-MMU-5679205", "R-MMU-5679206", "R-MMU-5679239", "R-MMU-5679255", "R-MMU-5679266", "R-MMU-5681980", "R-MMU-5681981", "R-MMU-5681987", "R-MMU-5682010", "R-MMU-5682011", "R-MMU-5682377", "R-MMU-5682385", "R-MMU-5682388", "R-MMU-5682690", "R-MMU-5682893", "R-MMU-5682896", "R-MMU-5683588", "R-MMU-5683593", "R-MMU-5683925", "R-MMU-9020616" ], "resource": "Reactome", "description": "Macroautophagy", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1632852", "id": "R-MMU-1632852", "name": "Macroautophagy" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "GIT1 interacted with Beclin1 and promoted Beclin1 phosphorylation at Thr119, which induced the disruption of Beclin1 and Bcl2 binding under starvation conditions, thereby, positively regulating autophagy. Taken together, the findings suggest a previously unappreciated role of GIT1 in autophagy of OCs during fracture repair Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "MG53 overexpression could promote the expression of Ambra1 in C2C12 cells and restore mitochondrial autophagy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AH22#function", "annotation": "Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AH22#function", "id": "A2AH22", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "annotation": "These data identify interaction of Parkin with Ambra1 as a key mechanism for induction of the final clearance step of Parkin-mediated mitophagy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LNQ2-1", "protein_name": "Autophagy and beclin 1 regulator 1", "sequence": { "length": 1300, "sequence": "MKVVPEKNAVRILWGRERGTRAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPTLDFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTTVECCQHPGILCLCSRCAGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHRELAPGLTGSEWTRTVLTLNSRSEVESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPSSGLATESDGGNGSSQNNSGNIRHELQCDLRRFFLEYDRLQELDQSLSGETPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWHVSTTFEGMPPSGNQLPPLERTEGQMPNSSRLELSSSASSQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGIEYYWDQLNETVFTVHSSSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPTTSVTSQGTQTLALQLQNAETQTEREEEEPGTASSGPGEGEGSEYGGSGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTESGAARTSSPQPSTSRGLLSEPGQLAERGLSPRTASWDQPSTSGRELPQPALSSSSPVPIPVPLASNEGPTMHCNVTNNSHLPEGDSSNVGEAAGPSGEPRNR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18204", "id": "18204", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AH22/", "id": "A2AH22", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ambra1", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9C0C7-1", "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1", "sequence": { "length": 1298, "sequence": "MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18204", "id": "18204", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AH22/", "id": "A2AH22", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "AMBRA1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "ac": "NP_001074223.1", "name": "activating molecule in BECN1-regulated autophagy protein 1 isoform 2", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 1274, "annotation": "n_glycosylation_sequon", "start_pos": 1272 }, { "end_pos": 1277, "annotation": "n_glycosylation_sequon", "start_pos": 1275 }, { "end_pos": 388, "annotation": "n_glycosylation_sequon", "start_pos": 386 }, { "end_pos": 488, "annotation": "n_glycosylation_sequon", "start_pos": 486 }, { "end_pos": 493, "annotation": "n_glycosylation_sequon", "start_pos": 491 }, { "end_pos": 559, "annotation": "n_glycosylation_sequon", "start_pos": 557 }, { "end_pos": 562, "annotation": "n_glycosylation_sequon", "start_pos": 560 }, { "end_pos": 582, "annotation": "n_glycosylation_sequon", "start_pos": 580 }, { "end_pos": 593, "annotation": "n_glycosylation_sequon", "start_pos": 591 }, { "end_pos": 860, "annotation": "n_glycosylation_sequon", "start_pos": 858 }, { "end_pos": 880, "annotation": "n_glycosylation_sequon", "start_pos": 878 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040506", "id": "ENSMUSG00000040506", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228361", "id": "228361", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AH22*", "id": "A2AH22", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228361", "id": "mmu:228361", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2443564", "id": "2443564", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/PPAECCQ/", "id": "PPAECCQ", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=488527at2759", "id": "488527at2759", "database": "OrthoDB" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AH22", "id": "PR_A2AH22", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1632852", "id": "R-MMU-1632852", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223", "id": "NP_001074223", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074223.1", "id": "NP_001074223.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AH22", "id": "A2AH22", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AH22-1", "id": "A2AH22-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AH22-2", "id": "A2AH22-2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AH22-3", "id": "A2AH22-3", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AH22-4", "id": "A2AH22-4", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2AH22-5", "id": "A2AH22-5", "database": 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"UniProtKB" } ], "start_pos": 640, "end_pos": 640, "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 142879.0, "chemical_mass": 142879.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AH22", "name": "Ambra1", "locus": { "end_pos": 91918849, "strand": "+", "start_pos": 91730134, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040506", "id": "ENSMUSG00000040506", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AH22#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Activating molecule in BECN1-regulated autophagy protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AH22", "type": "synonym", "resource": "RefSeq", "name": "activating molecule in BECN1-regulated autophagy protein 1 isoform 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AH22", "type": "synonym", "resource": "RefSeq", "name": "activating molecule in BECN1-regulated autophagy protein 1; activating molecule in Beclin1-regulated autophagy" } ] }