{
    "uniprot_canonical_ac": "A2ADA5-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2ADA5-1|PUSL1_MOUSE Isoform 1 of tRNA pseudouridine synthase-like 1  OS=Mus musculus OX=10090 GN=Pusl1 PE=1 SV=1 CANONICAL=A2ADA5-1", 
        "length": 291, 
        "sequence": "MGSCGAVGSVRARYLVFLQYLGTDFNGVAAVRGNPRAVGVLNFLEEAAKRLNSVDPVRFTISSRTDAGVHALSNAAHLDIQRRPGQSPFSPEVVAKALNTHLKHPAIRVLKAFRVPNDFHARHAATSRTYQYRLATGCSWPNQLPVFEQNVCWALQTEYLDMAAMQEAAQHLLGTHDFSAFQSAGSPVTNTVRTLRRVSVSPGPASPFVLPEGSRRLQFWTLEFESQSFLYRQVRRMTAVLVAVGLGILAPTQVKVILESQDPLGKYQARVAPARGLFLKSVLYDNFGPTS"
    }, 
    "uniprot_id": "PUSL1_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "5.4.99.-", 
            "activity": ""
        }
    ], 
    "glycation": [], 
    "keywords": [
        "enzyme"
    ], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ADA5", 
                    "id": "A2ADA5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADA5", 
                                "id": "A2ADA5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "pseudouridine synthase activity", 
                        "id": "GO:0009982"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADA5", 
                                "id": "A2ADA5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA binding", 
                        "id": "GO:0003723"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADA5", 
                                "id": "A2ADA5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular membrane-bounded organelle", 
                        "id": "GO:0043231"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031119", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADA5", 
                                "id": "A2ADA5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tRNA pseudouridine synthesis", 
                        "id": "GO:0031119"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11319557", 
                    "type": "PubMed", 
                    "id": "11319557"
                }
            ], 
            "title": "A candidate taste receptor gene near a sweet taste locus.", 
            "journal": "Nature neuroscience", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
                    "id": "NP_001028662.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Montmayeur JP, Liberles SD, Matsunami H, Buck LB", 
            "date": "2001"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11326277", 
                    "type": "PubMed", 
                    "id": "11326277"
                }
            ], 
            "title": "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.", 
            "journal": "Nature genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
                    "id": "NP_001028662.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF", 
            "date": "2001"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11555487", 
                    "type": "PubMed", 
                    "id": "11555487"
                }
            ], 
            "title": "Positional cloning of the mouse saccharin preference (Sac) locus.", 
            "journal": "Chemical senses", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
                    "id": "NP_001028662.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Bachmanov AA, Li X, Reed DR, Ohmen JD, Li S, Chen Z, Tordoff MG, de Jong PJ, Wu C, West DB, Chatterjee A, Ross DA, Beauchamp GK", 
            "date": "2001"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/31693908", 
                    "type": "PubMed", 
                    "id": "31693908"
                }
            ], 
            "title": "MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.", 
            "journal": "Cell reports", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
                    "id": "NP_001028662.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Busch JD, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, Li X, Pearce SF, Milenkovic D, Rorbach J, Larsson NG", 
            "date": "2019"
        }
    ], 
    "uniprot_ac": "A2ADA5", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADA5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "2810021I11Rik; AI853843; D18346"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADA5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Pusl1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Pusl1"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#A2ADA5-1", 
            "isoform_ac": "A2ADA5-1", 
            "locus": {
                "end_pos": 155889158, 
                "strand": "+", 
                "start_pos": 155891707, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000097737", 
                        "id": "ENSMUST00000097737", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000095344", 
                        "id": "ENSMUSP00000095344", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2ADA5-1|PUSL1_MOUSE Isoform 1 of tRNA pseudouridine synthase-like 1  OS=Mus musculus OX=10090 GN=Pusl1 PE=1 SV=1 CANONICAL=A2ADA5-1", 
                "length": 291, 
                "sequence": "MGSCGAVGSVRARYLVFLQYLGTDFNGVAAVRGNPRAVGVLNFLEEAAKRLNSVDPVRFTISSRTDAGVHALSNAAHLDIQRRPGQSPFSPEVVAKALNTHLKHPAIRVLKAFRVPNDFHARHAATSRTYQYRLATGCSWPNQLPVFEQNVCWALQTEYLDMAAMQEAAQHLLGTHDFSAFQSAGSPVTNTVRTLRRVSVSPGPASPFVLPEGSRRLQFWTLEFESQSFLYRQVRRMTAVLVAVGLGILAPTQVKVILESQDPLGKYQARVAPARGLFLKSVLYDNFGPTS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#A2ADA5-2", 
            "isoform_ac": "A2ADA5-2", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2ADA5-2|PUSL1_MOUSE Isoform 2 of tRNA pseudouridine synthase-like 1  OS=Mus musculus OX=10090 GN=Pusl1 PE=1 SV=1 CANONICAL=A2ADA5-1", 
                "length": 280, 
                "sequence": "MWQPPVRFPQEAAKRLNSVDPVRFTISSRTDAGVHALSNAAHLDIQRRPGQSPFSPEVVAKALNTHLKHPAIRVLKAFRVPNDFHARHAATSRTYQYRLATGCSWPNQLPVFEQNVCWALQTEYLDMAAMQEAAQHLLGTHDFSAFQSAGSPVTNTVRTLRRVSVSPGPASPFVLPEGSRRLQFWTLEFESQSFLYRQVGCLNPHRMGSGRHTCDNLSSLLQVRRMTAVLVAVGLGILAPTQVKVILESQDPLGKYQARVAPARGLFLKSVLYDNFGPTS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#A2ADA5-3", 
            "isoform_ac": "A2ADA5-3", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2ADA5-3|PUSL1_MOUSE Isoform 3 of tRNA pseudouridine synthase-like 1  OS=Mus musculus OX=10090 GN=Pusl1 PE=1 SV=1 CANONICAL=A2ADA5-1", 
                "length": 219, 
                "sequence": "MPGLHALSNAAHLDIQRRPGQSPFSPEVVAKALNTHLKHPAIRVLKAFRVPNDFHARHAATSRTYQYRLATGCSWPNQLPVFEQNVCWALQTEYLDMAAMQEAAQHLLGTHDFSAFQSAGSPVTNTVRTLRRVSVSPGPASPFVLPEGSRRLQFWTLEFESQSFLYRQVRRMTAVLVAVGLGILAPTQVKVILESQDPLGQVSGSSCSSPWPVLEVSAV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:433813", 
            "resource": "KEGG Pathway", 
            "id": "mmu:433813", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
            "annotation": "MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
                    "id": "NP_001028662.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2K730-1", 
            "protein_name": "tRNA pseudouridine synthase", 
            "sequence": {
                "length": 291, 
                "sequence": "MGSCGAVGSVRARYLVFFQYLGTDFNGVAAVRGNHRAVGVQNFLEEAAKRLNSVEPVRFTISSRTDAGVHALSNAAHLDIQRRPGRPPFSPEIVTKALNTHLKHPAIRVLKAFRVPNDFHARHAATSRTYLYRLATGCSGPNQLPVFEQNVCWSLQTEYLDIAAMQEAAQHLLGTHDFSAFQSAGSPVPHAVRTLRRVSVSPGPASLFVLPQESRRLQFWTLEFESQSFLYRQVRRMTAVLVAVGLGILAPTQVKVILESQDPLGKYQARVAPAHGLFLKSVLYDNFGPTS"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2ADA5/", 
                    "id": "A2ADA5", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/13655", 
                    "id": "13655", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Pusl1", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8N0Z8-1", 
            "protein_name": "tRNA pseudouridine synthase", 
            "sequence": {
                "length": 303, 
                "sequence": "MSSAPASGSVRARYLVYFQYVGTDFNGVAAVRGTQRAVGVQNYLEEAAERLNSVEPVRFTISSRTDAGVHALSNAAHLDVQRRSGRPPFPPEVLAEALNTHLRHPAIRVLRAFRVPSDFHARHAATSRTYLYRLATGCHRRDELPVFERNLCWTLPADCLDMVAMQEAAQHLLGTHDFSAFQSAGSPVPSPVRTLRRVSVSPGQASPLVTPEESRKLRFWNLEFESQSFLYRQVRRMTAVLVAVGLGALAPAQVKTILESQDPLGKHQTRVAPAHGLFLKSVLYGNLGAASCTLQGPQFGSHG"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2ADA5/", 
                    "id": "A2ADA5", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/13655", 
                    "id": "13655", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "PUSL1", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
        "ac": "NP_001028662.1", 
        "name": "tRNA pseudouridine synthase-like 1", 
        "summary": ""
    }, 
    "reaction_enzymes": [], 
    "site_annotation": [], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000051557", 
            "id": "ENSMUSG00000051557", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/433813", 
            "id": "433813", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001406", 
            "id": "IPR001406", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020095", 
            "id": "IPR020095", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020097", 
            "id": "IPR020097", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", 
            "id": "IPR020103", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:433813", 
            "id": "mmu:433813", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3047787", 
            "id": "3047787", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FLYGMVR/", 
            "id": "FLYGMVR", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=831280at2759", 
            "id": "831280at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11142", 
            "id": "PTHR11142", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01416", 
            "id": "PF01416", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2ADA5", 
            "id": "PR_A2ADA5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662", 
            "id": "NP_001028662", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028662.1", 
            "id": "NP_001028662.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5", 
            "id": "A2ADA5", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5-1", 
            "id": "A2ADA5-1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5-2", 
            "id": "A2ADA5-2", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5-3", 
            "id": "A2ADA5-3", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 31993.0, 
        "chemical_mass": 31993.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5", 
            "name": "Pusl1", 
            "locus": {
                "end_pos": 155887879, 
                "strand": "-", 
                "start_pos": 155891781, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000051557", 
                        "id": "ENSMUSG00000051557", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "5.4.99.-"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADA5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "tRNA pseudouridine synthase-like 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "tRNA pseudouridine synthase-like 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "tRNA pseudouridylate synthase-like 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADA5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "tRNA-uridine isomerase-like 1; tRNA pseudouridylate synthase-like 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADA5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "tRNA-uridine isomerase-like 1"
        }
    ]
}