{ "uniprot_canonical_ac": "A2A761-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A761-1|ZFP69_MOUSE Isoform 1 of Zinc finger protein 69 OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1", "length": 587, "sequence": "MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "26232096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019216", "pmid": "26232096", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "regulation of lipid metabolic process", "id": "GO:0019216" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "lipid metabolic process", "id": "GO:0006629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" } ], "name": "regulation of transcription, DNA-templated", "id": "GO:0006355" } ], "total": 5, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19539053", "type": "PubMed", "id": "19539053" } ], "title": "Identification of novel oocyte and granulosa cell markers.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Malcuit C, Trask MC, Santiago L, Beaudoin E, Tremblay KD, Mager J", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19578398", "type": "PubMed", "id": "19578398" } ], "title": "Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.", "journal": "PLoS Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Al-Hasani H., Schuermann A., Vogel H., Scherneck S., Teichert M., Blueher M., Joost H.G., Nestler M., Kluge R., Herzig S., Schulz N., Berriel Diaz M., Block M.D., Tischer S.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20865372", "type": "PubMed", "id": "20865372" } ], "title": "Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.", "journal": "Results and problems in cell differentiation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Scherneck S, Vogel H, Nestler M, Kluge R, Schurmann A, Joost HG", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23641944", "type": "PubMed", "id": "23641944" } ], "title": "Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss.", "journal": "BMC genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Suto J, Satou K", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2542606", "type": "PubMed", "id": "2542606" } ], "title": "Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.", "journal": "Journal of virology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Ihle JN, Smith-White B, Sisson B, Parker D, Blair DG, Schultz A, Kozak C, Lunsford RD, Askew D, Weinstein Y, et al.", "date": "1989" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26232096", "type": "PubMed", "id": "26232096" } ], "title": "The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.", "journal": "Diabetologia", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Jain D., Schuermann A., Scherneck S., Chung B., Joost H.G., Schulz N., Stadion M.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7479878", "type": "PubMed", "id": "7479878" } ], "title": "Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Bellefroid EJ, Marine JC, Matera AG, Bourguignon C, Desai T, Healy KC, Bray-Ward P, Martial JA, Ihle JN, Ward DC", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8662221", "type": "PubMed", "id": "8662221" } ], "title": "Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ], "authors": "Marine JC, Gilbert DJ, Bellefroid EJ, Martial JA, Ihle JN, Copeland NG, Jenkins NA", "date": "1996" } ], "uniprot_ac": "A2A761", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A761", "type": "synonym", "resource": "RefSeq", "name": "Gm1029; KRA; Krab2; Zfp6; Zfp63" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A761", "type": "synonym", "resource": "RefSeq", "name": "Zfp69" }, { "url": "https://www.uniprot.org/uniprot/A2A761", "type": "recommended", "resource": "UniProtKB", "name": "Zfp69" }, { "url": "https://www.uniprot.org/uniprot/A2A761", "type": "synonym", "resource": "UniProtKB", "name": "Znf642" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A761#A2A761-1", "isoform_ac": "A2A761-1", "locus": { "end_pos": 120930356, "strand": "+", "start_pos": 120949434, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106280", "id": "ENSMUST00000106280", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101887", "id": "ENSMUSP00000101887", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A761-1|ZFP69_MOUSE Isoform 1 of Zinc finger protein 69 OS=Mus musculus OX=10090 GN=Zfp69 PE=3 SV=1 CANONICAL=A2A761-1", "length": 587, "sequence": "MPQQLLITPATEATWVKLKEVSLWEDVTKMFGGEALLSHDANGTQQESLADGTTPGTPAAGSHDGATPGTTATGSHDEATPGTPAAGSHDGETPGIPAAGSHDGETPGTPTAGSHDGVTPGTTAAGSQESLTFKDIAVDLSQEEWGQLAPAYQDLYREVMLENYRNLVSVAGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWTHKKKRQEGNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCMRARRYPCNVCEKMFKQPIHLVEHMRTHTGEKPFRCKECGRAFSQSASLNTHQRIHTGEKPFACEECGKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGEKPYKCTSCCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHRTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSRHQKIHRRNTFRDDPGHENKRQL" } }, { "url": "https://www.uniprot.org/uniprot/A2A761#G3UWJ2-1", "isoform_ac": "G3UWJ2-1", "locus": { "end_pos": 120931307, "strand": "+", "start_pos": 120935100, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000130702", "id": "ENSMUST00000130702", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000133312", "id": "ENSMUSP00000133312", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3UWJ2-1|G3UWJ2_MOUSE Computationally mapped isoform of Zinc finger protein 69 OS=Mus musculus OX=10090 GN=Zfp69 PE=4 SV=1 CANONICAL=A2A761-1", "length": 110, "sequence": "MLENYRNLVSVGYQLSKPTVISQLEKGEGPCMAESQGPEDPILDVKNKLETKESTAEDDISVKLDHGITRGRLIEDDIVCSPLKKASSYSDTLESHRATCGKGTRRAIWT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381549", "resource": "KEGG Pathway", "id": "mmu:381549", "name": "" }, { "reaction_list": [ "R-MMU-212352", "R-MMU-212380", "R-MMU-212432", "R-MMU-975040" ], "resource": "Reactome", "description": "Generic Transcription Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "id": "R-MMU-212436", "name": "Generic Transcription Pathway" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A761#function", "annotation": "Putative transcription factor that appears to regulate lipid metabolism.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A761#function", "id": "A2A761", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "annotation": "Zfp69 is the most likely candidate for the diabetogenic effect of Nidd/SJL locus.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "annotation": "Zfp69 mRNA-expression was significantly higher in diabetic subjects than in unaffected controls. Review article", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "annotation": "Zfp69 mediates hyperlipidaemia, liver fat accumulation and mild insulin resistance. However, it does not induce type 2 diabetes, suggesting that the diabetogenic effect of the Zfp69 locus requires synergy with other as yet unidentified genes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q49AA0-1", "protein_name": "Zinc finger protein 69 homolog", "sequence": { "length": 526, "sequence": "MPQQLLITLPTEASTWVKLQHPKKAVEGAPLWEDVTKMFEGEALLSQDAEDVKTQRESLEDEVTPGLPTAESQELLTFKDISIDFTQEEWGQLAPAHQNLYREVMLENYSNLVSVGYQLSKPSVISQLEKGEEPWMAEKEGPGDPSSDLKSKIETIESTAKSTISQERLYHGIMMESFMRDDIIYSTLRKVSTYDDVLERHQETCMRDVRQAILTHKKRVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSYIRTKTYECNICEKIFKQPIHLTEHMRIHTGEKPFRCKECGRAFSQSASLSTHQRIHTGEKPFECEECGKAFRHRSSLNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHSGEKPFTCNECGKTFRQIRHLSEHIRIHTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECGKAFRQRIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNSSLSRHHEIHRRNAFRNKV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/45693", "id": "45693", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ZFP69", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "ac": "NP_001005788.2", "name": "zinc finger protein 69 isoform 1", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 422, "annotation": "n_glycosylation_sequon", "start_pos": 420 }, { "end_pos": 44, "annotation": "n_glycosylation_sequon", "start_pos": 42 }, { "end_pos": 562, "annotation": "n_glycosylation_sequon", "start_pos": 560 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000064141", "id": "ENSMUSG00000064141", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "id": "cd07765", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/381549", "id": "381549", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "id": "IPR001909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "id": "IPR036051", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381549", "id": "mmu:381549", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:107794", "id": "107794", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/IHVRCVH/", "id": "IHVRCVH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1318335at2759", "id": "1318335at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01352", "id": "PF01352", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2A761", "id": "PR_A2A761", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "id": "R-MMU-212436", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788", "id": "NP_001005788", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005788.2", "id": "NP_001005788.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A761", "id": "A2A761", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A2A761-1", "id": "A2A761-1", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/G3UWJ2", "id": "G3UWJ2", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/G3UWJ2-1", "id": "G3UWJ2-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 65725.0, "chemical_mass": 65725.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A761", "name": "Zfp69", "locus": { "end_pos": 120930137, "strand": "-", "start_pos": 120951699, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000064141", "id": "ENSMUSG00000064141", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A761", "type": "synonym", "resource": "RefSeq", "name": "Zfp63p; zinc finger protein 642" }, { "url": "https://www.uniprot.org/uniprot/A2A761#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Zinc finger protein 642" }, { "url": "https://www.uniprot.org/uniprot/A2A761#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Zinc finger protein 69" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A761", "type": "synonym", "resource": "RefSeq", "name": "zinc finger protein 69 isoform 1" } ] }