{ "uniprot_canonical_ac": "A1L1J7-1", "ptm_annotation": [], "sequence": { "header": "tr|A1L1J7-1|A1L1J7_RAT Isoform 1 of PDZ-binding kinase OS=Rattus norvegicus OX=10116 GN=Pbk PE=1 SV=1 CANONICAL=A1L1J7-1", "length": 337, "sequence": "MEGISNFKTPNKLSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKINPLCDDHYRTVYQKRLTDEAKILKNLNHPNIVGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADMFAFGLTLWEMMTLCIPHINLPDDDDDEDATFDESDFDDEAYYAALGTRPSINMEELDESYQKVIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKHSLYGNC" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "mitotic cell cycle", "id": "GO:0000278" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001933", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of protein phosphorylation", "id": "GO:0001933" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of inflammatory response", "id": "GO:0050728" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "cellular response to UV", "id": "GO:0034644" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032873", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "name": "negative regulation of stress-activated MAPK cascade", "id": "GO:0032873" } ], "total": 6, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": "PubMed", "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25065601", "type": "PubMed", "id": "25065601" } ], "title": "Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury.", "journal": "The FEBS journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "id": "NP_001073406.1", "database": "RefSeq" } ], "authors": "Zhao H, Wang R, Tao Z, Yan F, Gao L, Liu X, Wang N, Min L, Jia Y, Zhao Y, Ji X, Luo Y", "date": "2014" } ], "uniprot_ac": "A1L1J7", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1J7", "type": "synonym", "resource": "RefSeq", "name": "Pbk" }, { "url": "https://www.uniprot.org/uniprot/A1L1J7", "type": "recommended", "resource": "UniProtKB", "name": "Pbk" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7#A1L1J7-1", "isoform_ac": "A1L1J7-1", "locus": { "end_pos": 42492367, "strand": "-", "start_pos": 42499822, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000064306", "id": "ENSRNOT00000064306", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000061382", "id": "ENSRNOP00000061382", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A1L1J7-1|A1L1J7_RAT Isoform 1 of PDZ-binding kinase OS=Rattus norvegicus OX=10116 GN=Pbk PE=1 SV=1 CANONICAL=A1L1J7-1", "length": 337, "sequence": "MEGISNFKTPNKLSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKINPLCDDHYRTVYQKRLTDEAKILKNLNHPNIVGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADMFAFGLTLWEMMTLCIPHINLPDDDDDEDATFDESDFDDEAYYAALGTRPSINMEELDESYQKVIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKHSLYGNC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:290326", "resource": "KEGG Pathway", "id": "rno:290326", "name": "" } ], "reaction_participants": [], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "annotation": "TOPK confers neuroprotection against focal cerebral ischemia-reperfusion injury by antioxidative function.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "id": "NP_001073406.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q96KB5-1", "protein_name": "Lymphokine-activated killer T-cell-originated protein kinase", "sequence": { "length": 322, "sequence": "MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32415", "id": "32415", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PBK", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9JJ78-1", "protein_name": "Lymphokine-activated killer T-cell-originated protein kinase", "sequence": { "length": 330, "sequence": "MEGINNFKTPNKSEKRKSVLCSTPCVNIPASPFMQKLGFGTGVSVYLMKRSPRGLSHSPWAVKKISLLCDDHYRTVYQKRLTDEAKILKNLNHPNIIGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERNKDSGSPFPAAVILRVALHMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADVFAFGLTLWEMMTLCIPHVNLPDDDVDEDATFDESDFDDEAYYAALGTRPSINMEELDDSYQKAIELFCVCTNEDPKDRPSAAHIVEALELDGQCCGLSSKH" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1L1J7/", "id": "A1L1J7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/32415", "id": "32415", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Pbk", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "ac": "NP_001073406.1", "name": "lymphokine-activated killer T-cell-originated protein kinase", "summary": "" }, "reaction_enzymes": [], "site_annotation": [ { "end_pos": 198, "annotation": "n_glycosylation_sequon", "start_pos": 196 } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015308", "id": "ENSRNOG00000015308", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14001", "id": "cd14001", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/290326", "id": "290326", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034368", "id": "IPR034368", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041989", "id": "IPR041989", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:290326", "id": "rno:290326", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/KMIMDIA/", "id": "KMIMDIA", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1093418at2759", "id": "1093418at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43289:SF14", "id": "PTHR43289:SF14", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406", "id": "NP_001073406", "database": "RefSeq" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073406.1", "id": "NP_001073406.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309565", "id": "1309565", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A1L1J7", "id": "A1L1J7", "database": "UniProtKB" }, { "url": "https://www.uniprot.org/uniprot/A1L1J7-1", "id": "A1L1J7-1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 37570.0, "chemical_mass": 37570.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7", "name": "Pbk", "locus": { "end_pos": 42500395, "strand": "+", "start_pos": 42489377, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015308", "id": "ENSRNOG00000015308", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1L1J7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "PDZ-binding kinase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1J7", "type": "synonym", "resource": "RefSeq", "name": "lymphokine-activated killer T-cell-originated protein kinase" } ] }