{
    "uniprot_canonical_ac": "A1E5L0-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A1E5L0-1|A1E5L0_MOUSE Isoform 1 of Cytokine-like protein C17  OS=Mus musculus OX=10090 GN=Cytl1 PE=1 SV=1 CANONICAL=A1E5L0-1", 
        "length": 139, 
        "sequence": "MSPKTLPLLLLLVVVVIAWPLAVQSAPPTCYSRMLTLSREIMADFQSLQASEPEDSCVRYLPRLYLDIHNYCVLAKLRDFVASPQCWKMAEVDTLKDRVRKLYTIMNSFCRRDLVFLSDDCSALEDPIPEATGPPDWQS"
    }, 
    "uniprot_id": "", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                    "id": "A1E5L0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "pmid": "17644814", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                                "id": "A1E5L0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051091", 
                        "pmid": "17644814", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                                "id": "A1E5L0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of DNA-binding transcription factor activity", 
                        "id": "GO:0051091"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002062", 
                        "pmid": "17644814", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                                "id": "A1E5L0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chondrocyte differentiation", 
                        "id": "GO:0002062"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048839", 
                        "pmid": "21795542", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                                "id": "A1E5L0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "inner ear development", 
                        "id": "GO:0048839"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", 
                        "pmid": "17644814", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                                "id": "A1E5L0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chondroitin sulfate proteoglycan biosynthetic process", 
                        "id": "GO:0050650"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990079", 
                        "pmid": "21652695", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                                "id": "A1E5L0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cartilage homeostasis", 
                        "id": "GO:1990079"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15031101", 
                    "type": "PubMed", 
                    "id": "15031101"
                }
            ], 
            "title": "Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule.", 
            "journal": "Developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ficker M, Powles N, Warr N, Pirvola U, Maconochie M", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17644814", 
                    "type": "PubMed", 
                    "id": "17644814"
                }
            ], 
            "title": "Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells.", 
            "journal": "J. Biol. Chem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1E5L0", 
                    "id": "A1E5L0", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kim J.S., Ryoo Z.Y., Chun J.S.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21652695", 
                    "type": "PubMed", 
                    "id": "21652695"
                }
            ], 
            "title": "Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Jeon J, Oh H, Lee G, Ryu JH, Rhee J, Kim JH, Chung KH, Song WK, Chun CH, Chun JS", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24738827", 
                    "type": "PubMed", 
                    "id": "24738827"
                }
            ], 
            "title": "Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos.", 
            "journal": "Stem cells and development", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Jenner F, IJpma A, Cleary M, Heijsman D, Narcisi R, van der Spek PJ, Kremer A, van Weeren R, Brama P, van Osch GJ", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26273529", 
                    "type": "PubMed", 
                    "id": "26273529"
                }
            ], 
            "title": "High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.", 
            "journal": "Bone research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Brommage R, Liu J, Hansen GM, Kirkpatrick LL, Potter DG, Sands AT, Zambrowicz B, Powell DR, Vogel P", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27835665", 
                    "type": "PubMed", 
                    "id": "27835665"
                }
            ], 
            "title": "Cytokine-Like 1 Regulates Cardiac Fibrosis via Modulation of TGF-beta Signaling.", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kim J, Kim J, Lee SH, Kepreotis SV, Yoo J, Chun JS, Hajjar RJ, Jeong D, Park WJ", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/30718470", 
                    "type": "PubMed", 
                    "id": "30718470"
                }
            ], 
            "title": "CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages.", 
            "journal": "Cell death & disease", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Shin Y, Won Y, Yang JI, Chun JS", 
            "date": "2019"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/31823178", 
                    "type": "PubMed", 
                    "id": "31823178"
                }
            ], 
            "title": "CYTL1 Promotes the Activation of Neutrophils in a Sepsis Model.", 
            "journal": "Inflammation", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Xue H, Li S, Zhao X, Guo F, Jiang L, Wang Y, Zhu F", 
            "date": "2020"
        }
    ], 
    "uniprot_ac": "A1E5L0", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1E5L0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1E5L0", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "4Cytl1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1E5L0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Cytl1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1E5L0", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Cytl1"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1E5L0#A1E5L0-1", 
            "isoform_ac": "A1E5L0-1", 
            "locus": {
                "end_pos": 37735548, 
                "strand": "-", 
                "start_pos": 37739292, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000073554", 
                        "id": "ENSMUST00000073554", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000073244", 
                        "id": "ENSMUSP00000073244", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A1E5L0-1|A1E5L0_MOUSE Isoform 1 of Cytokine-like protein C17  OS=Mus musculus OX=10090 GN=Cytl1 PE=1 SV=1 CANONICAL=A1E5L0-1", 
                "length": 139, 
                "sequence": "MSPKTLPLLLLLVVVVIAWPLAVQSAPPTCYSRMLTLSREIMADFQSLQASEPEDSCVRYLPRLYLDIHNYCVLAKLRDFVASPQCWKMAEVDTLKDRVRKLYTIMNSFCRRDLVFLSDDCSALEDPIPEATGPPDWQS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:231162", 
            "resource": "KEGG Pathway", 
            "id": "mmu:231162", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
            "annotation": "CYTL1 Promotes the Activation of Neutrophils in a Sepsis Model.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
            "annotation": "Chondrocyte-specific Cytl1 regulates chondrogenesis as a novel autocrine factor, but not hypertrophic maturation of chondrocytes during cartilage development", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
            "annotation": "Collectively, the data suggest that Cytl1 plays an essential role in cardiac fibrosis likely through activating the TGF-beta-SMAD signaling pathway. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
            "annotation": "Results collectively suggest that CYTL1 negatively regulates the osteogenesis of MSCs and positively regulates osteoclastogenesis to modulate bone mass. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
            "annotation": "Results suggest that, rather than regulating cartilage and bone development, Cytl1 is required for the maintenance of cartilage homeostasis, and loss of Cytl1 function is associated with experimental OA cartilage destruction in mice", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
                    "id": "NP_001074575.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
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        {
            "uniprot_canonical_ac": "B5DFG7-1", 
            "protein_name": "Cytl1 protein", 
            "sequence": {
                "length": 137, 
                "sequence": "MAPKTLPLLLSLLLVVWPLTVQPAPPTCYSRMLTLSREIMADFQSLQASEPEDSCVRYLPRLYLDIHNYCVLTKLRDFVASPQCWKMAEVDMLKDRVRKLYTIMNSFCRRDLVFLSDDCSVLEHPIPETTDPPDWQS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/10254", 
                    "id": "10254", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1E5L0/", 
                    "id": "A1E5L0", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Cytl1", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9NRR1-1", 
            "protein_name": "Cytokine-like protein 1", 
            "sequence": {
                "length": 136, 
                "sequence": "MRTPGPLPVLLLLLAGAPAARPTPPTCYSRMRALSQEITRDFNLLQVSEPSEPCVRYLPRLYLDIHNYCVLDKLRDFVASPPCWKVAQVDSLKDKARKLYTIMNSFCRRDLVFLLDDCNALEYPIPVTTVLPDRQR"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/10254", 
                    "id": "10254", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1E5L0/", 
                    "id": "A1E5L0", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "CYTL1", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
        "ac": "NP_001074575.1", 
        "name": "cytokine-like protein 1 precursor", 
        "summary": ""
    }, 
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    "pro_annotation": [], 
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        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000062329", 
            "id": "ENSMUSG00000062329", 
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        {
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            "id": "231162", 
            "database": "GeneID"
        }, 
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            "database": "InterPro"
        }, 
        {
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            "id": "mmu:231162", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2684993", 
            "id": "2684993", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/CYSRMLT/", 
            "id": "CYSRMLT", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1466674at2759", 
            "id": "1466674at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15974", 
            "id": "PTHR15974", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15153", 
            "id": "PF15153", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575", 
            "id": "NP_001074575", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074575.1", 
            "id": "NP_001074575.1", 
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        {
            "url": "https://www.uniprot.org/uniprot/A1E5L0", 
            "id": "A1E5L0", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1E5L0-1", 
            "id": "A1E5L0-1", 
            "database": "UniProtKB"
        }
    ], 
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    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 15854.0, 
        "chemical_mass": 15854.0
    }, 
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            "url": "https://www.uniprot.org/uniprot/A1E5L0", 
            "name": "Cytl1", 
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                "strand": "+", 
                "start_pos": 37735519, 
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                "evidence": [
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                        "id": "ENSMUSG00000062329", 
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            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Cytokine-like 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1E5L0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
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        }, 
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            "url": "https://www.ncbi.nlm.nih.gov/protein/A1E5L0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "cytokine-like protein 1 precursor"
        }
    ]
}