{
    "uniprot_canonical_ac": "A0JPP1-1", 
    "ptm_annotation": [
        {
            "annotation": "Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                    "id": "A0JPP1", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q14919", 
                    "id": "Q14919", 
                    "database": "PubMed"
                }
            ]
        }
    ], 
    "sequence": {
        "header": "sp|A0JPP1-1|NC2A_RAT Isoform 1 of Dr1-associated corepressor  OS=Rattus norvegicus OX=10116 GN=Drap1 PE=2 SV=1 CANONICAL=A0JPP1-1", 
        "length": 205, 
        "sequence": "MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHTDGDKGPRRGRKPGSSGRKNGGTGSKSKDKKLSGTDSEQEDESEDTDTDGEEETPQAPPQASHPPAHFQSPPTPFMPFTSPLPLPPAPPGPSAPEAEDEEDYDS"
    }, 
    "uniprot_id": "", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                    "id": "A0JPP1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription coactivator activity", 
                        "id": "GO:0003713"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001046", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "core promoter sequence-specific DNA binding", 
                        "id": "GO:0001046"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein heterodimerization activity", 
                        "id": "GO:0046982"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription corepressor activity", 
                        "id": "GO:0003714"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008134", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription factor binding", 
                        "id": "GO:0008134"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017025", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "TBP-class protein binding", 
                        "id": "GO:0017025"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II general transcription initiation factor activity", 
                        "id": "GO:0016251"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001091", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II general transcription initiation factor binding", 
                        "id": "GO:0001091"
                    }
                ], 
                "total": 9, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017054", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative cofactor 2 complex", 
                        "id": "GO:0017054"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II transcription regulator complex", 
                        "id": "GO:0090575"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of transcription by RNA polymerase II", 
                        "id": "GO:0045944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription, DNA-templated", 
                        "id": "GO:0006355"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription by RNA polymerase II", 
                        "id": "GO:0006366"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPP1", 
                                "id": "A0JPP1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription by RNA polymerase II", 
                        "id": "GO:0000122"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27107012", 
                    "type": "PubMed", 
                    "id": "27107012"
                }
            ], 
            "title": "Pooled-matrix protein interaction screens using Barcode Fusion Genetics.", 
            "journal": "Molecular systems biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071136.1", 
                    "id": "NP_001071136.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A0JPP1", 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPP1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Drap1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Drap1"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1#A0JPP1-1", 
            "isoform_ac": "A0JPP1-1", 
            "locus": {
                "end_pos": 220804382, 
                "strand": "+", 
                "start_pos": 220806228, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000038138", 
                        "id": "ENSRNOT00000038138", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000032674", 
                        "id": "ENSRNOP00000032674", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0JPP1-1|NC2A_RAT Isoform 1 of Dr1-associated corepressor  OS=Rattus norvegicus OX=10116 GN=Drap1 PE=2 SV=1 CANONICAL=A0JPP1-1", 
                "length": 205, 
                "sequence": "MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHTDGDKGPRRGRKPGSSGRKNGGTGSKSKDKKLSGTDSEQEDESEDTDTDGEEETPQAPPQASHPPAHFQSPPTPFMPFTSPLPLPPAPPGPSAPEAEDEEDYDS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:293674", 
            "resource": "KEGG Pathway", 
            "id": "rno:293674", 
            "name": ""
        }, 
        {
            "reaction_list": [
                "R-RNO-1535903", 
                "R-RNO-1225919", 
                "R-RNO-170847", 
                "R-RNO-173488"
            ], 
            "resource": "Reactome", 
            "description": "Signaling by NODAL", 
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1181150", 
            "id": "R-RNO-1181150", 
            "name": "Signaling by NODAL"
        }, 
        {
            "reaction_list": [
                "R-RNO-1181149", 
                "R-RNO-1181153", 
                "R-RNO-1225919", 
                "R-RNO-1549526", 
                "R-RNO-170847", 
                "R-RNO-173488"
            ], 
            "resource": "Reactome", 
            "description": "Signaling by Activin", 
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1502540", 
            "id": "R-RNO-1502540", 
            "name": "Signaling by Activin"
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1#function", 
            "annotation": "The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPP1#function", 
                    "id": "A0JPP1", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q14919-1", 
            "protein_name": "Dr1-associated corepressor", 
            "sequence": {
                "length": 205, 
                "sequence": "MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLPFASTLPLPPAPPGPSAPDEEDEEDYDS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/4703", 
                    "id": "4703", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "DRAP1", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q9D6N5-1", 
            "protein_name": "Dr1-associated corepressor", 
            "sequence": {
                "length": 205, 
                "sequence": "MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHVDGDKGPRRGRKPGSSGRKNGGTGSKGKDKKLSGTDSEQEDESEDTDTDGEEETPQLPPQASHPPAHFQSPPTPFIPFTSPLPLPPAPPGPSAADAEDEEDYDS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/4703", 
                    "id": "4703", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0JPP1/", 
                    "id": "A0JPP1", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Drap1", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071136.1", 
        "ac": "NP_001071136.1", 
        "name": "dr1-associated corepressor", 
        "summary": ""
    }, 
    "reaction_enzymes": [], 
    "site_annotation": [
        {
            "end_pos": 102, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 100
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020527", 
            "id": "ENSRNOG00000020527", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/293674", 
            "id": "293674", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003958", 
            "id": "IPR003958", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", 
            "id": "IPR009072", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:293674", 
            "id": "rno:293674", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/GHPPAHF/", 
            "id": "GHPPAHF", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1504101at2759", 
            "id": "1504101at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00808", 
            "id": "PF00808", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A0JPP1", 
            "id": "PR_A0JPP1", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1181150", 
            "id": "R-RNO-1181150", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1502540", 
            "id": "R-RNO-1502540", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071136", 
            "id": "NP_001071136", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071136.1", 
            "id": "NP_001071136.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308477", 
            "id": "1308477", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1", 
            "id": "A0JPP1", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1-1", 
            "id": "A0JPP1-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 22326.0, 
        "chemical_mass": 22326.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1", 
            "name": "Drap1", 
            "locus": {
                "end_pos": 220803796, 
                "strand": "-", 
                "start_pos": 220806433, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000020527", 
                        "id": "ENSRNOG00000020527", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPP1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Dr1 associated protein 1 (negative cofactor 2 alpha); NC2-alpha; dr1-associated protein 1; negative co-factor 2-alpha; negative cofactor 2-alpha"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Dr1-associated corepressor"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Dr1-associated protein 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "NC2-alpha"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPP1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Negative cofactor 2-alpha"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPP1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "dr1-associated corepressor"
        }
    ]
}