{
    "uniprot_canonical_ac": "A0JN29-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0JN29-1|A0JN29_RAT Isoform 1 of Endoplasmic reticulum junction formation protein lunapark  OS=Rattus norvegicus OX=10116 GN=Lnpk PE=1 SV=1 CANONICAL=A0JN29-1", 
        "length": 376, 
        "sequence": "MGGLFSRWRAKPSTVEVLENIDKEIQALEEFREKNQRLQKLWVGRLIIYSSILYLFTCLIVYLWYLPDEFIARLVMTLPFFAFPLIIWTLRTVLIFFFSKRTERNNEALDDLKSQKKKILEEVMEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAATAKPGQEIRQRTAAQRNLSPAPANSNQGPPPQVPVSPGPSKDASAPGGPPERTVAPALPRRLGSPATSVPGMGLHPPGPPLARPVLPRERGALDRIVEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQAVEGSSSTGPMLLESVPSPENQLTEGGTIPQMSHFLSEISGMKSNWLKVNPSKTL"
    }, 
    "uniprot_id": "A0JN29_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JN29", 
                    "id": "A0JN29", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum tubular network", 
                        "id": "GO:0071782"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030176", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of endoplasmic reticulum membrane", 
                        "id": "GO:0030176"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098826", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum tubular network membrane", 
                        "id": "GO:0098826"
                    }
                ], 
                "total": 5, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071786", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum tubular network organization", 
                        "id": "GO:0071786"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "blood coagulation", 
                        "id": "GO:0007596"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035115", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "embryonic forelimb morphogenesis", 
                        "id": "GO:0035115"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042733", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "embryonic digit morphogenesis", 
                        "id": "GO:0042733"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032330", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of chondrocyte differentiation", 
                        "id": "GO:0032330"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007029", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum organization", 
                        "id": "GO:0007029"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903373", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of endoplasmic reticulum tubular network organization", 
                        "id": "GO:1903373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071788", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JN29", 
                                "id": "A0JN29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum tubular network maintenance", 
                        "id": "GO:0071788"
                    }
                ], 
                "total": 8, 
                "name": "Biological Process"
            }
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22916278", 
                    "type": "PubMed", 
                    "id": "22916278"
                }
            ], 
            "title": "Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
                    "id": "NP_001070897.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Gross S, Krause Y, Wuelling M, Vortkamp A", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24223779", 
                    "type": "PubMed", 
                    "id": "24223779"
                }
            ], 
            "title": "Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum.", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
                    "id": "NP_001070897.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Moriya K, Nagatoshi K, Noriyasu Y, Okamura T, Takamitsu E, Suzuki T, Utsumi T", 
            "date": "2013"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25404289", 
                    "type": "PubMed", 
                    "id": "25404289"
                }
            ], 
            "title": "A model for the generation and interconversion of ER morphologies.", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
                    "id": "NP_001070897.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Shemesh T, Klemm RW, Romano FB, Wang S, Vaughan J, Zhuang X, Tukachinsky H, Kozlov MM, Rapoport TA", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25548161", 
                    "type": "PubMed", 
                    "id": "25548161"
                }
            ], 
            "title": "Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum.", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
                    "id": "NP_001070897.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Chen S, Desai T, McNew JA, Gerard P, Novick PJ, Ferro-Novick S", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/30032983", 
                    "type": "PubMed", 
                    "id": "30032983"
                }
            ], 
            "title": "Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome.", 
            "journal": "American journal of human genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
                    "id": "NP_001070897.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Breuss MW, Nguyen A, Song Q, Nguyen T, Stanley V, James KN, Musaev D, Chai G, Wirth SA, Anzenberg P, George RD, Johansen A, Ali S, Zia-Ur-Rehman M, Sultan T, Zaki MS, Gleeson JG", 
            "date": "2018"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9342042", 
                    "type": "PubMed", 
                    "id": "9342042"
                }
            ], 
            "title": "Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes.", 
            "journal": "Development (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
                    "id": "NP_001070897.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Herault Y, Fraudeau N, Zakany J, Duboule D", 
            "date": "1997"
        }
    ], 
    "uniprot_ac": "A0JN29", 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Lnp_predicted"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JN29", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Lnpk"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Lnpk"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JN29", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Lnp"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Lnp"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_27205"
        }
    ], 
    "reactions": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29#A0JN29-1", 
            "isoform_ac": "A0JN29-1", 
            "locus": {
                "end_pos": 61434062, 
                "strand": "+", 
                "start_pos": 61488696, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000068018", 
                        "id": "ENSRNOT00000068018", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000062011", 
                        "id": "ENSRNOP00000062011", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0JN29-1|A0JN29_RAT Isoform 1 of Endoplasmic reticulum junction formation protein lunapark  OS=Rattus norvegicus OX=10116 GN=Lnpk PE=1 SV=1 CANONICAL=A0JN29-1", 
                "length": 376, 
                "sequence": "MGGLFSRWRAKPSTVEVLENIDKEIQALEEFREKNQRLQKLWVGRLIIYSSILYLFTCLIVYLWYLPDEFIARLVMTLPFFAFPLIIWTLRTVLIFFFSKRTERNNEALDDLKSQKKKILEEVMEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAATAKPGQEIRQRTAAQRNLSPAPANSNQGPPPQVPVSPGPSKDASAPGGPPERTVAPALPRRLGSPATSVPGMGLHPPGPPLARPVLPRERGALDRIVEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQAVEGSSSTGPMLLESVPSPENQLTEGGTIPQMSHFLSEISGMKSNWLKVNPSKTL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362151", 
            "resource": "KEGG Pathway", 
            "id": "rno:362151", 
            "name": ""
        }
    ], 
    "reaction_participants": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29#function", 
            "annotation": "Plays a role in determining ER morphology.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JN29#function", 
                    "id": "A0JN29", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q7TQ95-1", 
            "protein_name": "Endoplasmic reticulum junction formation protein lunapark", 
            "sequence": {
                "length": 425, 
                "sequence": "MGGLFSRWRAKPSTVEVLENIDKEIQALEEFREKNQRLQKLWVGRLIIYSSILYLFTCLIVYLWYLPDEFTARLVMTLPFFAFPLIIWTLRTVLIFFFSKRTERNNEALDDLKSQKKKILEEVMEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAVTAKPGQEIRQRTAAQRNLSPAPASSSQGPPPQGPVSPGPAKDASAPGGPPERTVAPALPRRLGSPATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQAVEGSSSTGPTLLESVPSAESQLIEDSLEEQDVLDNSTEQRDDKIPVTEQTSQVIEKTSGPEEPAENQEETENEETSTNEAKSPVLRADSVPNLEPSEESLVTK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12319", 
                    "id": "12319", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0JN29/", 
                    "id": "A0JN29", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Lnpk", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9C0E8-1", 
            "protein_name": "Endoplasmic reticulum junction formation protein lunapark", 
            "sequence": {
                "length": 428, 
                "sequence": "MGGLFSRWRTKPSTVEVLESIDKEIQALEEFREKNQRLQKLWVGRLILYSSVLYLFTCLIVYLWYLPDEFTARLAMTLPFFAFPLIIWSIRTVIIFFFSKRTERNNEALDDLKSQRKKILEEVMEKETYKTAKLILERFDPDSKKAKECEPPSAGAAVTARPGQEIRQRTAAQRNLSPTPASPNQGPPPQVPVSPGPPKDSSAPGGPPERTVTPALSSNVLPRHLGSPATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQVVEGSSSVGPLPSGSVLSSDNQFNEESLEHDVLDDNTEQTDDKIPATEQTNQVIEKASDSEEPEEKQETENEEASVIETNSTVPGADSIPDPELSGESLTAE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12319", 
                    "id": "12319", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "LNPK", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
        "ac": "NP_001070897.1", 
        "name": "protein lunapark", 
        "summary": ""
    }, 
    "reaction_enzymes": [], 
    "site_annotation": [
        {
            "end_pos": 177, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 175
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000001593", 
            "id": "ENSRNOG00000001593", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/362151", 
            "id": "362151", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019273", 
            "id": "IPR019273", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040115", 
            "id": "IPR040115", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362151", 
            "id": "rno:362151", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TAPKNRI/", 
            "id": "TAPKNRI", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1595535at2759", 
            "id": "1595535at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22166", 
            "id": "PTHR22166", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF10058", 
            "id": "PF10058", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897", 
            "id": "NP_001070897", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070897.1", 
            "id": "NP_001070897.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1312042", 
            "id": "1312042", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29", 
            "id": "A0JN29", 
            "database": "UniProtKB"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29-1", 
            "id": "A0JN29-1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 42170.0, 
        "chemical_mass": 42170.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29", 
            "name": "Lnpk", 
            "locus": {
                "end_pos": 61433863, 
                "strand": "-", 
                "start_pos": 61494778, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000001593", 
                        "id": "ENSRNOG00000001593", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JN29#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Endoplasmic reticulum junction formation protein lunapark"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JN29", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "limb and neural patterns"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JN29", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "protein lunapark"
        }
    ]
}