{ "uniprot_canonical_ac": "A0FGR9-1", "ptm_annotation": [], "sequence": { "header": "sp|A0FGR9-1|ESYT3_HUMAN Isoform 1 of Extended synaptotagmin-3 OS=Homo sapiens OX=9606 GN=ESYT3 PE=1 SV=1 CANONICAL=A0FGR9-1", "length": 886, "sequence": "MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS" }, "uniprot_id": "", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "calcium-dependent phospholipid binding", "id": "GO:0005544" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "phosphatidylethanolamine binding", "id": "GO:0008429" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "phosphatidylcholine binding", "id": "GO:0031210" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "phosphatidylinositol binding", "id": "GO:0035091" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "lipid binding", "id": "GO:0008289" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031227", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "intrinsic component of endoplasmic reticulum membrane", "id": "GO:0031227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044232", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "organelle membrane contact site", "id": "GO:0044232" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "pmid": "17360437", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "integral component of plasma membrane", "id": "GO:0005887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031234", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "extrinsic component of cytoplasmic side of plasma membrane", "id": "GO:0031234" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "pmid": "30220461", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "lipid transport", "id": "GO:0006869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006687", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "glycosphingolipid metabolic process", "id": "GO:0006687" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061817", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane tethering", "id": "GO:0061817" } ], "total": 3, "name": "Biological Process" } ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11543631", "type": "PubMed", "id": "11543631" } ], "title": "Genomic analysis of synaptotagmin genes.", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "authors": "Craxton M.A.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17360437", "type": "PubMed", "id": "17360437" } ], "title": "E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" } ], "authors": "Suedhof T.C., Chang W.-P., Min S.-W.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17672888", "type": "PubMed", "id": "17672888" } ], "title": "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans.", "journal": "BMC genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ], "authors": "Craxton M", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21733517", "type": "PubMed", "id": "21733517" } ], "title": "Fine mapping of chromosome 3q22.3 identifies two haplotype blocks in ESYT3 associated with coronary artery disease in female Han Chinese.", "journal": "Atherosclerosis", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ], "authors": "Jiang F, Dong Y, Wu C, Yang X, Zhao L, Guo J, Li Y, Dong J, Zheng GY, Cao H, Jin L, Ren Y, Cheng W, Li W, Tian XL, Li X", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23791178", "type": "PubMed", "id": "23791178" } ], "title": "PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ], "authors": "Gracheva E.O., De Camilli P., Borgese N., Pirruccello M., Bagriantsev S.N., Colombo S.F., Giordano F., Idevall-Hagren O., Milosevic I., Saheki Y.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25922075", "type": "PubMed", "id": "25922075" } ], "title": "Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ], "authors": "Tremblay MG, Herdman C, Guillou F, Mishra PK, Baril J, Bellenfant S, Moss T", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27065097", "type": "PubMed", "id": "27065097" } ], "title": "Control of plasma membrane lipid homeostasis by the extended synaptotagmins.", "journal": "Nature cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ], "authors": "Saheki Y, Bian X, Schauder CM, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, De Camilli P", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30220461", "type": "PubMed", "id": "30220461" } ], "title": "Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9", "id": "A0FGR9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ], "authors": "Jiang H., Li S., He C., Xiao X., Young S.G., Ikonen E., Lee R., Gatta A.T., Levine T.P., Hong C., Ferrari A., Fairall L., Tontonoz P., Schwabe J.W.R., Lee S.D., Sandhu J., Pfisterer S.G., Bentolila L.A., Ferng A., Ford D.A., Gurnett J.E., Hartman C.L., Orozco J.L., Strugatsky D., Vashi D., Weston T.A.", "date": "2018" } ], "uniprot_ac": "A0FGR9", "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0FGR9", "type": "synonym", "resource": "RefSeq", "name": "CHR3SYT; E-Syt3; FAM62C" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0FGR9", "type": "synonym", "resource": "RefSeq", "name": "ESYT3" }, { "url": "https://www.uniprot.org/uniprot/A0FGR9", "type": "recommended", "resource": "UniProtKB", "name": "ESYT3" }, { "url": "https://www.uniprot.org/uniprot/A0FGR9", "type": "synonym", "resource": "UniProtKB", "name": "FAM62C" } ], "reactions": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9#A0FGR9-1", "isoform_ac": "A0FGR9-1", "locus": { "end_pos": 138434799, "strand": "-", "start_pos": 138476851, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000389567", "id": "ENST00000389567", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000374218", "id": "ENSP00000374218", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0FGR9-1|ESYT3_HUMAN Isoform 1 of Extended synaptotagmin-3 OS=Homo sapiens OX=9606 GN=ESYT3 PE=1 SV=1 CANONICAL=A0FGR9-1", "length": 886, "sequence": "MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR9#A0FGR9-2", "isoform_ac": "A0FGR9-2", "locus": { "end_pos": 138434799, "strand": "-", "start_pos": 138469500, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000490835", "id": "ENST00000490835", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000417388", "id": "ENSP00000417388", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0FGR9-2|ESYT3_HUMAN Isoform 2 of Extended synaptotagmin-3 OS=Homo sapiens OX=9606 GN=ESYT3 PE=1 SV=1 CANONICAL=A0FGR9-1", "length": 501, "sequence": "MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARVKQGQQRPFFLCQTICRQEDTYK" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR9#H7BXJ6-1", "isoform_ac": "H7BXJ6-1", "locus": { "end_pos": 138434799, "strand": "-", "start_pos": 138462221, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000289135", "id": "ENST00000289135", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000289135", "id": "ENSP00000289135", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H7BXJ6-1|H7BXJ6_HUMAN Computationally mapped isoform of Extended synaptotagmin-3 OS=Homo sapiens OX=9606 GN=ESYT3 PE=1 SV=1 CANONICAL=A0FGR9-1", "length": 310, "sequence": "MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEWANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNTCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCVSTQY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:83850", "resource": "KEGG Pathway", "id": "hsa:83850", "name": "" }, { "reaction_list": [ "R-HSA-1605591", "R-HSA-1605595", "R-HSA-1605624", "R-HSA-1605632", "R-HSA-1605717", "R-HSA-1605723", "R-HSA-1605724", "R-HSA-1605736", "R-HSA-1605768", "R-HSA-1605797", "R-HSA-1606273", "R-HSA-1606288", "R-HSA-1606312", "R-HSA-1606564", "R-HSA-1606583", "R-HSA-1606602", "R-HSA-1606807", "R-HSA-1606839", "R-HSA-1614336", "R-HSA-1614362", "R-HSA-1638104", "R-HSA-1638845", "R-HSA-1640164", "R-HSA-1861788", "R-HSA-1861789", "R-HSA-2248891", "R-HSA-5339535", "R-HSA-5340320", "R-HSA-6785933", "R-HSA-8856223", "R-HSA-8857662", "R-HSA-8878914" ], "resource": "Reactome", "description": "Glycosphingolipid metabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660662", "id": "R-HSA-1660662", "name": "Glycosphingolipid metabolism" } ], "reaction_participants": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9#function", "annotation": "Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR9#function", "id": "A0FGR9", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "annotation": "ESyt2 and ESyt3, but not ESyt1, interact with activated FGFR1. Erratum:[J Biol Chem. 2016 Feb 12;291(7):3173. PMID: 26873909]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "id": "NP_001309760.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309760.1", "annotation": "The extended synaptotagmins (E-Syt1, E-Syt2, and E-Syt3) are endoplasmic reticulum-anchored proteins. They form homo- and heteromeric complexes that mediate contacts with the plasma membrane. 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