{ "uniprot_canonical_ac": "A4D2G3-1", "ptm_annotation": [], "sequence": { "header": "sp|A4D2G3-1|O2A25_HUMAN Isoform 1 of Olfactory receptor 2A25 OS=Homo sapiens OX=9606 GN=OR2A25 PE=2 SV=2 CANONICAL=A4D2G3-1", "length": 310, "sequence": "MGGNQTSITEFLLLGFPIGPRIQMLLFGLFSLFYIFILLGNGTILGLISLDSRLHTPMYFFLSHLAVVDIACACSTVPQMLVNLLHPAKPISFAGCMTQMFLFLSFAHTECLLLVVMSYDRYVAICHPLRYSTIMTWKVCITLALTSWILGVLLALVHLVLLLPLSFCGPQKLNHFFCEIMAVLKLACADTHINEVMVLAGAVSVLVGAFFSTVISYVHILCAILKIQSGEGCQKAFSICSSHLCVVGLFYGTAIIMYVEPQYESPKEQKKYLLLFHSLFNPMLNPLIYSLRNKEVQGTLKRMLEKKRTS" }, "uniprot_id": "O2A25_HUMAN", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly", "reported_with_glycan.oglcnac_db" ], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4D2G3", "id": "A4D2G3", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17975119", "type": "PubMed", "id": "17975119" } ], "title": "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004488.1", "id": "NP_001004488.1", "database": "RefSeq" } ], "authors": "Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19023099", "type": "PubMed", "id": "19023099" } ], "title": "Gene variants associated with ischemic stroke: the cardiovascular health study.", "journal": "Stroke", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004488.1", "id": "NP_001004488.1", "database": "RefSeq" } ], "authors": "Luke MM, O'Meara ES, Rowland CM, Shiffman D, Bare LA, Arellano AR, Longstreth WT Jr, Lumley T, Rice K, Tracy RP, Devlin JJ, Psaty BM", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28411811", "type": "PubMed", "id": "28411811" } ], "title": "A novel strategy for global mapping of O-GlcNAc proteins and peptides using selective enzymatic deglycosylation, HILIC enrichment and mass spectrometry identification.", "journal": "Talanta", "evidence": [ { "url": "https://data.glygen.org/GLYDS000517", "id": "GLYDS000517", "database": "GlyGen" } ], "authors": "Shen B, Zhang W, Shi Z, Tian F, Deng Y, Sun C, Wang G, Qin W, Qian X", "date": "2017" } ], "uniprot_ac": "A4D2G3", "site_annotation": [ { "end_pos": 43, "annotation": "n_glycosylation_sequon", "start_pos": 41 }, { "end_pos": 6, "annotation": "n_glycosylation_sequon", "start_pos": 4 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4D2G3#A4D2G3-1", "isoform_ac": "A4D2G3-1", "locus": { "end_pos": 144074220, "strand": "-", "start_pos": 144075149, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000641441", "id": "ENST00000641441", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000493159", "id": "ENSP00000493159", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4D2G3-1|O2A25_HUMAN Isoform 1 of Olfactory receptor 2A25 OS=Homo sapiens OX=9606 GN=OR2A25 PE=2 SV=2 CANONICAL=A4D2G3-1", "length": 310, "sequence": "MGGNQTSITEFLLLGFPIGPRIQMLLFGLFSLFYIFILLGNGTILGLISLDSRLHTPMYFFLSHLAVVDIACACSTVPQMLVNLLHPAKPISFAGCMTQMFLFLSFAHTECLLLVVMSYDRYVAICHPLRYSTIMTWKVCITLALTSWILGVLLALVHLVLLLPLSFCGPQKLNHFFCEIMAVLKLACADTHINEVMVLAGAVSVLVGAFFSTVISYVHILCAILKIQSGEGCQKAFSICSSHLCVVGLFYGTAIIMYVEPQYESPKEQKKYLLLFHSLFNPMLNPLIYSLRNKEVQGTLKRMLEKKRTS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:392138", "resource": "KEGG Pathway", "id": "hsa:392138", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381753", "resource": "Reactome", "id": "R-HSA-381753", "name": "Olfactory Signaling Pathway" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004488.1", "annotation": "Observational study of gene-disease association. 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"id": "MONDO:0007576" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007576", "resource": "MONDO", "description": "", "name": "malignant esophagus tumor", "id": "MONDO:0007576" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007576", "resource": "MONDO", "description": "", "name": "esophagus cancer", "id": "MONDO:0007576" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007576", "resource": "MONDO", "description": "", "name": "malignant neoplasm of distal third of esophagus", "id": "MONDO:0007576" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007576", "resource": "MONDO", "description": "", "name": "Ca middle third oesophagus", "id": "MONDO:0007576" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007576", "resource": "MONDO", "description": "", "name": "malignant tumor of the esophagus", "id": "MONDO:0007576" }, { "url": "https://monarchinitiative.org/disease/MONDO:0007576", "resource": "MONDO", "description": "", "name": "esophageal squamous cell carcinoma, susceptibility to", "id": "MONDO:0007576" }, { "url": "https://www.omim.org/entry/133239", "resource": "MIM", "description": "Esophageal cancer", "name": "Esophageal cancer", "id": "MIM:133239" } ], "recommended_name": { "url": "http://disease-ontology.org/term/DOID:5041", "resource": "Disease Ontology", "description": "A gastrointestinal system cancer that is located_in the esophagus.", "name": "esophageal cancer", "id": "DOID:5041" } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D2G3", "id": "A4D2G3", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:5041", "significant": "No" } ], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 4, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4D2G3#ptm_processing", "id": "A4D2G3", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 4, "glytoucan_ac": "", "type": "N-linked" }, { "site_category": "reported_with_glycan", "evidence": [ { "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A4D2G3", "id": "A4D2G3", "database": "O-GlcNAc Database" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28411811", "id": "28411811", "database": "PubMed" } ], "subtype": "O-GlcNAcylation", "relation": "attached", "glytoucan_ac": "G49108TO", "type": "O-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 34606.0, "chemical_mass": 34606.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4D2G3", "name": "OR2A25", "locus": { "end_pos": 144075870, "strand": "+", "start_pos": 144069811, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000221933", "id": "ENSG00000221933", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A4D2G3#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Olfactory receptor 2A25" }, { "url": "https://www.uniprot.org/uniprot/A4D2G3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Olfactory receptor 2A27" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4D2G3", "type": "synonym", "resource": "RefSeq", "name": "olfactory receptor 2A25" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4D2G3", "type": "synonym", "resource": "RefSeq", "name": "olfactory receptor, family 2, subfamily A, member 25 pseudogene; olfactory receptor, family 2, subfamily A, member 27; olfactory receptor, family 2, subfamily A, member 24 pseudogene; olfactory receptor 2A27" } ] }