{
    "uniprot_canonical_ac": "A2VDH7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2VDH7-1|A2VDH7_MOUSE Isoform 1 of Apolipoprotein L 8  OS=Mus musculus OX=10090 GN=Apol8 PE=2 SV=1 CANONICAL=A2VDH7-1", 
        "length": 339, 
        "sequence": "MDPSDCEDAPGDRTFIEEAAEYLQHTSGREDLRLLLTEDGAWEAFVAEAELSRADADTLRDALHALTANLAVEDQERLQRDLQDMERFMDAFPQVKLELEGHIGKLRTLADKVDKVHRDCTISKLVAGSTSTVSGILTLLGLTLVPVTAGISLVLLATGMGLGAAAAVTSVSSGIVDYTSRSLAKTEASHLVSTGMAKVKMVADAVVHSGPQVLSLSENCCRVLRCIEQSIYAIKLTKANPALAASAMGSTSAQSGKHVKKAFKGTALAISRRARIMGIATAGVSLVGDVISLVKQSKNLHKGTKAKSAEELRQQARELEEKLEALIQMYEGLQAGSRR"
    }, 
    "uniprot_id": "A2VDH7_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2VDH7", 
                    "id": "A2VDH7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A2VDH7", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7#A0A2R8VHH5-1", 
            "isoform_ac": "A0A2R8VHH5-1", 
            "locus": {
                "end_pos": 77750141, 
                "strand": "+", 
                "start_pos": 77753274, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000229445", 
                        "id": "ENSMUST00000229445", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000155102", 
                        "id": "ENSMUSP00000155102", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A2R8VHH5-1|A2VDH7_MOUSE Computationally mapped isoform of Apolipoprotein L 8  OS=Mus musculus OX=10090 GN=Apol8 PE=2 SV=1 CANONICAL=A2VDH7-1", 
                "length": 78, 
                "sequence": "MDPSDCEDAPGDRTFIEEAAEYLQHTSGREDLRLLLTEDGAWEAFVAEAELSRADADTLRDALHALTANLAVEDQERL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7#A0A2R8VHV6-1", 
            "isoform_ac": "A0A2R8VHV6-1", 
            "locus": {
                "end_pos": 77752882, 
                "strand": "+", 
                "start_pos": 77753274, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000229332", 
                        "id": "ENSMUST00000229332", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000155474", 
                        "id": "ENSMUSP00000155474", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A2R8VHV6-1|A2VDH7_MOUSE Computationally mapped isoform of Apolipoprotein L 8  OS=Mus musculus OX=10090 GN=Apol8 PE=2 SV=1 CANONICAL=A2VDH7-1", 
                "length": 25, 
                "sequence": "MDPSDCEDAPGDRTFIEEAAEYLQH"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7#A2VDH7-1", 
            "isoform_ac": "A2VDH7-1", 
            "locus": {
                "end_pos": 77749358, 
                "strand": "+", 
                "start_pos": 77753274, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000070911", 
                        "id": "ENSMUST00000070911", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000064237", 
                        "id": "ENSMUSP00000064237", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2VDH7-1|A2VDH7_MOUSE Isoform 1 of Apolipoprotein L 8  OS=Mus musculus OX=10090 GN=Apol8 PE=2 SV=1 CANONICAL=A2VDH7-1", 
                "length": 339, 
                "sequence": "MDPSDCEDAPGDRTFIEEAAEYLQHTSGREDLRLLLTEDGAWEAFVAEAELSRADADTLRDALHALTANLAVEDQERLQRDLQDMERFMDAFPQVKLELEGHIGKLRTLADKVDKVHRDCTISKLVAGSTSTVSGILTLLGLTLVPVTAGISLVLLATGMGLGAAAAVTSVSSGIVDYTSRSLAKTEASHLVSTGMAKVKMVADAVVHSGPQVLSLSENCCRVLRCIEQSIYAIKLTKANPALAASAMGSTSAQSGKHVKKAFKGTALAISRRARIMGIATAGVSLVGDVISLVKQSKNLHKGTKAKSAEELRQQARELEEKLEALIQMYEGLQAGSRR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:239552", 
            "resource": "KEGG Pathway", 
            "id": "mmu:239552", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2168880", 
            "resource": "Reactome", 
            "id": "R-MMU-2168880", 
            "name": "Scavenging of heme from plasma"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381426", 
            "resource": "Reactome", 
            "id": "R-MMU-381426", 
            "name": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8957275", 
            "resource": "Reactome", 
            "id": "R-MMU-8957275", 
            "name": "Post-translational protein phosphorylation"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9BQE5-1", 
            "protein_name": "Apolipoprotein L2", 
            "sequence": {
                "length": 337, 
                "sequence": "MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHIIGRISAEGGEQVERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/12785", 
                    "id": "12785", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "APOL2", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075439.1", 
        "ac": "NP_001075439.1", 
        "name": "apolipoprotein L2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VDH7", 
                                "id": "A2VDH7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid binding", 
                        "id": "GO:0008289"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VDH7", 
                                "id": "A2VDH7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VDH7", 
                                "id": "A2VDH7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VDH7", 
                                "id": "A2VDH7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid transport", 
                        "id": "GO:0006869"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042157", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VDH7", 
                                "id": "A2VDH7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipoprotein metabolic process", 
                        "id": "GO:0042157"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VDH7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "9830006J20Rik; A; APOL-II; Apol2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VDH7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Apol8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Apol8"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000056656", 
            "id": "ENSMUSG00000056656", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/239552", 
            "id": "239552", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008405", 
            "id": "IPR008405", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:239552", 
            "id": "mmu:239552", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2444921", 
            "id": "2444921", 
            "database": "MGI"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1060131at2759", 
            "id": "1060131at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14096", 
            "id": "PTHR14096", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF05461", 
            "id": "PF05461", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2168880", 
            "id": "R-MMU-2168880", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381426", 
            "id": "R-MMU-381426", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8957275", 
            "id": "R-MMU-8957275", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075439", 
            "id": "NP_001075439", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075439.1", 
            "id": "NP_001075439.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7", 
            "id": "A2VDH7", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "disease_id": "DOID:1312", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:1312", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "focal glomerular sclerosis", 
                    "id": "DOID:1312"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1312", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "FSGS", 
                    "id": "DOID:1312"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1312", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "focal glomerulosclerosis", 
                    "id": "DOID:1312"
                }, 
                {
                    "url": "http://disease-ontology.org/term/DOID:1312", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "FGS", 
                    "id": "DOID:1312"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "Any focal segmental glomerulosclerosis in which the cause of the disease is a mutation in the ACTN4 gene.", 
                    "name": "focal segmental glomerulosclerosis 1", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "glomerulosclerosis, focal segmental, 1", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "FSGS1", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "focal segmental glomerulosclerosis caused by mutation in ACTN4", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "focal segmental glomerulosclerosis 1; FSGS1", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "focal segmental glomerulosclerosis type 1", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "ACTN4 focal segmental glomerulosclerosis", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "focal segmental glomerulosclerosis 1", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0011303", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "familial idiopathic steroid-resistant nephrotic syndrome with focal segmental glomerulosclerosis", 
                    "id": "MONDO:0011303"
                }, 
                {
                    "url": "https://www.omim.org/entry/603278", 
                    "resource": "MIM", 
                    "description": "Focal segmental glomerulosclerosis 1", 
                    "name": "Focal segmental glomerulosclerosis 1", 
                    "id": "MIM:603278"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:1312", 
                "resource": "Disease Ontology", 
                "description": "", 
                "name": "focal segmental glomerulosclerosis", 
                "id": "DOID:1312"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1312#disease-associations", 
                    "id": "1312", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "disease_id": "DOID:5419", 
            "synonyms": [
                {
                    "url": "http://disease-ontology.org/term/DOID:5419", 
                    "resource": "Disease Ontology", 
                    "description": "", 
                    "name": "schizophrenia-1", 
                    "id": "DOID:5419"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.", 
                    "name": "schizophrenia (disease)", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "schizophrenia with or without an affective disorder", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "schizophrenia; SCZD", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "schizophrenia-1", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "schizophrenia", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "schizoaffective disorder", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://monarchinitiative.org/disease/MONDO:0005090", 
                    "resource": "MONDO", 
                    "description": "", 
                    "name": "SCZD", 
                    "id": "MONDO:0005090"
                }, 
                {
                    "url": "https://www.omim.org/entry/181500", 
                    "resource": "MIM", 
                    "description": "Schizophrenia", 
                    "name": "Schizophrenia", 
                    "id": "MIM:181500"
                }
            ], 
            "recommended_name": {
                "url": "http://disease-ontology.org/term/DOID:5419", 
                "resource": "Disease Ontology", 
                "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.", 
                "name": "schizophrenia", 
                "id": "DOID:5419"
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/5419#disease-associations", 
                    "id": "5419", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 36196.0, 
        "chemical_mass": 36196.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7", 
            "name": "Apol8", 
            "locus": {
                "end_pos": 77747798, 
                "strand": "-", 
                "start_pos": 77757003, 
                "chromosome": "15", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000056656", 
                        "id": "ENSMUSG00000056656", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VDH7#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Apolipoprotein L 8"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VDH7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "apolipoprotein L, 2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VDH7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "apolipoprotein L2"
        }
    ]
}