{
    "uniprot_canonical_ac": "A2ALV5-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2ALV5-1|SHOC1_MOUSE Isoform 1 of Protein shortage in chiasmata 1 ortholog  OS=Mus musculus OX=10090 GN=Shoc1 PE=2 SV=1 CANONICAL=A2ALV5-1", 
        "length": 1481, 
        "sequence": "MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQDKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEIVPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKAMDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAEETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKGDITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHMGFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLADMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIFLPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESISVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQDDLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSKAPEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNFDQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYLSNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKVLIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHSIGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGGFLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTVDEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETLRHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDKSWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVLKHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSEGTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVPSWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPENSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDVTYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPVSSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL"
    }, 
    "uniprot_id": "SHOC1_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "3.6.-.-", 
            "activity": ""
        }
    ], 
    "glycation": [], 
    "keywords": [
        "enzyme"
    ], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ALV5", 
                    "id": "A2ALV5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/29742103", 
                    "type": "PubMed", 
                    "id": "29742103"
                }
            ], 
            "title": "SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.", 
            "journal": "PLoS Genet.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ALV5", 
                    "id": "A2ALV5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Pezza R.J., Guiraldelli M.F., Almeida L.P., Felberg A., Parikh A., de Castro R.O.", 
            "date": "2018"
        }
    ], 
    "uniprot_ac": "A2ALV5", 
    "site_annotation": [
        {
            "end_pos": 1179, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1177
        }, 
        {
            "end_pos": 198, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 196
        }, 
        {
            "end_pos": 294, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 292
        }, 
        {
            "end_pos": 298, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 296
        }, 
        {
            "end_pos": 856, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 854
        }, 
        {
            "end_pos": 948, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 946
        }, 
        {
            "end_pos": 98, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 96
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5#A2ALV5-1", 
            "isoform_ac": "A2ALV5-1", 
            "locus": {
                "end_pos": 59043870, 
                "strand": "+", 
                "start_pos": 59113963, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000107547", 
                        "id": "ENSMUST00000107547", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000103171", 
                        "id": "ENSMUSP00000103171", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2ALV5-1|SHOC1_MOUSE Isoform 1 of Protein shortage in chiasmata 1 ortholog  OS=Mus musculus OX=10090 GN=Shoc1 PE=2 SV=1 CANONICAL=A2ALV5-1", 
                "length": 1481, 
                "sequence": "MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQDKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEIVPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKAMDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAEETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKGDITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHMGFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLADMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIFLPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESISVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQDDLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSKAPEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNFDQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYLSNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKVLIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHSIGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGGFLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTVDEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETLRHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDKSWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVLKHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSEGTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVPSWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPENSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDVTYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPVSSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5#function", 
            "annotation": "ATPase required during meiosis for the formation of crossover recombination intermediates (PubMed:29742103). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ALV5#function", 
                    "id": "A2ALV5", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ALV5", 
                                "id": "A2ALV5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATPase activity", 
                        "id": "GO:0016887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ALV5", 
                                "id": "A2ALV5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "single-stranded DNA binding", 
                        "id": "GO:0003697"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", 
                        "pmid": "29742103", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ALV5", 
                                "id": "A2ALV5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "condensed nuclear chromosome", 
                        "id": "GO:0000794"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", 
                        "pmid": "29742103", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ALV5", 
                                "id": "A2ALV5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "resolution of meiotic recombination intermediates", 
                        "id": "GO:0000712"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Shoc1"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038598", 
            "id": "ENSMUSG00000038598", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039991", 
            "id": "IPR039991", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2140313", 
            "id": "2140313", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PNFINYQ/", 
            "id": "PNFINYQ", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=60413at2759", 
            "id": "60413at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35668", 
            "id": "PTHR35668", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF17825", 
            "id": "PF17825", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2ALV5", 
            "id": "PR_A2ALV5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017175979", 
            "id": "XP_017175979", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017175979.1", 
            "id": "XP_017175979.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5", 
            "id": "A2ALV5", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 168065.0, 
        "chemical_mass": 168065.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5", 
            "name": "Shoc1", 
            "locus": {}
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "3.6.-.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ALV5#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Protein shortage in chiasmata 1 ortholog"
        }
    ]
}