{
    "uniprot_canonical_ac": "A2RUB6-1", 
    "publication_count": 10, 
    "reported_interactions": 0, 
    "record_type": "protein", 
    "predicted_glycosites": 0, 
    "protein_names_refseq": "coiled-coil domain-containing protein 66 isoform 2; coiled-coil domain-containing protein 66", 
    "refseq_ac": "NP_001012524.4", 
    "reported_n_glycosites": 0, 
    "refseq_name": "coiled-coil domain-containing protein 66 isoform 2", 
    "record_id": "A2RUB6-1", 
    "protein_names_uniprotkb": "Coiled-coil domain-containing protein 66; Coiled-coil domain-containing protein 66", 
    "pathway": " (hsa:285331)", 
    "function": "Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors. Publication Status: Online-Only, [RefSeq]; Circ-CCDC66 accelerates proliferation and invasion of gastric cancer via binding to miRNA-1238-3p., [RefSeq]; HGF/c-Met regulates expression of SAE2 and cirRNA CCDC66 to increase epithelial-to-mesenchymal transition and drug resistance of lung adenocarcinoma cells. Publication Status: Online-Only, [RefSeq]; In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively. Taken together, these findings highlight a novel oncogenic function of circRNA in cancer progression and metastasis., [RefSeq]; Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Plays a role in retina morphogenesis and/or homeostasis (By similarity)., [UniProtKB]; Results associate a distinct retinal dystrophy phenotype with nicotinamide-nucleotide adenylyltransferase 1 protein (NMNAT1) mutation and suggest coiled-coil domain containing 66 (CCDC66) should not be considered a retinal dystrophy candidate gene., [RefSeq]; This is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of Hirschsprung's disease., [RefSeq]; This study identifies CCDC66 as a targeting factor for centrosome and cilium proteins, [RefSeq]", 
    "protein_name": "Coiled-coil domain-containing protein 66", 
    "reported_mutagensis": 1, 
    "reported_phosphosites": 6, 
    "reported_o_glycosites_with_glycan": 0, 
    "tax_id": 9606, 
    "organism": "Homo sapiens", 
    "disease": "", 
    "reported_glycation": 0, 
    "reported_snv": 11, 
    "mass": 109411.0, 
    "gene_names_uniprotkb": "CCDC66", 
    "reported_n_glycosites_with_glycan": 0, 
    "reported_o_glycosites": 0, 
    "gene_names_refseq": "CCDC66", 
    "gene_name": "CCDC66"
}