{
    "uniprot_canonical_ac": "A2APX8-1", 
    "publication_count": 13, 
    "reported_interactions": 0, 
    "record_type": "protein", 
    "predicted_glycosites": 4, 
    "protein_names_refseq": "sodium channel protein type 1 subunit alpha isoform 1; sodium channel protein type I subunit alpha; sodium channel protein brain I subunit alpha; voltage-gated sodium channel subunit alpha Nav1.1; sodium channel protein type 1 subunit alpha", 
    "refseq_ac": "NP_001300926.1", 
    "reported_n_glycosites": 0, 
    "refseq_name": "sodium channel protein type 1 subunit alpha isoform 1", 
    "record_id": "A2APX8-1", 
    "protein_names_uniprotkb": "Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1", 
    "pathway": " (mmu:20265); Phase 0 - rapid depolarisation (R-MMU-5576892)", 
    "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:16921370, PubMed:17928448, PubMed:27281198). Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons (PubMed:16921370, PubMed:22914087). Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli (PubMed:27281198)., [UniProtKB]", 
    "protein_name": "Sodium channel protein type 1 subunit alpha", 
    "reported_mutagensis": 1, 
    "reported_phosphosites": 9, 
    "reported_o_glycosites_with_glycan": 0, 
    "tax_id": 10090, 
    "organism": "Mus musculus", 
    "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); familial hemiplegic migraine 3 (Disease Ontology:DOID:0111183); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", 
    "reported_glycation": 0, 
    "reported_snv": 1, 
    "mass": 228800.0, 
    "gene_names_uniprotkb": "Scn1a", 
    "reported_n_glycosites_with_glycan": 1, 
    "reported_o_glycosites": 0, 
    "gene_names_refseq": "B230332M13; Nav; Nav1.1; Scn1a", 
    "gene_name": "Scn1a"
}