{
    "uniprot_canonical_ac": "A2AFR3-1", 
    "publication_count": 6, 
    "reported_interactions": 0, 
    "record_type": "protein", 
    "predicted_glycosites": 0, 
    "protein_names_refseq": "FERM and PDZ domain-containing protein 4 isoform a; PDZ domain-containing protein 10; PSD-95-interacting regulator of spine morphogenesis; FERM and PDZ domain-containing protein 4", 
    "refseq_ac": "NP_001028502.1", 
    "reported_n_glycosites": 0, 
    "refseq_name": "FERM and PDZ domain-containing protein 4 isoform a", 
    "record_id": "A2AFR3-1", 
    "protein_names_uniprotkb": "FERM and PDZ domain-containing protein 4; FERM and PDZ domain-containing protein 4; PDZ domain-containing protein 10; PSD-95-interacting regulator of spine morphogenesis; Preso", 
    "pathway": " (mmu:333605)", 
    "function": "Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate., [UniProtKB]; The findings point to an important role of FRMPD4 in normal cognitive development and function in humans and mice, and support the hypothesis that FRMPD4 mutations cause ID by disrupting dendritic spine morphogenesis in glutamatergic neurons., [RefSeq]; Uncoupling the linkage between Preso and PSD-95 attenuated the stability of this complex and suppressed the regulatory effect of Preso on the NO response. In addition, phosphorylation of NMDAR by cyclin-dependent kinase 5 (CDK5) was shown to be responsible for the Preso-mediated Ca(2+) response, which was dependent on the interaction between Preso and CDK5. Publication Status: Online-Only, [RefSeq]", 
    "protein_name": "FERM and PDZ domain-containing protein 4", 
    "reported_mutagensis": 0, 
    "reported_phosphosites": 0, 
    "reported_o_glycosites_with_glycan": 0, 
    "tax_id": 10090, 
    "organism": "Mus musculus", 
    "disease": "", 
    "reported_glycation": 0, 
    "reported_snv": 0, 
    "mass": 144978.0, 
    "gene_names_uniprotkb": "Frmpd4; Gm196; Kiaa0316; Pdzd10; Pdzk10", 
    "reported_n_glycosites_with_glycan": 0, 
    "reported_o_glycosites": 0, 
    "gene_names_refseq": "Frmpd4; Gm196; P; Pdzd1; Pdzd10; Pdzk1; Pdzk10; PK; PKAP1; Pr; preso; Preso1", 
    "gene_name": "Frmpd4"
}