{
    "uniprot_canonical_ac": "A2AF47-1", 
    "publication_count": 10, 
    "reported_interactions": 0, 
    "record_type": "protein", 
    "predicted_glycosites": 0, 
    "protein_names_refseq": "dedicator of cytokinesis protein 11; spleen specific 238 kDa protein with PH domain; ACG; zizimin-2; activated Cdc42-associated guanine nucleotide exchange factor", 
    "refseq_ac": "NP_001009947.2", 
    "reported_n_glycosites": 0, 
    "refseq_name": "dedicator of cytokinesis protein 11", 
    "record_id": "A2AF47-1", 
    "protein_names_uniprotkb": "Dedicator of cytokinesis protein 11; ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Dedicator of cytokinesis protein 11; Zizimin-2", 
    "pathway": " (mmu:75974); Factors involved in megakaryocyte development and platelet production (R-MMU-983231)", 
    "function": "Cloning of zizimin2; expressed predominantly in lymphocytes with an opposite pattern than zizimin1 [zizimin2], [RefSeq]; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997)., [UniProtKB]; These data suggested that Zizimin2 is associated with the reduction of immune response in acquired immunity along with aging., [RefSeq]; This study shows that Zizimin2 is involved in age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM, [RefSeq]", 
    "protein_name": "Dedicator of cytokinesis protein 11", 
    "reported_mutagensis": 0, 
    "reported_phosphosites": 10, 
    "reported_o_glycosites_with_glycan": 0, 
    "tax_id": 10090, 
    "organism": "Mus musculus", 
    "disease": "", 
    "reported_glycation": 0, 
    "reported_snv": 0, 
    "mass": 237771.0, 
    "gene_names_uniprotkb": "Dock11; Ziz2", 
    "reported_n_glycosites_with_glycan": 0, 
    "reported_o_glycosites": 0, 
    "gene_names_refseq": "5033414A21Rik; 8030476J24; sph238; Zizi; Zizimin2; Dock11", 
    "gene_name": "Dock11"
}