{ "uniprot_canonical_ac": "A3QPB9-1", "ptm_annotation": [], "sequence": { "header": "sp|A3QPB9-1|IL21_RAT Isoform 1 of Interleukin-21 OS=Rattus norvegicus OX=10116 GN=Il21 PE=2 SV=1 CANONICAL=A3QPB9-1", "length": 146, "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS" }, "uniprot_id": "IL21_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11081504", "type": [ "PubMed" ], "id": "11081504" } ], "title": "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" } ], "authors": "Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12244150", "type": [ "PubMed" ], "id": "12244150" } ], "title": "IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" } ], "authors": "Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12504082", "type": [ "PubMed" ], "id": "12504082" } ], "title": "Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" } ], "authors": "Zhang JL, Foster D, Sebald W", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14635054", "type": [ "PubMed" ], "id": "14635054" } ], "title": "IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors.", "journal": "European journal of immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" } ], "authors": "Sivori S, Cantoni C, Parolini S, Marcenaro E, Conte R, Moretta L, Moretta A", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14764669", "type": [ "PubMed" ], "id": "14764669" } ], "title": "IL-21 induces the functional maturation of murine NK cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" } ], "authors": "Brady J, Hayakawa Y, Smyth MJ, Nutt SL", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18802358", "type": [ "PubMed" ], "id": "18802358" } ], "title": "A common exonic variant of interleukin21 confers susceptibility to atopic asthma.", "journal": "International archives of allergy and immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" } ], "authors": "Chatterjee R, Batra J, Ghosh B", "date": "2009" } ], "uniprot_ac": "A3QPB9", "site_annotation": [ { "end_pos": 87, "annotation": "n_glycosylation_sequon", "start_pos": 85 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9#A3QPB9-1", "isoform_ac": "A3QPB9-1", "locus": { "end_pos": 123965024, "strand": "+", "start_pos": 123972356, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000023348", "id": "ENSRNOT00000023348", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000023348", "id": "ENSRNOP00000023348", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3QPB9-1|IL21_RAT Isoform 1 of Interleukin-21 OS=Rattus norvegicus OX=10116 GN=Il21 PE=2 SV=1 CANONICAL=A3QPB9-1", "length": 146, "sequence": "MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365769", "resource": "KEGG Pathway", "id": "rno:365769", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020958", "resource": "Reactome", "id": "R-RNO-9020958", "name": "Interleukin-21 signaling" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9#function", "annotation": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9#function", "id": "A3QPB9", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9ES17-1", "protein_name": "Interleukin-21", "sequence": { "length": 146, "sequence": "MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11032", "id": "11032", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A3QPB9/", "id": "A3QPB9", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9HBE4-1", "protein_name": "Interleukin-21", "sequence": { "length": 162, "sequence": "MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11032", "id": "11032", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "ac": "NP_001102413.1", "name": "interleukin-21 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "cytokine activity", "id": "GO:0005125" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005134", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "interleukin-2 receptor binding", "id": "GO:0005134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005126", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "cytokine receptor binding", "id": "GO:0005126" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032740", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-17 production", "id": "GO:0032740" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of cell population proliferation", "id": "GO:0008284" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001819", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of cytokine production", "id": "GO:0001819" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002314", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "germinal center B cell differentiation", "id": "GO:0002314" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030890", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of B cell proliferation", "id": "GO:0030890" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-gamma production", "id": "GO:0032729" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042102", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of T cell proliferation", "id": "GO:0042102" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048469", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "cell maturation", "id": "GO:0048469" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098586", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "cellular response to virus", "id": "GO:0098586" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042531", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of tyrosine phosphorylation of STAT protein", "id": "GO:0042531" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002377", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "immunoglobulin production", "id": "GO:0002377" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032733", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-10 production", "id": "GO:0032733" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007260", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "tyrosine phosphorylation of STAT protein", "id": "GO:0007260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032825", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of natural killer cell differentiation", "id": "GO:0032825" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002729", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "positive regulation of natural killer cell cytokine production", "id": "GO:0002729" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061470", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "id": "A3QPB9", "database": "UniProtKB" } ], "name": "T follicular helper cell differentiation", "id": "GO:0061470" } ], "total": 17, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3QPB9", "type": "synonym", "resource": "RefSeq", "name": "IL-21" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3QPB9", "type": "synonym", "resource": "RefSeq", "name": "Il21" }, { "url": "https://www.uniprot.org/uniprot/A3QPB9", "type": "recommended", "resource": "UniProtKB", "name": "Il21" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017376", "id": "ENSRNOG00000017376", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/365769", "id": "365769", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003443", "id": "IPR003443", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009079", "id": "IPR009079", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038327", "id": "IPR038327", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365769", "id": "rno:365769", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/HCEWSAF/", "id": "HCEWSAF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1439856at2759", "id": "1439856at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14356", "id": "PTHR14356", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02372", "id": "PF02372", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A3QPB9", "id": "PR_A3QPB9", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9020958", "id": "R-RNO-9020958", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413.1", "id": "NP_001102413.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307384", "id": "1307384", "database": "RGD" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 85, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9#ptm_processing", "id": "A3QPB9", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 85, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 17065.0, "chemical_mass": 17065.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "name": "Il21", "locus": { "end_pos": 123965021, "strand": "-", "start_pos": 123972356, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000017376", "id": "ENSRNOG00000017376", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A3QPB9", "type": "synonym", "resource": "UniProtKB", "name": "IL-21" }, { "url": "https://www.uniprot.org/uniprot/A3QPB9", "type": "recommended", "resource": "UniProtKB", "name": "Interleukin-21" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3QPB9", "type": "synonym", "resource": "RefSeq", "name": "interleukin-21 precursor" } ] }